CN109985090A - A kind of Compound Resisting vermin composition and preparation method thereof - Google Patents
A kind of Compound Resisting vermin composition and preparation method thereof Download PDFInfo
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- CN109985090A CN109985090A CN201711486330.6A CN201711486330A CN109985090A CN 109985090 A CN109985090 A CN 109985090A CN 201711486330 A CN201711486330 A CN 201711486330A CN 109985090 A CN109985090 A CN 109985090A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
Abstract
The invention discloses a kind of mammal or fowl Compound Resisting vermin composition and preparation method thereof, the Compound Resisting vermin composition efficiently, low toxicity, it is low stimulation, can mosquito repellent the features such as.Litsea citrate oil merges Fipronil, while synergy, reduces the toxicity of composition；The effect for having both simultaneously and repairing skin, walk quickly and keep away mosquito, alleviates the adverse reaction and limitation of clinical application；Meanwhile the distinctive natural pleasant odor of litsea citrate oil improves the compliance of pet medication.Fenoxycarb has a double action mechanism, while efficient ovicidal, improves the efficiency of composition tickicide.Compound Resisting vermin composition of the present invention can be used for mammal, especially cat or dog, and epizoon is killed.The present invention uses the form of externally used solution agent, drips the skin between animal shoulder blade or pours leaching in animal head back, calculates dosage according to weight.
Description
Technical field
It is the present invention relates to a kind of compound anti-parasitic drug, in particular to a kind of for the efficient, low of cat, dog or birds
Malicious, low stimulation, can mosquito repellent, and the Compound Resisting vermin composition and preparation method thereof with natural pleasant smell.
Background technique
Parasitic disease can all generate harm to human health and Animal husbandry production.The parasitic animals and plants such as flea, mite, tick, lice can be to perhaps
The pets such as more animals especially cat, dog bring invasion and infection, cause cute pet uneasy and disease.Simultaneously by pathogen infection, or
Person brings the disease of a variety of infecting both domestic animals and humans as communication media to the mankind.
The extracorporeal treatment mode for being usually used in parasitic animal and plant has: dipping, shampoo, necklace, transdermal solution agent, drops, spray etc..
Traditional animal ectoparsite driving and killing agent includes chemicals such as organic phosphates, carbamates and plant extracts
Such as pyrethroid, it is commonly used for antibody ectoparasite, such as tick, mite class.Fipronil (Fipronil) also known as fluorine worm
Nitrile is French Luo Na-Rhone-Poulenc researcher in discovery in 1987 there is desinsection, mite killing, nematicidal and to kill segmental appendage dynamic
The active pyrazole compound of object is applied to agriculturally in early days to the evil such as the snout moth's larva of rice, aphid, Lepidoptera, coleoptera and flies
The prevention and treatment of worm.The nineties in last century is taken the lead in developing as the external anthelmintic drug of pet by Merial company, lists in Britain, quotient
Name of an article Frontline.China by Zhejiang Haizheng Pharmaceutical Co first by raw medicine from pesticide developing be for animals, Fipronil drops in 2015
" Chinese is doted on glad " lists at home.The drug mainly has two kinds of dosage forms of drops and spray for pet, is stored in animal after application
Sebaceous glands in, by skin surface grease spread, play general action.The internal and blood that drug will not enter cat and dog follows
Ring will not hurt the hepatic and renal function of cat and dog.For the product using more convenient but expensive, Oral toxicity is big, is easy to induce peace
Full accident.
The fruit of a cubeb litsea tree also known as cubeb litsen tree [Litsea cubeba (Lour) Pers] are Lauraceae Litsea plant, litsea citrate oil
It is the volatile oil extracted from fruit of a cubeb litsea tree fruit.Litsea citrate oil is widely used in medical and health in China, flavors and fragrances, anti-cures the disease
The fields such as insect pest.Since the seventies, China has carried out a series of researchs to the chemical component of litsea citrate oil, pharmacological action, hair
Now wherein contain tens of kinds of chemical components.Liang Qing et al. (2015) carries out autonomous extract to the ingredient in fruit of a cubeb litsea tree fruit and reflects
Not, it was demonstrated that the main component of natural litsea citrate oil is D- limonene (w=26.51%), citral (w=11.94%) and horsewhip
Enol (w=11.84%).Foreign countries have been reported that D- limonene can increase sensory cell activity by neurotoxic effect, from
And error signal is issued to muscle, cause insect paralysis lethal.And the spray and medicine of certain country's approved D- limonenes
Bath, the killing of body surface flea, louse for dog cat, while having avoidance effect to mosquito.In addition, litsea citrate oil is grown because it has
Functions, the Abroad in Recent Years such as profit, nutrition, protection skin are widely used in preparing medical cosmetics.Its sterilizing power is strong, will not cause
Allergy has made an addition in a variety of skin-protection products；Do not have light sensitivity, also there is patent CN103622880B to be applied to sun-proof articles
In.Patent CN02147862A describes litsea citrate oil for killing the effect of people and animals epizoon, and uses lot of experimental data
Demonstrate this conclusion.
