CN111773367A - Compound preparation for treating animal skin diseases and preparation method thereof - Google Patents
Compound preparation for treating animal skin diseases and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a compound preparation for treating animal skin diseases and a preparation method thereof, relating to the technical field of veterinary medicines; in order to solve the problem of inconvenient outdoor painting; the compound preparation comprises the following components in parts by weight: 2 parts of ozone oil, 1.5 parts of olive oil, 1.5 parts of peppermint oil, 2 parts of matrine, 2 parts of camphor, 1 part of borneol, 3 parts of mint, 2 parts of common cnidium fruit, 2 parts of litharge, 2 parts of Chinese gall, 1 part of evodia rutaecarpa, 2 parts of dried ginger and 2 parts of Chinese violet; the preparation method of the compound preparation comprises the following steps: taking ozone oil, camphor, olive oil, peppermint oil, matrine, borneol and dried ginger for later use; picking herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae and herba Violae, removing impurities respectively, cleaning, cutting into segments or slicing, and air drying. The invention slightly cleans the wounded parts of the animals with hydrogen peroxide solution and then wipes the wounded parts dry, and the compound preparation can be applied to the wounded parts of the animals without wiping, and has simple preparation and convenient use.
Description
Technical Field
The invention relates to the technical field of veterinary drugs, in particular to a compound preparation for treating animal skin diseases and a preparation method thereof.
Background
In recent years, with the rapid development of the livestock breeding industry, the animal breeding industry develops rapidly, the skin diseases of animals are increased gradually, and once outbreak occurs, the skin diseases are difficult to be cured radically in a collective mode. On one hand, if the dairy cow group has a skin disease, nutrient substances such as feed and the like of the dairy cow are influenced, and further, the milk yield and the milk quality are influenced. On the other hand, animal fur is an indispensable wealth, and can be used for keeping out cold and keeping warm and manufacturing articles for daily use such as leather clothing, leather shoes and the like, but if infectious skin diseases occur in fur-bearing animal farms, the skin of animals can be itchy, unhaired, serious and even ulcerated and scabbed, and the use value of the fur-bearing animal farms is influenced to a great extent, so that the treatment of the animal skin diseases is of great importance to the cost saving and cost reduction of large-scale farms.
Through retrieval, the Chinese patent with the application number of CN201210474609.3 discloses a traditional Chinese medicine specially used for treating animal skin diseases, which comprises the following components in parts by weight: 10-20 parts of sulfur, 20-40 parts of rhizoma atractylodis, 15-20 parts of phellodendron, 20-40 parts of rheum officinale, 15-30 parts of radix angelicae, 10-20 parts of mint, 10-20 parts of camphor and 1-10 parts of borneol. The traditional Chinese medicine specially used for treating animal skin diseases in the patent has the following defects: when the vinegar is used, the vinegar is mixed into paste and then applied to the affected part, and the vinegar cannot be applied when people forget to carry the vinegar outdoors, which is troublesome.
Disclosure of Invention
The invention aims to solve the defects in the prior art and provides a compound preparation for treating animal skin diseases and a preparation method thereof.
In order to achieve the purpose, the invention adopts the following technical scheme:
a compound preparation for treating animal skin diseases comprises the following components by weight: 2 parts of ozone oil, 1.5 parts of olive oil, 1.5 parts of peppermint oil, 2 parts of matrine, 2 parts of camphor, 1 part of borneol, 3 parts of mint, 2 parts of common cnidium fruit, 2 parts of litharge, 2 parts of Chinese gall, 1 part of evodia rutaecarpa, 2 parts of dried ginger and 2 parts of Chinese violet.
Preferably: the content of the ozone oil is 15-25 g/L, and the pH value is 3-5.
Preferably: the preparation method of the matrine comprises the following steps:
s31: extracting oxymatrine from herba Sophorae Alopecuroidis by supercritical CO2 fluid extraction;
s32: 0.1mL/L ammonia water is used as an alkalizer, and the extraction is carried out for 2h under the conditions of the temperature of 45 ℃ and the pressure of 42MPa to obtain the product.
Preferably: the preparation method of the dried ginger comprises the following steps:
s41: removing impurities from the ginger blocks, cleaning, soaking for 20 minutes, and draining;
s42: placing the treated ginger blocks in a drying room at 30 ℃ and sealing to sweat for 25 h;
s43: putting the sweated ginger blocks into the magnolia officinalis extracting solution, moistening for 2.5h, frying with strong fire, and continuously frying for 10 min after the temperature reaches 120 ℃;
s44: drying to obtain the dried ginger.
