CN113729153A - Formula and preparation method of plant selenium earthworm and tempeh tablet - Google Patents
Formula and preparation method of plant selenium earthworm and tempeh tablet Download PDFInfo
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- CN113729153A CN113729153A CN202111073811.0A CN202111073811A CN113729153A CN 113729153 A CN113729153 A CN 113729153A CN 202111073811 A CN202111073811 A CN 202111073811A CN 113729153 A CN113729153 A CN 113729153A
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- tempeh
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Abstract
The invention discloses a formula of a plant selenium earthworm and tempeh slice, which comprises the following components: selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, chicken's gizzard-membrane and food rich in bamboo leaf flavone. The medicinal composition provided by the invention has the advantages that through scientific and reasonable compatibility of the components, the components supplement each other, the immunity of a human body can be improved, and meanwhile, the anti-tumor effect can be realized; and the components are both used as medicine and food, are safe and reliable, have no toxic or side effect, and are economical and practical.
Description
Technical Field
The invention relates to a formula of a plant selenium earthworm and tempeh tablet.
Background
Health is a big phenomenon of civilian life, wherein the trace element selenium has irreplaceable effect on human health, and scientific research shows that the selenium is a trace element necessary for human bodies. The Chinese Nutrition society lists selenium as one of the 15 nutrients essential to human body, and a large number of clinical experiments at home and abroad prove that the selenium deficiency of human body can cause dysfunction of some important organs to cause a plurality of serious diseases, 40 countries all over the world are in selenium deficiency areas, a plurality of hundred million of 22 provinces of China are in selenium deficiency or low selenium zones, and the incidence of tumors, liver diseases, cardiovascular diseases and the like of population in the areas is high. Research shows that the people with low selenium or selenium deficiency can prevent tumor, liver disease, etc. by supplementing selenium with proper amount, improve immunity, maintain normal functions of heart, liver, lung, stomach and other important organs, and prevent senile cardiovascular and cerebrovascular diseases.
Selenium is called heart protection spirit by medical and nutritional circles at home and abroad, and selenium protects the hypoxic injury of the heart. (1) Selenium has effect in protecting myocardial cell membrane system permeability, and can maintain normal metabolism of cell; when the lesion develops into structural damage, selenium can stabilize the integrity of the membrane structure and delay the occurrence of irreversible damage. (2) Selenium can reduce blood lipid and prevent fatty liver. Selenium supplement can significantly reduce cholesterol, triglycerides and low density lipoprotein levels, and significantly increase high density lipoprotein levels. (3) Selenium reduces blood viscosity and reduces thrombosis. (4) The selenium supplement for patients with hypertension and hyperlipemia can reduce the viscosity of blood in vivo, promote the biosynthesis of blood-relaxing factor PGI2, coenzyme Q and coenzyme A in vivo, and achieve the effect of reducing blood pressure. In addition, the selenium supplement for the hyperlipemia patients can improve the function of the body antioxidant protection system, regulate the blood lipid metabolism in vivo and prevent the generation of various complications caused by high blood lipid.
Disclosure of Invention
The technical problem to be solved by the invention is to provide a formula of plant selenium earthworm and tempeh tablet, which is prepared by scientifically and reasonably matching a plurality of components, wherein the components supplement each other, maintain the balance of functions in vivo by regulating the endocrine of an organism, support the healthy energy and combine treatment and maintenance, can improve the immunity of a human body, reduce blood fat and blood pressure, regulate intestines and stomach, strengthen stomach, promote digestion and remove calculi, effectively block a path for synthesizing cholesterol, and play a role in treating and preventing cardiovascular and cerebrovascular diseases; the composition has good effect of dissolving thrombus in blood vessels, can clean impurities in the blood vessels, has the effect of softening the blood vessels, can promote the hardened capillaries to recover vitality, and can effectively dissolve thrombus and prevent cardiovascular and cerebrovascular diseases such as myocardial infarction, cerebral apoplexy and the like; reducing platelet clotting, preventing the occurrence of thrombosis, preventing the occurrence of atherosclerosis and coronary heart disease; meanwhile, the composition can also resist tumors; the components are both medicinal and edible, are safe and reliable, have no toxic or side effect, are economical and practical, are convenient to carry, and can obviously improve the immunity of the organism, protect the health of the body, prevent the invasion of exogenous pathogenic factors, reduce the probability of infection diseases of a user, improve the life quality and improve the working efficiency after being taken for a long time; has the characteristics of long-term use, safety, reliability, economy and practicability, and has wide market prospect.
