CN102885737A - Application of common lantana leaf or branchlet active extract to preparation of cosmetics - Google Patents
Application of common lantana leaf or branchlet active extract to preparation of cosmetics Download PDFInfo
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- CN102885737A CN102885737A CN2012103614557A CN201210361455A CN102885737A CN 102885737 A CN102885737 A CN 102885737A CN 2012103614557 A CN2012103614557 A CN 2012103614557A CN 201210361455 A CN201210361455 A CN 201210361455A CN 102885737 A CN102885737 A CN 102885737A
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Abstract
The invention belongs to the field of cosmetics. The invention discloses an application of a common lantana leaf or branchlet active extract to preparation of functional cosmetics, and aims to provide a natural active additive having the effects of fighting bacteria, diminishing inflammation, removing measles, relieving itching and clearing dandruff for the cosmetics industry. The common lantana leaf or branchlet active extract can be obtained by extracting from the root, stalk, leaves, fruits or whole body of a medicinal plant, i.e., common lantana leaf or branchlet and further purifying. As proved by researches, the major component of the extract is a pentacyclic triterpene compound. As proved by a test, the extract has remarkable antibacterial activity, and can be taken as an active additive for applying to multiple types of cosmetics such as shampoos, body lotions, face cleansing creams and the like.
Description
Technical field
The invention relates to the application of Folium Lantanae Camarae activity extract in preparation function cosmetics, belong to cosmetic field.
Background technology
Along with Chinese Cosmetic Market moves to maturity gradually, consumer has recognized more and more that the safety of cosmetics is more important more than beauty treatment itself buying and make when applying some make up.Because media are conducted vigorous propaganda synthesis of chemicals injury skin, and some consumers may be responsive to the cosmetics usage comparison, so that consumer has been placed on attention on safe, the effective and health of product when buying cosmetics more.
In the last few years, " natural " was the maximum attraction of cosmetics publicity, contained the consumption demand sustainable growth of the personal care articles of natural component.At present, natural component has become the main flow of Cosmetic Market, and people have directly promoted the demand in natural cosmetics market to the increase of the attention degree of healthy and health preserving.The company that has international well-known cosmetics brand all wants to occupy a tiny space in natural organic products market.With the cosmetics of natural material as active component preparation, not only promoted the image of high-quality cosmetics, the also firm confidence of consumer.
Chinese herbal medicine cosmetic is the distinctive class cosmetics of China, is an ingredient of China's Chinese Traditional Medicine, and its research has become one of focus in the recent year cosmetic field.The characteristics of Chinese herbal medicine cosmetic be not only adopt naturally move, plant, raw mineral materials (the effect composition of prescription), of paramount importance is that the theory of its component, prescription is with theoretical.Generally speaking, Chinese herbal medicine cosmetic refers to by Chinese herbal medicine and makes, or adds the cosmetics of Chinese herbal medicine effective ingredients in substrate.Chinese herbal medicine, ancient claim " book on Chinese herbal medicine " is the medicine of disease preventing and treating under the Chinese medicine and pharmacy theoretical direction, is mainly crude drug and processed goods thereof, comprises plant, animal, mineral and part chemistry or biological product etc.
Skin pruritus, scytitis, skin eczema and the dandruff are common dermatosis, tracing it to its cause all is because due to the microorganism of skin surface pathogenic infection, therefore how to prepare have bactericidal antiphlogistic concurrently, the rash and relieving itching of dispelling, the Chinese herbal medicine cosmetic of removing the effects such as the dandruff be one of primary study exploitation direction of cosmetic field.
Folium Lantanae Camarae Latana camara Linn is Verenaceae, Lantana originates in american torrid zone, and there is introducing and planting in China north and south, but take Guangdong, the provinces and regions such as Fujian, Taiwan, Zhejiang, Yunnan, Sichuan are as many, there is large stretch of wild distribution in the field, wilderness of South China more.Its root, stem, leaf, flower can be done medicinal, have the effect of the pain relieving of powder for clearing heat and detoxicating solution, dispelling wind for relieving itching.The diseases such as high heat hot, of a specified duration is not moved back, dysentery, pulmonary tuberculosis, asthma bronchiectasis, hypertension can cure cold.Stem and leaf fry in shallow oil soup wash control eczema, mange skin infection, dermatitis, skin itch, too fat to move, mash and apply the affected part and can control traumatic injury of tendon and muscle." south of the Five Ridges gather medicinal herbs record ": wash the noxious dampness mange." Nanning City's medicine will ": leaf: control the mange skin infection, the traumatic injury hemostasis.Flower: can stop blooding." Guangdong Chinese medicine ": dispelling wind for relieving itching, reducing swelling and alleviating pain, loose poison applies large intestine infections carbuncle." Guangxi Chinese herbal medicine ": herb: bring down a fever, killing parasites for relieving itching, skin infection disappears.Yet at present the utilization of Folium Lantanae Camarae also is confined to view and admire, its medical value does not also obtain the full-scale development utilization, more has no the application of its activity extract in the preparation cosmetics.