Preferably: the preparation method of the magnolia officinalis extracting solution comprises the following steps:
s51: pulverizing 30g of cortex Magnolia officinalis, adding 4% ammonia water, reflux extracting for 3 times, and boiling for 4 hr each time;
s52: filtering, adjusting pH of the filtrate to 3 with concentrated hydrochloric acid, standing at room temperature for 12h, filtering, oven drying the residue, cutting the precipitate, refluxing with 100ml of cyclohexane for 3h, filtering, and concentrating the filtrate;
s53: and combining the filtrates to obtain the finished product.
A method for preparing a compound preparation for treating animal skin diseases comprises the following steps:
s1: taking ozone oil, camphor, olive oil, peppermint oil, matrine, borneol and dried ginger for later use;
s2: picking herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae and herba Violae, removing impurities respectively, cleaning, cutting or slicing, and air drying;
s3: drying Camphora, matrine, Borneolum Syntheticum, herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae, Zingiberis rhizoma and herba Violae, pulverizing, and sieving with 120 mesh sieve;
s4: weighing raw material powder according to the weight components, stirring and mixing to obtain a compound preparation, and packaging.
Preferably: replacing the weight components with the following weight components: 2 parts of ozone oil, 2 parts of olive oil, 2 parts of peppermint oil, 1 part of matrine, 2 parts of camphor, 2 parts of borneol, 3.5 parts of mint, 3 parts of common cnidium fruit, 1.5 parts of litharge, 1.5 parts of Chinese gall, 1 part of evodia rutaecarpa, 1 part of dried ginger and 1 part of Chinese violet.
The invention has the beneficial effects that:
1. the preparation is prepared by slightly cleaning the animal wound with hydrogen peroxide solution, wiping, optionally wiping, and directly spreading the powder on the animal wound for 2 times per day for 3-7 days according to the condition of the animal, and has good therapeutic effect on intractable dermatosis of animal, and is beneficial for improving survival rate of livestock.
2. The sealed sweating can ensure that the moisture of the dried ginger overflows, is beneficial to the drying of medicinal materials and prevents crusting, is soaked in the extract of the magnolia officinalis to be stuffy and moist, ensures that the dissolution rate of the components is improved, combines a plurality of components to synergically act together, stimulates and synthesizes a plurality of growth factors, promotes wound healing, and plays a role in improving the metabolism and the immunologic function of patients.
3. The high-purity ozone oil is added, compared with the traditional low-concentration ozone oil, the bacteriostatic effect is good, the borneol, the mint and the fructus evodiae are added, the effects of diminishing swelling, clearing heat, relieving itching, dispelling cold and relieving pain are achieved, the fructus cnidii and the lithargite are added to effectively kill insects and relieve itching, and the gallnut, the dried ginger and the philippine violet herb are added to effectively perform the effects of arresting sweating, stopping bleeding and detoxifying.
4. The animal wound is slightly cleaned by hydrogen peroxide solution and then wiped off, or white spirit, physiological saline or clean water is used for mixing a powdery preparation into paste to be applied to the wound.
Drawings
FIG. 1 is a schematic flow chart of a method for preparing a compound preparation for treating animal skin diseases according to the present invention;
fig. 2 is a schematic diagram of curing cases of examples 1-3 and comparative examples of a compound preparation for treating animal skin diseases according to the present invention.
Detailed Description
The technical solution of the present patent will be described in further detail with reference to the following embodiments.
Reference will now be made in detail to embodiments of the present patent, examples of which are illustrated in the accompanying drawings, wherein like or similar reference numerals refer to the same or similar elements or elements having the same or similar function throughout. The embodiments described below with reference to the drawings are exemplary only for the purpose of explaining the present patent and are not to be construed as limiting the present patent.
In the description of this patent, it is to be understood that the terms "center," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in the orientations and positional relationships indicated in the drawings for the convenience of describing the patent and for the simplicity of description, and are not intended to indicate or imply that the referenced devices or elements must have a particular orientation, be constructed and operated in a particular orientation, and are not to be considered limiting of the patent.
In the description of this patent, it is noted that unless otherwise specifically stated or limited, the terms "mounted," "connected," and "disposed" are to be construed broadly and can include, for example, fixedly connected, disposed, detachably connected, disposed, or integrally connected and disposed. The specific meaning of the above terms in this patent may be understood by those of ordinary skill in the art as appropriate.
