CN115812966A - Dandelion extract, betel nut buccal product and preparation method - Google Patents
Dandelion extract, betel nut buccal product and preparation method Download PDFInfo
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Abstract
The invention discloses dandelion extract, a betel nut buccal product and a preparation method thereof, and relates to the technical field of food. The dandelion extract provided by the invention is prepared by an enzyme method assisted by a supercritical extraction method, has no solvent residue, and reaches a safe and edible level. Compared with the methods of alcohol extraction and water extraction, the method has milder conditions; the total flavone yield is higher. The functional composition for relieving oral ulcer provided by the invention is prepared by compounding a dandelion extract, a elephantopus scaber extract, a mint extract, a scutellaria baicalensis extract and a propolis extract. The betel nut buccal product provided by the invention is compounded with the functional composition, the betel nut polysaccharide polyphenol and the betel nut essence, has the taste of betel nuts, can attract people chewing the betel nuts for a long time to taste the buccal product, and becomes a substitute of people fond of betel nuts, so that a plurality of withdrawal products are provided for people chewing the betel nuts, the risk of injuring the oral cavity by chewing the betel nuts is reduced, and the betel nut buccal product has good addiction removing property.
Description
Technical Field
The invention relates to the technical field of food, in particular to dandelion extract, a betel nut buccal product and a preparation method thereof.
Background
Betel nut is native to malaysia, and China is mainly distributed in tropical areas such as Yunnan and Hainan. The tropical region of Asia is cultivated widely. Betel nut is an important Chinese medicinal material and has the functions of expelling parasites, promoting digestion, treating edema and the like.
The damage of betel nuts refers to the damage of chewing betel nuts, and long-term chewing of the betel nuts can cause physical damage to oral mucosa and gum, so that teeth become black, are worn, shake and gum atrophy to cause periodontal diseases; in addition, the betel nut also contains a substance called arecoline, which has mutagenicity to human body and can cause harm.
Chewing betel nuts is strongly addictive and more people understand and realize the hazards of chewing betel nuts. Therefore, there is a need to develop a buccal product which can replace chewing areca to provide a withdrawal product for people chewing areca and reduce the risk of injuring the oral cavity by chewing areca.
Disclosure of Invention
The invention aims to provide a buccal product which can replace chewing areca for people chewing areca and reduce the risk of injuring the oral cavity by chewing areca.
Furthermore, the invention aims to provide the dandelion extract, the betel nut buccal product and the preparation method, which have the advantages of helping a user to get rid of dependence on chewing betel nuts and have the effect of relieving canker sore.
In order to solve the above problems, the present invention proposes the following technical solutions:
in a first aspect, the present invention provides a method for preparing a dandelion extract, comprising the steps of:
(1) Pulverizing herba Taraxaci with pulverizer, and sieving with 30-80 mesh sieve to obtain herba Taraxaci powder;
(2) Dispersing the dandelion powder in water, adding 10-20 times of water by mass, adjusting the pH of the solution to 5.0-6.5, and adding cellulase for crude extraction; the addition amount of the cellulase is 0.1-0.5% of the total mass of the solution;
(3) Filtering the solution in the step (2) and taking a supernatant;
(4) Subjecting the supernatant to supercritical CO 2 Extracting to obtain an extract liquid;
(5) And carrying out spray drying on the extract liquor to obtain the dandelion extract.
The further technical scheme is that in the step (2), the extraction temperature is 40-60 ℃, and the extraction time is 0.5-2.0h.
The further technical proposal is that in the step (4), CO is added 2 The flow rate is 2-4mL/min, the extraction pressure is 20-40MPa, the extraction temperature is 35-55 ℃, the extraction time is 70-90min, the separation temperature is 30-50 ℃, the separation pressure is 4-8MPa, the entrainer is ethanol, and the addition amount of the ethanol is 10-90% of the extraction liquid.
