CN113520955B - Whitening and moisturizing composition and application thereof - Google Patents

Whitening and moisturizing composition and application thereof Download PDF

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Publication number
CN113520955B
CN113520955B CN202110986960.XA CN202110986960A CN113520955B CN 113520955 B CN113520955 B CN 113520955B CN 202110986960 A CN202110986960 A CN 202110986960A CN 113520955 B CN113520955 B CN 113520955B
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parts
whitening
moisturizing composition
combination
preparation example
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CN113520955A (en
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聂艳峰
裴运林
旷小珊
郭朝万
王娟
蒲艳
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Guangdong Marubi Biological Technology Co Ltd
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Guangdong Marubi Biological Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/23—Sulfur; Selenium; Tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/35—Ketones, e.g. benzophenone
    • A61K8/355—Quinones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/678—Tocopherol, i.e. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706—Algae
    • A61K8/9711—Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59—Mixtures
    • A61K2800/592—Mixtures of compounds complementing their respective functions

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Abstract

The invention provides a whitening and moisturizing composition and application thereof, wherein the whitening and moisturizing composition comprises, by weight, 8-12 parts of a moisturizing agent, 4-8 parts of a thickening agent, 0.2-1 part of an antioxidant and 5-9 parts of a skin conditioning agent, and the skin conditioning agent comprises any one or a combination of at least two of allantoin, ubiquinone, nicotinamide, diglucosylgallic acid, a glycyrrhiza glabra root extract, an undaria pinnatifida extract, alpha-arbutin, ceramide NP, ceramide EOP, ceramide AP, a centella asiatica extract, a polygonum cuspidatum root extract, a scutellaria baicalensis root extract, a chamomile flower extract or a rosemary leaf extract. The whitening and moisturizing composition provided by the invention is mild, has no stimulation, has a good moisturizing effect, and can effectively remove melanin and brighten skin.

Description

Whitening and moisturizing composition and application thereof
Technical Field
The invention belongs to the field of cosmetics, particularly relates to a whitening and moisturizing composition and application thereof, and particularly relates to a whitening and moisturizing composition with a good moisturizing effect and application thereof.
Background
Melanin (Melanin) is mainly produced by melanocytes (melanocytes) in the basal layer of the epidermis of human skin, and it reduces the damage of ultraviolet rays to the skin. The content and distribution of melanin determine the color of the skin. However, abnormal accumulation of melanin in the basal layer causes hyperpigmentation to cause melasma, freckles, age spots, etc., affecting the quality of life of people.
Skin dryness is a problem that people often encounter in daily life. Reasons for dry skin include: (1) the physiological requirements of the human body, the water in the human body is consumed; (2) the air humidity is low, and the moisture of the skin is lost due to the dryness of the surrounding environment; (3) the stratum corneum of the skin loses function, the water loss is serious, the water channel between the epidermis layer and the dermis layer is not smooth, and the supplement is slow.
The water content of the stratum corneum of human skin is about 15-30%, and if the stratum corneum becomes thin, the barrier function will be reduced; if the water passage is not open, the moisture in the dermis cannot be transferred to the stratum corneum in time. If the barrier function of the stratum corneum is abnormal, the problems of dry skin, itching, easy allergy, easy skin aging, easy wrinkle and the like can be caused.
CN107362090B discloses a long-acting moisturizing water-based cosmetic capable of generating pearly luster and a preparation method thereof. The long-acting moisturizing water-based cosmetic capable of generating pearlescence comprises the following components in percentage by weight: soybean phospholipid liposome 1.0-8.0%, Adansonia dubia seed extract 1.0-8.0% and water. The water-based cosmetic of the invention may further comprise components such as polyol, glyceryl polyether-26, luba gum oil and thickener. The soybean phospholipid liposome and the Adansonia dubia seed extract are applied to the water cosmetics, so that the long-acting moisturizing effect is excellent, the skin feeling is fresh and cool without stickiness, and the unique pearl crystal appearance and the soft skin can be formed.