Example 1:
a compound preparation for treating animal skin diseases is shown in figure 1 and figure 2, and comprises the following components in parts by weight: 2 parts of ozone oil, 1.5 parts of olive oil, 1.5 parts of peppermint oil, 2 parts of matrine, 2 parts of camphor, 1 part of borneol, 3 parts of mint, 2 parts of common cnidium fruit, 2 parts of litharge, 2 parts of Chinese gall, 1 part of evodia rutaecarpa, 2 parts of dried ginger and 2 parts of Chinese violet.
The content of the ozone oil is 15-25 g/L, and the pH value is 3-5.
The preparation method of the matrine comprises the following steps:
s31: extracting oxymatrine from herba Sophorae Alopecuroidis by supercritical CO2 fluid extraction;
s32: 0.1mL/L ammonia water is used as an alkalizer, and the extraction is carried out for 2h under the conditions of the temperature of 45 ℃ and the pressure of 42MPa to obtain the product.
The preparation method of the dried ginger comprises the following steps:
s41: removing impurities from the ginger blocks, cleaning, soaking for 20 minutes, and draining;
s42: placing the treated ginger blocks in a drying room at 30 ℃ and sealing to sweat for 25 h;
s43: putting the sweated ginger blocks into the magnolia officinalis extracting solution, moistening for 2.5h, frying with strong fire, and continuously frying for 10 min when the temperature reaches 120 ℃;
s44: drying to obtain the dried ginger.
Further, the preparation method of the magnolia bark extract comprises the following steps:
s51: pulverizing 30g of cortex Magnolia officinalis, adding 4% ammonia water, reflux extracting for 3 times, and boiling for 4 hr each time;
s52: filtering, adjusting pH of the filtrate to 3 with concentrated hydrochloric acid, standing at room temperature for 12h, filtering, oven drying the residue, cutting the precipitate, refluxing with 100ml of cyclohexane for 3h, filtering, and concentrating the filtrate;
s53: and combining the filtrates to obtain the finished product.
A method for preparing a compound preparation for treating animal skin diseases comprises the following steps:
s1: taking ozone oil, camphor, olive oil, peppermint oil, matrine, borneol and dried ginger for later use;
s2: picking herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae and herba Violae, removing impurities respectively, cleaning, cutting or slicing, and air drying;
s3: drying Camphora, matrine, Borneolum Syntheticum, herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae, Zingiberis rhizoma and herba Violae, pulverizing, and sieving with 120 mesh sieve;
s4: weighing raw material powder according to the weight components, stirring and mixing to obtain a compound preparation, and packaging.
When the preparation is used, the wounded parts of animals are slightly cleaned by hydrogen peroxide solution and then wiped dry without scrubbing, and then the preparation powder is directly sprayed on the wounded parts of the animals; 2 times a day, according to the state of an illness and using 3-7 days together, the preparation is simple, the use is convenient, the prepared medicine has good curative effect for treating intractable dermatosis of animals, is beneficial to improving the survival rate of livestock, high-purity ozone oil is added, the bacteriostatic effect is better than that of the traditional low-concentration ozone oil, borneol, mint and fructus evodiae components are added to play the roles of detumescence, heat clearing, itching relieving, cold dispelling and pain relieving, common cnidium fruit and litharge are added to effectively kill insects and relieve itching, the water of the dried ginger can overflow by closed sweating, the medicine is beneficial to drying and preventing crusting of medicinal materials, and the medicine is soaked in the extract of magnolia officinalis and moistened, the dissolution rate of the components is improved, the Chinese gall, the dried ginger and the Chinese violet are added to effectively perform the effects of arresting sweating, stopping bleeding and detoxifying, the multiple components are combined together to realize synergistic interaction, the synthesis of multiple growth factors is stimulated, the wound healing is promoted, and the effects of improving the metabolism and the immune function of a patient are achieved.
Example 2:
a compound preparation for treating animal skin diseases is shown in figure 1 and figure 2, and comprises the following components in parts by weight: 2 parts of ozone oil, 2 parts of olive oil, 2 parts of peppermint oil, 1 part of matrine, 2 parts of camphor, 2 parts of borneol, 3.5 parts of mint, 3 parts of common cnidium fruit, 1.5 parts of litharge, 1.5 parts of Chinese gall, 1 part of evodia rutaecarpa, 1 part of dried ginger and 1 part of Chinese violet.