Preferably, supercritical CO is carried out 2 During extraction ， Static extraction is carried out for 60-80min, then dynamic extraction is carried out for 2-3h, and an extraction product is collected, namely the extraction liquid.
In a second aspect, the present invention provides a dandelion extract, which is prepared by the preparation method of the first aspect.
In a third aspect, the invention provides an effective composition for relieving oral ulcer, which consists of the dandelion extract, the elephantopus scaber extract, the mint extract, the scutellaria baicalensis extract and the propolis extract according to the weight ratio of 1-5:1-4:1-3:1-2:1-2.
In a fourth aspect, the invention provides an areca catechu buccal product with an effect of relieving canker sore, which comprises the effect composition in the third aspect, wherein the addition amount of the effect composition in the areca catechu buccal product is 0.05-40wt%.
In a fifth aspect, the invention provides an areca chewing gum with an effect of relieving oral ulcer, which comprises the following components in percentage by mass: 0.05-40% of efficacy composition, 1-20% of betel nut polysaccharide polyphenol, 1-10% of betel nut essence, 30-50% of chewing gum base, 0.01-5% of carrageenan, 0.01-5% of pigment, 1-10% of wheat alcohol-soluble protein, 1-10% of maltodextrin, 1-10% of high fructose corn syrup and 1-10% of xylitol.
The areca chewing gum is further prepared by the following process:
(1) Dissolving the effective composition, arecae semen polysaccharide polyphenol, high fructose syrup and xylitol at 85-95 deg.C, and stirring;
(2) Uniformly stirring gum base of chewing gum and wheat gliadin at 55-65 deg.C for 3-7h;
(3) Mixing maltodextrin, arecae semen essence, carrageenan and pigment;
(4) Putting the products obtained in the steps (1) to (3) into the same container, uniformly mixing, putting into a chewing gum mold to prepare the betel nut chewing gum, and putting into a refrigerator at 4 ℃ for aging for 24-48h;
(5) And (4) carrying out temperature-returning treatment on the areca chewing gum, sterilizing and packaging.
In a sixth aspect, the invention provides betel nut buccal tablets with the effect of relieving oral ulcer, which comprise the following components in parts by mass: 0.05-40 parts of efficacy composition, 1-30 parts of areca polysaccharide polyphenol, 5-20 parts of xylitol, 5-20 parts of maltodextrin, 1-5 parts of citric acid, 1-5 parts of areca essence, 1-5 parts of mint essence, 1-5 parts of magnesium stearate and 230.1-5 parts of cooling agent WS.
The further technical scheme is that the betel palm buccal tablet is prepared by adopting the following process:
m1, performing ultraviolet sterilization treatment on all the raw materials, and sterilizing for 20-40min under an ultraviolet condition;
m2, weighing the efficacy composition, the betel nut polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the betel nut essence and the mint essence, putting the components into a double-helix conical mixer, adjusting the rotating speed to 40rpm/min, and mixing for 2-5 hours until the components are uniform to obtain a mixture;
m3, preparing the mixture into a soft material by taking water as a wetting agent;
m4, sieving and granulating the soft material, drying the prepared granules, and controlling the moisture of the granules to be below 5%;
and M5, adding magnesium stearate, uniformly mixing, putting into a tablet press, tabletting to obtain the betel nut buccal tablet, sterilizing and packaging.
In a further embodiment, in the step M3, water is added in an amount of 5 to 8% by weight, and the soft material is required to be in a state of being agglomerated by hand and being immediately dispersed by light touch.
The further technical scheme is that in the step M4, the prepared particles are dried in a 60 ℃ constant temperature air blast drying oven for 4-8 hours.
The further technical scheme is that in the step M5, during tabletting, the maximum tabletting diameter is 25mm, the rotating speed is 1400rpm/min, and the power is 1.1kw.
