CN101336880A - Art pumpkin leaves extract and use in cosmetics - Google Patents
Art pumpkin leaves extract and use in cosmetics Download PDFInfo
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- CN101336880A CN101336880A CNA2008101473172A CN200810147317A CN101336880A CN 101336880 A CN101336880 A CN 101336880A CN A2008101473172 A CNA2008101473172 A CN A2008101473172A CN 200810147317 A CN200810147317 A CN 200810147317A CN 101336880 A CN101336880 A CN 101336880A
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- momordicae charantiae
- folium momordicae
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- charantiae extract
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Abstract
The present invention discloses an extract of balsam pear leaves. The extracts of balsam pear leaves are obtained by the following steps: cleaning balsam pear leaves and removing impurities, mechanically grinding and crushing the balsam pear leaves after drying, preparing balsam pear leaves into balsam pear leaf powders, putting balsam pear leaf powders into mixed solvent made of water and ethanol for heating extraction, purifying and separating the components extracted from solvent by chromatography or fractionation. The extract of balsam pear leaves is used as a plant active additive to be applied in cosmetic, the adding amount of balsam pear leaf extract accounts for 0.1 to 30 wt% of the cosmetic, and the extract of balsam pear leaves is also used as a corrosion protection bacteriostatic agent, an acne-dispelling substance or a whitening and speckle-removing agent in cosmetic.
Description
Technical field
The present invention relates to cosmetics industry, what be particularly related to is a kind of preparation of Folium Momordicae Charantiae extract and the application in cosmetics thereof, specifically Folium Momordicae Charantiae is through extracting, obtaining Folium Momordicae Charantiae extract behind the purification and agent is applied in the cosmetics as antiseptic and inhibiting bacteria function, also can be used as anti-acne or whitening anti-freckle agent is applied in the cosmetics.
Background technology
Cosmetics are a kind of daily necessities, and it comprises cold cream frost, facial treatment milk, skin-clean cream frost, skin cleansing cream liquid, astringent, wet tissue, facial film and shampoo etc.The raw material of these cosmetics is similar, and the raw material great majority are the side-product of PETROLEUM PROCESSING, and safety and effect are limited.At present; people are in order to protect and improve oneself skin and hair; improve security of products; one after another vegetable raw material with health role is added in the cosmetics; wish by adding these effective ingredient; the safety of very high cosmetics, and in apply some make up cleaning and nursing, play that better antiinflammatory is antibacterial, the effect of whitening and speckle dispelling.
Summary of the invention
Fructus Momordicae charantiae (Monlordica charantia L.) is the annual climing property herbaceous plant of Cucurbitaceae Momordica, have another name called balsam pear, balsam pear, leprosy Fructus Vitis viniferae and bright and beautiful Fructus Litchi etc., be a kind of medicinal and edible plant, its leaf is big, kidney shape circle, each about 5-12cm of length and width, common 5-7 drastic crack, sliver ovum shape ellipse, base portion shrinks, edge tool wave-formed mouth, the two sides is bordering on smooth or hairiness; The long 3-6cm of petiole.
Folium Momordicae Charantiae can be used as medicine, Compendium of Material Medica record: " leaf dries and is the end, controls all red fire-toxin gas, incised wound knot poison, sesame furuncle, big furuncle, and unbearably painful, gastric qi is ached, GUNTANG, ophthalmalgia, and sub-bitter cold is nontoxic under the Medulla Junci soup, but the QI invigorating tonifying YANG ".
Find to have the effect of antiseptic and inhibiting bacteria function, anti-acne and the generation of inhibition melanin through the Folium Momordicae Charantiae extract of extraction, purification after deliberation.
Therefore, the invention provides a kind of Folium Momordicae Charantiae extract, pulverize carrying out mechanical lapping after the clean roguing of Folium Momordicae Charantiae, the drying earlier, make the Folium Momordicae Charantiae powder; Again the Folium Momordicae Charantiae powder is put into the mixed solvent that makes with water and ethanol and add extraction heat; The component that solvent extraction goes out is further purified, separates and obtain product through chromatography or fractionating process.
The grinding particle size of described Folium Momordicae Charantiae is 10 μ m-500 μ m; The allocation ratio of solvent is a water: ethanol 1: 1-1: 19; The ratio of Folium Momordicae Charantiae and solvent is 1: 5-1: 40; The temperature of extraction remains between 35 ℃-100 ℃ Celsius; Time was grasped between 8-24 hour; The purifies and separates concrete measure is spray drying, lyophilization etc.