Summary of the invention
The object of the invention is to natural have anti-inflammation for cosmetic industry provides a kind of, the rash and relieving itching of dispelling, remove the active additive of the effects such as the dandruff for the common dermatosis such as skin pruritus, scytitis, skin eczema and the dandruff.
The technical solution that the present invention adopts in order to achieve the above object is as follows:
The water extract of root, stem, leaf, fruit or herb that Folium Lantanae Camarae activity extract of the present invention is the medicinal plants Folium Lantanae Camarae or organic solvent (chloroform, ethanol, methanol, ethyl acetate, petroleum ether, acetone etc.) extract distributes extraction, recrystallizing methanol to be further purified the white crystal that obtains through activated carbon decolorizing, water-chloroform, and its main component is pentacyclic triterpenoid.
Antibacterial tests result of the present invention proves, above-mentioned Folium Lantanae Camarae activity extract is to having significant inhibitory action for the examination pathogen, can be used as natural have anti-inflammation, the rash and relieving itching of dispelling, the active additive of removing the effects such as the dandruff be applied in the multiple cosmetics such as shampoo, bath gel, facial milk cleanser.
The specific embodiment
Following examples are to further specify of the present invention, are not limitations of the present invention.
Embodiment 1: the preparation of Folium Lantanae Camarae activity extract
Gather medicinal plants Folium Lantanae Camarae aerial parts, air-dry, pulverize, take by weighing 1kg medicated powder, add 5L methanol soaking at room temperature and extract 24h, frequently rock between soak period, filter, get methanol soaked extracting solution and medicinal residues, medicinal residues add 5L methanol heating and refluxing extraction 1h again, filter to get the methanol eddy extracting solution.Methanol soaked extracting solution and reflux extracting liquid merge, add the 200g activated carbon and under room temperature, stir decolouring, sucking filtration gets golden yellow filtrate, filtrate obtains extracting extractum after concentrating under reduced pressure below 50 ℃ reclaims methanol, to extract extractum suspends in water, with equal-volume chloroform extraction 2 times, chloroform extraction liquid is incorporated in and obtains chloroform extract after concentrating under reduced pressure below 50 ℃ reclaims chloroform, chloroform extract adds an amount of methanol slight fever dissolving, leave standstill 24h in-18 ℃, separate out a large amount of white crystals, sucking filtration, dry, get the Folium Lantanae Camarae activity extract.
Embodiment 2: Folium Lantanae Camarae activity extract main component is analyzed
Get above-mentioned Folium Lantanae Camarae activity extract 1g, cross 30g silica gel (60-120 order) post, the petroleum ether-ethyl acetate gradient elution, thin layer chromatography is followed the tracks of, merge main elution fraction, silica gel column chromatography repeatedly, and through the further separation and purification of silica gel preparative thin layer chromatography, recrystallizing methanol obtains 2 main component A and B.Compd A
1H NMR (300MHz, DMSO-d
6) 1 carboxyl active hydrogen signal of spectrum demonstration is at 12.06 (br s, 1H), 2 alkene hydrogen signals are respectively at 6.03 (dd, 1H) with 5.39 (s, 1H), methyl signals [0.70 (s in 7 rings, 3H), (0.85 s, 3H), 0.86 (s, 3H), (0.91 s, 3H), 0.93 (s, 3H), (1.11 s, 3H), 1.17 (s, 3H)] with the outer methyl signals [2.07 (s that link to each other with double key carbon of 2 rings, 3H) with 1.89 (s, 3H)], identify that this chemical compound is lantadene A.Compd B
1H NMR spectrum is closely similar with the spectrogram of compd A, also presents the feature of triterpenoid, and apparent in view difference is to encircle outer alkene hydrogen signal by 6.03 (dd, 1H) shift to 5.52 (s, 1H), peak shape has also become unimodal, thereby identifies that this chemical compound is lantadene B.Show that above-mentioned Folium Lantanae Camarae activity extract main component is pentacyclic triterpenoid lantadene A and lantadene B, its structural formula is