In order to solve the technical problems, the formula of the plant selenium earthworm tempeh tablet comprises the following components: selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, chicken's gizzard-membrane and food rich in bamboo leaf flavone.
As an improved technical scheme, the formula of the plant selenium earthworm tempeh tablet comprises the following components in parts by weight: 0.05-3 parts of selenium-enriched food, 5-20 parts of red yeast rice, 6-8 parts of earthworm protein food, 10-15 parts of tempeh, 10-15 parts of peach kernel, 5-10 parts of black fungus, 8-13 parts of hawthorn flavone, 8-11 parts of endothelium corneum gigeriae galli and 3-5 parts of bamboo leaf flavone-enriched food, wherein the sum of the components is equal to 100.
As an improved technical scheme, the selenium-enriched food comprises one or a mixture of two of plant active selenium food and artificial organic selenium food.
As an improved technical scheme, the red yeast rice is prepared by fermenting rice such as indica rice, japonica rice, glutinous rice and the like serving as raw materials by monascus mould, and preparing one or two of granular or powdery black rice residues after pigment extraction.
As an improved technical scheme, the earthworm protein is active earthworm protein, and the content of the active earthworm protein is 65%.
As an improved technical scheme, the tempeh is low-purine tempeh, wherein the purine content in the tempeh is lower than 30 mg/g.
As an improved technical scheme, the peach kernel is oily or powdery, the peach kernel comprises 95-99.9% of triglyceride, 0.01-3% of diglyceride, 0.01-0.5% of monoglyceride, 0.1-1.5% of sitosterol and 0.01-0.5% of cyclolanosterol, and the sum of the components is equal to 100%.
As an improved technical scheme, the black fungus is black fungus superfine powder which can be sieved by a 200-300-mesh sieve.
The preparation method of the plant selenium Tongtong tablet comprises the following steps:
(1) selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, endothelium corneum gigeriae galli and powder of food rich in bamboo leaf flavone are prepared by selecting and cleaning the food without rottenness, then ventilating and drying the cleaned food at the temperature of 80 ℃, carrying out superfine grinding and sieving the powder by a 100-mesh sieve;
(2) mixing the solid powder obtained in the step (1) with oligosaccharide, sorbitol and magnesium stearate according to the formula parts, and fully mixing to ensure that the colloid is uniform;
(3) and (3) directly tabletting the mixed powder obtained in the step (2) to obtain edible tablets, and filling the edible tablets to obtain the product.
The invention has the following advantages: aiming at the characteristics of fast pace of life, high working pressure, unreasonable dietary structure, environmental pollution and the like of people in the present society, the pharmaceutical composition of the invention scientifically and reasonably combines a plurality of components which supplement each other, maintains the balance of functions in vivo by regulating the endocrine of organisms, supports the healthy energy, combines treatment and nourishment, can improve the immunity of human bodies, and simultaneously can resist tumors; the components are both medicinal and edible, are safe and reliable, have no toxic or side effect, are economical and practical, are convenient to carry, and can obviously improve the immunity of the organism, protect the health of the body, prevent the invasion of exogenous pathogenic factors, reduce the probability of infection diseases of a user, improve the life quality and improve the working efficiency after being taken for a long time. Has the characteristics of long-term use, safety, reliability, economy and practicability, and has wide market prospect.
Detailed Description
In order to more clearly illustrate the invention, the invention is further described below in connection with preferred embodiments. It is to be understood by persons skilled in the art that the following detailed description is illustrative and not restrictive, and is not to be taken as limiting the scope of the invention.
The formula of the plant selenium earthworm and tempeh tablet comprises the following components: selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, endothelium corneum gigeriae galli and food rich in bamboo leaf flavone; the formula of the plant selenium earthworm and tempeh tablet comprises the following components in parts by weight: 0.05-3 parts of selenium-enriched food, 5-20 parts of red yeast rice, 6-8 parts of earthworm protein food, 10-15 parts of tempeh, 10-15 parts of peach kernel, 5-10 parts of black fungus, 8-13 parts of hawthorn flavone, 8-11 parts of endothelium corneum gigeriae galli and 3-5 parts of bamboo leaf flavone-enriched food, wherein the sum of the components is equal to 100.