CN104940047B discloses a moisturizing cosmetic composition and a preparation method thereof, wherein the moisturizing cosmetic composition comprises the following moisturizing components in percentage by mass: 0.02-0.10% of macromolecular sodium hyaluronate, 1.00-4.00% of Alps glacier water, 1.00-4.005% of erythritol and 1.00-3.00% of aquaporin. In the invention, the protective film is formed by macromolecular sodium hyaluronate, which has the effect of barrier; after the Alps glacier water and the erythritol reach the target area, the water is continuously supplemented; the aquaporins play a role in transportation and improve the water replenishing effect; the three steps form the complementary and complementary functions, and the water replenishing and moisturizing functions are effectively realized. The product of the invention does not cause phenomena of allergy, stimulation and the like to users, and is safe to use; the product has obvious effect on the efficacy of moisturizing.
People's daily life is affected by melanin deposition and dry skin. Therefore, it is an urgent problem to provide a cosmetic that can supplement water and moisturize skin and reduce skin melanin.
Disclosure of Invention
Aiming at the defects of the prior art, the invention aims to provide a whitening and moisturizing composition and application thereof, and particularly provides a whitening and moisturizing composition with a good moisturizing effect and application thereof. The whitening and moisturizing composition provided by the invention is mild, has no stimulation, has a good moisturizing effect, and can effectively remove melanin and brighten skin.
In order to achieve the purpose, the invention adopts the following technical scheme:
in a first aspect, the invention provides a whitening and moisturizing composition which comprises, by weight, 8-12 parts of a moisturizing agent, 4-8 parts of a thickening agent, 0.2-1 part of an antioxidant and 5-9 parts of a skin conditioning agent.
The skin conditioner includes one or a combination of at least two of allantoin, ubiquinone, niacinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract, alpha-arbutin, ceramide NP, ceramide EOP, ceramide AP, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, chamomile flower extract, or rosemary leaf extract, for example, a combination of allantoin and ubiquinone, a combination of ubiquinone and niacinamide, or a combination of ubiquinone and diglucosylgallic acid, but is not limited to the above-listed combinations, and other combinations not listed within the above-mentioned combinations are also applicable.
The amount of the humectant may be 8 parts, 9 parts, 10 parts, 11 parts or 12 parts, the amount of the thickener may be 4 parts, 5 parts, 6 parts, 7 parts or 8 parts, the amount of the antioxidant may be 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts or 1 part, the amount of the skin conditioner may be 5 parts, 6 parts, 7 parts, 8 parts or 9 parts, but is not limited to the above-mentioned values, and other values not listed in the above-mentioned numerical ranges are also applicable.
The whitening and moisturizing composition adopts the compounding of the antioxidant and the skin conditioner, and the synergistic effect improves the whitening and melanin removing effects of the composition.
Preferably, the humectant comprises any one or a combination of at least two of glycerin, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, sodium hyaluronate, or ethylhexylglycerin, preferably a combination of glycerin, sodium hyaluronate, and ethylhexylglycerin.
The combination of the specific moisturizing agents further improves the moisturizing effect of the whitening and moisturizing composition.
Preferably, the thickener comprises any one or a combination of at least two of carbomer, xanthan gum or ethylcellulose.
Preferably, the antioxidant comprises sodium metabisulphite and/or tocopherol acetate.
Preferably, the pH adjusting agent comprises any one of arginine, citric acid or sodium citrate or a combination of at least two thereof.
Among them, the humectant may be a combination of glycerin and butylene glycol, a combination of butylene glycol and 1, 2-pentanediol, or a combination of glycerin and 1, 2-hexanediol, etc., and the thickener may be a combination of carbomer and xanthan gum, a combination of xanthan gum and ethylcellulose, or a combination of carbomer and ethylcellulose, etc., but is not limited to the above-listed combinations, and other combinations not listed within the above-mentioned combination range are also applicable.
Preferably, the skin conditioner is a combination of ubiquinone, niacinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract, and alpha-arbutin.
The skin conditioner with the specific combination can further remove melanin and whiten the skin; meanwhile, ubiquinone, nicotinamide, diglucosylgallic acid, a glycyrrhiza glabra root extract, an undaria pinnatifida extract and alpha-arbutin are compounded to achieve a synergistic effect, so that the melanin removing effect of the composition is remarkably improved.