Embodiment 3: Folium Lantanae Camarae activity extract In Vitro Bacteriostatic drug sensitive experiment
Adopt agar diffusion method of the paper to measure the bacteriostatic activity of Folium Lantanae Camarae activity extract, according to the antibacterial as a result criterion of disk diffusion method, antibacterial circle diameter＞20mm is for extremely quick, 15-20mm is Gao Min, 10-15mm is quick in being,＜10mm is hypoallergenic, and is then insensitive without inhibition zone.For the examination antibacterial staphylococcus aureus (Staphylococcus aureu), escherichia coli (Escherichia coli), bacillus pyocyaneus (Pseudomonas aeruginosa) and bacillus subtilis (Bacillus subtilis) are arranged, for the examination fungus Fusarium solani (Fusarium solani) and aspergillus parasiticus (Aspergillus parasiticus) are arranged.Take DMSO as solvent above-mentioned Folium Lantanae Camarae activity extract is mixed with concentration and is the medicinal liquid of 5mg/mL, take neat solvent DMSO as blank, the positive contrast of streptomycin, antibacterial hatches the rear antibacterial circle diameter size of measuring of 24h (fungus 48h) in 37 ℃ after the inoculation, parallel laboratory test three times is averaged.Result of the test sees Table 1.
The bacteriostatic activity result of the test of table 1 Folium Lantanae Camarae activity extract
The bacteriostatic activity drug sensitive experiment is the result show, when concentration was 5mg/mL, the Folium Lantanae Camarae activity extract had the effect of establishment gram-bacteria and target fungus propagation.Thereby can be used as natural have anti-inflammation, the rash and relieving itching of dispelling, the active additive of removing the effects such as the dandruff be applied in the multiple cosmetics such as shampoo, bath gel, facial milk cleanser.This is innovation of the present invention especially.
Claims (1)
1. the application of Folium Lantanae Camarae activity extract in preparation function cosmetics is characterized in that the Folium Lantanae Camarae activity extract is applied in the function cosmetics as active additive.
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| CN2012103614557A CN102885737A (en) | 2012-09-24 | 2012-09-24 | Application of common lantana leaf or branchlet active extract to preparation of cosmetics |
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| CN2012103614557A CN102885737A (en) | 2012-09-24 | 2012-09-24 | Application of common lantana leaf or branchlet active extract to preparation of cosmetics |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138460A (en) * | 2015-03-30 | 2016-11-23 | 陆海燕 | A kind of medical herbs treating dysentery |
| CN109470810A (en) * | 2017-09-07 | 2019-03-15 | 海南九芝堂药业有限公司 | A kind of detection method of lantana medicinal material |
| CN113693989A (en) * | 2021-09-23 | 2021-11-26 | 柳州两面针股份有限公司 | Traditional Chinese medicine composition for removing turbidity and relieving itching and application of traditional Chinese medicine composition in personal care products |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664482A (en) * | 2009-07-24 | 2010-03-10 | 温益雄 | Externally-applied Zhuang medicine for treating beriberi and skin pruritus and preparation method thereof |
-
2012
- 2012-09-24 CN CN2012103614557A patent/CN102885737A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101664482A (en) * | 2009-07-24 | 2010-03-10 | 温益雄 | Externally-applied Zhuang medicine for treating beriberi and skin pruritus and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| O.P.SHARMA, ET AL: "ISOLATION AND PARTIAL PURIFICATION OF LANTANA (Lantana camara L.) TOXINS", 《TOXICOLOGY LETTERS》 * |
| 朱小薇 等: "马缨丹化学成分与生物活性", 《国外医药.植物药分册》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106138460A (en) * | 2015-03-30 | 2016-11-23 | 陆海燕 | A kind of medical herbs treating dysentery |
| CN109470810A (en) * | 2017-09-07 | 2019-03-15 | 海南九芝堂药业有限公司 | A kind of detection method of lantana medicinal material |
| CN113693989A (en) * | 2021-09-23 | 2021-11-26 | 柳州两面针股份有限公司 | Traditional Chinese medicine composition for removing turbidity and relieving itching and application of traditional Chinese medicine composition in personal care products |
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Application publication date: 20130123 |