The application of above-mentioned described Folium Momordicae Charantiae extract in cosmetics is applied to Folium Momordicae Charantiae extract in the cosmetics as the vegetable active additive, and the addition of Folium Momordicae Charantiae extract is the 0.1-30% of cosmetics.
Agent is applied in the cosmetics above-mentioned Folium Momordicae Charantiae extract as antiseptic and inhibiting bacteria function.
Above-mentioned Folium Momordicae Charantiae extract is applied in the cosmetics as the anti-acne material.
Above-mentioned Folium Momordicae Charantiae extract is applied in the cosmetics as whitening anti-freckle agent.
Above-mentioned described cosmetics be cold cream frost, facial treatment milk, skin-clean cream frost, skin cleansing cream liquid, astringent, wet tissue, facial film or shampoo one of them.
The present invention extracts by the active substance in the Folium Momordicae Charantiae that will have anti-corrosive antibacterial, anti-acne, whitening and speckle dispelling effect, adds to after separation and purification in the various cosmetics.Further improve the effect of cosmetics, and made full use of the bioactive substance in the Folium Momordicae Charantiae.
The specific embodiment
The extraction of Folium Momordicae Charantiae active substance:
Folium Momordicae Charantiae is cleaned and dries for 5 kilograms, pulverize after 50 ℃ of oven dry, cross 40 mesh sieves, add 10 kilogram 60% ethanol then, 60 ℃ of water-bath reflux, extract, three times, each 4 hours, merging filtrate, be lower than 50 ℃ concentrate after, 1.0～1.5 kilograms of Folium Momordicae Charantiae extracting solution, extracting solution can be further purified.
Folium Momordicae Charantiae extract of the present invention has following effect:
Test one: bacteriostasis efficacy
Adopt staphylococcus aureus, escherichia coli and propionibacterium acne as representing bacterium, detect the bacteriostasis of this pharmaceutical composition.Filter paper is made the scraps of paper of ф 5mm, standby behind the autoclaving, filter paper after will sterilizing with tweezers is put into the solution that contains Folium Momordicae Charantiae extract, soak to take out after 30 minutes and dry, draw various bacteria suspension 0.1mL in aseptic plate with suction pipe, pour chilled sterilising medium 15mL then into, horizontal positioned behind the abundant mixing, difference because of strains tested, used kinds of culture medium is also different, treat the culture medium condensation after, the scraps of paper that will contain Folium Momordicae Charantiae extract are affixed on the flat board, with sterilized water in contrast, put into 37 ℃ of following antibacterial culturing 24h of incubator, fungal culture 48h.Take out on time, measure antibacterial circle diameter with slide calliper rule, more than operation is all finished on superclean bench, the results are shown in Table 1.
Table 1 Folium Momordicae Charantiae extract is to the inhibition zone (mm) of different strain
Experiment showed, that Folium Momordicae Charantiae extract all has the good restraining effect to staphylococcus aureus, escherichia coli and propionibacterium acne, illustrate that Folium Momordicae Charantiae extract is the tangible natural plants antiseptic of a kind of fungistatic effect.
Test two: acne-removing
1. therapeutic scheme
The pox point is appearred in face, and occur repeatedly, the person of not healing for a long time mixes Folium Momordicae Charantiae extract as treatment target with protective skin cream substrate, production method according to protective skin cream is made protective skin cream, and treatment target is smeared the protective skin cream that adds Folium Momordicae Charantiae extract 1.0～10.0% every day, and each is once sooner or later.
2. treatment evaluation criteria
(1) cure: pox point disappears, and pox point no longer occurs;
(2) produce effects: pox point is basic to disappear;
(3) effective: the pox point has in various degree minimizing, alleviates or weaken;
(4) invalid: symptom does not have any improvement, even the trend of increasing the weight of is arranged.