The dog cat of domestic market sale and the external anti-parasitic drug price of birds are different, anti-parasitic difference on effect
Obviously.Major product for pet is the Fu Laien dog cat depulization drops of French Cimmeria company production, not only can be with
Flea and tick are killed, can be also used for the infection of prevention and treatment flea and tick, Synergistic preparations even have the effect of ovicidal.But
It is, due to its unique mechanism of action, on the one hand, in order to ensure curative effect, specification recommends the 2-7d after medication to forbid to pet
It has a bath, this is just difficult to avoid that licking for pet is licked and contacted with the direct of owner, causes security risk；On the other hand, have many cases
Report that the hard to bear allergic reaction waited of itch occurs for Fipronil related preparations, point medicine area skin；Meanwhile also having and doting on main reflection good fortune
Bite by mosquitos cannot be prevented by carrying out grace, be not suitable in the more wet environment of mosquitos and flies using.
The present invention endeavours to invent that a kind of insecticidal effect is good, and safety is higher, mild to skin, can walk quickly and keep away mosquito, and band
There is the Compound Resisting vermin composition of natural pleasant smell.
Summary of the invention
It is an object of the present invention to provide one kind dedicated for the drive of the ectoparsite of mammal and birds, especially cat or dog
The composition killed while providing potentiating pesticidal characteristic, can reduce Oral toxicity effect, mild to skin, can walk quickly and keep away mosquito,
And with natural pleasant smell, the compliance of pet when expanding the scope of application and medication of drug dotes on main pleasant feeling.
To achieve the above object the present invention adopts the following technical scheme:
A kind of Compound Resisting vermin composition, it includes following components:
The insect growth regulator, IGR is selected from one of juvenoid and chitin synthesis inhibitor or a kind of
Combination of the above object；The juvenoid is selected from fenoxycarb, hydroprene, pyriproxyfen, nimbin, kinoprene, pyridazine
One of ketone compounds；The chitin synthesis inhibitor is selected from that Buprofezin, cyromazine, diflubenzuron, pyrrole worm be grand, volt worm
Grand, lufenuron, flufenoxuron, tebufenozide, flucycloxuron, triflumuron, CGA 183893, N- [[the chloro- 4- of the 3- [fluoro- 2- (fluoroform of 1,1,2- tri-
One of oxygroup) ethyoxyl] phenyl] carbamoyl] the double fluorobenzamides of -2,6-.
The antioxidant is selected from butylated hydroxyarisol, dibutyl hydroxy toluene, di-tert-butyl p-cresol, special fourth
Base hydroquinone, propylgallate, vitamin E, vitamin C, carotenoid and its derivative, arabo-ascorbic acid, citron
One of acid, sodium isoascorbate, caryophyllus oil, rosemary oil or more than one compositions.
The crystallization inhibitor is selected from one of cation, anion, nonionic and amphoteric surfactant or a kind of
Combination of the above object；The cationic surfactant is one of dihexadecyldimethylammonium bromide, octylame hydrochloride；Institute
Stating anionic surfactant is that alkali metal stearic acid salt, sodium abietate, alkyl sulfate, neopelex and two are pungent
One of base sulfosuccinate sodium；The nonionic surfactant is Sorbitan ethoxylate, myristic acid is different
Propyl ester, polyoxyethylated alkyl ether, polyethylene glycol stearate, castor oil derivatives, polyglycerol ester, polyoxyethylene
Change one of fatty alcohol, ethylene oxide and epoxy propane copolymer；The amphoteric surfactant is the sweet tea that lauryl replaces
In dish alkali cpd, polyvinylpyrrolidone, polyvinyl alcohol, vinyl pyrrolidone vinyl acetate copolymer and lecithin
It is a kind of.
The solvent is selected from ethyl acetate, acetone, acetonitrile, dimethylformamide, dimethyl acetamide, N- methyl vinyl
Amine, diethylmethyl formamide, diethylene glycol dimethyl ether, dipropylene glycol n-butyl ether, ethylene glycol monoethyl ether, glycol monoethyl ether,
Dipropylene glycol monomethyl ether, diethylene glycol monoethyl ether, ethylene glycol monobutyl ether, benzyl alcohol, glycerol, liquid macrogol, 2- pyrrolidines
Ketone, glyceryl triacetate, cyclohexanol, sec-octyl alcohol, fatty acid methyl ester, N, N- parvoline amide, Ergol, lactic acid second
Ester, diethyl phthalate, one of or more than one compositions.
