CN105687188A - Parasite prevention and/or treatment pharmaceutical composition and preparation method and application thereof - Google Patents
Parasite prevention and/or treatment pharmaceutical composition and preparation method and application thereof Download PDFInfo
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- CN105687188A CN105687188A CN201410691251.9A CN201410691251A CN105687188A CN 105687188 A CN105687188 A CN 105687188A CN 201410691251 A CN201410691251 A CN 201410691251A CN 105687188 A CN105687188 A CN 105687188A
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Abstract
The present invention relates to a parasite prevention and/or treatment pharmaceutical composition, and the pharmaceutical composition comprises the following components: 5-20% of Fipronil, 4-18% of methoprene, 2-10% of an emollient, and the balance of a pharmaceutically acceptable carrier. The present invention also relates to a preparation method and application of the pharmaceutical composition in preparation of drugs for the prevention and / or treatment of pet diseases.
Description
Technical field
The present invention relates to a kind of prevention and/or the pharmaceutical composition for the treatment of house pet disease, particularly relate to a kind of prevention and/or the pharmaceutical composition for the treatment of house pet parasitic disease。The invention still further relates to the preparation method of this pharmaceutical composition and its in preparation for preventing and/or treating the application in the medicine of house pet disease。
Background technology
One of disease that during parasitic disease, house pet is common, the health of serious threat animal, not only affect its growth and development, also the intrusion for other pathogen creates conditions。Especially the ectozoa such as Ticks, demodicid mite, mosquito, flea, except passing through to bite skin and inject in animal body by cause of disease, making trouble poultry infection chance increase, it is stimulating animal skin that house pet is the most directly injured, and causes gargalesthesia, animal is made constantly to scratch, thus animal skin hair follicles damage can be caused, animal skin slightly disorderly, affects the outward appearance of animal, suppurating, even occur in severe patient skin ulceration, infection。
The drug main of anti-house pet body surface parasitic disease conventional at present to have spray and 2 kinds of types of drop, and drop enjoys high praise because of easy to use。The making a pet of greatly of the You Shuoteng animal health-care product company limited that market sale is more, the dog that Merial Limited produces, cat Fu Laien。Fu Laien comprises the composition such as Fipronil and methoprene, for killing the flea of animal body surface, Ticks etc., adult, larva, worm's ovum all has effect, therefore is subject to liking of vast house pet master。It arrives whole body mainly through animal skins adipose gland and plays a role, although positive common medicine is not easy to be absorbed by the blood, but animal is when infecting the ectozoa such as flea, Ticks, there will be the symptoms such as skin ulceration, hair follicle be impaired owing to biting, use pharmaceutical procedures Chinese medicine still can along with damaged wound intravasation, thus animal is damaged。Therefore, this area need badly for a long time a kind of can while effectively prevention and/or treatment house pet body surface parasitic disease, toxic and side effects is less and/or can advantageously promote the medicine of wound healing。
Summary of the invention
In order to solve problems of the prior art, improve and enter the internal injury that animal is caused at medicine by the skin of ulceration, improve Drug safety, the invention provides a kind of prevention and/or the treatment ectozoal pharmaceutical composition of house pet, it is characterized in that, described pharmaceutical composition includes following components:
The Fipronil of 5-20%,
The methoprene of 4-18%,
The emollient of 2-10%, and
Surplus pharmaceutically can carrier。
Wherein, Fipronil (Fipronil) has another name called ethiprole, chemistry 5-Amino 3 cyano-1-(2,6-bis-chloro-4-fluoroform phenyl)-4-trifluoromethyl sulfinyl pyrazole by name, it is possible to commercially buy with trade name " Frontline "。
Inventors hereof have unexpectedly found that, the toxic and side effects of this pharmaceutical composition is less and/or can advantageously promote wound healing。
One of the present invention preferred embodiment in, the ratio of described Fipronil and methoprene is in the scope of 10:8 to 10:9。In an embodiment more preferably of the present invention, the ratio of described Fipronil and methoprene is 10:9。
One of the present invention preferred embodiment in, described emollient is lanonol and/or acetylated lanolin。
One of the present invention preferred embodiment in, described emollient ratio is 2-5%。
One of the present invention preferred embodiment in, described pharmaceutical composition is the pharmaceutical composition of drop form。