The content of the ozone oil is 15-25 g/L, and the pH value is 3-5.
The preparation method of the matrine comprises the following steps:
s31: extracting oxymatrine from herba Sophorae Alopecuroidis by supercritical CO2 fluid extraction;
s32: 0.1mL/L ammonia water is used as an alkalizer, and the extraction is carried out for 2h under the conditions of the temperature of 45 ℃ and the pressure of 42MPa to obtain the product.
The preparation method of the dried ginger comprises the following steps:
s41: removing impurities from the ginger blocks, cleaning, soaking for 20 minutes, and draining;
s42: placing the treated ginger blocks in a drying room at 30 ℃ and sealing to sweat for 25 h;
s43: putting the sweated ginger blocks into the magnolia officinalis extracting solution, moistening for 2.5h, frying with strong fire, and continuously frying for 10 min when the temperature reaches 120 ℃;
s44: drying to obtain the dried ginger.
Further, the preparation method of the magnolia bark extract comprises the following steps:
s51: pulverizing 30g of cortex Magnolia officinalis, adding 4% ammonia water, reflux extracting for 3 times, and boiling for 4 hr each time;
s52: filtering, adjusting pH of the filtrate to 3 with concentrated hydrochloric acid, standing at room temperature for 12h, filtering, oven drying the residue, cutting the precipitate, refluxing with 100ml of cyclohexane for 3h, filtering, and concentrating the filtrate;
s53: and combining the filtrates to obtain the finished product.
A method for preparing a compound preparation for treating animal skin diseases comprises the following steps:
s1: taking ozone oil, camphor, olive oil, peppermint oil, matrine, borneol and dried ginger for later use;
s2: picking herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae and herba Violae, removing impurities respectively, cleaning, cutting or slicing, and air drying;
s3: drying Camphora, matrine, Borneolum Syntheticum, herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae, Zingiberis rhizoma and herba Violae, pulverizing, and sieving with 120 mesh sieve;
s4: weighing raw material powder according to the weight components, stirring and mixing to obtain a compound preparation, and packaging.
When the preparation is used, the affected part of the animal is slightly cleaned by hydrogen peroxide solution and then wiped off, or white spirit, normal saline or clean water is used for concocting a powdery preparation into paste to be applied to the affected part, and the paste is applied to the affected part for 2 times a day and for 3 to 9 days according to the state of illness.
Example 3
A compound preparation for treating animal skin diseases is shown in figure 1 and figure 2, and comprises the following components in parts by weight: 1 part of ozone oil, 11 parts of olive oil, 2 parts of peppermint oil, 1.5 parts of matrine, 2 parts of camphor, 1 part of borneol, 2 parts of mint, 1 part of common cnidium fruit, 1 part of litharge, 1 part of Chinese gall, 1.5 parts of evodia, 2.5 parts of dried ginger and 1 part of Chinese violet.
The content of the ozone oil is 15-25 g/L, and the pH value is 3-5.
The preparation method of the matrine comprises the following steps:
s31: extracting oxymatrine from herba Sophorae Alopecuroidis by supercritical CO2 fluid extraction;
s32: 0.1mL/L ammonia water is used as an alkalizer, and the extraction is carried out for 2h under the conditions of the temperature of 45 ℃ and the pressure of 42MPa to obtain the product.
The preparation method of the dried ginger comprises the following steps:
s41: removing impurities from the ginger blocks, cleaning, soaking for 20 minutes, and draining;
s42: placing the treated ginger blocks in a drying room at 30 ℃ and sealing to sweat for 25 h;
s43: putting the sweated ginger blocks into the magnolia officinalis extracting solution, moistening for 2.5h, frying with strong fire, and continuously frying for 10 min when the temperature reaches 120 ℃;
s44: drying to obtain the dried ginger.
Further, the preparation method of the magnolia bark extract comprises the following steps:
s51: pulverizing 30g of cortex Magnolia officinalis, adding 4% ammonia water, reflux extracting for 3 times, and boiling for 4 hr each time;
s52: filtering, adjusting pH of the filtrate to 3 with concentrated hydrochloric acid, standing at room temperature for 12h, filtering, oven drying the residue, cutting the precipitate, refluxing with 100ml of cyclohexane for 3h, filtering, and concentrating the filtrate;
s53: and combining the filtrates to obtain the finished product.
