CN113498783A - Mite-killing missible oil and preparation method and application thereof - Google Patents
Mite-killing missible oil and preparation method and application thereof Download PDFInfo
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- CN113498783A CN113498783A CN202110718568.7A CN202110718568A CN113498783A CN 113498783 A CN113498783 A CN 113498783A CN 202110718568 A CN202110718568 A CN 202110718568A CN 113498783 A CN113498783 A CN 113498783A
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- 238000002360 preparation method Methods 0.000 title abstract description 12
- ZYEMGPIYFIJGTP-UHFFFAOYSA-N O-methyleugenol Chemical compound COC1=CC=C(CC=C)C=C1OC ZYEMGPIYFIJGTP-UHFFFAOYSA-N 0.000 claims abstract description 46
- 230000000895 acaricidal effect Effects 0.000 claims abstract description 45
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 claims abstract description 42
- 239000003995 emulsifying agent Substances 0.000 claims abstract description 41
- 239000003921 oil Substances 0.000 claims abstract description 37
- 239000000341 volatile oil Substances 0.000 claims abstract description 24
- 229940116837 methyleugenol Drugs 0.000 claims abstract description 23
- PRHTXAOWJQTLBO-UHFFFAOYSA-N methyleugenol Natural products COC1=CC=C(C(C)=C)C=C1OC PRHTXAOWJQTLBO-UHFFFAOYSA-N 0.000 claims abstract description 23
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000005770 Eugenol Substances 0.000 claims abstract description 21
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 claims abstract description 21
- 241000246358 Thymus Species 0.000 claims abstract description 21
- 235000007303 Thymus vulgaris Nutrition 0.000 claims abstract description 21
- 229960002217 eugenol Drugs 0.000 claims abstract description 21
- 239000001585 thymus vulgaris Substances 0.000 claims abstract description 21
- 239000004495 emulsifiable concentrate Substances 0.000 claims abstract description 18
- 239000000642 acaricide Substances 0.000 claims abstract description 17
- 241000287828 Gallus gallus Species 0.000 claims abstract description 15
- 239000002480 mineral oil Substances 0.000 claims abstract description 15
- 235000010446 mineral oil Nutrition 0.000 claims abstract description 15
- 239000002994 raw material Substances 0.000 claims abstract description 10
- 229940018333 calcium pyruvate Drugs 0.000 claims abstract description 9
- UZWMCCLZMHPPKW-UHFFFAOYSA-L calcium;2-oxopropanoate Chemical compound [Ca+2].CC(=O)C([O-])=O.CC(=O)C([O-])=O UZWMCCLZMHPPKW-UHFFFAOYSA-L 0.000 claims abstract description 9
- 239000000839 emulsion Substances 0.000 claims abstract description 9
- 241001584775 Tunga penetrans Species 0.000 claims abstract description 8
- 238000004519 manufacturing process Methods 0.000 claims abstract description 6
- 238000003756 stirring Methods 0.000 claims description 18
- 235000013330 chicken meat Nutrition 0.000 claims description 11
- 238000010438 heat treatment Methods 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
- 241000238876 Acari Species 0.000 claims description 7
- 159000000007 calcium salts Chemical class 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 2
- 239000006071 cream Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 abstract description 13
- 239000007788 liquid Substances 0.000 abstract description 9
- 229940079593 drug Drugs 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 230000003129 miticidal effect Effects 0.000 abstract description 5
- 241000196324 Embryophyta Species 0.000 abstract description 3
- 239000004480 active ingredient Substances 0.000 abstract description 2
- 230000009044 synergistic interaction Effects 0.000 abstract description 2
- 231100000331 toxic Toxicity 0.000 abstract description 2
- 230000002588 toxic effect Effects 0.000 abstract description 2
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 39
- 238000012360 testing method Methods 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 5
- 206010000351 Acariasis Diseases 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 241000331598 Trombiculidae Species 0.000 description 4
- 201000002266 mite infestation Diseases 0.000 description 4
- 238000009395 breeding Methods 0.000 description 3
