CN113648376A

CN113648376A - Plaster for treating mastitis of dairy goat and preparation method thereof

Info

Publication number: CN113648376A
Application number: CN202111123546.2A
Authority: CN
Inventors: 崔武超; 黄俊杰; 崔武君; 崔长松
Original assignee: Huaibei Qianqian Biotechnology Co ltd
Current assignee: Huaibei Qianqian Biotechnology Co ltd
Priority date: 2021-09-24
Filing date: 2021-09-24
Publication date: 2021-11-16

Abstract

The invention relates to a plaster for treating mastitis of a milk goat and a preparation method thereof, belonging to the technical field of veterinary drugs, and the plaster comprises the following raw materials: realgar, phellodendron, borneol, madder, rhubarb, dandelion, bletilla, keel, ampelopsis japonica, pseudo-ginseng, astragalus and skin penetrant; the raw materials of the invention include realgar and phellodendron bark for detoxification and sore treatment; borneol has the effects of relieving swelling and pain; rhubarb has the effects of clearing heat, relieving swelling, removing blood stasis and stimulating the menstrual flow; radix Rubiae has effects of cooling blood, promoting blood circulation, removing blood stasis, and dredging channels; the dandelion powder has the functions of clearing away heat and toxic material, and relieving pain and stopping pain; notoginseng radix has effects in promoting blood circulation, dispelling blood stasis, relieving pain, and relieving swelling; radix astragali, rhizoma Bletillae, radix Angelicae Dahuricae, radix Ampelopsis, and Os Draconis have effects of relieving swelling and promoting granulation. The traditional Chinese medicine is used together, has the effects of clearing away heat and toxic materials, reducing swelling and dissipating blood stasis, can increase the permeability and the drug absorption of the skin by matching with a skin penetrating agent, accelerates the transmission and the blood circulation of the drug, has no stimulation to animals, has no influence on dairy products, and has obvious effect on treating mastitis.

Description

Plaster for treating mastitis of dairy goat and preparation method thereof

Technical Field

The invention belongs to the technical field of veterinary medicines, and particularly relates to a plaster for treating mastitis of a milk goat and a preparation method thereof.

Background

Mastitis is the most common disease in the frequently encountered diseases of the milk goat ewes, and is also a disease with relatively high hazard. The occurrence of mastitis can not only cause the reduction of the yield and the quality of milk sources, but also increase the breeding cost and the medical expense, cause huge economic loss to the dairy industry, influence the quality of raw milk and mutton, promote the growth of harmful microorganisms, cause food safety problems and harm human health.

The current treatment method for the mastitis of the dairy goats comprises the following steps: the method comprises the steps of intramuscular injection of antibiotics, local injection of antibiotics, and drenching of Chinese herbal medicines or antibiotics, wherein the method has the drug residues, and after the antibiotics are locally used (breast injection), substantial lesions can be formed on a focus area, so that the milk yield after diseases is greatly reduced, and the production performance is difficult to recover; the intramuscular or intravenous injection of antibiotics can cause the residual time of antibiotics in the organism to be overlong, generally 7 to 10 days, and the recurrence rate after illness is higher; the traditional Chinese medicine irrigation is difficult to operate, particularly, the air inlet pipe is easily caused to be irrigated, foreign pneumonia even death is caused, and physical damage can occur due to irrigation stress in individual cases.

Disclosure of Invention

The invention aims to provide a plaster for treating mastitis of a milk goat and a preparation method thereof, and solves the problems in the prior art.