One of the present invention preferred embodiment in, described pharmaceutically can carrier be solvent。In an embodiment more preferably of the present invention, described solvent preferably includes one or more in tween 80, ethanol, water, diethylene glycol monoethyl ether。In an especially preferred embodiment of the present invention, described pharmaceutically can carrier also include solid carrier。
The preparation method that present invention also offers aforementioned pharmaceutical compositions, described preparation method comprises the following steps:
I) each component is weighed respectively according to the component of above-mentioned pharmaceutical composition and content thereof；
Ii) first emollient is dissolved in solvent, is then sequentially added into Fipronil and methoprene, stirring and dissolving, finally add pharmaceutically can carrier to full dose。
Present invention also offers the usage of aforementioned pharmaceutical compositions and consumption。The usage of this pharmaceutical composition can be: the separately hair between the scapula of animal, and along shoulder skin of back, branch extrudes for several times, completely directly drops on skin to medicament。Described is one or many for several times。The consumption of this pharmaceutical composition can be the body weight of 0.67ml/10kg animal。
Invention further provides aforementioned pharmaceutical compositions in preparation for driving away and/or killing the application on ectozoal medicine, particularly in preparing the application on the medicine driving away and/or killing flea and/or Ticks。Wherein, described flea can be flea ovum, and can be the flea of each stage of development。Wherein, described Ticks is alternatively the Ticks of each stage of development。
The present invention still further provides aforementioned pharmaceutical compositions in preparation for driving away and/or killing the application on the ectozoal medicine of house pet, particularly in preparation for driving away and/or kill the application on dog and/or the ectozoal medicine of cat, wherein said ectozoa is preferably flea and/or Ticks。
In the present invention, described " ectozoa " can be used interchangeably with " vermin ", and does not affect its implication。
The beneficial effects of the present invention is:
1. can effectively drive away and/or kill house pet ectozoa, for instance flea and/or Ticks, it is possible to effectively prevention and/or treatment house pet ectozoa。
2. playing drug effect simultaneously, safety is higher, and the toxic and side effects of animal is little。The pharmaceutical composition of the present invention can form layer protective layer at skin surface, it is to avoid animal is produced harm by damaged skin wound intravasation by medicine。
3. repair impaired skin, hair follicle, especially for the animal that skin ulceration is serious, it is possible to advantageously promote the healing of wound；Nourishing hair follicle, make animal skin smooth, outward appearance is beautiful。
4. stable in properties。
Detailed description of the invention
Below in conjunction with non-limiting example, the present invention is made further explanation and description。It is to be noted, however, that the present invention is not made any restriction by the following detailed description of the present invention。It will be understood by those skilled in the art that and the details of technical solution of the present invention and form can be modified or replace lower without departing from the spirit and scope of the present invention, but these amendments and replacement each fall within protection scope of the present invention。
Under be classified as in the embodiment of the present invention source and the lot number of raw material used and preparation:
Fipronil, lot number: G140201, content: 98.5%, Bamda medication chemistry company limited of Wuhan state；
Ethanol, lot number: 20130929, analytical pure, Yantai City is Chemical Co., Ltd. in pairs；
Diethylene glycol monoethyl ether, lot number: NP6EFDF, purity: > 99.0%, Tokyo is melted into Co., Ltd.；
Tween 80, lot number: 090902M, Shanghai Shen Yu medication chemistry company limited；
Water is purified water。
Embodiment 1: preparation embodiment 1
Prescription: the diethylene glycol monoethyl ether of Fipronil 5%, methoprene 4%, acetylated lanolin 2%, tween 80 5%, ethanol 10%, purified water 5% and surplus。
Preparation method: weigh Fipronil 5.211g, acetylated lanolin 2.033g, is placed in clean container, adds diethylene glycol monoethyl ether 50ml, stirring and dissolving。Add methoprene 4.507g, tween 80 5.137g, stirring and dissolving。Add purified water 5ml, add the single ether of diethyl two to 100ml, stir, encapsulate and obtain the faint yellow clear liquid that relative density is 1.018。
Embodiment 2: preparation embodiment 2
Prescription: the diethylene glycol monoethyl ether of Fipronil 10%, methoprene 9%, lanonol 3%, tween 80 5%, ethanol 10%, purified water 5% and surplus。
Preparation method: weigh Fipronil 10.265g, lanonol 3.051g, is placed in clean container, adds diethylene glycol monoethyl ether 50ml, stirring and dissolving。Add methoprene 9.035g, tween 80 5.124g, stirring and dissolving。Add purified water 5ml, add the single ether of diethyl two to 100ml, stir, encapsulate and obtain the faint yellow clear liquid that relative density is 1.025。
Embodiment 3: preparation embodiment 3