The cosolvent be selected from one of ethyl alcohol, isopropanol, dimethyl sulfoxide, methanol, fat oil, propylene glycol or it is a kind of with
Upper composition.
The Compound Resisting vermin composition also includes macrolides or pyrethroid insecticides, imidazoles
One of antihelmintic and praziquantel or more than one compositions.
The preparation method of Compound Resisting vermin composition as described above, comprising the following steps:
(1) solvent for accounting for output 1-30% is added in Agitation Tank；
(2) by the insect growth regulator, IGR for accounting for output 2%-18% and the antioxidant for accounting for output 0.005%-5%
It is added in Agitation Tank, stirring makes to mix, and sequentially adds the litsea citrate oil for accounting for output 2%-18% later, accounts for output 1%-
15% crystallization inhibitor, is stirred well to and is completely dissolved；
(3) under continuous agitation, the Fipronil for accounting for output 1%-10% is added, is slowly added to cosolvent extremely
Solution clarification, after add to output.
The Compound Resisting vermin composition is applied to prevention, control or tick and the jump of eliminating mammal or fowl
Flea, the preparation including applying a effective amount of claim 1 to mammal and birds.
The mammal is cat or dog.
As a further optimization solution of the present invention, the mammal or birds are combined with Compound Resisting vermin
Object, by mass percentage comprising following component:
As a further optimization solution of the present invention, the preparation method of Compound Resisting vermin composition as described above,
The following steps are included:
(1) diethylene glycol monoethyl ether for accounting for output 20% is added in Agitation Tank；
(2) it by the fenoxycarb for accounting for output 6% and accounts for the butylated hydroxyarisol of output 0.02%, account for output
0.01% dibutyl hydroxy toluene is added in Agitation Tank, and stirring makes to mix, sequentially add later account for output 10% mountain it is grey
Seed oil (lemon aldehyde >=65%), the polyvinylpyrrolidone that accounts for the polyoxyethylene sorbitan monoleate of output 5% and account for output 5%,
It is stirred well to and is completely dissolved；
(3) under continuous agitation, the Fipronil for accounting for output 5% is added, it is clear to solution to be slowly added to ethyl alcohol
Clearly, it is added after to output.
The beneficial effects of the present invention are:
The present invention is directed to dog cat ectoparsite, and tick worm and flea etc. utilize the high antibody ectoparasite of occupation rate of market
Drug --- Fu Laien, kills high-efficient, but toxic effect is big, skin irritation is strong, is unable to the disadvantages of mosquito repellent, using to people
Poultry epibiont has the Chinese medicine natural extract litsea citrate oil of killing effect, merges use with active principle Fipronil.Table
Revealing not is simple addition, but while synergy, reduce the toxicity of entire composition；Reparation skin is had both simultaneously
Skin, the effect for walking quickly and keeping away mosquito, alleviate the adverse reaction of clinical application, solve medication limitation；In insect growth regulator, IGR
With fenoxycarb for optimal, double action mechanism, while ensure that composition kills worm's ovum, the effect for killing tick worm is improved
Rate, while the active principle dosage of equivalent ovicidal is only the 1/3 of commercial like product, significant effect.In addition, the mountain in the present invention
The compliance of pet and main fragrance is doted on when the included natural pleasant breath of grey seed oil improves medication.
Its application method of the Compound Resisting vermin composition is: external application, and drip the skin between shoulder blade: every dynamic
Object, cat 0.5ml；Dog weight 10kg or less 0.67ml, weight 10~20kg 1.34ml, weight 20~40kg 2.68ml,
The dog of weight 40kg or more uses 4.02ml, monthly.
Detailed description of the invention
Fig. 1: mouse repellency test Effective Vate of Protection figure
Specific embodiment
To make the object, technical solutions and advantages of the present invention clearer, the technical solution in the present invention is carried out below
Clear, complete description, it is clear that described embodiments are some of the embodiments of the present invention, instead of all the embodiments.Base
Embodiment in the present invention, it is obtained by those of ordinary skill in the art without making creative efforts it is all its
His embodiment, shall fall within the protection scope of the present invention.
Embodiment one
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), the dibutyl hydroxy toluene addition of the butylated hydroxyarisol of the fenoxycarb of 3000g and 10g, 5g are matched
In flow container, stirring makes to mix, and sequentially adds the litsea citrate oil (lemon aldehyde >=65%) of 5000g, the poly- sorb of 2500g later
The polyvinylpyrrolidone of ester 80 and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment two
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the dimethylformamide of 15000g is added in Agitation Tank；
(2), the caryophyllus oil of the fenoxycarb of 5000g and 2500g are added in Agitation Tank, stirring makes to mix, and successively adds later
Enter the litsea citrate oil (lemon aldehyde >=65%) of 9000g, the neopelex of 1000g, is stirred well to completely molten
Solution；
(3), the Fipronil of 1000g under continuous agitation, is added, is slowly added to propylene glycol to solution and clarifies,
After add to output.
