CN113693989A - Traditional Chinese medicine composition for removing turbidity and relieving itching and application of traditional Chinese medicine composition in personal care products - Google Patents
Traditional Chinese medicine composition for removing turbidity and relieving itching and application of traditional Chinese medicine composition in personal care products Download PDFInfo
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
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Abstract
The invention provides a traditional Chinese medicine composition for removing turbid pathogen and relieving itching and application thereof in personal care products, wherein the traditional Chinese medicine composition comprises the following components: an extract of clausena lansium, an extract of grapefruit leaf, an extract of lantana leaf, an extract of loquat leaf and an extract of honeysuckle flower. The traditional Chinese medicine composition has an itching relieving effect, has a good itching relieving effect when being applied to personal care products, and is safe, and small in toxic and side effects and irritation.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicine nursing products, in particular to a traditional Chinese medicine composition for removing turbid pathogen and relieving itching and application thereof in personal nursing products.
Background
Personal care products are a daily product that can be divided into: bath product, shampoo product, and hand washing product. In order to broaden the functionality of personal care products to human bodies, people have to add chemical substances with corresponding functions into the personal care products, so that some personal care products have other additional functions besides the basic personal care function, such as itching-relieving personal care products.
At present, chemical bactericides such as ketoconazole, zinc pyrithione, hexamidine di (isethionic acid) salt, galangin, pyridone ethanolamine salt, triclosan and the like are mainly added into antipruritic personal care products in the market, and most of the chemical bactericides have high irritation and are harmful to health after being used for a long time. With the continuous development of economy, consumers pay more and more attention to the safety of products, so that natural and safe products are more and more advocated. Therefore, a personal care product added with a natural and safe substance with the functions of removing turbid urine and relieving itching can better meet the requirements of consumers, thereby being favored.
Disclosure of Invention
The traditional Chinese medicine composition has an itching relieving effect, has a good itching relieving effect when being applied to personal care products, and is safe, and small in toxic and side effects and irritation.
In order to achieve the purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for removing turbid pathogen and relieving itching comprises the following components in parts by weight: the clausena lansium extract, the pomelo leaf extract, the lantana leaf extract, the loquat leaf extract and the honeysuckle extract are 0.5-2: 1.5-3: 0.5-2.
Preferably, the traditional Chinese medicine composition for removing turbid pathogen and relieving itching comprises the following components in parts by weight: the clausena lansium extract, the pomelo leaf extract, the lantana leaf extract, the loquat leaf extract and the honeysuckle extract are 1:2:2:1: 1.
Preferably, the phellodendron amurense extract is a phellodendron amurense leaf extract.
The invention also provides application of the traditional Chinese medicine composition for removing turbid pathogen and relieving itching in personal care products.
Preferably, the personal care products comprise bath products, shampoo products, hand washing products, body care products and soap cosmetics.
Preferably, the soap cosmetic comprises toilet soap, handmade soap and liquid soap.
Preferably, the traditional Chinese medicine composition for removing turbid pathogen and relieving itching accounts for 1-30 wt% of the personal care product.
More preferably, the traditional Chinese medicine composition for removing turbid pathogen and relieving itching accounts for 1-10% of the personal care product by weight.
The Chinese medicine of the phellodendron amurense is phellodendron amurense, rutaceae and phellodendron, and root and leaf of the phellodendron amurense can be used as the medicine. The invention preferably uses the extract of the Chinese wampee leaf, which has the effects of discharging turbidity, relieving exterior syndrome, dissipating heat, dispelling wind and removing toxicity (toxic heat, scabies, snake and insect bites).
The pomelo leaf extract disclosed by the invention can be used for detoxifying and detumescence (mastitis and tonsillitis), and has the functions of discharging turbidity and detoxifying.
The lantana camara is named as lantana camara, is called as lantana camara, common rue herb, ruyi herb and lantana camara, and is a dicotyledon plant of Verbenaceae. The root, leaf and flower of the above-mentioned plants can be used as medicine, and its extract has the functions of clearing away heat and toxic material, removing stasis, stopping pain, dispelling wind and stopping itching.
The loquat disclosed by the invention is named as loquat by the name of traditional Chinese medicine, namely, gold pill, reed branch, tangerine and the like, and is a plant in the genus of loquat in the family of Rosaceae. The folium Eriobotryae extract has heat and toxic materials clearing away effect.