3. the present invention treats variola 106 people, wherein male 56 people, and women 50 people, the age is 15-30 year, presses the protective skin cream that Folium Momordicae Charantiae extract is added in the such scheme application, every day, each once added up curative effect after 7 days sooner or later, and is as follows:
| Sex | Example number (people) | Cure (people) | Produce effects (people) | Effectively (people) | Invalid (people) | Total effective rate |
| The man | 56 | 36 | 15 | 4 | 1 | 98.21％ |
| The woman | 50 | 24 | 22 | 3 | 1 | 98.00％ |
| Add up to | 106 | 60 | 37 | 7 | 2 | 98.11％ |
Last table shows that it is splendid that the present invention is used for the treatment of teenager variola curative effect, and curative effect is up to 98.11%, and treatment time is short, easy to use.Simultaneously, in clinical trial, all do not find any reaction, use with as safe as a house, stable and reliable for performance.
Test three: suppress tyrosinase activity in the B16 mouse melanin tumor cell
Experimental technique: after the B16 mouse melanin tumor cell activating ligand of cultivating made the individual cells suspension, with 1 * 10
5Individual/ml cell density is inoculated in 6 orifice plates, and 6 orifice plates are put into CO
2Incubator is at 37 ℃, 5%CO
2And under the saturated humidity condition, cultivate and add the culture fluid 2ml that contains Fructus Momordicae charantiae extract, collecting cell after 72 hours after 24 hours., wash 2 times with phosphate buffer (pH6.8) with the centrifugal 5min of 1000r/min rotating speed with centrifuge, add phosphate buffer (pH6.8) and make cell suspension, after the counting cells density, adjusting cell density is 1 * 10
6Individual/ml, get 1ml cell suspension and remove supernatant after centrifugal, add 1%Triton X-100 (with the phosphate buffer preparation of pH7.4) 1ml, it is freezing to put into-80 ℃ of refrigerators rapidly, take out behind the 30min 37 ℃ of dissolvings, add the L-3 of 5mM, 4-dihydroxyphenylalanine (L-DOPA) 2ml.The wavelength of regulating ultraviolet spectrophotometer is A475, measures the absorbance of immediate reaction, places under 37 ℃ of conditions again and measures absorbance behind the 30min, use L-3, the autoxidation of 4-dihydroxyphenylalanine (L-DOPA) is made reference, and as positive control, experiment repeats 3 times with kojic acid.
Calculate enzyme inhibition rate=[(A-B)-(C-D)] ÷ (A-B) according to following formula
Wherein:
A: 475nm place absorbance behind the negative control group 30min;
B: the instant 475nm of negative control group place absorbance;
C: tried 475nm place absorbance behind the thing group 30min;
D: tried the instant 475nm of thing group place absorbance.
Experimental data back by statistics shows that the Fructus Momordicae charantiae extract of 31.25～250 μ g/ml is inhibited to melanin content in live body B16 mouse melanin tumor cell tyrosinase activity and the cell, tyrosinase inhibition rate is 9.85～83.74%, and inhibition of tyrosinase activity is increased with concentration, and be dose dependent (P＜0.05).See Table 2.
Table 2 Folium Momordicae Charantiae extract is to the influence of B16 cell tyrosinase activity (X ± S)
People's the colour of skin is to be decided by melanin density in the skin and distribution, and the mechanism of mainly using in the cosmetics of whitening is the restraint of tyrosinase activity mechanism now, is exactly this class whitening agent as arbutin, kojic acid.In melanocyte, tyrosine is converted into DOPA under the effect of tryrosinase, DOPA quinone and dopachrome etc., and finally change melanin into, be secreted into the contiguous keratinocyte from melanocyte again, thereby the colour of skin is changed or the formation mottle, and tryrosinase is the key enzyme that melanin forms, by the restraint of tyrosinase activity, block melanic synthetic reaction chain, thereby reduce the effect that melanic formation reaches whitening and speckle dispelling, Folium Momordicae Charantiae extract of the present invention has the active and melanogenic effect of restraint of tyrosinase, so Folium Momordicae Charantiae extract can be used as whitening anti-freckle agent and is applied in the cosmetics.
Test four: rat acute percutaneous toxicity test
The employing maximum limit is mensuration.If dosage group of 5000mg/kg, 20 SD rats, male and female half and half.Preserved skin: deduct the quilt hair of rat spine both sides, unhairing area 4 * 4cm
2Confirm no skin injury after 24 hours, with 1ml/100gbw with this dosage group Fructus Momordicae charantiae liquid extract drips of solution on 6 layers of gauze, stick on plucked skin covering pan paper, immobilization with adhesive tape.Take off gauze behind the 4h, the flush away residue is observed its poisoning symptom, sign, observes for two weeks continuously, judges its toxicity category.