Embodiment three
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the triacetyl glycerine of 2500g is added in Agitation Tank；
(2), the vitamin E of the sodium isoascorbate of the fenoxycarb of 1000g and 25g, 10g are added in Agitation Tank, stirring
Make to mix, sequentially adds the litsea citrate oil (lemon aldehyde >=65%) of 1000g, the di-cetyl dimethyl of 5000g later
The benzyl alcohol of ammonium bromide and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 5000g under continuous agitation, is added, is slowly added to fat oil to solution and clarifies,
After add to output.
Example IV:
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol dimethyl ether of 12500g is added in Agitation Tank；
(2), Agitation Tank is added to biphenol in the tertiary butyl of the dibutyl hydroxy toluene of the methoprene of 3500g and 5g, 10g
In, stirring makes to mix, and litsea citrate oil (lemon aldehyde >=65%), the myristic acid of 4000g for sequentially adding 6000g later are different
Propyl ester is stirred well to and is completely dissolved；
(3), the Fipronil of 3000g under continuous agitation, is added, is slowly added to methanol to solution and clarifies, after
It adds to output.
Embodiment five
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the dipropylene glycol n-butyl ether of 5000g is added in Agitation Tank；
(2), the rosemary oil of the methoprene of 1000g and 2500g are added in Agitation Tank, stirring makes to mix, later successively
The litsea citrate oil (lemon aldehyde >=65%) of 9000g, the polyvinyl alcohol of the odium stearate of 500g and 500g is added, is sufficiently stirred
To substantially uniformity；
(3), the Fipronil of 500g under continuous agitation, is added, is slowly added to dimethyl sulfoxide to solution and clarifies,
After add to output.
Embodiment six
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the ethylene glycol monoethyl ether of 7500g is added in Agitation Tank；
(2), the arabo-ascorbic acid of the pyriproxyfen of 5000g and 250g are added in Agitation Tank, stirring makes to mix, later successively
Litsea citrate oil (lemon aldehyde >=65%), the octylame hydrochloride of 6000g and the benzyl alcohol of 3000g of 1500g is added, sufficiently stirs
It mixes to being completely dissolved；
(3), the Fipronil of 5000g under continuous agitation, is added, is slowly added to fat oil to solution and clarifies,
After add to output.
Embodiment seven
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the liquid 2-Pyrrolidone (using after heating when necessary) of 7500g is added in Agitation Tank；
(2), the citric acid of the propylgallate of the pyriproxyfen of 1000g and 5g, 500g are added in Agitation Tank, stirring makes
It mixes, sequentially adds the lecithin of litsea citrate oil (lemon aldehyde >=65%) and 1000g of 8000g later, be stirred well to
It is completely dissolved；
(3), the Fipronil of 2000g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment eight
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the liquid polyethylene glycol of 5000g is added in Agitation Tank；
(2), the alpha-carotene of the lufenuron of 4000g and 1500g are added in Agitation Tank, stirring makes to mix, later successively
The polyethylene glycol stearate of litsea citrate oil (lemon aldehyde >=65%) and 8000g of 7500g is added, is stirred well to completely
Dissolution；
(3), it under continuous agitation, is added and accounts for the Fipronil of output 1500g, be slowly added to isopropanol to molten
Liquid clarification, after add to output.
Embodiment nine
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the glycol monoethyl ether of 15000g is added in Agitation Tank；
(2), Agitation Tank is added in the dibutyl hydroxy toluene of the di-tert-butyl p-cresol of the lufenuron of 1500g and 10g, 5g
In, stirring makes to mix, sequentially add later the litsea citrate oil (lemon aldehyde >=65%) of 4000g, 1500g it is polyoxyethylated
The polyvinylpyrrolidone of alkyl ether and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 3500g under continuous agitation, is added, is slowly added to methanol to solution and clarifies, after
It adds to output.
Embodiment ten
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the dipropylene glycol monomethyl ether of 10000g is added in Agitation Tank；
(2), the beta carotene of the Buprofezin of 3000g and 1000g are added in Agitation Tank, stirring makes to mix, later successively
The litsea citrate oil (lemon aldehyde >=65%) of 8000g, the sodium abietate of 500g is added, is stirred well to and is completely dissolved；
(3), the Fipronil of 1500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 11
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the ethylene glycol monobutyl ether of 7500g is added in Agitation Tank；
(2), the astaxanthin of the tebufenozide of 2000g and 1000g are added in Agitation Tank, stirring makes to mix, and successively adds later
Enter the litsea citrate oil (lemon aldehyde >=65%) of 2500g, the cyclohexanol of the lauryl sodium sulfate of 1500g and 2500g, sufficiently
Stirring is to being completely dissolved；
(3), the Fipronil of 4500g under continuous agitation, is added, is slowly added to isopropanol to solution and clarifies,
After add to output.