Compared with the prior art, the invention can achieve the following technical effects:
the preparation method of the dandelion extract provided by the invention firstly adopts the enzyme method to perform crude extraction, and then adopts supercritical CO to perform the crude extraction 2 Extracting, and spray drying to obtain herba Taraxaci extract. The cellulose in the dandelion raw material can be pre-enzymolyzed by the cellulase, so that more flavonoids are released, and the conditions are milder compared with the ethanol extraction and water extraction methods; the total flavone yield is higher.
The dandelion extract provided by the invention is prepared by an enzyme method assisted supercritical extraction method, the total flavone yield is higher, and the dandelion extract reaches a safe edible level.
The functional composition for relieving oral ulcer provided by the invention is prepared by compounding a dandelion extract, a elephantopus scaber extract, a mint extract, a scutellaria baicalensis extract and a propolis extract. The herba Taraxaci extract has effects of removing toxic substances and improving liver function; the elephantopus scaber extract has the effects of clearing away heat and toxic materials, relieving swelling and promoting urination; the herba Menthae extract has effects of dispelling pathogenic wind heat, refreshing head, and promoting eruption; the Scutellariae radix extract has effects of clearing heat, eliminating dampness, purging pathogenic fire, and removing toxic substances; propolis has good anti-inflammatory effect. The five extracts are compounded, so that the oral ulcer can be effectively relieved.
The betel nut buccal product with the effect of relieving canker sore, which is provided by the invention, is compounded with the composition with the effect, the betel nut polysaccharide polyphenol and the betel nut essence, has the taste of betel nuts, can attract people chewing the betel nuts for a long time to taste the buccal product, and becomes a substitute of people fond of betel nuts, so that a plurality of withdrawal products are provided for people chewing the betel nuts, the risk of injuring the oral cavity by chewing the betel nuts is reduced, and the betel nut buccal product has good addiction removing property.
The areca chewing gum with the effect of relieving canker sore, which is provided by the invention, is compounded with the effect composition, the areca polysaccharide polyphenol and the areca essence, has the flavor of areca, can be chewed, has the effect of relieving canker sore, and is a good areca substitute.
The betel nut buccal tablet with the effect of relieving canker sore, provided by the invention, is compounded with the effect composition, the betel nut polysaccharide polyphenol and the betel nut essence, has the betel nut flavor, has the effect of relieving canker sore, and is a good betel nut substitute.
Detailed Description
The technical solutions in the examples will be clearly and completely described below. It is apparent that the embodiments to be described below are only a part of the embodiments of the present invention, and not all of them. All other embodiments, which can be obtained by a person skilled in the art without inventive step based on the embodiments of the present invention, are within the scope of protection of the present invention.
It will be understood that the terms "comprises" and/or "comprising," when used in this specification and the appended claims, specify the presence of stated features, integers, steps, operations, elements, and/or components, but do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, and/or groups thereof.
Example 1
The embodiment of the invention provides a dandelion extract, which is prepared by an enzyme method assisted supercritical extraction method. The preparation method is described in detail as follows:
(1) Crushing: pulverizing herba Taraxaci, and sieving with 30-80 mesh sieve to obtain herba Taraxaci powder.
(2) Enzyme crude extraction: dispersing the dandelion powder in water, adjusting the pH value to be 5.0-6.5, and adding cellulase for crude extraction, wherein the addition amount of the cellulase is 0.1-0.5%;
(3) And (3) filtering: filtering the solution after crude extraction, and taking supernatant;
(4) Supercritical CO is adopted for supernatant fluid 2 The extraction process is used for extracting to obtain more flavonoid substances in the dandelion. The optimal conditions are that the extraction pressure is 30MPa, the extraction temperature is 35-45 ℃, and the extraction time is 70-90min;
(5) And carrying out spray drying on the extract liquor to obtain the dandelion extract.
In the embodiment, sucrose and dextrin are subjected to spray drying with the extract liquor according to the mass ratio of 4:1; the temperature of the air inlet is 80-90 ℃; the temperature of the air outlet is 40-50 ℃; the liquid inlet speed is 4-10mL/min, and herba Taraxaci extract powder is prepared into brown powder.