Preferably, the whitening and moisturizing composition further comprises 0.08-0.2 parts by weight of a pH adjusting agent, wherein the pH adjusting agent comprises any one or a combination of at least two of arginine, citric acid or sodium citrate, the parts of the pH adjusting agent can be 0.08 parts, 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts or 0.2 parts, and the like, and the pH adjusting agent can be a combination of arginine and sodium citrate, a combination of citric acid and sodium citrate, or a combination of arginine and citric acid, and the like, but is not limited to the above-listed values or combinations, and other values in the above-listed values or combinations are also applicable.
In a second aspect, the present invention provides the use of the whitening and moisturizing composition as described above in the preparation of cosmetics.
In a third aspect, the invention provides an emulsion, which comprises, by weight, 17.28 to 30.2 parts of the whitening and moisturizing composition, 0.04 to 0.08 part of a metal ion blocking agent, 0.5 to 1.5 parts of an emulsifier, 4 to 8 parts of an emollient and water.
The whitening and moisturizing composition may be 17.28 parts, 18 parts, 19 parts, 20 parts, 21 parts, 22 parts, 23 parts, 24 parts, 25 parts, 26 parts, 27 parts, 28 parts, 29 parts or 30.2 parts, the metal ion blocking agent may be 0.04 parts, 0.05 parts, 0.06 parts, 0.07 parts or 0.08 parts, the emulsifier may be 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 part, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts or 1.5 parts, the emollient may be 4 parts, 5 parts, 6 parts, 7 parts or 8 parts, but not limited to the above-mentioned values, and other values not listed in the above-mentioned value range may be applied as well.
The whitening and moisturizing composition is adopted in the emulsion, so that the moisturizing and whitening effects are obviously improved, and skin melanin can be effectively removed.
Preferably, the metal ion blocking agent comprises disodium EDTA.
Preferably, the emulsifier comprises any one or a combination of at least two of isostearyl alcohol, butylene glycol cocoate, glyceryl stearate or PEG-100 stearate.
Preferably, the emollient comprises any one or combination of at least two of polydimethylsiloxane, squalane or jojoba seed oil.
The emulsifier may be a combination of isostearyl alcohol and butylene glycol cocoate, butylene glycol cocoate and glyceryl stearate, or a combination of isostearyl alcohol and glyceryl stearate, and the emollient may be a combination of polydimethylsiloxane and squalane, a combination of squalane and jojoba seed oil, or a combination of jojoba seed oil and polydimethylsiloxane, but is not limited to the above-mentioned combinations, and other combinations not listed in the above-mentioned combination range are also applicable.
Preferably, the emulsion further comprises 0.02 to 0.06 parts by weight of a preservative, such as 0.02 parts, 0.03 parts, 0.04 parts, 0.05 parts, or 0.06 parts, and the like, but not limited to the above-listed values, and other values not listed within the above range of values are equally applicable, and the preservative comprises butylated hydroxytoluene.
In a fourth aspect, the present invention also provides a process for the preparation of an emulsion as described above, comprising the steps of:
(1) mixing water, a humectant, a metal ion locking agent and a thickening agent, and heating to obtain a water phase;
(2) mixing emulsifier, emollient and antioxidant, and heating to obtain oil phase;
(3) and (3) mixing the water phase obtained in the step (1) and the oil phase obtained in the step (2) for homogenization, then cooling, and mixing with a skin conditioner to obtain the emulsion.
The step (1) and the step (2) do not distinguish the sequence.
The steps are simple and convenient, and the emulsion can be quickly prepared.
Preferably, the elevated temperature of step (1) and step (2) is independently 80-85 ℃.
Preferably, the mixing of step (2) further comprises mixing with a preservative.
Preferably, the mixing with the skin conditioning agent of step (3) further comprises mixing with a pH adjusting agent.
Preferably, the temperature reduction in the step (3) is carried out to a temperature of 44-46 ℃.
Preferably, the homogenizing rate in step (3) is 2000-3000 r/min.