After the contamination of Folium Momordicae Charantiae extract 5g/kgbw dosage percutaneous, do not see animal dead in two weeks, also do not have tangible poisoning symptom and untoward reaction, the results are shown in Table 3.Cut open all animals extremely after two week experiments finish, internal organs show no obvious abnormalities change, promptly Folium Momordicae Charantiae extract to the acute percutaneous MTD of female, male SD rat greater than 5g/kgbw, true border non-toxic type.
Table 3 Folium Momordicae Charantiae extract is to the acute dermal toxicity experimental result of SD rat
Can draw as drawing a conclusion according to above-mentioned result of the test, adding proportion was grasped in 0.1～5.0% scope when Folium Momordicae Charantiae extract used as antiseptic and antibiotic agent; Adding proportion is grasped in 1.0～10.0% scopes when using as the anti-acne agent; Adding proportion is grasped in 1.0～30.0% scopes when using as the freckle removing and whitening agent.
For example product of the present invention is done more detailed description below:
Embodiment 1:
By 1.0% addition, Folium Momordicae Charantiae extract is mixed with articles for washing substrate, make articles for washing according to the production method of articles for washing, promptly get have anti-acne, the articles for washing of whitening and speckle dispelling effect, these articless for washing can be facial milk cleanser liquid, facial cleaning cream frost.
Embodiment 2:
By 5.0% addition, Folium Momordicae Charantiae extract is mixed with astringent substrate, make astringent according to the production method of astringent, promptly get have anti-acne, the astringent of whitening and speckle dispelling effect.
Embodiment 3:
By 10.0% addition, balsam pear extract is added in the wet tissue, promptly get have anti-acne, the wet tissue of whitening and speckle dispelling effect.
Embodiment 4:
By 20.0% addition, Folium Momordicae Charantiae extract is mixed with facial film substrate, make facial film according to the production method of facial film, promptly get have anti-acne, the facial film of whitening and speckle dispelling effect.
Embodiment 5:
By 30.0% addition, Folium Momordicae Charantiae extract is mixed with skin care item substrate, make skin care item according to the production method of skin care item, promptly get have anti-acne, the skin care item of whitening and speckle dispelling effect, these skin care item comprise cold cream frost, facial treatment milk.
Embodiment 6:
Addition by 0.3%, Folium Momordicae Charantiae extract is mixed with articles for washing substrate, production method according to articles for washing is made articles for washing, promptly gets the articles for washing with certain shelf-life, and these articless for washing can be handwashing liquid, bath foam, facial milk cleanser liquid, facial cleaning cream frost.
Embodiment 7:
Addition by 0.4% mixes Folium Momordicae Charantiae extract with astringent substrate, make astringent according to the production method of astringent, promptly gets the astringent with certain shelf-life.
Embodiment 8:
Addition by 0.6% adds balsam pear extract in the wet tissue, promptly gets the wet tissue with certain shelf-life.
Embodiment 9:
Addition by 0.8% mixes Folium Momordicae Charantiae extract with facial film substrate, make facial film according to the production method of facial film, promptly gets the facial film with certain shelf-life.
Embodiment 10:
Addition by 1.0% mixes Folium Momordicae Charantiae extract with skin care item substrate, make skin care item according to the production method of skin care item, promptly gets the skin care item with certain shelf-life, and these skin care item comprise cold cream frost, facial treatment milk.
Claims (7)
1. a Folium Momordicae Charantiae extract is characterized in that: carry out the mechanical lapping pulverizing after Folium Momordicae Charantiae being cleaned roguing, drying earlier, make the Folium Momordicae Charantiae powder; Again the Folium Momordicae Charantiae powder is put into the mixed solvent that makes with water and ethanol and add extraction heat; The component that solvent extraction goes out is further purified, separates and obtain product through chromatography or fractionating process.
2. Folium Momordicae Charantiae extract according to claim 1 is characterized in that: the grinding particle size of described Folium Momordicae Charantiae is 10 μ m-500 μ m; The allocation ratio of solvent is a water: ethanol 1: 1-1: 19; The ratio of Folium Momordicae Charantiae and solvent is 1: 5-1: 40; The temperature of extraction remains between 35 ℃-100 ℃ Celsius; Time was grasped between 8-24 hour; The purifies and separates concrete measure is spray drying or lyophilization.