Embodiment 12
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the ethyl lactate (using after heating when necessary) of 5000g is added in Agitation Tank；
(2), the citric acid of the propylgallate of the CGA 183893 of 3000g and 5g, 500g are added in Agitation Tank, stirring makes
It mixes, sequentially adds the litsea citrate oil (lemon aldehyde >=65%) of 6000g and the ethyl laurate base beet of 5000g later
Alkali is stirred well to and is completely dissolved；
(3), the Fipronil of 4000g under continuous agitation, is added, is slowly added to methanol to solution and clarifies, after
It adds to output.
Embodiment 13
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the polyoxyethylated alkyl ether of 5000g is added in Agitation Tank；
(2), the vitamin C of the nimbin of 2000g and 500g are added in Agitation Tank, stirring makes to mix, and successively adds later
The polyoxyethylenated alcohol for entering litsea citrate oil (lemon aldehyde >=65%) and 5000g of 3000g is stirred well to completely molten
Solution；
(3), the Fipronil for accounting for output 5000g under continuous agitation, is added, is slowly added to ethyl alcohol to solution
Clarification, after add to output.
Embodiment 14
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the acetone of 3500g is added in Agitation Tank；
(2), the dibutyl hydroxy toluene addition of the butylated hydroxyarisol of the pyridazinone of 2500g and 8g, 4g are matched
In flow container, stirring makes to mix, and sequentially adds the litsea citrate oil (lemon aldehyde >=65%) of 6500g, the polyoxy second of 5000g later
The polyvinylpyrrolidone of alkenyl castor oil and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 3000g under continuous agitation, is added, is slowly added to propylene glycol to solution and clarifies,
After add to output.
Embodiment 15
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the dimethyl acetamide of 6000g is added in Agitation Tank；
(2), the caryophyllus oil of the cyromazine of 3500g and 2500g are added in Agitation Tank, stirring makes to mix, and successively adds later
Enter the litsea citrate oil (lemon aldehyde >=65%) of 7000g, the sodium dioctyl sulfosuccinate of 750g, is stirred well to completely molten
Solution；
(3), the Fipronil of 1000g under continuous agitation, is added, is slowly added to fat oil to solution and clarifies,
After add to output.
Embodiment 16:
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the ethyl acetate of 5000g is added in Agitation Tank；
(2), by the pyrrole worm of 1500g is grand and the vitamin E of the sodium isoascorbate of 25g, 10g is added in Agitation Tank, stirring
Make to mix, sequentially adds the litsea citrate oil (lemon aldehyde >=65%) of 3000g, the polyglycerol ester of 5000g later, be sufficiently stirred
To being completely dissolved；
(3), the Fipronil of 4500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 17
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the polyoxyethylene groups castor oil of 4000g is added in Agitation Tank；
(2), by the N- of 4000g [[the chloro- 4- of 3- [1,1,2- tri- fluoro- 2- (trifluoromethoxy) ethyoxyl] phenyl] amino first
Acyl group] propylgallate of the bis- fluorobenzamides of -2,6- and 5g, the vitamin E of 10g be added in Agitation Tank, and stirring makes to mix,
Vinyl pyrrolidone-vinyl acetate of litsea citrate oil (lemon aldehyde >=65%) and 1000g of 3000g is sequentially added later
Ester copolymer is stirred well to mixing；
(3), the Fipronil of 4000g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 18
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the sec-octyl alcohol of 5000g is added in Agitation Tank；
(2), Agitation Tank is added in the di-tert-butyl p-cresol of the dibutyl hydroxy toluene of the Teflubenzuron of 5000g and 5g, 10g
In, stirring make to mix, sequentially add later 4500g litsea citrate oil (lemon aldehyde >=65%) and 7500g ethylene oxide/
Epoxy propane copolymer is stirred well to mixing；
(3), the Fipronil for accounting for output 3500g under continuous agitation, is added, is slowly added to dimethyl sulfoxide extremely
Solution clarification, after add to output.