Prescription: the diethylene glycol monoethyl ether of Fipronil 20%, methoprene 18%, acetylated lanolin 4%, tween 80 5%, ethanol 10%, purified water 5% and surplus。
Preparation method: weigh Fipronil 20.158g, lanonol 4.133g, is placed in clean container, adds diethylene glycol monoethyl ether 30ml, stirring and dissolving。Add methoprene 18.365g, tween 80 5.036g, stirring and dissolving。Add purified water 5ml, add the single ether of diethyl two to 100ml, stir, encapsulate and obtain the faint yellow clear liquid that relative density is 1.037。
Embodiment 4: the zoopery of the curative effect of the pharmaceutical composition of the checking present invention
Take the medicine of the embodiment of the present invention 2 preparation, and the dog Fu Laien produced with Tu Luzi factory of France of Merial Limited carries out compareing and observes the therapeutic effect that dog-tick is infected by medicine。
Fu Laien (dog is used), lot number: J61107BR, specification: 1ml: Fipronil 100mg, methoprene 90mg, Tu Luzi factory of France of Merial Limited。
Luoyang pets hospital is diagnosed a disease example, Yiyang County Mr. Wang, supports the Canis familiaris L. 2 of the age same breed roughly the same with health status, dog A and dog B。Dog A body weight, body weight 7.5kg；Dog B body weight 8.2kg。From before 10 days, all there are the symptoms such as scratching, on the wall friction in two Canis familiaris L.s, and originally not serious, after about 5 days, inflammation occurs in skin, has recurrent ulceration and incrustation。Other drug such as metrifonate all can not effectively be eradicated。Through going through, it has been found that all have flea and worm's ovum with 2 dogs。Considering that skin has wound, the pharmaceutical composition prepared by Fu Laien and the embodiment of the present invention 2 respectively is treated。A 0.67ml good fortune Lay grace 1, the sample 0.67ml that B is prepared by the embodiment of the present invention 2, usage: by the hair between dog scapula separately, along shoulder skin of back, extrude bottle, divide 8-10 point by medicament dropping on skin。And raise and main do not have a bath to animal in the recent period。The action of the 2nd day power rubdown that is out of use after medication, ulceration place with it gradually forms incrustation。The 3rd day ulceration of A dog loses substantially, but the 5th day still has incrustation, and wound does not heal completely, and hair color is slightly disorderly。Within 3rd day, check that within the 5th day, skin recovers normal, and fur is more smooth without incrustation, the complete healing of wound with B dog。Through going through, without flea and worm's ovum with A, B dog。
This experiment is repeated three times on different Canis familiaris L.s, all achieves similar results。
Test result indicate that, for the expeling of flea, the drug effect of the two is the same, but for promoting the recovery of skin trauma, the present invention prepares sample prepared by example and is substantially better than the Fu Laien of Merial Limited。
Embodiment 5: the zoopery of the safety of the pharmaceutical composition of the checking present invention
Taking the medicine of the embodiment of the present invention 2 preparation, the Fu Laien simultaneously produced with Tu Luzi factory of France of Merial Limited carries out compareing the safety observing medicine to dog。
Fu Laien (dog is used), lot number: J61107BR, specification: 1ml: Fipronil 100mg, methoprene 90mg, Tu Luzi factory of France of Merial Limited。
Choose the 5-10kg beasle dog 12 that age, health status are roughly the same, be randomly divided into 3 groups, often group 4, male and female half and half。A group is Fu Laien matched group (dog is numbered 1-4), B group be experimental group (dog is numbered 5-8), C group is blank group (dog is numbered 9-12)。By the hair between test dog scapula separately, it is interrupted line with line place in skin, 10ml syringe needle tip, produces the skin trauma of 3 3cm length。A group uses Fu Laien by 3 times amount of normal using dosage, and namely 2ml/10kg body weight uses Fu Laien, and usage, referring to mentioned above, every day 1 time, is used in conjunction 3 days。B 3 times amount of normal using dosage use the pharmaceutical composition of the embodiment of the present invention 2 preparation, and C group is not administered as comparison。During test, test dog is only carried out tight clinical observation itemized record by every day, whether main detection laboratory animal there is the untoward reaction relevant with medicine, including body temperature, heart beating, breathing, dystropy, psychological problem and defecation paruria etc., observe the dermoreaction of medicine-feeding part simultaneously。In time being administered first 1 day, be administered the 3rd day, be administered and terminate the 7th day, gather EDTA anticoagulation 1-2ml, be used for measuring its hematological examination and include leukocyte count (WBC), RBC number (RBC), hematocrit (HCT), content of hemoglobin (HGB), total number of blood platelet (PLT) and granulocyte sum, total lymphocyte count, mononuclear cell sum。
(1) overview