Wherein, the temperature raising of step (1) and step (2) may be 80 ℃, 81 ℃, 82 ℃, 83 ℃, 84 ℃ or 85 ℃ and the like, the temperature lowering of step (3) may be 44 ℃, 44.5 ℃, 45 ℃, 45.5 ℃ or 46 ℃ and the like, the homogenizing rate may be 2000r/min, 2100r/min, 2200r/min, 2300r/min, 2400r/min, 2500r/min, 2600r/min, 2700r/min, 2800r/min, 2900r/min or 3000r/min and the like, but not limited to the above-listed values, and other values not listed in the above-mentioned value range are also applicable.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a whitening and moisturizing composition, which improves the whitening and melanin removing effects of the composition by compounding an antioxidant and a skin conditioner and a synergistic effect; the moisturizing effect of the whitening moisturizing composition is further improved by selecting a specific moisturizing agent combination; the skin conditioner with specific combination can further dispel melanin and whiten the skin; meanwhile, ubiquinone, nicotinamide, diglucosylgallic acid, a glycyrrhiza glabra root extract, an undaria pinnatifida extract and alpha-arbutin are compounded to achieve a synergistic effect, so that the melanin removing effect of the composition is remarkably improved.
Drawings
Fig. 1 is a graph of the trend of the moisture content of the facial stratum corneum in an effectiveness test of the product of example 1, wherein n.s.,. represents p >0.05, p <0.01, respectively;
fig. 2 is a graph of the change in the amount of transdermal moisture loss in an efficacy test of the product of example 1, wherein n.s.,. represents p >0.05, p <0.01, respectively;
fig. 3 is a graph of the trend of the change in melanin values of the skin at the site of the spot in the efficacy test for the product of example 1, wherein n.s.,. represents p >0.05, p <0.01 and p <0.001, respectively;
fig. 4 is a graph showing the trend of change in melanin value of the skin at non-pigmented spots in the effect test of the product of example 1, where n.s. represents p > 0.05.
Detailed Description
The technical solution of the present invention is further explained by the following embodiments. It should be understood by those skilled in the art that the examples are only for the understanding of the present invention and should not be construed as the specific limitations of the present invention.
In the following examples, Glycyrrhiza glabra root extract is available from Qihuadun daily essences & fragrances (Shanghai) Co., Ltd;
undaria pinnatifida extract was purchased from Qihuadun daily essence and fragrance (Shanghai) Co., Ltd;
polydimethylsiloxane was purchased from dow (zhang) investment limited.
Preparation example 1
The preparation example provides a whitening and moisturizing composition, which comprises the following specific raw material components in parts by weight:
3 parts of glycerin, 3 parts of sodium hyaluronate, 4 parts of ethylhexyl glycerin, 6 parts of carbomer, 0.6 part of sodium metabisulfite, 0.14 part of arginine, 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 1 part of alpha-arbutin.
The preparation method comprises the following steps: mixing the raw materials, heating to 80 ℃, and stirring to obtain the whitening and moisturizing composition.
Preparation example 2
The preparation example provides a whitening and moisturizing composition, which comprises the following specific raw material components in parts by weight:
8 parts of butanediol, 8 parts of carbomer, 0.2 part of tocopheryl acetate, 0.1 part of citric acid, 0.1 part of sodium citrate, 1 part of ubiquinone, 1 part of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 0.5 part of undaria pinnatifida extract and 0.5 part of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 3
The preparation example provides a whitening and moisturizing composition, which comprises the following specific raw material components in parts by weight:
12 parts of 1, 2-pentanediol, 4 parts of xanthan gum, 1 part of tocopherol acetate, 0.02 part of citric acid, 0.06 part of sodium citrate, 1 part of ubiquinone, 1 part of nicotinamide, 2 parts of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 2 parts of undaria pinnatifida extract and 2 parts of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 4
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 1 part of alpha-arbutin are replaced by 7 parts of allantoin.
The preparation method was the same as in preparation example 1.
Preparation example 5
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 1 part of alpha-arbutin are replaced by 7 parts of ceramide NP.
The preparation method was the same as in preparation example 1.
Preparation example 6
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 1 part of alpha-arbutin are replaced by 3 parts of ceramide EOP and 4 parts of ceramide AP, and the rest is consistent with the preparation example 1.
The preparation method was the same as in preparation example 1.
Preparation example 7
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are consistent with preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 7 parts of alpha-arbutin are replaced by ubiquinone.
The preparation method was the same as in preparation example 1.