Embodiment 19
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by the fenoxycarb of 3000g, the butylated hydroxyarisol of the praziquantel of 2500g and 10g, 5g dibutyl
Hydroxy-methylbenzene be added Agitation Tank in, stirring make to mix, sequentially add later 5000g litsea citrate oil (lemon aldehyde >=
65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 20
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by the fenoxycarb of 3000g, the butylated hydroxyarisol of the praziquantel of 5000g and 10g, 5g dibutyl
Hydroxy-methylbenzene be added Agitation Tank in, stirring make to mix, sequentially add later 5000g litsea citrate oil (lemon aldehyde >=
65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 21
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by two fourths of the fenoxycarb of 3000g, the butylated hydroxyarisol of the ivermectin of 200g and 10g, 5g
Base hydroxy-methylbenzene be added Agitation Tank in, stirring make to mix, sequentially add later 5000g litsea citrate oil (lemon aldehyde >=
65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 22
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 5000g is added in Agitation Tank；
(2), by the fenoxycarb of 3000g, the butylated hydroxyarisol of the permethrin of 17500g and 10g, 5g
Dibutyl hydroxy toluene be added in Agitation Tank, stirring makes to mix, and sequentially adding the litsea citrate oil of 5000g later, (citral contains
Amount >=65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, be stirred well to and be completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 23
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by two fourths of the fenoxycarb of 3000g, the butylated hydroxyarisol of the Moxidectin of 1000g and 10g, 5g
Base hydroxy-methylbenzene be added Agitation Tank in, stirring make to mix, sequentially add later 5000g litsea citrate oil (lemon aldehyde >=
65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 24
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 5000g is added in Agitation Tank；
(2), by the fenoxycarb of 3000g, the butylated hydroxyarisol of the flumethrin of 10000g and 10g, 5g
Dibutyl hydroxy toluene is added in Agitation Tank, and stirring makes to mix, and sequentially adds litsea citrate oil (the lemon aldehyde of 5000g later
>=65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 25
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by two fourths of the fenoxycarb of 3000g, the butylated hydroxyarisol of the decis of 7500g and 10g, 5g
Base hydroxy-methylbenzene be added Agitation Tank in, stirring make to mix, sequentially add later 5000g litsea citrate oil (lemon aldehyde >=
65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 26
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by the fenoxycarb of 3000g, the butylated hydroxyarisol of the levamisole hydrochloride of 8000g and 10g, 5g
Dibutyl hydroxy toluene is added in Agitation Tank, and stirring makes to mix, and sequentially adds litsea citrate oil (the lemon aldehyde of 5000g later
>=65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 27
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by the fenoxycarb of 3000g, the acetylamino evericin of 200g and 10g butylated hydroxyarisol,
The dibutyl hydroxy toluene of 5g is added in Agitation Tank, and stirring makes to mix, and sequentially adds the litsea citrate oil (citral of 5000g later
Content >=65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, be stirred well to and be completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 28
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), by two fourths of the fenoxycarb of 3000g, the butylated hydroxyarisol of the selamectin of 3000g and 10g, 5g
Base hydroxy-methylbenzene be added Agitation Tank in, stirring make to mix, sequentially add later 5000g litsea citrate oil (lemon aldehyde >=
65%), the polyvinylpyrrolidone of the polyoxyethylene sorbitan monoleate of 2500g and 2500g, is stirred well to and is completely dissolved；
(3), the Fipronil of 2500g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Embodiment 29: clinical effectiveness test
Below by particular condition in use of the product of the present invention in clinical test, to illustrate that product posts cat or dog body surface
Infested and worm's ovum repelling and killing efficacy, effect test is in the case where non-specified otherwise, using being formulated in embodiment one.
Reference examples one:
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), the dibutyl hydroxy toluene of the butylated hydroxyarisol of 10g, 5g are added in Agitation Tank, stirring makes to mix
It is even, the polyvinylpyrrolidone of 2500g and the polyoxyethylene sorbitan monoleate of 2500g are sequentially added later, are stirred well to and are completely dissolved；
(3), the Fipronil of 5000g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Reference examples two:
A kind of Compound Resisting vermin composition, by launching based on quality, every preparation 50L, raw material forms as follows:
Preparation method:
(1), the diethylene glycol monoethyl ether of 10000g is added in Agitation Tank；
(2), the dibutyl hydroxy toluene addition of the butylated hydroxyarisol of the fenoxycarb of 4500g and 10g, 5g are matched
In flow container, stirring makes to mix, and sequentially adds the polyvinylpyrrolidone of 2500g and the polyoxyethylene sorbitan monoleate of 2500g later, sufficiently stirs
It mixes to being completely dissolved；
(3), the Fipronil of 5000g under continuous agitation, is added, is slowly added to ethyl alcohol to solution and clarifies, after
It adds to output.
Performance test:
1, product of the present invention tests brown dog tick in the attachment of dog body surface, the influence of transfer case
Test method: 24 pretreated experimental dogs are assigned to 4 processing groups (6/group): the group 1- present invention is implemented
Example one, group 2- reference examples one (10% Fipronil) of the present invention, group 3-FrontlinePlus (+9% methoxy of 10% Fipronil
General alkene), group 4- placebo treatment make blank control.After test the 0th day calculates dosage according to weight, to three groups of experimental dogs etc.