- 230000001488 breeding effect Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 201000004624 Dermatitis Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- 239000008267 milk Substances 0.000 description 2
- 235000013336 milk Nutrition 0.000 description 2
- 210000004080 milk Anatomy 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 239000005660 Abamectin Substances 0.000 description 1
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000282421 Canidae Species 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 206010061819 Disease recurrence Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 208000029639 Ectoparasitic disease Diseases 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000735356 Gazania Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 208000030852 Parasitic disease Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 244000082204 Phyllostachys viridis Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039509 Scab Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010053262 Skin swelling Diseases 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 206010042674 Swelling Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- VXSIXFKKSNGRRO-MXOVTSAMSA-N [(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate;[(1s)-2-methyl-4-oxo-3-[(2z)-penta-2,4-dienyl]cyclopent-2-en-1-yl] (1r,3r)-3-[(e)-3-methoxy-2-methyl-3-oxoprop-1-enyl Chemical class CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1.CC1(C)[C@H](/C=C(\C)C(=O)OC)[C@H]1C(=O)O[C@@H]1C(C)=C(C\C=C/C=C)C(=O)C1 VXSIXFKKSNGRRO-MXOVTSAMSA-N 0.000 description 1
- 229960002587 amitraz Drugs 0.000 description 1
- QXAITBQSYVNQDR-ZIOPAAQOSA-N amitraz Chemical compound C=1C=C(C)C=C(C)C=1/N=C/N(C)\C=N\C1=CC=C(C)C=C1C QXAITBQSYVNQDR-ZIOPAAQOSA-N 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- UOAMTSKGCBMZTC-UHFFFAOYSA-N dicofol Chemical compound C=1C=C(Cl)C=CC=1C(C(Cl)(Cl)Cl)(O)C1=CC=C(Cl)C=C1 UOAMTSKGCBMZTC-UHFFFAOYSA-N 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000002932 luster Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229960001952 metrifonate Drugs 0.000 description 1
- 238000009304 pastoral farming Methods 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- HYJYGLGUBUDSLJ-UHFFFAOYSA-N pyrethrin Natural products CCC(=O)OC1CC(=C)C2CC3OC3(C)C2C2OC(=O)C(=C)C12 HYJYGLGUBUDSLJ-UHFFFAOYSA-N 0.000 description 1
- 229940070846 pyrethrins Drugs 0.000 description 1
- 239000002728 pyrethroid Substances 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 206010039766 scrub typhus Diseases 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/14—Ethers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/02—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing liquids as carriers, diluents or solvents
- A01N25/04—Dispersions, emulsions, suspoemulsions, suspension concentrates or gels
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N65/00—Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
- A01N65/08—Magnoliopsida [dicotyledons]
- A01N65/22—Lamiaceae or Labiatae [Mint family], e.g. thyme, rosemary, skullcap, selfheal, lavender, perilla, pennyroyal, peppermint or spearmint
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Pest Control & Pesticides (AREA)
- Dispersion Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an acaricide missible oil, and a preparation method and application thereof, and belongs to the field of veterinary medicines. The miticidal emulsifiable concentrate comprises 1-5 parts of eugenol, 2-4 parts of thyme essential oil, 10-20 parts of methyl eugenol and 1-2 parts of emulsifier, wherein the emulsifier comprises calcium pyruvate, 26 parts of white mineral oil, OP-10 parts of emulsifier and 700 parts of agricultural emulsion. The acaricidal missible oil disclosed by the invention is uniform and stable in liquid medicine after being diluted, does not layer, has a remarkable synergistic interaction effect among active ingredients of plant essential oil serving as a main raw material, and is safe, green, efficient and free of toxic and side effects; the new chigger on the chicken body can be effectively killed in the production application, and the production cost is reduced.