Preparation example 8
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are consistent with preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 7 parts of nicotinamide instead of 1 part of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 9
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are consistent with the preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 7 parts of diglucosylgallic acid substituted by 1 part of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 10
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are consistent with the preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 7 parts of glycyrrhiza glabra root extract replaced by 1 part of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 11
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are consistent with the preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 7 parts of undaria pinnatifida extract replaced by 1 part of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 12
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are consistent with preparation example 1 except that 1 part of ubiquinone, 2 parts of nicotinamide, 1 part of diglucosylgallic acid, 1 part of glycyrrhiza glabra root extract, 1 part of undaria pinnatifida extract and 7 parts of alpha-arbutin substituted by 1 part of alpha-arbutin.
The preparation method was the same as in preparation example 1.
Preparation example 13
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that ubiquinone is not contained, and the reduced parts are proportionally distributed to nicotinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract and alpha-arbutin.
The preparation method is referred to preparation example 1.
Preparation example 14
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that nicotinamide is not contained, and the reduced parts are proportionally distributed to ubiquinone, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract and alpha-arbutin.
The preparation method is referred to preparation example 1.
Preparation example 15
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as the preparation example 1 except that the specific raw materials do not contain diglucosylgallic acid, and the reduced parts are proportionally distributed to nicotinamide, ubiquinone, glycyrrhiza glabra root extract, undaria pinnatifida extract and alpha-arbutin.
The preparation method is referred to preparation example 1.
Preparation example 16
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as the preparation example 1 except that the composition does not contain the glycyrrhiza glabra root extract, and the reduced parts are proportionally distributed to nicotinamide, diglucosylgallic acid, ubiquinone, the undaria pinnatifida extract and alpha-arbutin.
The preparation method is referred to preparation example 1.
Preparation example 17
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as the preparation example 1 except that the composition does not contain the undaria pinnatifida extract, and the reduced parts are proportionally distributed to nicotinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, ubiquinone and alpha-arbutin.
The preparation method is referred to preparation example 1.
Preparation example 18
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that alpha-arbutin is not contained, and the reduced parts are proportionally distributed to nicotinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract and ubiquinone.
The preparation method is referred to preparation example 1.
Preparation example 19
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that 3 parts of glycerin, 3 parts of sodium hyaluronate and 4 parts of ethylhexyl glycerin are replaced by 5 parts of glycerin and 5 parts of sodium hyaluronate.
The preparation method was the same as in preparation example 1.
Preparation example 20
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that 3 parts of glycerin, 3 parts of sodium hyaluronate and 4 parts of ethylhexyl glycerin are replaced by 10 parts of glycerin.
The preparation method was the same as in preparation example 1.
Preparation example 21
The preparation example provides a whitening and moisturizing composition, and the specific raw materials are the same as those in preparation example 1 except that 3 parts of glycerin, 3 parts of sodium hyaluronate and 4 parts of ethylhexyl glycerin are replaced by 3 parts of butanediol, 4 parts of sodium hyaluronate and 3 parts of 1, 2-hexanediol.
The preparation method was the same as in preparation example 1.
Comparative preparation example 1
This comparative preparation provides a whitening and moisturizing composition, the specific raw materials of which are identical to those of preparation example 1 except that sodium metabisulfite is not contained, and the reduced part is proportionally allocated to ubiquinone, niacinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract, and alpha-arbutin.
The preparation method was the same as in preparation example 1.
Comparative preparation example 2
This comparative preparation example provides a whitening and moisturizing composition, which is identical to preparation example 1 except that the raw materials do not contain ubiquinone, niacinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract and alpha-arbutin, and a reduced portion is distributed to sodium metabisulfite.
The preparation method was the same as in preparation example 1.
Example 1
The embodiment provides an emulsion, which comprises the following specific raw materials in percentage by mass:
preparation example 1 provides a whitening and moisturizing composition 25%, disodium EDTA 0.06%, isostearyl alcohol 1%, polydimethylsiloxane 6%, and the balance water.
The preparation method comprises the following steps:
(1) mixing water, glycerol, EDTA disodium and sodium hyaluronate, heating to 82 ℃, and stirring to obtain a water phase;
(2) mixing isostearyl alcohol, polydimethylsiloxane and sodium metabisulfite, heating to 82 ℃, and stirring to obtain an oil phase;
(3) mixing the water phase obtained in step (1) and the oil phase obtained in step (2), homogenizing at 2500r/min, cooling to 45 deg.C, and mixing with arginine, ubiquinone, nicotinamide, diglucosylgallic acid, Glycyrrhiza glabra root extract, Undaria pinnatifida extract, and alpha-arbutin to obtain the emulsion.
