AU2016290065B2 - Combination therapy with an anti-HER2 antibody-drug conjugate and a Bcl-2 inhibitor - Google Patents

Combination therapy with an anti-HER2 antibody-drug conjugate and a Bcl-2 inhibitor Download PDF

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AU2016290065B2
AU2016290065B2 AU2016290065A AU2016290065A AU2016290065B2 AU 2016290065 B2 AU2016290065 B2 AU 2016290065B2 AU 2016290065 A AU2016290065 A AU 2016290065A AU 2016290065 A AU2016290065 A AU 2016290065A AU 2016290065 B2 AU2016290065 B2 AU 2016290065B2
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cancer
trastuzumab
her2
mcc
administered
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AU2016290065A1 (en
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Gail Lewis Phillips
Deepak Sampath
Ingrid WERTZ
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Genentech Inc
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Genentech Inc
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C07K2317/00—Immunoglobulins specific features
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AU2016290065A 2015-07-07 2016-07-06 Combination therapy with an anti-HER2 antibody-drug conjugate and a Bcl-2 inhibitor Active AU2016290065B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562189610P 2015-07-07 2015-07-07
US62/189,610 2015-07-07
PCT/US2016/041184 WO2017007846A1 (en) 2015-07-07 2016-07-06 Combination therapy with an anti-her2 antibody-drug conjugate and a bcl-2 inhibitor

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AU2022228214 Division 2016-07-06

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AU2016290065A1 AU2016290065A1 (en) 2018-01-18
AU2016290065B2 true AU2016290065B2 (en) 2022-08-11