In the embodiment, the suitable temperature of the crude extraction is 40-60 ℃, preferably 40-50 ℃, the cellulase activity is better at the temperature, and the extraction time is 0.5-2.0h.
In the embodiment, the yield of the total flavonoids in the dandelion extract powder obtained by adopting the enzyme method assisted supercritical extraction method is as high as 2.539%, which is much higher than that of the total flavonoids extracted by a common method of 1.724%.
TABLE 1 Effect of the addition of different cellulases on the yield of Total Flavonoids
| NO | Cellulase addition amount | Crude extraction temperature | Extraction time | Total flavone content |
| Example 1-1 | 0.5％ | 50℃ | 2h | 2.539％ |
| Examples 1 to 2 | 0.45％ | 48℃ | 1.5h | 2.468％ |
| Examples 1 to 3 | 0.4％ | 45℃ | 1.2h | 2.395％ |
| Examples 1 to 4 | 0.35％ | 43℃ | 1h | 2.416％ |
| Examples 1 to 5 | 0.3％ | 40℃ | 0.8h | 2.327％ |
| Comparative examples 1 to 1 | - | - | 2h | 1.724％ |
| Comparative examples 1 to 2 | 0.5％ | 50℃ | 2h | 1.325％ |
| Comparative examples 1 to 3 | 0.5％ | 50℃ | 2h | 1.238％ |
Wherein, comparative example 1-1 is that the crude extraction is not carried out, and the supercritical CO is directly adopted 2 Is prepared by an extraction process; the comparative examples 1-2 are prepared by adopting an alcohol extraction method after crude extraction by an enzyme method, and the specific process comprises the following steps: adding 15-20 times of 40% -60% ethanol solution of herba Taraxaci, extracting at 180-240 deg.C for 3-5 hr, filtering, and collecting filtrate; adding 40% -60% ethanol solution 10-15 times of the weight of herba Taraxaci into the residue, extracting at 180 deg.C-240 deg.C for 3-5 hr, filtering, mixing the filtrates, and concentrating under reduced pressure (50-60 deg.C and 0.08 Mpa) to obtain the final extract.
The comparative examples 1-3 are prepared by adopting an enzyme method to perform crude extraction and then performing water extraction, and the specific process comprises the following steps: adding 15-20 times of water solution of herba Taraxaci into the herba Taraxaci powder, extracting at 180-240 deg.C for 3-5 hr, filtering, collecting filtrate, adding 10-15 times of water solution of herba Taraxaci for the second time, extracting at 180-240 deg.C for 3-5 hr, filtering, mixing filtrates, and concentrating under reduced pressure (60-70 deg.C and 0.08 Mpa) to obtain final extract.
Example 2
This example provides a composition 1 for alleviating oral ulcer, which is prepared from the dandelion extract, the elephantopus scaber extract, the mint extract, the scutellaria baicalensis extract and the propolis extract prepared in example 1-1 in a weight ratio of 2.
This example provides an efficacious composition 2 for alleviating oral ulcers, which is composed of the dandelion extract, elephantopus scaber extract, mint extract, scutellaria baicalensis extract and propolis extract prepared in example 1-1 in a weight ratio of 3.
This example provides a combination 3 for alleviating oral ulcers, which is composed of the dandelion extract, elephantopus scaber extract, mint extract, scutellaria baicalensis extract and propolis extract prepared in example 1-1 in a weight ratio of 4.
This example provides an efficacy combination 4 for alleviating oral ulcers, consisting of the dandelion extract, elephantopus scaber extract, mint extract, scutellaria baicalensis extract and propolis extract prepared in example 1-1 in a weight ratio of 5.
For comparison, the following examples each use the addition of the efficacy composition 1 as an example to verify the efficacy of the efficacy composition.