Example 2
The embodiment provides an emulsion, which comprises the following specific raw materials in percentage by mass:
preparation example 2 provides 17.28% of the whitening and moisturizing composition, 0.08% of disodium EDTA, 0.5% of butanediol cocoate, 8% of squalane and the balance of water.
The preparation process is referred to example 1.
Example 3
The embodiment provides an emulsion, which comprises the following specific raw materials in percentage by mass:
preparation example 3 provides a whitening and moisturizing composition 30.2%, disodium EDTA 0.04%, glyceryl stearate 1.5%, jojoba seed oil 4%, and the balance water.
The preparation process is referred to example 1.
Examples 4 to 21
Examples 4 to 21 each provide an emulsion, and the specific materials were the same as in example 1 except that the whitening and moisturizing composition provided in preparation example 1 was replaced with the same amount of the whitening and moisturizing composition provided in preparation examples 4 to 21.
The preparation process is referred to example 1.
Comparative examples 1 to 2
Comparative examples 1 to 2 each provide an emulsion, and the specific materials were identical to those of example 1 except that the whitening and moisturizing composition provided in preparation example 1 was replaced with the whitening and moisturizing composition provided in comparative preparation examples 1 to 2, respectively, in equal amounts.
The preparation process is referred to example 1.
And (3) effect testing:
115 healthy Chinese female subjects with dark, dark yellow and uneven facial skin are selected, the age range is 25-60 years, and the average age is 46.3 +/-5.6 years. Subjects were randomly and evenly divided into 23 groups, and the stratum corneum water content (Corneometer) of the skin was measured before use (D0), after use for 1 week (D7), after use for 2 weeks (D14), after use for 4 weeks (D28), using the emulsions provided in examples 1-21 and comparative examples 1-2 (2 mL each time twice a day, evenly applied to the skin at the site of pigmented spots and the skin at the site of non-pigmented spots), respectively, for 4 weeks continuouslyRCM 825 Skin moisture content test probe), transdermal moisture loss (AquaFlux AF200 Skin moisture loss tester), melanin value of Skin at mottle part and non-mottle part (Skin-Colorimeter CL 400 Skin color test probe), and the change rate of effect after using for 4 weeks was calculated, and the average value was calculated as follows:
moisture content of stratum corneum:
Figure BDA0003231050150000151
Figure BDA0003231050150000161
percutaneous water loss:
Figure BDA0003231050150000162
Figure BDA0003231050150000171
counting melanin values of skin at the color spot part:
Figure BDA0003231050150000172
Figure BDA0003231050150000181
statistics of melanin values of skin at non-pigmented spots:
Figure BDA0003231050150000182
Figure BDA0003231050150000191
the results show that the emulsion prepared from the whitening and moisturizing composition provided by the invention has obvious moisturizing, whitening and blackening effects; comparing example 1 with examples 19-21, it can be seen that the present invention further increases the moisture content of the stratum corneum of the skin, decreasing the amount of transdermal moisture loss by selecting a specific combination of humectants; compared with the comparative examples 1 and 1-2, the invention has the advantages that the antioxidant and the skin conditioner are compounded and have synergistic effect, so that the melanin value of the skin at the color spot part is obviously reduced, the melanin value of the skin at the non-color spot part is also reduced to a certain extent, and the whitening and skin brightening effects are excellent; comparing examples 1, 4-6, it can be seen that the present invention further improves the whitening and anti-tanning effect of the emulsion by optimizing the combination of specific skin conditioning agents; comparing examples 1 and 7-18, the invention can find that the combination of ubiquinone, nicotinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract and alpha-arbutin can further improve the melanin removing effect of the emulsion by synergistic action.
In addition, each test data of example 1 was subjected to significance analysis and p values were calculated, and the results are shown in fig. 1-4, where n.s., represent p >0.05, p <0.01, and p <0.001, respectively.
The product provided by the invention can obviously increase the moisture content of the horny layer of the face, improve the moisture loss of the cheek, improve the barrier function of the skin, obviously reduce the melanin of a color spot part and brighten the skin.