The purpose of the invention can be realized by the following technical scheme:

a preparation method of a plaster for treating mastitis of a milk goat comprises the following steps:

firstly, weighing raw materials in parts by weight; cutting radix Rubiae, radix et rhizoma Rhei, herba Taraxaci, rhizoma Bletillae, radix Ampelopsis, Notoginseng radix and radix astragali into small segments, mashing, soaking in edible oil for three days, heating, controlling oil temperature at 220 deg.C until the surface of the medicinal materials turns black and the inner part is brown, removing residue, and keeping medicinal oil; grinding realgar, phellodendron and keel and sieving by a 100-mesh sieve for later use;

heating the medicinal oil to 320-;

thirdly, soaking the obtained ointment in cold water for 3 days, and changing water for 2 times every day; taking out the soaked ointment, drying, re-melting, adding borneol and skin penetrant, uniformly mixing, rolling the ointment with bamboo chopsticks, taking paper cloth, spreading the ointment on the I type medicine area or the II type medicine area on the paper cloth clockwise by pointing the center of the paper cloth with the bamboo chopsticks, and cooling to obtain the plaster for treating the mastitis of the milch goat.

Further, the edible oil is one of soybean oil, rapeseed oil and tea oil.

Further, paper cloth is divided into type i and type ii, type i: the width of the upper top is 30 cm, the total height is 40 cm, the diameter and the length of the blank area are 5 cm, and the width of the I-type adhesive area is 1 cm; type II: the overall diameter was 5 cm, with the type II drug region having a diameter of 4 cm and the type II viscose region having a width of 1 cm.

A plaster for treating mastitis of a milk goat comprises the following raw materials in parts by weight:

10-12 parts of realgar, 50-55 parts of golden cypress, 5-6 parts of borneol, 22-24 parts of madder, 20-24 parts of rhubarb, 100 parts of dandelion, 20-24 parts of bletilla striata, 20-24 parts of keel, 20-22 parts of ampelopsis japonica, 10-12 parts of pseudo-ginseng, 35-38 parts of astragalus mongholicus and 75-80 parts of skin penetrant;

further, the skin penetrating agent is N-N-alkyl benzisothiazolone.

Further, the adhesives used in the type i and type ii adhesive zones are prepared by the following steps:

step S11, mixing carboxymethyl chitosan and deionized water, adding 2, 3-epoxypropyltrimethylammonium chloride, stirring and reacting for 24 hours at the temperature of 60 ℃, precipitating with absolute ethyl alcohol after the reaction is finished, centrifugally washing the precipitate with deionized water, and drying in vacuum to constant weight after the washing is finished to obtain an antibacterial component;

and step S12, mixing isophorone diisocyanate, an antibacterial component and butanone, then adding dibutyltin dilaurate, adding a mixed solution of an amine chain extender and butanone under the protection of nitrogen at the temperature of 80 ℃, stirring for reacting for 2 hours, removing the solvent through decompression, and discharging to obtain a crude product. And (4) transferring the crude product to a vacuum drying oven, and performing vacuum drying for 24h to obtain the adhesive. The common pressure-sensitive adhesive has extremely poor water vapor permeability and oxygen permeability, and can cause water accumulation on skin to whiten the skin after long-term use, and is often accompanied with allergy.

Further, in step S11, the ratio of the carboxymethyl chitosan to the 2, 3-epoxypropyltrimethylammonium chloride to the deionized water is 1 g: 20mL of: 80 mg; in the step S12, the amine chain extender is one of ethylenediamine and diethylenediamine; the mixed solution of the amine chain extender and butanone is prepared from the following components in a ratio of 1 g: 10mL of the mixture is mixed; the using amount ratio of isophorone diisocyanate, antibacterial component, butanone, dibutyltin dilaurate and amine chain extender is 20 g: 12 g: 200mL of: 0.5 g: 6 g.

The invention has the beneficial effects that:

the raw materials of the invention include realgar and phellodendron bark for detoxification and sore treatment; borneol has the effects of relieving swelling and pain; rhubarb has the effects of clearing heat, relieving swelling, removing blood stasis and stimulating the menstrual flow; radix Rubiae has effects of cooling blood, promoting blood circulation, removing blood stasis, and dredging channels; the dandelion powder has the functions of clearing away heat and toxic material, and relieving pain and stopping pain; notoginseng radix has effects in promoting blood circulation, dispelling blood stasis, relieving pain, and relieving swelling; radix astragali, rhizoma Bletillae, radix Angelicae Dahuricae, radix Ampelopsis, and Os Draconis have effects of relieving swelling and promoting granulation. The traditional Chinese medicine is used together, has the effects of clearing away heat and toxic materials, reducing swelling and dissipating blood stasis, can increase the permeability and drug absorption of the skin by matching with a skin penetrating agent, stimulates nerve endings to enhance the body circulation, accelerates the transmission and the blood circulation of the drug, can be absorbed by a body more quickly, is externally applied by the Chinese herbal medicines, has no stimulation to animals, has no influence on dairy products, is beneficial to relieving the pain feeling of the animals, repairs mammary glands, is beneficial to the recovery of the production performance after diseases, is not influenced, and has obvious effect on treating mastitis.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the description of the embodiments will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art that other drawings can be obtained according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of a type I paper cloth in a plaster for treating mastitis of a milk goat;

FIG. 2 is a schematic structural diagram of type II paper cloth in the plaster for treating mastitis of milk goats;

in the drawings, the components represented by the respective reference numerals are listed below:

1. a type i drug region; 2. a type I viscose zone; 3. a blank area; 4. a type II drug region; 5. type II viscose area.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

Preparing an adhesive:

step S11, mixing carboxymethyl chitosan and deionized water, adding 2, 3-epoxypropyltrimethylammonium chloride, stirring and reacting for 24 hours at the temperature of 60 ℃, precipitating with absolute ethyl alcohol after the reaction is finished, centrifugally washing the precipitate with deionized water, and drying in vacuum to constant weight after the washing is finished to obtain an antibacterial component; wherein the dosage ratio of the carboxymethyl chitosan, the 2, 3-epoxypropyl trimethyl ammonium chloride and the deionized water is 1 g: 20mL of: 80 mg;

and step S12, mixing isophorone diisocyanate, an antibacterial component and butanone, then adding dibutyltin dilaurate, adding a mixed solution of an amine chain extender and butanone under the protection of nitrogen at the temperature of 80 ℃, stirring for reacting for 2 hours, removing the solvent through decompression, and discharging to obtain a crude product. Transferring the crude product into a vacuum drying oven, and carrying out vacuum drying for 24h to obtain an adhesive; wherein the amine chain extender is one of ethylenediamine and diethylenediamine; the mixed solution of the amine chain extender and butanone is prepared from the following components in a ratio of 1 g: 10mL of the mixture is mixed; the using amount ratio of isophorone diisocyanate, antibacterial component, butanone, dibutyltin dilaurate and amine chain extender is 20 g: 12 g: 200mL of: 0.5 g: 6 g.

Example 2

heating the medicinal oil to 310 ℃, adding realgar, golden cypress and keel, simultaneously stirring clockwise, dipping the ointment in a pot with bamboo chopsticks when smoke is not emitted any more and the ointment is a black oil paste, dripping cold water into the ointment, enabling the ointment on the water surface to be bead-shaped and not to be scattered, taking out the beads, wiping the surface moisture, trying to pinch with dry hands, stopping the fire when the beads are stuck to the hands and are not greasy when the beads are separated from the hands, and continuously stirring until the ointment is cooled to room temperature after the fire is stopped;

thirdly, soaking the obtained ointment in cold water for 3 days, and changing water for 2 times every day; taking out the soaked ointment, air drying, re-melting, adding Borneolum Syntheticum and skin penetrating agent, and mixing to obtain ointment;

wherein the edible oil is one of soybean oil, rapeseed oil and tea oil; the weight portions of the raw materials are: 10 parts of realgar, 50 parts of phellodendron, 5 parts of borneol, 22 parts of madder, 20 parts of rhubarb, 100 parts of dandelion, 20 parts of bletilla, 20 parts of keel, 20 parts of ampelopsis japonica, 10 parts of pseudo-ginseng, 35 parts of astragalus mongholicus and 75 parts of skin penetrant; the skin penetrating agent is N-N-alkyl benzisothiazolinone.