The honeysuckle, the traditional Chinese medicine named honeysuckle, is also named honeysuckle, honeysuckle stem, bicolor vine, honeysuckle stem, ivy, etc., and is a plant of the honeysuckle of the Caprifoliaceae family. The honeysuckle has the effects of clearing away heat and toxic materials, resisting inflammation, tonifying deficiency and treating wind, and is mainly used for treating diseases such as distending pain, epidemic febrile disease, fever, toxic heat, carbuncle and ulcer, tumor and the like. The honeysuckle flower has certain treatment effect on skin itch of children, such as eczema and the like.
The bath product provided by the invention is bath foam/lotion/oil/cream/gel/foam, foot bath liquid, hand sanitizer or hand soap.
The shampoo product provided by the invention is shampoo/liquid/dew/cream or shampoo soap.
The body skin care product is body milk/essence cream/essence.
The invention provides a preferable extraction method, which comprises the steps of mixing and crushing corresponding compound traditional Chinese medicines according to the weight ratio, extracting by heating and refluxing with 3-5 times of 70-80 vol.% ethanol, and then concentrating and drying an extracting solution under reduced pressure to obtain a powder; of course, the extraction method is not limited to the above method, and supercritical extraction, ultrasonic extraction, etc. can be used for extraction; the extractant or extractant is not limited to ethanol, and may be extracted or extracted with water or the like.
In addition, the above-mentioned traditional Chinese medicine extract used in the present invention may preferably be pure extract powder corresponding to 100% of active ingredient, but is not limited to extract powder, and may also be in other forms such as extract liquid or extract, and when applied to personal care products in other forms, the amount added in the formulation should be converted to the amount in the form of pure extract disclosed in the present invention.
Due to the adoption of the technical scheme, the invention has the beneficial effects that:
the itching relieving auxiliary component adopted by the invention is a traditional Chinese medicine composition for removing turbid urine and relieving itching, namely a mixture extract of five traditional Chinese medicines, namely a clausena lansium extract, a shaddock leaf extract, a lantana leaf extract, a loquat leaf extract and a honeysuckle extract. The clausena lansium extract plays roles of discharging turbidity, relieving exterior syndrome, dissipating heat, dispelling wind and removing toxicity in the formula, the pomelo leaf extract plays roles of removing toxicity and reducing swelling, the lantana leaf extract plays roles of clearing heat and removing toxicity, eliminating stagnation, relieving pain, dispelling wind and relieving itching, the loquat leaf extract plays roles of clearing heat and removing toxicity, and the honeysuckle plays roles of clearing heat and removing toxicity, resisting inflammation, tonifying deficiency and treating wind. The traditional Chinese medicine composition for removing turbid pathogen and relieving itching has natural raw materials, is safe, has less toxic and side effects and irritation, and is not easy to cause skin allergy, inflammation and other skin microecosystem disorder conditions; in addition, the composition for removing turbid urine and relieving itching is not easy to accumulate on skin and scalp, but can be decomposed quickly, has no residue, and has no adverse effect on skin even if a small amount of the composition is absorbed by skin.
Detailed Description
The present invention will be further described with reference to the following specific examples, but the scope of the present invention is not limited to the following examples.
Experiment 1 application of traditional Chinese medicine composition for removing turbid urine and relieving itching in liquid soap
1.1 preparation of traditional Chinese medicine composition for removing turbid pathogen and relieving itching and liquid soap
TABLE 1 traditional Chinese medicinal composition for removing turbid pathogen and relieving itching
The preparation method of the extract comprises the following steps: mixing the corresponding compound traditional Chinese medicines according to the weight ratio, crushing, extracting by heating and refluxing 5 times of 75% ethanol, and then concentrating and drying the extracting solution under reduced pressure to form powder.
TABLE 2 application of Chinese medicinal composition for removing turbid pathogen and relieving itching in liquid soap
The preparation method of the liquid soap comprises the following steps: adding dodecanoic acid into water, heating to dissolve, adding potassium hydroxide to saponify, and adding potassium hydroxide to saponify
Adding AES, CAB, potassium cocoyl glycinate, white sugar, glycerol and amino acid humectant, mixing and dissolving, cooling to room temperature, adding antiseptic, essence and Chinese medicinal materials for removing turbid pathogen and relieving itching, mixing, standing and defoaming.
1.2 clinical experiments
1.2.1 Effect on histamine Phosphorescent of Hartley Guinea pigs
The experimental method comprises the following steps:
experimental test article: liquid soap for removing turbid pathogen and relieving itching.
Three heat-clearing and itching-relieving lotions, which are produced by Guangxi Baiyunshanying pharmaceutical industry Co.
Histamine phosphate, produced by national drug group chemical agents, ltd.
Experimental animals: hartley guinea pigs weighing 250g to 400 g.
Method and results
Effect on histamine phosphate-induced itching in Hartley guinea pigs.