Example 3
The embodiment provides betel nut chewing gum with the effect of relieving oral ulcer, which comprises the following components in percentage by mass: the functional composition provided by the embodiment 2 comprises 1% of the composition, 15.5% of areca polysaccharide polyphenol, 8% of areca essence, 40% of chewing gum base, 4% of carrageenan, 0.5% of pigment, 1% of wheat alcohol-soluble protein, 1% of maltodextrin, 5% of high fructose syrup and 5% of xylitol.
The betel nut chewing gum is prepared by the following process:
(1) Dissolving the effective composition, arecae semen polysaccharide polyphenol, high fructose syrup and xylitol at 85-95 deg.C, and stirring;
(2) Uniformly stirring the chewing gum base and the wheat gliadin at the temperature of 55-65 ℃ for 3-7h;
(3) Mixing maltodextrin, arecae semen essence, carrageenan and pigment;
(4) Putting the products obtained in the steps (1) to (3) into the same container, uniformly mixing, putting into a chewing gum mold to prepare the betel nut chewing gum, and putting into a refrigerator at 4 ℃ for aging for 24-48h;
(5) And (4) carrying out temperature-returning treatment on the areca chewing gum, sterilizing and packaging.
In this embodiment, according to the difference in the shape of the chewing gum mold in the step (4), the chewing gum with different shapes can be obtained, so that the chewing gum has richer shapes.
Example 4
This example provides an areca chewing gum with the effect of relieving canker sore, which is different from example 3 in the amount of specific components. The betel nut chewing gum comprises the following components in percentage by mass: the functional composition comprises 1 25% of areca polysaccharide polyphenol, 10.5% of areca essence, 40% of chewing gum base, 4% of carrageenan, 0.5% of pigment, 1% of wheat alcohol-soluble protein, 1% of maltodextrin, 5% of high fructose corn syrup and 5% of xylitol.
Example 5
This example provides an areca chewing gum with the effect of relieving canker sore, which is different from example 3 in the amount of specific components. The betel nut chewing gum comprises the following components in percentage by mass: the functional composition comprises 115% of areca polysaccharide polyphenol 10.5%, 8% of areca essence, 45% of chewing gum base, 4% of carrageenan, 0.5% of pigment, 1% of wheat alcohol-soluble protein, 1% of maltodextrin, 5% of high fructose corn syrup and 5% of xylitol.
Example 6
The present example provides an areca chewing gum with the effect of relieving canker sore, which is different from example 3 in the amount of specific components. The betel nut chewing gum comprises the following components in percentage by mass: the functional composition comprises 1% of betel nut polysaccharide polyphenol 10.5%, 8% of betel nut essence, 47% of chewing gum base, 4% of carrageenan, 0.5% of pigment, 10% of wheat alcohol-soluble protein, 5% of maltodextrin, 5% of high fructose syrup and 5% of xylitol.
Example 7
The present example provides an areca chewing gum with the effect of relieving canker sore, which is different from example 3 in the amount of specific components. The betel nut chewing gum comprises the following components in percentage by mass: the functional composition comprises 11.5% of areca polysaccharide polyphenol 15.5%, 8% of areca essence, 47% of chewing gum base, 4% of carrageenan, 3% of pigment, 8% of wheat alcohol-soluble protein, 9% of maltodextrin, 2% of high fructose syrup and 2% of xylitol.
TABLE 2 quality evaluation table of betel nut chewing gum prepared in different examples
Of these, comparative example 1 is a chewing gum without efficacy composition 1.
As can be seen from table 2, compared to comparative example 1, the betel nut buccal tablets of examples 3 to 7 have the betel nut taste and the addiction-relieving effect, and can obtain recognizable burning sensation and alleviate canker sores by using the physiological synergistic effect of the betel nut alkali and the total flavonoids in the dandelion extract when the functional composition containing the dandelion extract and the betel nut alkali are simultaneously added into the product.
Example 8
The embodiment provides betel nut buccal tablets with the effect of relieving oral ulcer, which comprise the following components in parts by mass: the functional composition comprises, by weight, 1 part of an efficacy composition, 10 parts of areca polysaccharide polyphenol, 15 parts of xylitol, 15 parts of maltodextrin, 3 parts of citric acid, 2 parts of areca essence, 5 parts of mint essence, 1 part of magnesium stearate and 3 parts of a cooling agent WS-23.