Example 3

heating the medicinal oil to 315 ℃, adding realgar, golden cypress and keel, simultaneously stirring clockwise, dipping the ointment in a pot with bamboo chopsticks when smoke is not emitted any more and the ointment is a black oil paste, dripping cold water into the ointment, enabling the ointment on the water surface to be bead-shaped and not to be scattered, taking out the beads, wiping the surface moisture, trying to pinch with dry hands, stopping the fire when the beads are stuck to the hands and are not greasy when the beads are separated from the hands, and continuously stirring until the ointment is cooled to room temperature after the fire is stopped;

wherein the edible oil is one of soybean oil, rapeseed oil and tea oil; the weight portions of the raw materials are: 11 parts of realgar, 52 parts of golden cypress, 5 parts of borneol, 23 parts of madder, 22 parts of rheum officinale, 105 parts of dandelion, 22 parts of bletilla striata, 22 parts of keel, 21 parts of ampelopsis japonica, 11 parts of pseudo-ginseng, 36 parts of astragalus mongholicus and 78 parts of skin penetrant; the skin penetrating agent is N-N-alkyl benzisothiazolinone.

Example 4

heating the medicinal oil to 320 ℃, adding realgar, golden cypress and keel, simultaneously stirring clockwise, dipping the ointment in a pot with bamboo chopsticks when smoke is not emitted any more and the ointment is a black oil paste, dripping cold water into the ointment, enabling the ointment on the water surface to be bead-shaped and not to be scattered, taking out the beads, wiping the surface moisture, trying to pinch with dry hands, stopping the fire when the beads are stuck to the hands and are not greasy when the beads are separated from the hands, and continuously stirring until the ointment is cooled to room temperature after the fire is stopped;

wherein the edible oil is one of soybean oil, rapeseed oil and tea oil; the weight portions of the raw materials are: 12 parts of realgar, 55 parts of golden cypress, 6 parts of borneol, 24 parts of madder, 24 parts of rhubarb, 110 parts of dandelion, 24 parts of bletilla striata, 24 parts of keel, 22 parts of Japanese ampelopsis root, 12 parts of pseudo-ginseng, 38 parts of astragalus and 80 parts of skin penetrating agent; the skin penetrating agent is N-N-alkyl benzisothiazolinone.

Referring to fig. 1-2, the paper cloth is classified into types i and ii, wherein type i: the width of the upper top is 30 cm, the total height is 40 cm, the diameter and the length of the blank area 3 are 5 cm, two I-type medicine areas 1 which are symmetrical about the blank area 3 are arranged, and the width of the I-type viscose area 2 is 1 cm; the teat of the milk goat may pass through the blank area 3.

Type II: the overall shape is circular with a diameter of 5 cm, with type ii drug region 4 having a diameter of 4 cm and type ii viscose region 5 having a width of 1 cm.

Example 5

The ointment prepared in the embodiment 2 is rolled up by bamboo chopsticks, paper cloth is taken, and the ointment is respectively spread in the I-type medicine area 1 and the II-type medicine area 4 clockwise by pointing the bamboo chopsticks at the center of the paper cloth; cooling to obtain a plaster for treating the mastitis of the dairy goat; the adhesive prepared in example 1 was melt-coated on the type i adhesive region 2 and the type ii adhesive region 5.

Example 6

The ointment prepared in the embodiment 3 is rolled up by bamboo chopsticks, paper cloth is taken, and the ointment is respectively spread in the I-type medicine area 1 and the II-type medicine area 4 clockwise by pointing the bamboo chopsticks at the center of the paper cloth; cooling to obtain a plaster for treating the mastitis of the dairy goat; the adhesive prepared in example 1 was melt-coated on the type i adhesive region 2 and the type ii adhesive region 5.

Example 7

The ointment prepared in the embodiment 4 is rolled up by bamboo chopsticks, paper cloth is taken, and the ointment is respectively spread in the I-type medicine area 1 and the II-type medicine area 4 clockwise by pointing the bamboo chopsticks at the center of the paper cloth; cooling to obtain a plaster for treating the mastitis of the dairy goat; the adhesive prepared in example 1 was melt-coated on the type i adhesive region 2 and the type ii adhesive region 5.

