CN113607945B - 抗HER2抗体-药物缀合物和Bcl-2抑制剂的组合疗法 - Google Patents
抗HER2抗体-药物缀合物和Bcl-2抑制剂的组合疗法 Download PDFInfo
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- CN113607945B CN113607945B CN202110774906.9A CN202110774906A CN113607945B CN 113607945 B CN113607945 B CN 113607945B CN 202110774906 A CN202110774906 A CN 202110774906A CN 113607945 B CN113607945 B CN 113607945B
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| KR20190096384A (ko) | 2017-03-02 | 2019-08-19 | 제넨테크, 인크. | Her2-양성 유방암 어쥬번트 치료 |
| CN107349426B (zh) * | 2017-07-12 | 2018-03-23 | 马骥 | 阿司匹林与曲妥珠单抗联合或协同在肿瘤治疗中的应用 |
| WO2020252015A1 (en) * | 2019-06-10 | 2020-12-17 | Sutro Biopharma, Inc. | Immunomodulator antibody drug conjugates and uses thereof |
| WO2024211811A2 (en) * | 2023-04-05 | 2024-10-10 | Frezent Biological Solutions, Inc. | Methods and compositions for antibody-drug conjugates |
| CN119454975B (zh) * | 2024-12-02 | 2025-10-21 | 中国医学科学院医学实验动物研究所 | 一种药物组合物在治疗癌症中的应用 |
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| US5204244A (en) | 1987-10-27 | 1993-04-20 | Oncogen | Production of chimeric antibodies by homologous recombination |
| US5202238A (en) | 1987-10-27 | 1993-04-13 | Oncogen | Production of chimeric antibodies by homologous recombination |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
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| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| KR20010043323A (ko) | 1998-05-06 | 2001-05-25 | 제넨테크, 인크. | 이온 교환 크로마토그래피에 의한 단백질 정제 방법 |
| HK1040720A1 (zh) | 1998-05-15 | 2002-06-21 | 伊姆克罗尼系统公司 | 用辐射和生长因子受体酪氨酸激酶抑制剂治疗人肿瘤 |
| BR0012196A (pt) * | 1999-06-25 | 2002-03-19 | Genentech Inc | Método de tratamento de um tumor em mamìferos através do uso de conjugados de maitansinóide e anticorpo receptor anti-erbb e artigo industrializado |
| US7097840B2 (en) | 2000-03-16 | 2006-08-29 | Genentech, Inc. | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates |
| EP1282443B1 (en) * | 2000-05-19 | 2009-09-02 | Genentech, Inc. | Gene detection assay for improving the likelihood of an effective response to an erbb antagonist cancer therapy |
| US7795232B1 (en) * | 2000-08-25 | 2010-09-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| US6441163B1 (en) | 2001-05-31 | 2002-08-27 | Immunogen, Inc. | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents |
| US6790954B2 (en) | 2002-01-29 | 2004-09-14 | Immunogen, Inc. | Mutant Actinosynnema pretiosum strain with increased maytansinoid production |
| AU2003300414A1 (en) * | 2002-12-19 | 2004-07-14 | Genta Incorporated | Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers |
| US7432088B2 (en) | 2003-05-08 | 2008-10-07 | Immunogen Inc. | Methods for the production of ansamitocins |
| US7004206B2 (en) | 2004-01-29 | 2006-02-28 | Viken James P | Automatic fluid exchanger |
| BRPI0510883B8 (pt) | 2004-06-01 | 2021-05-25 | Genentech Inc | composto conjugado de droga e anticorpo, composição farmacêutica, método de fabricação de composto conjugado de droga e anticorpo e usos de uma formulação, de um conjugado de droga e anticorpo e um agente quimioterapêutico e de uma combinação |
| JP2006316040A (ja) | 2005-05-13 | 2006-11-24 | Genentech Inc | Herceptin(登録商標)補助療法 |
| AU2014240234B2 (en) * | 2008-03-18 | 2016-10-06 | Genentech, Inc. | Combinations of an anti-HER2 antibody-drug conjugate and chemotherapeutic agents, and methods of use |
| MY166445A (en) * | 2008-03-18 | 2018-06-27 | Genentech Inc | Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents,and methods of use |
| BR122019016429B1 (pt) | 2009-05-26 | 2020-03-24 | Abbvie Ireland Unlimited Company | Compostos inibidores da atividade de proteínas bcl-2 antiapoptótica e composição farmacêutica compreendendo ditos compostos |
| US8546399B2 (en) | 2009-05-26 | 2013-10-01 | Abbvie Inc. | Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases |
| EP2561368B1 (en) * | 2010-04-19 | 2017-08-02 | Biomarker Strategies, LLC. | Compositions and methods for prediction of drug sensitivity, resistance, and disease progression |
| WO2011146568A1 (en) * | 2010-05-19 | 2011-11-24 | Genentech, Inc. | Predicting response to a her inhibitor |
| AU2011332043C1 (en) * | 2010-11-23 | 2016-11-10 | Abbvie Inc. | Salts and crystalline forms of an apoptosis-inducing agent |
| CA2835203A1 (en) * | 2011-05-09 | 2012-11-15 | University Of Virginia Patent Foundation | Compositions and methods for treating cancer |
| SG10201706196XA (en) * | 2012-06-08 | 2017-08-30 | Hoffmann La Roche | Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer |
| CN111481552A (zh) * | 2012-09-07 | 2020-08-04 | 吉宁特有限公司 | II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗 |
| CN104370905B (zh) * | 2014-10-22 | 2016-06-01 | 南京友杰医药科技有限公司 | Bcl-2抑制剂ABT-199的合成 |
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Non-Patent Citations (1)
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| Targeting Bcl-2 in Herceptin-Resistant Breast Cancer Cell Lines;Anatasha Crawford等;《Curr Pharmacogenomics Person Med》;第9卷(第3期);第184-190页 * |
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