Description
Technical Field
The invention belongs to the technical field of veterinary medicines, and particularly relates to an acaricidal missible oil, and a preparation method and application thereof.
Background
Acariasis is a ubiquitous group of ectoparasitic diseases of humans and animals. The disease is characterized by contact infection, severe itching and severe skin inflammation. The occurrence of acariasis is very common and quite persistent, and animals such as rabbits, pigs, sheep, dogs, foxes, mice, cows, chickens and the like and human beings can be infected with acarids. Among them, in the production and sale of Guang chickens, skin disease caused by chigger newly is one of important diseases affecting the product quality. Most of the farms for raising yellow-feathered broilers are located in southern areas of China, the warm and humid climate is more suitable for breeding chiggers newly, and the grazing stadium located on the bamboo forest and shrub sides is a hotbed for breeding chiggers newly. Therefore, many breeding enterprises actively deploy the prevention and control work of new chiggers of broiler chickens, and strive to ensure the quality of Guangji products.
For a long time, the control of animal acariasis relies on acaricidal drugs such as avermectins, pyrethrins, amitraz, dicofol, trichlorfon and the like, and with the wide, long-term and frequent application of these drugs, more and more acarids have developed increasingly serious drug resistance, and the recurrence and repeated infection of acariasis become frequent. And the mite killing efficiency of the mite killing medicine aiming at preventing and treating the chigger disease of the broilers is low, and the insect expelling rate can be improved and the mite disease recurrence can be prevented only by repeatedly using the medicine for many times. Therefore, research and development of a green and safe acaricidal medicament with higher acaricidal efficiency are needed.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the invention provides an acaricide missible oil, and a preparation method and application thereof.
According to one aspect of the invention, the acaricidal missible oil comprises the following raw materials: eugenol, thyme essential oil, methyl eugenol and emulsifier.
In some embodiments of the invention, the starting materials are in the following parts by weight: 1-5 parts of eugenol, 2-4 parts of thyme essential oil, 10-20 parts of methyl eugenol and 1-2 parts of emulsifier.
In some embodiments of the invention, the emulsifier comprises calcium salt, mineral oil, emulsifier OP-10, agricultural milk 700.
In some embodiments of the invention, the mass ratio of the calcium salt, mineral oil, emulsifier OP-10 and farm milk 700 is 7: (18-23): (30-35): (18-23).
In some embodiments of the invention, the starting materials are in the following parts by weight: 2-3 parts of eugenol, 3-4 parts of thyme essential oil, 14-16 parts of methyl eugenol and 1-1.3 parts of emulsifier.
In some embodiments of the invention, the calcium salt is selected from calcium pyruvate.
In some embodiments of the invention, the mineral oil is selected from white mineral oil 26.
The invention also provides a preparation method of the acaricidal missible oil, which comprises the following steps:
s1: weighing the components in proportion, heating the solvent, adding the emulsifier into the solvent, and stirring;
s2: adding eugenol, thyme essential oil and methyl eugenol, stirring and mixing to obtain the acaricide missible oil.
In some embodiments of the invention, in step S1, the solvent is ethyl acetate.
In some embodiments of the invention, the heating temperature is 40-50 ℃ in step S1.
In some embodiments of the present invention, in step S2, the stirring speed is 1800-2200 r/min.
The invention also provides application of the mite-killing missible oil in prevention and treatment of chigger disease of chicken.
According to a preferred embodiment of the present invention, at least the following advantages are provided:
the acaricidal missible oil disclosed by the invention is uniform and stable in liquid medicine after being diluted, does not layer, has a remarkable synergistic interaction effect among active ingredients of plant essential oil serving as a main raw material, and is safe, green, efficient and free of toxic and side effects; the new chigger on the chicken body can be effectively killed in the production application, and the production cost is reduced.
Detailed Description
The concept and technical effects of the present invention will be clearly and completely described below in conjunction with the embodiments to fully understand the objects, features and effects of the present invention. It is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments, and those skilled in the art can obtain other embodiments without inventive effort based on the embodiments of the present invention, and all embodiments are within the protection scope of the present invention.