The selenium-rich food comprises one or a mixture of plant active selenium food and artificial organic selenium food; in the present embodiment, a plant active selenium food is used, which is composed of broccoli, shepherd's purse and rape, wherein broccoli is the main component, broccoli is the accepted "first anti-cancer vegetable", has abundant nutritive value, is rich in glucosinolate, and glucosinolate can be converted into isothiocyanate under the action of glucosidase to exert anti-cancer effect, which is one of the best anti-cancer substances in the current research. Selenium contained in the broccoli is a trace element necessary for human bodies, has an important role in maintaining normal metabolism of the human bodies, particularly the functions of autoimmune functions, local substance energy metabolism and important endocrine organs of the human bodies, and once lacking, not only can easily cause normal development disorder, but also can promote various diseases to occur. In 2003, selenium was recognized by the U.S. food and drug administration as an anticancer agent, which is a formal statement by the U.S. government on the antitumor ability of selenium.
The red yeast rice is prepared by fermenting rice such as indica rice, japonica rice, glutinous rice and the like serving as raw materials by monascus mould, and preparing one or two of granular or powdery black rice residues after pigment extraction. Wherein, one quasi-character medicine is named as Xuezhikang, and only one component is red yeast rice. In recent years, pharmacologists find that the red yeast rice is an excellent natural medicine for reducing blood fat and blood pressure. Cardiovascular and cerebrovascular diseases are the first killers threatening the lives of the middle-aged and elderly people at present, and hyperlipidemia and hypercholesterolemia are one of the main causes. Red yeast rice is extracted from selenium holy plant research and development laboratories, and the selenium holy is a professional company dedicated to animal and plant extracts by parents, and has advanced technology and mature process. The lovastatin content of the product reaches the dosage of western medicines, and is pure natural. Cholesterol accumulated in human body in real life mainly passes through two major ways, namely exogenous cholesterol from diet, which accounts for 1/4; endogenous means that the ratio of self-synthesis is 3/4, the largest. The metabolic pathway indicates that the human body needs to carry out a series of metabolic processes for synthesizing the cholesterol, wherein the key point is that hydroxymethyl pentadecanyl coenzyme A (HMG-CoA) generates mevalonic acid under the action of reductase (HMG-CoA-R) of the hydroxymethyl pentadecanyl coenzyme A, and then the cholesterol is further synthesized. The effective components in the red yeast rice are competitive inhibitors of HMG-CoA reductase, thereby blocking the pathway of synthesizing cholesterol and playing the role of treating and preventing cardiovascular and cerebrovascular diseases.
The earthworm protein is active earthworm protein, and the protein content of the active earthworm protein is 65%.
The earthworm protein is a common medicine for treating blood diseases, has a good effect of dissolving thrombus in blood vessels, can clean impurities in the blood vessels, also has an effect of softening the blood vessels, can promote the recovery of hardened capillaries, is a blood cleaner, can regularly and greatly clean blood, and has a good effect of preventing cardiovascular diseases. Wherein, part of earthworm peptide can regulate the cholesterol metabolism of human body;
dissolving large and small thrombi: thrombus is a "timing bomb" in the human body, which travels along with blood throughout the body where it is narrowly blocked. Especially middle-aged and elderly people with hyperlipidemia, blood viscosity and hypertension are easy to form thrombus and block blood vessels, so that the sudden onset of malignant events such as cerebral thrombosis, cerebral embolism, cerebral hemorrhage, cerebral apoplexy, angina pectoris, myocardial infarction and the like is caused, and the life is threatened; the earthworm protein can not only dissolve large thrombus, but also enter microvessels which are 20 times thinner than hair, dissolve tiny thrombus and improve microcirculation. Generally speaking, the earthworm protein is equivalent to the protection spirit of systemic blood vessels, can dredge the systemic large and small blood vessels and micro blood vessels, and prevent serious diseases;
cleaning the first enemy 'blood stain' in the blood vessel: blood stains are hard masses, plaques and deposits of long-term unhealthy diet and blood impurities deposited on the vessel wall, including cholesterol, triglycerides, low density lipoproteins, and the like. Blood stain is similar to rust spots on an aged water pipe, so that arteriosclerosis and stenosis are caused, and diseases of the aorta such as heart, brain, liver, kidney and the like are caused; further, the elasticity of the blood vessel wall is reduced, and the pressure resistance is weakened, resulting in fluctuation of blood pressure. The earthworm protein can dissolve fibrin network on the vessel wall, thereby cleaning blood dirt attached on the earthworm protein, further dredging the vessel and recovering the elasticity of the vessel. Like washing the dirty objects on hands with soap, the earthworm protein is neutralized with blood dirt, and the blood dirt is decomposed and liquefied.