80 healthy Hartley guinea pigs with the weight of 250-400 g are selected and divided into 10 groups at random, wherein each group comprises 10 male pigs and half female pigs. A blank control group (distilled water 0.1ml/100g), a positive control test object three-component heat-clearing itching-relieving lotion group (three-component heat-clearing itching-relieving lotion 0.1ml/100g), and a turbidity-discharging itching-relieving liquid soap group (0.1ml/100 g). Shaving the right hind paw and the back of each group of Hartley guinea pigs 2 days before experiment, and coating the shaved part of each group of animals with corresponding experimental subject 1 time a day for 2 consecutive days; on day 3 of the experiment, the shaved area of the back of the right hind paw was scratched with coarse sandpaper, and the area was 1cm, until the epidermis was damaged and the skin was slightly oozed2Each group of animals is coated with the corresponding test object for 1 time, after the test object is coated for the last time for 10min, 0.05 ml/body of 0.01% histamine phosphate solution is dripped on the wound surface, and then the concentration of 0.02%, 0.03% and 0.04% … … … … is increased every 3min, wherein each time is 0.05 ml/body until the Hartley guinea pig stops licking after head back, and the total histamine phosphate amount (mu g) given when the Hartley guinea pig finally licks the right hind foot back is taken as the scratchiness threshold, and each group of data is recorded, and the data is subjected to statistical t and t' tests, and the result is shown in Table 1.
Table 310 sets of turbid discharge antipruritic liquid soap sample pairs HartlEffect of histamine Phosphoric acid of ey Guinea pigs on the itchy reaction (
n＝10)
| Group of | Dosage (ml/100g) | Itch threshold (histamine phosphate total amount. mu.g) |
| Blank control group | - | 50.6±27.8 |
| Three-ingredient heat-clearing and itching-relieving lotion group | 0.1 | 232.0.0±98.4*** |
| Example 1 | 0.1 | 97.0±76.6* |
| Example 2 | 0.1 | 157.5±82.5** |
| Example 3 | 0.1 | 195.5±70.2 |
| Example 4 | 0.1 | 183.5±70.6* |
| Example 5 | 0.1 | 174.5±70.2* |
| Example 6 | 0.1 | 86.5±70.5* |
| Example 7 | 0.1 | 76.5±71.5 |
| Example 8 | 0.1 | 79.5±73.3 |
| Example 9 | 0.1 | 90.0±74.6* |
| Example 10 | 0.1 | 87.0±72.6* |
Note: comparison with blank control: p < 0.05, P < 0.01, P < 0.001.
Experimental results show that the turbid discharging and itching relieving liquid soap group (example 3, example 4 and example 5) is 0.1ml/100g) and can obviously improve the itching threshold value of histamine phosphate on guinea pigs when being externally applied, and has obvious turbid discharging and itching relieving effects. In example 1, the effect is obviously inferior to that of examples 3, 4 and 5 because the adding proportion of the sample is too small, and the itch-causing threshold value of the individual medicinal materials of the Chinese wampee tree extract, the pomelo leaf extract, the lantana leaf extract, the loquat leaf extract and the honeysuckle extract to the guinea pigs is relatively low. The above experimental results show that the mixture of the five traditional Chinese medicine extracts has stronger effects of removing turbid pathogen and relieving itching than the single traditional Chinese medicine extract. The experiment result shows that the mixing ratio of the five traditional Chinese medicines is 0.5-2: 1.5-3: 0.5-2, and good turbidity-discharging and itching-relieving effects can be achieved. The antipruritic effects of examples 3 to 5 were far greater than the single-acting effects of examples 6 to 10.
1.2.2 experiments on the bacteriostatic Properties
The test was carried out by the QB/T2738-2012 (7.3) method. The action concentration and time are as follows: 10% concentration, action time 20 minutes. The experimental results are as follows:
TABLE 4 results of the tests of the bacteriostatic properties
Experiments show that the mixed extract of five traditional Chinese medicines including common lantana, shaddock leaf, loquat leaf extract, honeysuckle and Chinese wampee in examples 1-5 has a bacteriostatic property obviously higher than that of examples 6-10, and the bacteriostatic effect is obviously reduced by using only a single traditional Chinese medicine extract. When the concentration of the traditional Chinese medicine mixed extract containing the lantana camara, the shaddock leaf, the loquat leaf extract, the honeysuckle and the phellodendron amurense is gradually increased from 1% to 10%, the bacteriostasis rate is also increased from 50% to 90%, and the bacteriostasis effect is related to the use concentration. In the embodiments 3 to 5, the composition ratio of the five traditional Chinese medicines is within the range (0.5-2: 1.5-3: 0.5-2), so that the bacteriostatic performance of the product can be ensured.