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US (5) US10898570B2 (enExample)
EP (1) EP3319995B1 (enExample)
JP (2) JP6910339B2 (enExample)
KR (2) KR102697939B1 (enExample)
CN (2) CN113607945B (enExample)
AU (1) AU2016290065B2 (enExample)
BR (1) BR112017028012A2 (enExample)
CA (1) CA2990465A1 (enExample)
DK (1) DK3319995T3 (enExample)
ES (1) ES2731377T3 (enExample)
HR (1) HRP20191019T1 (enExample)
HU (1) HUE044139T2 (enExample)
IL (1) IL256451B (enExample)
LT (1) LT3319995T (enExample)
MX (1) MX2018000135A (enExample)
PL (1) PL3319995T3 (enExample)
PT (1) PT3319995T (enExample)
RS (1) RS58823B1 (enExample)
SI (1) SI3319995T1 (enExample)
TR (1) TR201908138T4 (enExample)
WO (1) WO2017007846A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2969041T3 (es) 2017-03-02 2024-05-16 Genentech Inc Tratamiento adyuvante del cáncer de mama positivo para HER2
CN107349426B (zh) * 2017-07-12 2018-03-23 马骥 阿司匹林与曲妥珠单抗联合或协同在肿瘤治疗中的应用
CN114206392A (zh) * 2019-06-10 2022-03-18 苏特罗生物制药公司 免疫调节剂抗体药物偶联物及其用途
WO2024211811A2 (en) * 2023-04-05 2024-10-10 Frezent Biological Solutions, Inc. Methods and compositions for antibody-drug conjugates
CN119454975B (zh) * 2024-12-02 2025-10-21 中国医学科学院医学实验动物研究所 一种药物组合物在治疗癌症中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009117277A2 (en) * 2008-03-18 2009-09-24 Genentech, Inc. Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US5202238A (en) 1987-10-27 1993-04-13 Oncogen Production of chimeric antibodies by homologous recombination
US5204244A (en) 1987-10-27 1993-04-20 Oncogen Production of chimeric antibodies by homologous recombination
WO1989006692A1 (en) 1988-01-12 1989-07-27 Genentech, Inc. Method of treating tumor cells by inhibiting growth factor receptor function
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (en) 1991-06-14 1994-03-03 Genentech, Inc. Method for making humanized antibodies
US6489447B1 (en) 1998-05-06 2002-12-03 Genentech, Inc. Protein purification
AU4079999A (en) 1998-05-15 1999-12-06 Imclone Systems Incorporated Treatment of human tumors with radiation and inhibitors of growth factor receptor tyrosine kinases
HU230586B1 (hu) 1999-06-25 2017-02-28 Genentech, Inc. Anti-ErbB antitest/maytansinoid konjugátumok alkalmazása rákos betegségek kezelésére szolgáló gyógyszer előállítására
US7097840B2 (en) 2000-03-16 2006-08-29 Genentech, Inc. Methods of treatment using anti-ErbB antibody-maytansinoid conjugates
MXPA02011379A (es) * 2000-05-19 2003-06-06 Genentech Inc Ensayo de deteccion de genes para mejorar la probabilidad de una respuesta efectiva a terapia de cancer con el antagonista erbb.
US7795232B1 (en) * 2000-08-25 2010-09-14 Genta Incorporated Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
US6441163B1 (en) 2001-05-31 2002-08-27 Immunogen, Inc. Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
US6790954B2 (en) 2002-01-29 2004-09-14 Immunogen, Inc. Mutant Actinosynnema pretiosum strain with increased maytansinoid production
US20050276812A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
WO2004056971A2 (en) * 2002-12-19 2004-07-08 Genta Incorporated Methods of treatment of a bcl-2 disorder using bcl-2 antisense oligomers
US7432088B2 (en) 2003-05-08 2008-10-07 Immunogen Inc. Methods for the production of ansamitocins
US7004206B2 (en) 2004-01-29 2006-02-28 Viken James P Automatic fluid exchanger
JP2006316040A (ja) 2005-05-13 2006-11-24 Genentech Inc Ｈｅｒｃｅｐｔｉｎ（登録商標）補助療法
AU2014240234B2 (en) * 2008-03-18 2016-10-06 Genentech, Inc. Combinations of an anti-HER2 antibody-drug conjugate and chemotherapeutic agents, and methods of use
PE20120345A1 (es) 2009-05-26 2012-05-17 Abbvie Bahamas Ltd Derivados de 2-(1h-pirrolo[2,3-b]piridin-5-iloxi)-n-fenilsulfonilbenzamida como inhibidores de proteinas anti-apoptoticas
US8546399B2 (en) 2009-05-26 2013-10-01 Abbvie Inc. Apoptosis inducing agents for the treatment of cancer and immune and autoimmune diseases
CN102947706B (zh) * 2010-04-19 2018-04-13 生物标志物策略公司 预测药物敏感性、抗性和疾病进展的组合物和方法
WO2011146568A1 (en) * 2010-05-19 2011-11-24 Genentech, Inc. Predicting response to a her inhibitor
SG190361A1 (en) * 2010-11-23 2013-06-28 Abbvie Inc Salts and crystalline forms of an apoptosis-inducing agent
SG194735A1 (en) * 2011-05-09 2013-12-30 Univ Virginia Patent Found Compositions and methods for treating cancer
EP2858666B1 (en) * 2012-06-08 2019-09-04 F.Hoffmann-La Roche Ag Mutant selectivity and combinations of a phosphoinositide 3 kinase inhibitor compound and chemotherapeutic agents for the treatment of cancer
CN111437386A (zh) * 2012-09-07 2020-07-24 吉宁特有限公司 II型抗CD20抗体与选择性Bcl-2抑制剂的组合治疗
CN104370905B (zh) * 2014-10-22 2016-06-01 南京友杰医药科技有限公司 Bcl-2抑制剂ABT-199的合成

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009117277A2 (en) * 2008-03-18 2009-09-24 Genentech, Inc. Combinations of an anti-her2 antibody-drug conjugate and chemotherapeutic agents, and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CRAWFORD ANATASHA ET AL, "Targeting Bcl-2 in Herceptin-Resistant Breast Cancer Cell Lines", CURRENT PHARMACOGENOMICS & PERSONALIZED MEDICINE, vol. 9, no. 3, pages 184 - 190 *

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