Restoration of systemic sclerosis of capillaries to the vital organs: the microvessels, also called capillaries, are the "basal blood vessels" that are in direct contact with the tissue cells of the whole body, and they are densely distributed around the cells and function as the numerous "small canals" in the field for irrigating the seedlings. The cells draw nutrients and oxygen from the capillaries, and their metabolic waste products are also excreted through the capillaries.
On one hand, the earthworm protein is a cleaner and is used for regularly and greatly sweeping blood and blood vessels; on the other hand, earthworm protein is also used by police to dredge, from large to arteries to small to microvasculature, where there is a blockage, where it is to be dredged. The earthworm protein is also a mason, and is used for repairing and repairing the aged and hardened vascular wall and restoring the smoothness and elasticity of the blood vessel.
The tempeh is low-purine tempeh, wherein the purine content in the tempeh is lower than 30 mg/g. The following are the beneficial effects of tempeh:
the tempeh contains thrombolytics kinase, and like nattokinase, can effectively dissolve thrombus and prevent cardiovascular and cerebrovascular diseases such as myocardial infarction, cerebral apoplexy and the like. The onset time of various thrombotic diseases is mostly in the early morning, so that the tempeh kinase is removed when the tempeh is eaten at night, and the activity can be maintained until the early morning. The daily adherence to the diet in the morning and at night can ensure the thrombolytic effect of the tempeh to be exerted for a whole day. The health is more guaranteed.
Tempeh is a dietary fiber-rich food that swells in the intestinal tract by absorbing water, accelerating the passage of stool through the intestinal tract. Every 100 g of the tempeh contains 6 g of dietary fiber, 1.6 g of sweet potato and 1.2 g of banana in the same amount. A person needs 25 grams of dietary fiber per day, eating a box of tempeh, equal to 24% of the total demand ingested. If you insist on eating every day, constipation can be prevented and improved.
Tempeh does not contain cholesterol, but is rich in vegetable proteins and beneficial fatty acids. Animal experiments show that the tempeh can reduce 60-70% of cholesterol in blood and triglyceride, and has obvious improvement effect on people with high blood fat and blood pressure.
The peach kernel is oily or powdery, and comprises 95-99.9% of triglyceride, 0.01-3% of diglyceride, 0.01-0.5% of monoglyceride, 0.1-1.5% of sitosterol and 0.01-0.5% of cyclolanosterol, wherein the sum of the components is equal to 100%. Has the effects of promoting blood circulation, removing blood stasis, loosening bowel to relieve constipation, and relieving cough and asthma. Can be used for treating amenorrhea, dysmenorrhea, abdominal mass, pulmonary abscess, intestinal carbuncle, traumatic injury, constipation due to intestinal dryness, cough, and asthma.
The black fungus is black fungus superfine powder which can be sieved by a 200-300-mesh sieve. The black fungus for replenishing qi and blood is praised as 'meat in vegetable' and 'king of vegetable food' by nutriologists, each 100 g of black fungus contains 185 mg of iron, is 20 times higher than spinach with the highest iron content in green leaf vegetables and is about 7 times higher than pork liver with the highest iron content in animal food, is food with the highest iron content in various meat and vegetable foods, has the effects of nourishing blood and retaining youthful looks, can make human skin ruddy and glow, can also prevent and treat iron-deficiency anemia, reduce platelet clot, prevent thrombus and prevent atherosclerosis and coronary heart disease.