Experiment 2 application of traditional Chinese medicine composition for removing turbid pathogen and relieving itching in shampoo
Application of Table 51 # extract to shampoo
In examples 11 to 13, the shampoo was prepared by the following general shampoo manufacturing formula process: adding APG into deionized water, further adding citric acid, sequentially adding fatty alcohol succinate disodium, CAB, triisostearic acid PEG-120 methyl glucose, olive oil, jojoba oil ester, camellia seed oil, and Chinese medicinal composition for removing turbidity and relieving itching, stirring while adding, heating to about 75 deg.C, cooling to about 40 deg.C, and adding antiseptic and essence.
Experiment 3 application of traditional Chinese medicine composition for removing turbidity and relieving itching in shower gel
Application of extract # in table 61 to body wash
In examples 14-16, the formulation procedure for the conventional body wash was used: adding AES into deionized water, further adding APG, citric acid, CAB, cocamide methyl MEA, glycerol, amino acid humectant, and Chinese medicinal composition for removing turbid pathogen and relieving itching, sequentially adding raw materials while stirring, and finally adding essence and antiseptic.
Experiment 4 application of traditional Chinese medicine composition for removing turbid urine and relieving itching in handmade soap
Use of table 71 # extract on handmade soap
In examples 17-19, the conventional handmade soap formulation procedure was used: adding soap granules into a heating pot to dissolve at about 70-80 ℃, adding a chelating agent, an antioxidant, essential oil and traditional Chinese medicine components for removing turbidity and relieving itching, transferring into a forming device, standing at low temperature, forming and demoulding.
Experiment 5 application of traditional Chinese medicine composition for removing turbid pathogen and relieving itching in body milk
TABLE 81 application of extract on body milk
In examples 20-22, the conventional body lotion formulation process was used: adding emulsifier, vegetable oil, mineral oil and polydimethylsiloxane into an oil phase pot, heating to about 85 ℃ and keeping the temperature for 20 minutes, adding water, carbomer and amino acid humectant into a water phase pot, heating to about 85 ℃ and keeping the temperature for 20 minutes. Then adding the oil phase solution into the water-oil solution, stirring, homogenizing, cooling to 40 deg.C, and adding essence and antiseptic.
The samples prepared in experiments 2-5 were used for clinical trials.
Effect on histamine phosphate-induced itching in Hartley guinea pigs
Selecting 30 healthy Hartley guinea pigs with the weight of 250-400 g, and dividing into 4 groups at random, wherein each group comprises 10 animals and male animals and half animals. Blank control group (distilled water 0.1ml/100g), test solution 0.1ml/100g of 20% of shower gel (example 13), test solution 0.1ml/100g of 20% of shampoo (example 16), and test solution 0.1ml/100g of 20% of handmade soap (example 19)). Shaving the right hind paw and the back of each group of Hartley guinea pigs 2 days before experiment, and coating the shaved part of each group of animals with corresponding experimental subject for 1 time for 2 consecutive days; on day 3 of the experiment, the shaved area of the back of the right hind paw was scratched with coarse sandpaper, and the area of the shaved area was 1cm, until the epidermis was damaged and the skin was slightly soaked in blood2Each group of animals was topically and then topically applied with the corresponding experimental test substanceAfter the test object is coated for 10min for the last time, 0.05 ml/mouse of 0.01 histamine phosphate solution is dripped on the wound surface, and after that, the concentration is increased by 0.02%, 0.03% and 0.04% … … every 3min, each time is 0.05 ml/mouse until the Hartley guinea pig licks the right hind paw by turning back the head, and the total amount (ug) of histamine phosphate given when the Hartley guinea pig finally licks the right hind paw by turning back the head is taken as the itch causing threshold, and each group of data is recorded, and the data is subjected to statistics t and t, and the test results are shown in Table 9.
Table 9 experimental results of examples 13, 16 and 19
Note: comparison with blank control: p < 0.05, P < 0.01, P < 0.001
Experiments show that the bath product, the shampoo product and the soap cosmetics containing the turbidity-removing and itching-relieving traditional Chinese medicine components of the clausena lansium extract, the pomelo leaf extract, the lantana leaf extract, the loquat leaf extract and the honeysuckle extract can obviously improve the itch-causing threshold value of histamine phosphate on Hartley guinea pig histamine phosphate when being externally used, namely, the bath product, the shampoo product and the soap cosmetics have obvious turbidity-removing and itching-relieving effects.
The samples prepared in experiments 2-5 were used for the effect of the population.