The betel nut buccal tablet is prepared by adopting the following process:
m1, performing ultraviolet sterilization treatment on all the raw materials, and sterilizing for 20-40min under an ultraviolet condition;
m2, weighing the efficacy composition, the areca polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the areca essence and the mint essence, placing the efficacy composition, the areca polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the areca essence and the mint essence in a double-helix conical mixer, adjusting the rotating speed to 40rpm/min, and mixing for 2-5 h until the efficacy composition, the areca polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the areca essence and the mint essence are uniform to obtain a mixture;
m3, adding 5-8 wt% of water as a wetting agent, and preparing the mixture into soft materials, wherein the soft materials are required to be in a state of being held by hands to be agglomerated and being scattered by light touch;
m4, sieving and granulating the soft material, drying the prepared granules, and drying the granules in a constant-temperature air blast drying oven at the temperature of 60 ℃ for 4-8 hours, wherein the moisture of the granules is controlled to be below 5%;
and M5, adding magnesium stearate, mixing uniformly, putting into a tablet press, tabletting, wherein the maximum tabletting diameter is 25mm, the rotation speed is 1400rpm/min, and the power is 1.1kw when tabletting is carried out, so as to obtain the betel nut buccal tablet, sterilizing for 20-40min under the ultraviolet condition, and packaging.
Example 9
The betel nut buccal tablet with the effect of relieving oral ulcer provided by the embodiment is different from the betel nut buccal tablet provided by the embodiment 8 in the specific component dosage. The betel nut buccal tablet comprises the following components in parts by mass: 120 parts of efficacy composition, 15 parts of areca polysaccharide polyphenol, 15 parts of xylitol, 15 parts of maltodextrin, 3 parts of citric acid, 2 parts of areca essence, 5 parts of mint essence, 1 part of magnesium stearate and 1 part of cooling agent WS-23.
Example 10
The betel nut buccal tablet with the effect of relieving oral ulcer provided by the embodiment is different from the betel nut buccal tablet provided by the embodiment 8 in the specific component dosage. The betel nut buccal tablet comprises the following components in parts by mass: the functional composition comprises, by weight, 1 part of an efficacy composition, 15 parts of areca polysaccharide polyphenol, 15 parts of xylitol, 15 parts of maltodextrin, 3 parts of citric acid, 2 parts of areca essence, 5 parts of mint essence, 1 part of magnesium stearate and WS-232 parts of a cooling agent.
Example 11
The betel nut buccal tablet with the effect of relieving oral ulcer provided by the embodiment is different from the betel nut buccal tablet provided by the embodiment 8 in the specific component dosage. The betel nut buccal tablet comprises the following components in parts by mass: the functional composition comprises, by weight, 1 part of an efficacy composition, 15 parts of areca polysaccharide polyphenol, 15 parts of xylitol, 15 parts of maltodextrin, 3 parts of citric acid, 2 parts of areca essence, 5 parts of mint essence, 1 part of magnesium stearate and WS-232 parts of a cooling agent.
Example 12
The betel nut buccal tablet with the effect of relieving oral ulcer provided by the embodiment is different from the betel nut buccal tablet provided by the embodiment 8 in the specific component dosage. The betel nut buccal tablet comprises the following components in parts by mass: 1 part of efficacy composition, 15 parts of areca polysaccharide polyphenol, 15 parts of xylitol, 15 parts of maltodextrin, 3 parts of citric acid, 2 parts of areca essence, 5 parts of mint essence, 1 part of magnesium stearate and WS-232 parts of cooling agent.
TABLE 3 quality evaluation table for betel nut buccal tablets prepared in different embodiments
Wherein, comparative example 2 is betel nut buccal tablet without efficacy composition 1.