The nutritional value is as follows: the black fungus has rich iron content, so that the black fungus can nourish blood, preserve youthful looks, make skin ruddy, glow and prevent and treat iron-deficiency anemia after being frequently eaten. The Auricularia contains vitamin K, and has effects of reducing blood clot, preventing thrombosis, and preventing and treating atherosclerosis and coronary heart disease. The colloid in the black fungus can adsorb and concentrate dust and impurities remained in the digestive system of human body and discharge the dust and impurities out of the body, thereby playing a role in clearing stomach and intestines.
The hawthorn flavone is extracted from dried hawthorn, the hawthorn flavone has the functions of reducing blood fat and resisting atherosclerosis, and can obviously reduce the concentration of serum Total Cholesterol (TC), low-density lipoprotein cholesterol (I.DI-C) and apolipoprotein B (ApoB) of experimental hyperlipidemic animals, and obviously increase the concentration of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A (ApoA), but has little influence on Triglyceride (TG). The hawthorn fruit has the function of reducing blood fat by inhibiting the synthesis of liver cholesterol and promoting the liver to take the effect of reducing blood fat on human body of plasma cholesterol. The fructus crataegi flavone can also reduce risk of Atherosclerosis (AS), and prevent AS development.
Effect on the cardiovascular system: the hawthorn has a protective effect on acute experimental myocardial ischemia. The hawthorn flavone and hydrolysate increase the ischemic myocardial nutritive blood flow, wherein the hawthorn hydrolysate has the strongest effect. The hawthorn can increase coronary blood flow, reduce myocardial oxygen consumption and improve oxygen utilization rate. The hawthorn flavone has the function of improving the ischemic electrocardiogram of animals. The hawthorn flavone can reduce the range of rabbit experimental myocardial infarction. The product has effects in strengthening heart, and promoting myocardial contraction and cardiac output. The fructus crataegi extract has effects of enhancing myocardial contractility for in vivo and in vitro heart of Bufo siccus, and has long action duration. The definite active ingredients are 3 ', 4', 5, 7-tetrahydroxyflavone-7-glucoside and rutin; blood pressure reduction, intravenous administration of hawthorn flavone, triterpenic acid, abdominal cavity and duodenum all show certain blood pressure reduction effect, and the action mechanism of the hawthorn flavone and triterpenic acid is mainly related to peripheral blood vessel dilation. The hawthorn and hawthorn flavone have antioxidation, can obviously reduce the content of Malondialdehyde (MDA) in serum and liver, enhance the activity of superoxide dismutase (SOD) of erythrocyte and liver, and simultaneously enhance the activity of glutathione peroxidase (GSH-Px) in blood plasma.
Endothelium corneum gigeriae galli: has high nutritive value, is a finished product of the chicken stomach inner wall skin after being dried in the sun, and has the effects of invigorating stomach, promoting digestion and removing calculus. A person with symptoms of dyspepsia, which indicates an aging of the intestine and an imbalance of the microbial flora in the intestine. The intestinal tract can not discharge redundant cholesterol in the body during aging, so that the cholesterol is accumulated in the body and is easy to cause high cholesterol. Dyspepsia is a trigger factor for cardiovascular and cerebrovascular diseases.
The bamboo leaf flavone in the bamboo leaf flavone food has the following functions:
1. the bamboo leaf flavone for protecting cardiovascular and cerebrovascular has the functions of reducing blood fat, inhibiting platelet aggregation and thrombosis, and has the health-care function of assisting in protecting cardiovascular and cerebrovascular. The rise of dyslipidemia is one of the risk factors of the attack of cardiovascular and cerebrovascular diseases, reduces the overhigh low-density lipoprotein cholesterol, total cholesterol and triglyceride in serum, improves the level of the high-density lipoprotein cholesterol, and is beneficial to preventing the cardiovascular and cerebrovascular diseases. The bamboo leaf flavone extract can obviously reduce the concentration of triglyceride, total cholesterol and LDL-cholesterol in the blood of SD rats, the medium-dose and high-dose groups can obviously improve the concentration of HDLC cholesterol, and the effect of reducing blood fat is equivalent to that of the ginkgo biloba extract. The bamboo leaf flavone extract can obviously improve the protection rate of the mouse with the pulmonary thrombosis induced by the collagen-epinephrine mixed inducer, and has significant difference (p is less than 0.05) compared with the normal saline; the bamboo leaf flavone extract can obviously inhibit the formation of carotid artery thrombosis of the rabbit, and can obviously prolong the thrombin time and prothrombin time of the rabbit.