Example 1
The acaricidal missible oil is composed of the following raw materials in parts by weight: 2 parts of eugenol, 3 parts of thyme essential oil, 15 parts of methyl eugenol and 1 part of emulsifier, wherein the emulsifier consists of calcium pyruvate, 26 parts of white mineral oil, OP-10 parts of emulsifier and 700 parts of agricultural emulsion according to the mass ratio of 7:20:33:20, and the obtained acaricidal missible oil is light milky transparent clear liquid, has uniform color and stable property.
The preparation method of the acaricide missible oil comprises the following steps: heating ethyl acetate to 45 ℃, adding the emulsifier components into the ethyl acetate, and stirring for dissolving; adding eugenol, thyme essential oil and methyl eugenol, stirring and mixing at 2000r/min to obtain the miticide emulsifiable concentrate.
Example 2
The acaricidal missible oil is composed of the following raw materials in parts by weight: 1.5 parts of eugenol, 3 parts of thyme essential oil, 15 parts of methyl eugenol and 1 part of emulsifier, wherein the emulsifier consists of calcium pyruvate, 26 parts of white mineral oil, OP-10 parts of emulsifier and 700 parts of agricultural emulsion according to the mass ratio of 7:20:33:20, and the obtained acaricidal missible oil is light milky transparent clear liquid, has uniform color and stable property.
The preparation method of the acaricide missible oil comprises the following steps: heating ethyl acetate to 45 ℃, adding the emulsifier components into the ethyl acetate, and stirring for dissolving; adding eugenol, thyme essential oil and methyl eugenol, stirring and mixing at 2000r/min to obtain the miticide emulsifiable concentrate.
Example 3
The acaricidal missible oil is composed of the following raw materials in parts by weight: 2 parts of eugenol, 2 parts of thyme essential oil, 10 parts of methyl eugenol and 1 part of emulsifier, wherein the emulsifier consists of calcium pyruvate, 26 parts of white mineral oil, OP-10 parts of emulsifier and 700 parts of agricultural emulsion according to the mass ratio of 7:20:33:20, and the obtained acaricidal missible oil is light milky transparent clear liquid, has uniform color and stable property.
The preparation method of the acaricide missible oil comprises the following steps: heating ethyl acetate to 50 ℃, adding the emulsifier components into the ethyl acetate, and stirring for dissolving; adding eugenol, thyme essential oil and methyl eugenol, stirring and mixing at 1800r/min to obtain the miticide emulsifiable concentrate.
Example 4
The acaricidal missible oil is composed of the following raw materials in parts by weight: 2 parts of eugenol, 4 parts of thyme essential oil, 15 parts of methyl eugenol and 1 part of emulsifier, wherein the emulsifier consists of calcium pyruvate, 26 parts of white mineral oil, OP-10 parts of emulsifier and 700 parts of agricultural emulsion according to the mass ratio of 7:20:33:20, and the obtained acaricidal missible oil is light milky transparent clear liquid, has uniform color and stable property.
The preparation method of the acaricide missible oil comprises the following steps: heating ethyl acetate to 40 ℃, adding the emulsifier components into the ethyl acetate, and stirring for dissolving; adding eugenol, thyme essential oil and methyl eugenol, stirring and mixing at 2200r/min to obtain the miticide emulsifiable concentrate.
Comparative example 1
The acaricidal missible oil is different from the acaricidal missible oil in example 1 in that thyme essential oil is not added, and the acaricidal missible oil specifically comprises the following components: 5 parts of eugenol, 15 parts of methyl eugenol and 1 part of emulsifier, wherein the emulsifier consists of calcium pyruvate, 26 parts of white mineral oil, OP-10 parts of emulsifier and 700 parts of agricultural emulsion according to the mass ratio of 7:20:33:20, and the obtained acaricidal missible oil is colorless clear liquid, has uniform color and luster and stable property.