As can be seen from table 3, in the betel nut buccal tablets of examples 8 to 12, compared to comparative example 2, the efficacy composition containing the dandelion extract and the arecoline are added to the product at the same time, and the recognizable burning sensation can be obtained by utilizing the physiological synergistic enhancement effect of the arecoline and the total flavonoids in the dandelion extract, the canker sore can be relieved, and the betel nut buccal tablets have the betel nut taste and the addiction relieving effect.
Evaluation of antibacterial Effect
The betel nut chewing gum and the betel nut buccal tablet prepared in the embodiment and the comparative example are taken and fully dissolved by 20ml of distilled water to prepare a dissolving solution, and four pathogenic bacteria related to the dental ulcer are selected: streptococcus mutans, diplococcus pneumoniae and Porphyromonas gingivalis are used as experimental strains, the experimental strains are cultured at 28 ℃, an agar punching diffusion method is adopted, a nutrient agar culture medium is sterilized and poured into a sterile culture dish, after the nutrient agar culture medium is solidified, 1000 mu L of the strains are sucked into the culture dish by a pipette gun and are uniformly coated, and each group is subjected to 3 parallel tests. After coating, punching a culture dish by using a sterilized stainless steel puncher with the outer diameter of 2mm, taking a proper amount of dissolving liquid by using a liquid transfer gun, injecting the proper amount of dissolving liquid into the holes, respectively culturing at 28 ℃ for 24-48h, measuring the diameter of a bacteriostatic circle (the bacteriostatic diameter is measured in mm), and taking the average value as the final result. The results are shown in Table 4, and the larger the bacteriostatic diameter is, the better the bacteriostatic effect is.
TABLE 4 bacteriostatic effect of the examples
Evaluation effect on alleviation of canker sore
240 oral ulcer patients are randomly extracted and divided into 6 groups, 40 patients are in each group, 1 betel nut buccal tablet prepared in the embodiment 8-12 and the comparative example 2 is used by each group of oral ulcer patients in the morning and evening, the cure condition of the oral ulcer of each group of oral ulcer patients is observed after 7 days (short period), the relapse condition of each group of oral ulcer patients is observed within 60 days (long period), the effective rate is calculated, and the results are shown in table 5.
TABLE 5
In the above embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.
While the invention has been described with reference to specific embodiments, the scope of the invention is not limited thereto, and various equivalent modifications and substitutions may be easily made by those skilled in the art within the technical scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (10)
1. A preparation method of a dandelion extract is characterized by comprising the following steps:
(1) Pulverizing herba Taraxaci with pulverizer, and sieving with 30-80 mesh sieve to obtain herba Taraxaci powder;
(2) Dispersing the dandelion powder in water, adding 10-20 times of water by mass, adjusting the pH of the solution to 5.0-6.5, and adding cellulase for crude extraction; the addition amount of the cellulase is 0.1-0.5% of the total mass of the solution;
(3) Filtering the solution in the step (2) and taking a supernatant;
(4) Subjecting the supernatant to supercritical CO 2 Extracting to obtain an extract liquid;
(5) And carrying out spray drying on the extract liquor to obtain the dandelion extract.
2. The method according to claim 1, wherein in the step (2), the extraction temperature is 40-60 ℃ and the extraction time is 0.5-2.0h.
3. The method according to claim 1, wherein in the step (4), CO is used 2 The flow rate is 2-4mL/min, the extraction pressure is 20-40MPa, the extraction temperature is 35-55 ℃, the extraction time is 70-90min, the separation temperature is 30-50 ℃, the separation pressure is 4-8MPa, the entrainer is ethanol, and the addition amount of the ethanol is 10-90% of the extraction liquid.
4. A dandelion extract characterized by being produced by the production method according to any one of claims 1 to 3.
5. An efficacious composition for relieving canker sores comprising the dandelion extract, elephantopus scaber extract, mint extract, scutellaria baicalensis extract and propolis extract of claim 4 in a weight ratio of 1-5:1-4:1-3:1-2:1-2.