2. Antioxidant bamboo leaf flavone has antioxidant effect. The bamboo leaf flavone has the functions of obviously reducing lipid peroxidation and increasing the activity of superoxide dismutase (SOD) and glutathione peroxidase. SOD is widely present in aerobic cells, is the most important enzyme in an organism antioxidant defense system, and the SOD-like activity becomes an important index of anti-aging medicaments and health-care foods. The SOD activity is measured by pyrogallol autoxidation, which proves that bamboo leaf flavone has excellent SOD-like activity and can be used as a new resource of an antioxidant functional factor to be researched.
3. The bamboo leaf flavone has an inhibiting effect on food pathogenic bacteria such as certain bacteria, mould and yeast, has a strong inhibiting effect on bacteria and escherichia coli, and has a weak inhibiting effect on the mould and the yeast. Research shows that the bamboo leaf flavone extract has different degrees of inhibiting effect on seven kinds of common urinary tract pathogenic bacteria, such as enterococcus faecalis, Streptococcus pyogenes and the like.
4. The bamboo leaf flavone with the function of regulating immunity can promote the generation of antibodies in a mouse body, improve the immune function of mouse cells and enhance the phagocytic function of macrophages in the abdominal cavity of the mouse. Researches prove that the bamboo leaf flavone can obviously improve the content of DNA and RNA in mouse spleen cells within a certain dosage range, promote the synthesis of DNA and protein of the spleen cells and further promote cell proliferation; meanwhile, the expression of IFN gamma mRNA of mouse spleen cells and the generation and secretion of IFN gamma are promoted, the IFN gamma activates NK cells in turn, T, B cell differentiation and CTL maturation are promoted, B cells are stimulated to secrete antibodies, and the immune regulation effect is enhanced.
5. Blocking nitrosamine reactions is one of the most interesting carcinogens today and it has been reported that of about 130N-nitroso compounds tested, about 80% are carcinogenic and blocking nitrosamine synthesis or scavenging precursors of synthetic nitrosamines is an effective way to prevent cancer. Research shows that the bamboo leaf flavone extract can effectively eliminate nitrite and block the synthesis of strong carcinogenic N-nitrosamine to some extent. And the composition shows obvious gradient change along with the increase of the mass concentration within a certain range, when the mass concentration reaches a certain value, the clearance rate and the blocking rate are slightly improved and tend to be stable, and the biological activity similar to that of vitamin C and extracts of hawthorn and garlic is shown, namely the cancer prevention and anticancer effect is achieved.
6. The flavonoid compound with the functions of resisting depression and improving memory has the functions of resisting depression and improving memory. The anti-depression activity of the bamboo leaf flavone is researched by using anti-depression evaluation models such as a mouse tail suspension test, a mouse forced swimming test, a 5-hydroxytryptophan induced mouse head shaking test, apomorphine induced mouse temperature reduction and the like, and the result shows that the bamboo leaf flavone has the anti-depression activity, and the anti-depression effect of the bamboo leaf flavone is possibly related to the improvement of brain tissue nutrition and microcirculation. Herein, "fresh" refers to the original product without any manual treatment. The "extract" refers to an extract obtained by extracting a raw material with an appropriate solvent, and the extraction method is not limited, and a method conventional in the art may be selected as needed. The "effective component" is a component in the raw material which plays a role in the metabolism or chemical reaction of the organism. Excipients may be added to the aforementioned component compositions as needed. Such excipients include, but are not limited to, starch, sugar, water, ethanol, honey, sodium carboxymethyl starch, microcrystalline cellulose, flavors, surfactants, and mixtures thereof.
The preparation method of the pharmaceutical composition of the invention is different according to different formulations, and comprises the steps of crushing and mixing, or extracting and mixing by using a proper reagent, or extracting by using a proper reagent after mixing, and carrying out conventional post-treatment according to the required formulations; the pharmaceutical composition of the present invention can be applied in the fields including but not limited to medical treatment, prevention, health care, beauty treatment, cosmetics, etc.