3. the application of Folium Momordicae Charantiae extract as claimed in claim 1 or 2 in cosmetics, it is characterized in that: described Folium Momordicae Charantiae extract is applied in the cosmetics as the vegetable active additive, and the addition of Folium Momordicae Charantiae extract is the 0.1-30% of cosmetics.
4. the application of Folium Momordicae Charantiae extract according to claim 3 in cosmetics is characterized in that: agent is applied in the cosmetics Folium Momordicae Charantiae extract as antiseptic and inhibiting bacteria function.
5. the application of Folium Momordicae Charantiae extract according to claim 3 in cosmetics, it is characterized in that: Folium Momordicae Charantiae extract is applied in the cosmetics as the anti-acne material.
6. the application of Folium Momordicae Charantiae extract according to claim 3 in cosmetics, it is characterized in that: Folium Momordicae Charantiae extract is applied in the cosmetics as whitening anti-freckle agent.
7. the application of Folium Momordicae Charantiae extract according to claim 3 in cosmetics is characterized in that: described cosmetics be cold cream frost, facial treatment milk, skin-clean cream frost, skin cleansing cream liquid, astringent, wet tissue, facial film or shampoo one of them.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101473172A CN101336880A (en) | 2008-08-07 | 2008-08-07 | Art pumpkin leaves extract and use in cosmetics |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008101473172A CN101336880A (en) | 2008-08-07 | 2008-08-07 | Art pumpkin leaves extract and use in cosmetics |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101923077A (en) * | 2010-07-14 | 2010-12-22 | 天津师范大学 | Method for detecting chemical components of ether extract of bitter gourd leaves |
| CN103190663A (en) * | 2013-04-08 | 2013-07-10 | 林华 | Balsam pear vine juice |
| JP2014105175A (en) * | 2012-11-27 | 2014-06-09 | Bloom Classic Co Ltd | Elastin production promoting agent and skin cosmetic |
| CN103954702A (en) * | 2014-04-18 | 2014-07-30 | 天津师范大学 | Method for detecting volatile insecticidal components of bitter gourd leaves |
| CN105352999A (en) * | 2015-10-12 | 2016-02-24 | 临沂大学 | Ex-situ determination method for pH value of plant sap |
| WO2018115582A1 (en) * | 2016-12-22 | 2018-06-28 | Teknologian Tutkimuskeskus Vtt Oy | Process for converting plant materials to plant extracts having antimicrobial activity |
| CN113881511A (en) * | 2021-10-29 | 2022-01-04 | 安徽高梵电子商务有限公司 | Efficient environment-friendly cleaning solution special for down jackets and preparation method thereof |
-
2008
- 2008-08-07 CN CNA2008101473172A patent/CN101336880A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101923077A (en) * | 2010-07-14 | 2010-12-22 | 天津师范大学 | Method for detecting chemical components of ether extract of bitter gourd leaves |
| CN101923077B (en) * | 2010-07-14 | 2013-01-23 | 天津师范大学 | Method for detecting chemical components of ether extract of bitter gourd leaves |
| JP2014105175A (en) * | 2012-11-27 | 2014-06-09 | Bloom Classic Co Ltd | Elastin production promoting agent and skin cosmetic |
| CN103190663A (en) * | 2013-04-08 | 2013-07-10 | 林华 | Balsam pear vine juice |
| CN103954702A (en) * | 2014-04-18 | 2014-07-30 | 天津师范大学 | Method for detecting volatile insecticidal components of bitter gourd leaves |
| CN105352999A (en) * | 2015-10-12 | 2016-02-24 | 临沂大学 | Ex-situ determination method for pH value of plant sap |
| WO2018115582A1 (en) * | 2016-12-22 | 2018-06-28 | Teknologian Tutkimuskeskus Vtt Oy | Process for converting plant materials to plant extracts having antimicrobial activity |
| CN113881511A (en) * | 2021-10-29 | 2022-01-04 | 安徽高梵电子商务有限公司 | Efficient environment-friendly cleaning solution special for down jackets and preparation method thereof |
| CN113881511B (en) * | 2021-10-29 | 2023-09-12 | 安徽高梵电子商务有限公司 | Environment-friendly cleaning fluid special for down jackets and preparation method thereof |
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