The plasters prepared in examples 5 to 7 were subjected to an anti-inflammatory test;

40 Kunming white mice were randomly divided into 4 groups of 10 mice each. The control group was not treated; experimental groups: the plasters prepared in examples 5-7 were applied to the left ear of the mouse, and the right ear was used as its control. And 1h after the last administration, the medicine is washed with distilled water and wiped dry with a dry cotton ball. 0.02mL of dimethylbenzene is dripped into and out of the left ear to cause inflammation, the cervical vertebra of the mouse is dislocated and killed after the inflammation is caused for 1h, double ears are cut at the base of the auricle, round lugs are taken down at the symmetrical positions of the left ear and the right ear by a puncher with the diameter of 0.6cm, the round lugs are weighed, and the weight difference of the left ear and the right ear is used as swelling degree. The inhibition rate of inflammatory swelling was calculated.

The inflammatory swelling inhibition (%) was 1- (difference in the weight of the left and right ear of the drug group/the weight of the left and right ear of the control group);

examples 5-7 had inhibition rates of 59.6%, 60.1% and 59.3%, respectively.

The plaster prepared in the embodiment 6 is applied to the mastitis of the milk goat, firstly, the breast of the milk goat is cleaned, and the long hair is removed, so that the plaster can be directly contacted with the skin conveniently. The medicine is replaced every 24 hours, is continuously used for three days, and has obvious improvement effect on mastitis after being used.

In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The foregoing is merely exemplary and illustrative of the principles of the present invention and various modifications, additions and substitutions of the specific embodiments described herein may be made by those skilled in the art without departing from the principles of the present invention or exceeding the scope of the claims set forth herein.

Claims

1. A plaster for treating mastitis of a milk goat is characterized by comprising the following raw materials in parts by weight: 10-12 parts of realgar, 50-55 parts of golden cypress, 5-6 parts of borneol, 22-24 parts of madder, 20-24 parts of rhubarb, 100 parts of dandelion, 20-24 parts of bletilla striata, 20-24 parts of keel, 20-22 parts of Japanese ampelopsis root, 10-12 parts of pseudo-ginseng, 35-38 parts of astragalus mongholicus and 75-80 parts of skin penetrant.

2. The plaster for treating mastitis in milk goats according to claim 1, wherein the skin penetrating agent is N-alkylbenzisothiazolinone.

3. The preparation method of the plaster for treating the mastitis of the milk goats according to claim 1, which is characterized by comprising the following steps:

secondly, heating the medicinal oil to 320 ℃ of 310-; stopping heating, and stirring to cool the ointment to room temperature;

thirdly, soaking the obtained ointment in cold water for 3 days, and changing water for 2 times every day; taking out the soaked ointment, drying, re-melting, adding borneol and a skin penetrating agent, uniformly mixing to obtain an ointment, spreading the ointment on a paper cloth, namely a type I medicine area (1) and a type II medicine area (4), and cooling to obtain the plaster for treating the mastitis of the dairy goat.

4. The method for preparing a plaster for treating mastitis in a milk goat according to claim 3, wherein the edible oil is one of soybean oil, rapeseed oil and tea oil.

5. The method for preparing a plaster for treating mastitis in a milk goat according to claim 3, wherein the paper cloth is divided into type I and type II.

6. The preparation method of the plaster for treating the mastitis of the milk goats according to claim 5, wherein the preparation method comprises the following steps: the width of the upper top is 30 cm, the total height is 40 cm, the diameter and the length of the blank area (3) are 5 cm, and the width of the I-type viscose area (2) is 1 cm.

7. The preparation method of the plaster for treating the mastitis of the milk goats according to claim 5, wherein the preparation method comprises the following steps: the diameter is 5 cm, wherein the diameter of the type II drug zone (4) is 4 cm and the width of the type II viscose zone (5) is 1 cm.