The preparation method of the formula of the plant selenium earthworm tempeh tablet comprises the following steps:
(1) selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, endothelium corneum gigeriae galli and food powder rich in bamboo leaf flavone are prepared by selecting and cleaning the selenium-enriched food without rotting, then ventilating and drying the cleaned food at 80 ℃, carrying out superfine grinding and sieving the powder with a 100-mesh sieve.
(2) Mixing the solid powder obtained in the step (1) with oligosaccharide, sorbitol and magnesium stearate according to the formula parts, fully mixing to make the colloid uniformly mixed for 30 minutes, adding the mixed powder, then using 60% ethanol solution as a wetting agent, continuously mixing uniformly,
(3) and (3) directly tabletting the mixed powder obtained in the step (2) to obtain edible tablets, finally adding magnesium stearate, tabletting by using a tabletting machine, and filling the edible tablets to obtain the product.
The curative effect evaluation experiment of the invention:
and (3) testing: the sample prepared by the embodiment of the invention is used for evaluating the effects of improving the immunity of animals and resisting tumors in vivo.
Materials and methods
1.1 animals and tumor strains
Kunming healthy mice, the body mass is 18-22g, the age is 6-8 weeks, and the mice can be used as both male and female;
transplanted tumor S180 ascites type mice.
1.2 materials and reagents
Prepared samples (prepared into solution with concentration required by experiment, 2 mg/ml);
india ink;
phosphate Buffered Saline (PBS): contains 8g of NaCl, 0.2g of KCl and 1.44g of Na2HPO4、0.24gKH2PO4、1000mlH2O。
1.3 instruments and devices
A single beam uv-vis spectrophotometer;
an electronic analytical balance.
1. Effect of samples of the examples of the present invention on thymus and spleen indices of mouse immune organs
24 mice, male and female halves, were taken and randomly divided into 2 groups, i.e., a physiological saline group and a sample group. Each group had 12. The administration was performed once daily for 10 days, with each group administered by gavage at 10 ml/kg. Mice had free access to food and water.
12h after the last dose, the mice were sacrificed by cervical dislocation and dissected, the thymus and spleen were removed, surface blood was aspirated, their mass was weighed with an analytical balance, and thymus and spleen indices were calculated according to formula (l):
thymus (or spleen) index (mg/g) ═ mass of organ (mg)/body mass of mouse (g)
(1) The results are shown in Table 1.
TABLE 1 Effect of samples on mouse immune organ thymus and spleen indices (X + -s, n-12)
Group of | Thymus index (mg/g) | Growth rate of thymus | Spleen index (mg/g) | Growth rate of spleen |
Physiological saline group | 2.65±0.23 | 9.43±0.43 | ||
Sample set | 3.68±0.16* | 38.9% | 12.16±0.68* | 29.0% |
Note: p <0.05 compared to saline group.
2. The effect of the samples of the examples of the invention on the ability of the mouse reticuloendothelial system to phagocytose inert carbon particles in the clearance blood stream.
24 Kunming mice with the body mass of 18-22g and males are randomly divided into 2 groups, namely a physiological saline group and a sample group. Each group had 12. The administration was performed once daily for 10 days, with each group administered by gavage at 10 ml/kg. Mice had free access to food and water.
24h after the last administration, mice were injected with 4 times diluted India ink 10ml/kg via tail vein, and the time is recorded immediately (the injection is abandoned), and 1min and 10min after injection of the ink, 0.05ml blood is collected under mouse orbit, 4ml 0.1% Na is insufflated2CO3In solution. Killing the mouse by removing cervical vertebra, taking liver, spleen and thymus, weighing the liver, spleen and thymus by using an analytical balance, and adding lyso Na2CO3The solution was shaken up and colorimetric at 675nm recording the absorbance lambda, calculating the phagocytic index k according to formula (2), the phagocytic coefficient (corrected phagocytic index) alpha according to formula (3) and the growth rate of each index according to formula (4): k ═ k (lgc1-lgc2)/(t1-t2)
Wherein t1 and t2 respectively represent that ink is injected for 1min and 10 min; c1 and c2 represent the concentrations of carbon particles in blood at times t1 and t 2;
the results of comparing the group of drugs with the control group are shown in Table 2. TABLE 2 Effect of samples on the ability of the mouse reticuloendothelial system to phagocytose inert carbon granules in the clearance blood stream (X + -s, n-12)
Note: p <0.05 compared to saline group.