The preparation method of the acaricide missible oil comprises the following steps: heating ethyl acetate to 45 ℃, adding the emulsifier components into the ethyl acetate, and stirring for dissolving; adding eugenol and methyl eugenol, stirring and mixing at 2000r/min to obtain the miticide emulsifiable concentrate.
Comparative example 2
The acaricidal missible oil is different from the acaricidal missible oil in example 1 in that eugenol and thyme essential oil are not added, and the acaricidal missible oil specifically comprises the following components: 20 parts of methyl eugenol and 1 part of emulsifier, wherein the emulsifier consists of calcium pyruvate, white mineral oil 26, emulsifier OP-10 and agricultural emulsion 700 according to the mass ratio of 7:20:33:20, and the obtained acaricidal missible oil is colorless clear liquid, and has uniform color and stable property.
The preparation method of the acaricide missible oil comprises the following steps: heating ethyl acetate to 45 ℃, adding the emulsifier components into the ethyl acetate, and stirring for dissolving; then adding methyl eugenol, stirring and mixing at 2000r/min to prepare the acaricide missible oil.
The first test example: acaricidal effect test of acaricidal missible oil
Scheme 1: 5 chiggers each group were collected from the affected chickens, and the miticidal emulsifiable concentrates of examples 1-4 and comparative examples 1-2 were mixed as follows: and (5) diluting by 2000 times. The death time of each group of new gazania was as shown in table 1.
TABLE 1
As can be seen from Table 1, the mite-killing emulsifiable concentrate for preventing and controlling New tsutsugamushi provided in example 1 of the present invention was prepared in the following manner: the 2000-fold dilution can kill new chigger within 5 minutes, but the killing time of comparative example 1 without adding thyme essential oil and comparative example 2 only using methyl eugenol is longer, which shows that the compound use of eugenol, thyme essential oil and methyl eugenol in the invention has obvious synergistic effect.
Scheme 2: the miticidal emulsifiable concentrate is delivered to different farmers of south-Ningwenshi of Guangxi province for animal tests, and is applied according to effective concentration, and test results are fed back as follows.
1, family maintenance: the chicken of the Shandong Dynasty of 64 days old. The house is a long-term mite house, the mites are serious before the drug is taken, most of the mites scab after the mites are observed on the 7 th day after the mites are directly sprayed on chicken bodies, the cure rate is over 98 percent, and the chickens only have no skin red swelling, injury and inflammation.
And (3) family maintenance: the chicken of the Shandong Dynasty of 66 days old. The house is a long-term mite house, the mites are not serious before the drug is taken, only the mites exist individually, the drug bath is used, the padding for raising the house is better managed, the treatment effect is good, the cure rate is more than 98%, and the chickens only have no skin swelling, injury and inflammation.
Test example two: stability test of miticidal emulsifiable concentrates
The test was carried out by referring to accelerated test measurement in stability of the first edition of pharmacopoeia of the people's republic of China 2015. Examples 1 and 2 were stored at 40 ℃. + -. 2 ℃ and 70%. + -. 5% relative temperature for 6 months, the temperature and humidity were monitored in real time, and samples were taken at the end of 1 month, 2 months, 3 months and 6 months during the test period to measure the content of plant essential oil.
The test results are shown in the table 2.
TABLE 2 stability test results of miticidal emulsifiable concentrates
The results in Table 2 show that the acaricide missible oil has the advantages of less content change, stable property, uniform liquid medicine and no layering after accelerated tests.
The embodiments of the present invention have been described in detail, but the present invention is not limited to the embodiments, and various changes can be made without departing from the gist of the present invention within the knowledge of those skilled in the art. Furthermore, the embodiments of the present invention and the features of the embodiments may be combined with each other without conflict.
Claims (10)
1. The acaricidal missible oil is characterized by comprising the following raw materials: eugenol, thyme essential oil, methyl eugenol and emulsifier.