6. An areca buccal product with the efficacy of relieving canker sore, which is characterized by comprising the efficacy composition of claim 5, wherein the addition amount of the efficacy composition in the areca buccal product is 0.05-40wt%.
7. The areca chewing gum with the effect of relieving oral ulcer is characterized by comprising the following components in percentage by mass: the functional composition of claim 5 comprises 0.05-40% of the composition, 1-20% of areca polysaccharide polyphenol, 1-10% of areca essence, 30-50% of chewing gum base, 0.01-5% of carrageenan, 0.01-5% of pigment, 1-10% of wheat gliadin, 1-10% of maltodextrin, 1-10% of high fructose syrup and 1-10% of xylitol.
8. The areca chewing gum with effect of relieving canker sore according to claim 7, which is prepared by the following process:
(1) Dissolving the effective composition, areca polysaccharide polyphenol, high fructose syrup and xylitol at 85-95 deg.C, and stirring;
(2) Uniformly stirring gum base of chewing gum and wheat gliadin at 55-65 deg.C for 3-7h;
(3) Mixing maltodextrin, arecae semen essence, carrageenan and pigment;
(4) Putting the products obtained in the steps (1) to (3) into the same container, uniformly mixing, putting into a chewing gum mold to prepare the betel nut chewing gum, and putting into a refrigerator at 4 ℃ for aging for 24-48h;
(5) And (4) carrying out temperature-returning treatment on the betel nut chewing gum, sterilizing and packaging.
9. The betel nut buccal tablet with the effect of relieving oral ulcer is characterized by comprising the following components in parts by mass: the functional composition of claim 5, wherein the functional composition comprises 0.05-40 parts of areca polysaccharide polyphenol, 1-30 parts of xylitol, 5-20 parts of maltodextrin, 1-5 parts of citric acid, 1-5 parts of areca essence, 1-5 parts of mint essence, 1-5 parts of magnesium stearate and 230.1-5 parts of cooling agent WS.
10. The betel nut buccal tablet with the efficacy of relieving canker sore according to claim 9, which is prepared by adopting the following process:
m1, performing ultraviolet sterilization treatment on all the raw materials, and sterilizing for 20-40min under an ultraviolet condition;
m2, weighing the efficacy composition, the areca polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the areca essence and the mint essence, placing the efficacy composition, the areca polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the areca essence and the mint essence in a double-helix conical mixer, adjusting the rotating speed to 40rpm/min, and mixing for 2-5 h until the efficacy composition, the areca polysaccharide polyphenol, the maltodextrin, the xylitol, the citric acid, the cooling agent WS-23, the areca essence and the mint essence are uniform to obtain a mixture;
m3, preparing the mixture into a soft material by taking water as a wetting agent;
m4, sieving and granulating the soft material, drying the prepared granules, and controlling the moisture of the granules to be below 5%;
and M5, adding magnesium stearate, uniformly mixing, putting into a tablet press, tabletting to obtain the betel nut buccal tablet, sterilizing and packaging.
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| US20050053678A1 (en) * | 2001-10-03 | 2005-03-10 | Gow Robert T. | Methods and compositions for betel nut chewing gum |
| CN103141829A (en) * | 2011-12-06 | 2013-06-12 | 林春梅 | Preparation method for concentrated dandelion juice |
| CN112335814A (en) * | 2019-08-08 | 2021-02-09 | 海南鑫禾生物工程有限公司 | Dandelion extract and preparation method thereof |
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| US20050053678A1 (en) * | 2001-10-03 | 2005-03-10 | Gow Robert T. | Methods and compositions for betel nut chewing gum |
| CN103141829A (en) * | 2011-12-06 | 2013-06-12 | 林春梅 | Preparation method for concentrated dandelion juice |
| CN112335814A (en) * | 2019-08-08 | 2021-02-09 | 海南鑫禾生物工程有限公司 | Dandelion extract and preparation method thereof |
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