A method for preparing a compound preparation for treating animal skin diseases comprises the following steps:
s1: taking ozone oil, camphor, olive oil, peppermint oil, matrine, borneol and dried ginger for later use;
s2: picking herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae and herba Violae, removing impurities respectively, cleaning, cutting or slicing, and air drying;
s3: drying Camphora, Borneolum Syntheticum, herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae, Zingiberis rhizoma and herba Violae, pulverizing, and sieving with 120 mesh sieve;
s4: weighing raw material powder according to the weight components, stirring and mixing to obtain a compound preparation, and packaging.
In the use of the embodiment, the preparation powder is directly sprayed on the wounded parts of animals; it is administered for 3-10 days for 2 times per day according to the disease condition.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be considered to be within the technical scope of the present invention, and the technical solutions and the inventive concepts thereof according to the present invention should be equivalent or changed within the scope of the present invention.
Claims (7)
1. The compound preparation for treating the animal skin diseases is characterized by comprising the following components in parts by weight: 2 parts of ozone oil, 1.5 parts of olive oil, 1.5 parts of peppermint oil, 2 parts of matrine, 2 parts of camphor, 1 part of borneol, 3 parts of mint, 2 parts of common cnidium fruit, 2 parts of litharge, 2 parts of Chinese gall, 1 part of evodia rutaecarpa, 2 parts of dried ginger and 2 parts of Chinese violet.
2. The compound preparation for treating animal skin diseases according to claim 1, wherein the content of ozone oil is 15-25 g/L, and the pH value is 3-5.
3. The compound preparation for treating animal skin diseases according to claim 2, wherein the preparation method of matrine comprises the following steps:
s31: extracting oxymatrine from herba Sophorae Alopecuroidis by supercritical CO2 fluid extraction;
s32: 0.1mL/L ammonia water is used as an alkalizer, and the extraction is carried out for 2h under the conditions of the temperature of 45 ℃ and the pressure of 42MPa to obtain the product.
4. The compound preparation for treating the animal skin diseases according to claim 3, wherein the preparation method of the dried ginger comprises the following steps:
s41: removing impurities from the ginger blocks, cleaning, soaking for 20 minutes, and draining;
s42: placing the treated ginger blocks in a drying room at 30 ℃ and sealing to sweat for 25 h;
s43: putting the sweated ginger blocks into the magnolia officinalis extracting solution, moistening for 2.5h, frying with strong fire, and continuously frying for 10 min after the temperature reaches 120 ℃;
s44: drying to obtain the dried ginger.
5. The compound preparation for treating animal skin diseases as claimed in claim 4, wherein the preparation method of the magnolia bark extract comprises the following steps:
s51: pulverizing 30g of cortex Magnolia officinalis, adding 4% ammonia water, reflux extracting for 3 times, and boiling for 4 hr each time;
s52: filtering, adjusting pH of the filtrate to 3 with concentrated hydrochloric acid, standing at room temperature for 12h, filtering, oven drying the residue, cutting the precipitate, refluxing with 100ml of cyclohexane for 3h, filtering, and concentrating the filtrate;
s53: and combining the filtrates to obtain the finished product.
6. A method for preparing a compound preparation for treating animal skin diseases according to any one of claims 1 to 5, which comprises the following steps:
s1: taking ozone oil, camphor, olive oil, peppermint oil, matrine, borneol and dried ginger for later use;
s2: picking herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae and herba Violae, removing impurities respectively, cleaning, cutting or slicing, and air drying;
s3: drying Camphora, matrine, Borneolum Syntheticum, herba Menthae, fructus Cnidii, Lithargyrum, Galla chinensis, fructus evodiae, Zingiberis rhizoma and herba Violae, pulverizing, and sieving with 120 mesh sieve;
s4: weighing raw material powder according to the weight components, stirring and mixing to obtain a compound preparation, and packaging.
7. The compound preparation for treating the animal skin diseases according to claim 1, wherein the weight components are replaced by the following components: 2 parts of ozone oil, 2 parts of olive oil, 2 parts of peppermint oil, 1 part of matrine, 2 parts of camphor, 2 parts of borneol, 3.5 parts of mint, 3 parts of common cnidium fruit, 1.5 parts of litharge, 1.5 parts of Chinese gall, 1 part of evodia rutaecarpa, 1 part of dried ginger and 1 part of Chinese violet.
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Application publication date: 20201016 |