From the experimental results, the pharmaceutical composition of the present invention has: promoting the proliferation of thymus and spleen of mice; the capability of phagocytizing and treating inert carbon granules in blood flow by a mouse reticuloendothelial system is improved; and has very obvious in-vivo anti-tumor effect on S180 tumor mice. It can enhance the nonspecific and specific immune functions of mouse. The composition of the present invention is considered to have the effects of anti-tumor and enhancing immunity.
According to one of ten functions of selenium, selenium is used for protecting the heart, traditional medicine and modern medicine are combined, and more than 30 thrombolytic diet medicine products for preventing and treating cardiovascular and cerebrovascular diseases are simplified in the aspect of reproduction and prescription. The key point is that the modern medical theory of red yeast rice, earthworm protein and tempeh is combined with the traditional Chinese medicine to utilize ingredients such as peach kernels and the like which are called by the general of the great general of breaking blood and removing blood stasis, and the selenium content is prone to be provided. Each expert is interested in talking about the latest ideas, methods and experiences. Forming a batching list and a formula.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (9)
1. The formula of the plant selenium earthworm and tempeh tablet is characterized by comprising the following components: selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, chicken's gizzard-membrane and food rich in bamboo leaf flavone.
2. The formula of the plant selenium earthworm and tempeh slice formula of claim 1, wherein the formula of the plant selenium earthworm and tempeh slice formula comprises the following components in parts by weight: 0.05-3 parts of selenium-enriched food, 5-20 parts of red yeast rice, 6-8 parts of earthworm protein food, 10-15 parts of tempeh, 10-15 parts of peach kernel, 5-10 parts of black fungus, 8-13 parts of hawthorn flavone, 8-11 parts of endothelium corneum gigeriae galli and 3-5 parts of bamboo leaf flavone-enriched food, wherein the sum of the components is equal to 100.
3. The formula of the plant selenium earthworm and tempeh slice formula of claim 1, wherein the selenium-enriched food comprises one or a mixture of plant active selenium food and artificial organic selenium food.
4. The formula of the plant selenium earthworm and tempeh slice as claimed in claim 1, wherein the red yeast rice is prepared by fermenting rice such as indica rice, japonica rice and glutinous rice with monascus, and the black rice residue is prepared into one or two of granular or powdery forms after pigment extraction.
5. The formula of the plant selenium earthworm and tempeh tablet formulation of claim 1, wherein the earthworm protein is active earthworm protein, and the protein content of the active earthworm protein is 65%.
6. The formula of the plant selenium earthworm tempeh tablet as claimed in claim 1, wherein the tempeh is low-purine tempeh, and purine content in the tempeh is lower than 30 mg/g.
7. The formula of the plant selenium earthworm and tempeh tablet as claimed in claim 1, wherein the peach kernel is oily or powdery, the peach kernel comprises 95-99.9% of triglyceride, 0.01-3% of diglyceride, 0.01-0.5% of monoglyceride, 0.1-1.5% of sitosterol, 0.01-0.5% of cyclolanosterol, and the sum of the components is equal to 100%.
8. The formula of the plant selenium earthworm and tempeh slice as claimed in claim 1, wherein the black fungus is black fungus superfine powder which can be sieved by a 200-300 mesh sieve.
9. The formula of the plant selenium earthworm and tempeh tablet formulation of any one of claims 1 to 8, wherein the preparation method of the plant selenium Tongtong tablet comprises the following steps:
(1) selenium-enriched food, red yeast rice, earthworm protein, tempeh, peach kernel, black fungus, hawthorn flavone, endothelium corneum gigeriae galli and powder of food rich in bamboo leaf flavone are prepared by selecting and cleaning the food without rottenness, then ventilating and drying the cleaned food at the temperature of 80 ℃, carrying out superfine grinding and sieving the powder by a 100-mesh sieve;
(2) mixing the solid powder obtained in the step (1) with oligosaccharide, sorbitol and magnesium stearate according to the formula parts, and fully mixing to ensure that the colloid is uniform;
(3) and (3) directly tabletting the mixed powder obtained in the step (2) to obtain edible tablets, and filling the edible tablets to obtain the product.
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