2. An acaricidal emulsifiable concentrate as set forth in claim 1, characterized in that said raw materials are in parts by weight as follows: 1-5 parts of eugenol, 2-4 parts of thyme essential oil, 10-20 parts of methyl eugenol and 1-2 parts of emulsifier.
3. An acaricidal emulsifiable concentrate according to claim 1 or 2, wherein the emulsifier comprises calcium salt, mineral oil, emulsifier OP-10, agricultural emulsion 700.
4. An acaricidal emulsifiable concentrate according to claim 3, wherein the mass ratio of the calcium salt to the mineral oil to the emulsifier OP-10 to the agricultural emulsion 700 is 7: (18-23): (30-35): (18-23).
5. An acaricidal emulsifiable concentrate as set forth in claim 1, characterized in that said raw materials are in parts by weight as follows: 2-3 parts of eugenol, 3-4 parts of thyme essential oil, 14-16 parts of methyl eugenol and 1-1.3 parts of emulsifier.
6. An acaricidal emulsifiable concentrate according to claim 3, characterized in that the calcium salt is selected from calcium pyruvate.
7. An acaricidal cream according to claim 3, characterized in that the mineral oil is chosen from white mineral oil 26.
8. A process for preparing an emulsifiable concentrate as claimed in claim 1, which comprises the steps of:
s1: weighing the components in proportion, heating the solvent, adding the emulsifier into the solvent, and stirring;
s2: adding eugenol, thyme essential oil and methyl eugenol, stirring and mixing to obtain the acaricide missible oil.
9. The method according to claim 8, wherein the heating is performed at a temperature of 40 to 50 ℃ in step S1; in step S2, the stirring speed is 1800-2200 r/min.
10. The use of the emulsifiable concentrate for killing mites of gazang chigger of chickens of claim 1 for the control of chigger mite disease.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110718568.7A CN113498783A (en) | 2021-06-28 | 2021-06-28 | Mite-killing missible oil and preparation method and application thereof |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202110718568.7A CN113498783A (en) | 2021-06-28 | 2021-06-28 | Mite-killing missible oil and preparation method and application thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115500364A (en) * | 2022-09-27 | 2022-12-23 | 上海家化联合股份有限公司 | Water-based product comprising lilac flower oil and thyme oil and mite-killing application thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078313A (en) * | 2011-01-06 | 2011-06-01 | 西北农林科技大学 | High-efficiency, low-toxicity and safe plant source acaricidal medicament and preparation method thereof |
| CN109999014A (en) * | 2019-03-28 | 2019-07-12 | 佛山市正典生物技术有限公司 | It is a kind of can the new merit chigger disease of prevention and control plants essential oil and preparation method thereof |
| CN110012903A (en) * | 2019-03-28 | 2019-07-16 | 佛山市正典生物技术有限公司 | Can the new merit chigger disease of prevention and control plants essential oil microcapsule formulation and preparation method thereof |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102078313A (en) * | 2011-01-06 | 2011-06-01 | 西北农林科技大学 | High-efficiency, low-toxicity and safe plant source acaricidal medicament and preparation method thereof |
| CN109999014A (en) * | 2019-03-28 | 2019-07-12 | 佛山市正典生物技术有限公司 | It is a kind of can the new merit chigger disease of prevention and control plants essential oil and preparation method thereof |
| CN110012903A (en) * | 2019-03-28 | 2019-07-16 | 佛山市正典生物技术有限公司 | Can the new merit chigger disease of prevention and control plants essential oil microcapsule formulation and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115500364A (en) * | 2022-09-27 | 2022-12-23 | 上海家化联合股份有限公司 | Water-based product comprising lilac flower oil and thyme oil and mite-killing application thereof |
| CN115500364B (en) * | 2022-09-27 | 2023-10-31 | 上海家化联合股份有限公司 | Water-based product comprising clove oil and thyme oil and its use for controlling mites |
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