The applicant states that the present invention is described by the above examples to describe the whitening and moisturizing composition and the application thereof, but the present invention is not limited to the above examples, that is, it does not mean that the present invention is implemented only by relying on the above examples. It should be understood by those skilled in the art that any modification of the present invention, equivalent substitutions of the raw materials of the product of the present invention, addition of auxiliary components, selection of specific modes, etc., are within the scope and disclosure of the present invention.
The preferred embodiments of the present invention have been described in detail, however, the present invention is not limited to the specific details of the above embodiments, and various simple modifications may be made to the technical solution of the present invention within the technical idea of the present invention, and these simple modifications are within the protective scope of the present invention.
It should be noted that the various technical features described in the above embodiments can be combined in any suitable manner without contradiction, and the invention is not described in any way for the possible combinations in order to avoid unnecessary repetition.

Claims (18)

1. The whitening and moisturizing composition is characterized by comprising 8-12 parts of a moisturizing agent, 4-8 parts of a thickening agent, 0.2-1 part of an antioxidant and 5-9 parts of a skin conditioning agent in parts by weight;
the skin conditioner is a combination of ubiquinone, niacinamide, diglucosylgallic acid, glycyrrhiza glabra root extract, undaria pinnatifida extract, and alpha-arbutin.
2. The whitening and moisturizing composition of claim 1, wherein the moisturizer comprises any one of glycerin, butylene glycol, 1, 2-pentanediol, 1, 2-hexanediol, sodium hyaluronate, or ethylhexylglycerin, or a combination of at least two of the glycerin, butylene glycol, 1, 2-pentanediol, and sodium hyaluronate.
3. The whitening and moisturizing composition of claim 2, wherein the moisturizer is a combination of glycerin, sodium hyaluronate, and ethylhexylglycerin.
4. The whitening and moisturizing composition of claim 1, wherein the thickener comprises any one or a combination of at least two of carbomer, xanthan gum, or ethylcellulose.
5. Whitening and moisturizing composition according to claim 1, characterized in that the antioxidants sodium metabisulphite and/or tocopheryl acetate.
6. The whitening and moisturizing composition of claim 1, further comprising 0.08-0.2 parts by weight of a pH regulator, wherein the pH regulator comprises any one or a combination of at least two of arginine, citric acid or sodium citrate.
7. Use of the whitening and moisturizing composition according to any one of claims 1 to 6 in the preparation of cosmetics.
8. An emulsion, which is characterized by comprising 17.28 to 30.2 parts by weight of the whitening and moisturizing composition as defined in any one of claims 1 to 5, 0.04 to 0.08 part by weight of a metal ion blocking agent, 0.5 to 1.5 parts by weight of an emulsifier, 4 to 8 parts by weight of an emollient and water.
9. The emulsion of claim 8, wherein the metal ion blocking agent comprises disodium EDTA.
10. An emulsion according to claim 8, wherein the emulsifier comprises any one or a combination of at least two of isostearyl alcohol, butylene glycol cocoate, glyceryl stearate or PEG-100 stearate.
11. The emulsion of claim 8, wherein the emollient comprises any one or a combination of at least two of polydimethylsiloxane, squalane, or jojoba oil.
12. The emulsion of claim 8, further comprising 0.02 to 0.06 parts by weight of a preservative comprising butylated hydroxytoluene.
13. A method for preparing an emulsion according to any one of claims 8 to 12, characterized in that it comprises the following steps:
(1) mixing water, a humectant, a metal ion locking agent and a thickening agent, and heating to obtain a water phase;
(2) mixing emulsifier, emollient and antioxidant, and heating to obtain oil phase;
(3) mixing the water phase obtained in the step (1) and the oil phase obtained in the step (2) for homogenization, then cooling, and mixing with a skin conditioner to obtain the emulsion;
the step (1) and the step (2) do not distinguish the sequence.
14. The method of preparing an emulsion according to claim 13, wherein the temperature raising to the temperature in step (1) and step (2) is independently 80 to 85 ℃.
15. The method of claim 13, wherein the mixing of step (2) further comprises mixing with a preservative.
16. The method of claim 13, wherein the step (3) of mixing with a skin conditioning agent further comprises mixing with a pH adjusting agent.
17. The method of claim 13, wherein the temperature of step (3) is reduced to a temperature of 44-46 ℃.
18. The method for preparing an emulsion as defined in claim 13, wherein the homogenizing rate in step (3) is 2000-3000 r/min.
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