According to the requirement of double blind tests, the number of the test samples is required to reach 30-50 parts. The sub-healthy skin people with certain pruritus and erythra on the skin and scalp are selected for trial use, and after 4 weeks of trial use (the use frequency of each week is at least 2 times), the use opinion table is filled. The experimental data are as follows:
| group (30 persons each group) | Itch relieving with turbid discharge (%) | No Effect (%) |
| Blank control group | 10.1 | 89.9 |
| Shampoo (example 13) | 69.3 | 31.7 |
| Handmade soap (example 19) | 78.8 | 21.2 |
| Shower cream (example 15) | 76.8 | 23.2 |
| Body lotion (example 22) | 85.6 | 14.4 |
Experiments show that the bath product, the shampoo product, the soaps and the body lotion product containing the turbidity-removing and itching-relieving traditional Chinese medicine components of the phellodendron amurense extract, the pomelo leaf extract, the lantana leaf extract, the loquat leaf extract and the honeysuckle extract can obviously remove pruritus and reduce erythra when being externally used, namely, the shampoo product has obvious turbidity-removing and itching-relieving effects.
Claims (8)
1. The traditional Chinese medicine composition for removing turbid pathogen and relieving itching is characterized by comprising the following components in parts by weight: the clausena lansium extract comprises a pomelo leaf extract, a lantana leaf extract, a loquat leaf extract and a honeysuckle extract, and the ratio is 0.5-2: 1.5-3: 0.5-2.
2. The traditional Chinese medicine composition for removing turbid pathogen and relieving itching as claimed in claim 1, is characterized by comprising the following components in parts by weight: the clausena lansium extract, the pomelo leaf extract, the lantana leaf extract, the loquat leaf extract and the honeysuckle extract are =1:2:2:1: 1.
3. The turbid pathogen-draining itching-relieving traditional Chinese medicine composition according to claim 1, wherein the phellodendron amurense extract is a phellodendron amurense leaf extract.
4. The use of the turbidity-expelling and itching-relieving traditional Chinese medicine composition according to any one of claims 1 to 3 in personal care products.
5. Use according to claim 4, characterized in that: the personal care products comprise bath products, shampoo products, hand washing products, body skin care products and soap cosmetics.
6. Use according to claim 5, characterized in that: the soap cosmetic includes soap, handmade soap and liquid soap.
7. Use according to any one of claims 4 to 6, characterized in that: the weight percentage of the traditional Chinese medicine composition for removing turbid pathogen and relieving itching in the personal care product is 1% -30%.
8. Use according to claim 7, characterized in that: the weight percentage of the traditional Chinese medicine composition for removing turbid pathogen and relieving itching in the personal care product is 1% -10%.
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885737A (en) * | 2012-09-24 | 2013-01-23 | 佛山市梦莎美容化妆品有限公司 | Application of common lantana leaf or branchlet active extract to preparation of cosmetics |
| CN108066238A (en) * | 2017-12-29 | 2018-05-25 | 柳州两面针股份有限公司 | Application of the Chinese medicine composition with antipyretic and itching-stopping on articles for washing |
| CN109010131A (en) * | 2018-10-16 | 2018-12-18 | 江门市君和办公用品有限公司 | A kind of removing miliaria and relieving itching shower cream and preparation method thereof |
| CN110856711A (en) * | 2018-08-25 | 2020-03-03 | 蒋成 | Plant itching-relieving and dandruff-removing shampoo |
| CN112006970A (en) * | 2020-08-14 | 2020-12-01 | 珀莱雅化妆品股份有限公司 | Anti-itch composition and preparation method and application thereof |
-
2021
- 2021-09-23 CN CN202111117097.0A patent/CN113693989B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102885737A (en) * | 2012-09-24 | 2013-01-23 | 佛山市梦莎美容化妆品有限公司 | Application of common lantana leaf or branchlet active extract to preparation of cosmetics |
| CN108066238A (en) * | 2017-12-29 | 2018-05-25 | 柳州两面针股份有限公司 | Application of the Chinese medicine composition with antipyretic and itching-stopping on articles for washing |
| CN110856711A (en) * | 2018-08-25 | 2020-03-03 | 蒋成 | Plant itching-relieving and dandruff-removing shampoo |
| CN109010131A (en) * | 2018-10-16 | 2018-12-18 | 江门市君和办公用品有限公司 | A kind of removing miliaria and relieving itching shower cream and preparation method thereof |
| CN112006970A (en) * | 2020-08-14 | 2020-12-01 | 珀莱雅化妆品股份有限公司 | Anti-itch composition and preparation method and application thereof |
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