Amount application.Using independent heavy type, 68 × 76 × 102cm of size, the lower plastic carrier for laying nylon carpet is tested to carry out.It will
Experimental dog is put into the carrier for filling 50 adult brown dog ticks 2 hours.Then dog is taken out, to the work tick of dog body surface and dead
The quantity of remaining tick is counted in tick and carrier.Ixodes infestation again and tick counting therewith are in the 2nd later 3,7,
What 14,21,28 and 35 days test days were carried out.During research, the average tick number of every dog is 12.0 to 29.5.Composition
Efficiency is determined by comparing the work tick average of drug-treated group dog and the work tick number of control group dog.Percentage effect
Work tick average-drug-treated group dog work tick average/control group dog work tick average of=control group dog.
Test result: by list data it is found that preparation of the invention than commercially available FrontlinePlus (10% Fipronil+
9% methoprene) show faster action speed and longer efficiency time, than the control for only adding 10% Fipronil
Example, advantage become apparent from.
2, product of the present invention acute toxicity testing result
2.1 test methods:
SD rat oral gavage is given with the embodiment of the present invention one and example IV, calculates half lethal dose (LD with Bliss method50) and
95% fiducial limit range.
2.2 test results: one rat of the embodiment of the present invention is through LD50For 3653.2 ± 567.6 (2998.7~4169.3) mg/
kg；Regression equation Y=6.37X-15.28.Example IV rat is through LD50For 637.2 ± 88.4 (536.7~750.8) mg/kg；
Regression equation Y=18.47X-7.36.Belong to less toxic product according to the Ministry of Agriculture's Pesticidal products toxicity grading standard.It is commercially available through inquiring
The MSDS file of Frontline Plus, for the acute through LD of rat50For 750mg/kg, acute percutaneous LD50>
5000mg/kg.Product of the present invention is respectively less than commercial product toxicity data, wherein the acute toxicity of optimal prescription embodiment one, about
It is the 1/5 of commercially available Frontline Plus.
3, product of the present invention mosquito repellent experimental result
3.1 test methods:
It screens the mouse and mosquito of attack qualification: the kunming mice that skin of abdomen exposed area is 5cm × 6cm is protruded into
In mosquito cage equipped with >=550 aedes albopictus, mosquito cage specification is 20cm × 20cm × 30cm, places 2min, and coming to dwell falls thorn and sting
Test worm >=30 mosquito number persons be that attack is qualified, this mouse and this cage mosquito can be used for repellency test.
3.2 mouse repellency tests: product to be measured be the embodiment of the present invention one, embodiment 21, FrontlinePlus,
Its abdomen, is fixed on 8cm × 10cm plank upward respectively, cuts off belly wool by the small white mouse of every group of 2 attack pass the tests,
Exposure 5cm × 6cm skin, wherein 1 is made blank control, 1cm × 1cm's smeared in another 1 small white mouse abdomen exposed skin center
To test agent, small white mouse is put into mosquito cage after 5min and is tested, come to dwell to fall thorn and sting and record whether there is or not mosquito in observation 2min and dwell
Fall mosquito time.Every 15min is tested 1 time later.It 2min mosquito is tested in record 2h every time dwells and fall thorn and sting mosquito time.The results are shown in attached figure 1.Often
A sample is repeated 3 times test, and effect examination calculates Effective Vate of Protection according to dwelling on falling thorn and sting number, and formula is as follows:
Effective Vate of Protection (%)=(control group averagely dwell fall thorn sting mosquito number-test group and averagely dwell fall thorn and sting mosquito number)/control
Group, which is averagely dwelt, to be fallen thorn and stings mosquito number × 100%.
Test result: the embodiment of the present invention one, 21 average effective protective rates reach 80% or more, are repellant
Effective Vate of Protection, especially one Effective Vate of Protection of embodiment reach its maximum value after 75min, and can be maintained at most the long period
Near big value, the repellent effect to mosquito is best.Commercially available FrontlinePlus is acted on without mosquito repelling substantially.
Finally, it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations；Although
Present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that: it still may be used
To modify the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features；
And these are modified or replaceed, technical solution of various embodiments of the present invention that it does not separate the essence of the corresponding technical solution spirit and
Range.
Claims (10)
1. a kind of Compound Resisting vermin composition, which is characterized in that the Compound Resisting vermin composition includes
The component of following mass percent (W/V):
2. a kind of Compound Resisting vermin composition according to claim 1, which is characterized in that the insect growth tune
It saves agent and is selected from one of juvenoid and chitin synthesis inhibitor or more than one compositions；The juvenile hormone
Analog in fenoxycarb, hydroprene, pyriproxyfen, methoprene, nimbin, kinoprene, pyridazinone compound one
Kind；The chitin synthesis inhibitor be selected from grand Buprofezin, cyromazine, diflubenzuron, pyrrole worm, Teflubenzuron, lufenuron, flufenoxuron,
Tebufenozide, flucycloxuron, triflumuron, CGA 183893, N- [[the chloro- 4- of 3- [1,1,2- tri- fluoro- 2- (trifluoromethoxy) ethyoxyl] phenyl]
One of carbamoyl] the double fluorobenzamides of -2,6-.
3. a kind of Compound Resisting vermin composition according to claim 1, which is characterized in that the antioxidant choosing
From butylated hydroxyarisol, dibutyl hydroxy toluene, di-tert-butyl p-cresol, tert-butylhydroquinone, gallic acid third
Ester, vitamin E, vitamin C, carotenoid and its derivative, arabo-ascorbic acid, citric acid, sodium isoascorbate, caryophyllus oil,
One of rosemary oil or more than one compositions.
4. a kind of Compound Resisting vermin composition according to claim 1, which is characterized in that the crystallization inhibitor
Selected from one of cation, anion, nonionic and amphoteric surfactant or more than one compositions；The cation form
Face activating agent is one of dihexadecyldimethylammonium bromide, octylame hydrochloride；The anionic surfactant is alkali
One in metallic stearate, sodium abietate, alkyl sulfate, neopelex and sodium dioctyl sulfosuccinate
Kind；The nonionic surfactant is polyoxyethylene sorbitan monoleate, isopropyl myristate, polyoxyethylated alkyl ether, polyethylene glycol
Stearate, castor oil derivatives, polyglycerol ester, polyoxyethylenated alcohol, ethylene oxide/propylene oxide copolymerization
One of object；The amphoteric surfactant is betaine compound, the polyvinylpyrrolidone, polyethylene that lauryl replaces
One of alcohol, vinyl pyrrolidone vinyl acetate copolymer and lecithin.
5. a kind of Compound Resisting vermin composition according to claim 1, which is characterized in that the solvent is selected from second
Acetoacetic ester, acetone, acetonitrile, dimethylformamide, dimethyl acetamide, N- methylacetamide, diethylmethyl formamide, diethyl
Glycol dimethyl ether, dipropylene glycol n-butyl ether, ethylene glycol monoethyl ether, glycol monoethyl ether, dipropylene glycol monomethyl ether, diethylene glycol list
It is ether, ethylene glycol monobutyl ether, benzyl alcohol, glycerol, liquid macrogol, 2-Pyrrolidone, glyceryl triacetate, cyclohexanol, secondary
Octanol, fatty acid methyl ester, N, N- parvoline amide, Ergol, ethyl lactate, diethyl phthalate, in
One or more kinds of compositions.
6. a kind of Compound Resisting vermin composition according to claim 1, which is characterized in that the cosolvent is selected from
One of ethyl alcohol, isopropanol, dimethyl sulfoxide, methanol, fat oil, propylene glycol or more than one compositions.
7. a kind of Compound Resisting vermin composition according to claim 1, which is characterized in that also include macrolide
One of class or pyrethroid insecticides, imidazoles antihelmintic and praziquantel or more than one compositions.
8. a kind of preparation method of Compound Resisting vermin composition as claimed in claim 1, which is characterized in that
The following steps are included:
(1), the solvent for accounting for output 1-30% is added in Agitation Tank；
(2), the insect growth regulator, IGR for accounting for output 2%-18% and the antioxidant for accounting for output 0.005%-5% are added
In Agitation Tank, stirring makes to mix, and sequentially adds the litsea citrate oil for accounting for output 2%-18% later, accounts for output 1%-15%'s
Crystallization inhibitor is stirred well to and is completely dissolved；
(3), it under continuous agitation, is added and accounts for the Fipronil of output 1%-10%, be slowly added to cosolvent to molten
Liquid clarification, after add to output.
9. a kind of application of Compound Resisting vermin composition a method as claimed in any one of claims 1-8, which is characterized in that described
Compound Resisting ectoparasite activity is applied to prevention, control or tick and the flea of eliminating mammal or fowl, including gives mammal
The preparation of a effective amount of claim 1 is applied with birds.
10. the application of Compound Resisting vermin composition according to claim 9, which is characterized in that the lactation is dynamic
Object is cat or dog.
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Cited By (3)
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| CN111388513A (en) * | 2020-04-14 | 2020-07-10 | 无锡派维药业科技有限公司 | Animal external antiparasitic composition and preparation method thereof |
| CN115530164A (en) * | 2022-10-19 | 2022-12-30 | 陕西天宠生物科技有限公司 | In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof |
| CN116173017A (en) * | 2022-12-01 | 2023-05-30 | 浙江科瑞特生物科技有限公司 | Safe and efficient general-purpose external insect repellent for non-prednisone Luo Niquan cats and preparation method |
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