A group: after administration, 6h observes, and No. 2, No. 3 dog spirit are depressed, movable minimizing。Dog skin 2h after administration in 3rd day, there is depressed, the rapid breathing of spirit, vomiting in No. 2 dogs, occasionally have chatter；6h after administration, there is sialorrhea, plant oneself in No. 3 dogs, the symptom such as One's eyesight is restrained；Within 4th day, observing nervous symptoms to disappear, the mental status is still not good, and dog only has dysentery symptom。After administration, 4h observes, and still has above-mentioned symptom。Administration recovers normal on the 3rd day after terminating。No. 1, No. 4 dogs have no obvious nervous symptoms, but 1,2, No. 3 dog red swelling of the skins after the 2nd administration。Before administration in 3rd day, symptom alleviates, and occurs again, and have liquid to ooze out after administration。To drug withdrawal, there is incrustation in the 2nd talent。
B group: between experimental period, body temperature, heart beating, breathing, behavior, spirit, defecation are urinated, searched for food and drink water all without ANOMALOUS VARIATIONS。In administration the 2nd day, 5,6, No. 8 dog cutaneous scarification places formation incrustations, substantially without red and swollen after administration, only No. 7 dog cutaneous scarification places also occur rubescent, but be not as obvious as 1,2, No. 3 dogs of A group, and do not occur after the 3rd administration。
C group: without exception。
(2) hematological indices inspection
Before administration, each group dog physiochemical indice is all normal, after administration the 3rd day, and red blood cell count(RBC), content of hemoglobin, packed cell volume are without significant change, and ascendant trend occurs in A group dog numeration of leukocyte, compared with C group, has significant difference。Granulocytopenia, mononuclear cell increase, not statistically significant。Administration terminate after the 7th day, total white blood cells remains above blank group, but no significant difference。Concrete outcome refers to table 1。
The change of each treated animal hematological indices during table 1. test
Result of the test shows: the dog of skin trauma is only given the Fu Laien of 3 multiple doses, continuous application 3 days, and slight poisoning (sialorrhea, vomiting, the nervous symptoms such as One's eyesight is restrained) only occur in indivedual dogs, and this symptom disappears for 5 days after drug withdrawal。But pressing same method administration with the medicine of the present invention, animal, without toxic reaction, illustrates that the pharmaceutical composition of the present invention can effectively prevent the skin that medicine passes through breakage from entering in animal body, has higher safety。
It addition, after giving the Fu Laien of 3 times amount as stated above, dog blood middle leukocytes increases, monocytic increasing proportion, granulocyte percentage rate reduce, it is possible to reason be the skin of ulceration after medicine irritation, cause inflammation reaction caused。The medicine using the present invention then there is no this phenomenon; the pharmaceutical composition that possible reason is the present invention can form layer protective layer at skin surface; avoiding medicine to pass through the skin wound intravasation of breakage, thus being effectively protected skin, alleviating the irritant reaction of medicine。
Embodiment 6: the experiment of the stability of the pharmaceutical composition of the checking present invention
1. accelerated test
Take the sample that the embodiment of the present invention 1,2,3 prepares, put into SPX-250 micro computer growth cabinet, select temperature 40 DEG C ± 2 DEG C, relative humidity 75% ± 5%, place 6 months with this understanding, in the 0th, 1,2,3, sampling in 6 months, investigating relevant item, the testing result contrast with 0 month, result of the test is in Table 2。
Table 2. accelerated test result
Measurement result shows, through 6 months accelerated test character, relative density, content and within 0 month, compare, basic zero difference, illustrates that the antibody table parasite medicine sample quality prepared by the present invention is stable, it is possible to long-term storage。
2. classical isothermal method prediction effect duration
Taking the present invention and prepare the sample 1,2,3 that example 1,2,3 prepares, be respectively put into 98 DEG C, 90 DEG C, 80 DEG C, 70 DEG C 4 temperature and sample once every 1h, measure the content of Fipronil, methoprene in sample, last sample time is 10h。Situation of change according to Fipronil, methoprene content, lists the temperature of each sample and decomposition rate equation of change, thus it is speculated that effect duration when going out 25 DEG C。
Predicted, in sample 1, sample 2, sample 3, Fipronil content drops to time of 90% and is respectively as follows: 2.53,2.96,2.42, and methoprene content drops to the time of 90% and is respectively as follows: 2.16,2.48,2.08。Therefore speculate that effect duration of this medicine is more than 2 years。
Claims (9)
1. prevention and/or the treatment ectozoal pharmaceutical composition of house pet, including following components:
The Fipronil of 5-20%,
The methoprene of 4-18%,
The emollient of 2-10%, and
Surplus pharmaceutically can carrier。
2. pharmaceutical composition according to claim 1, it is characterised in that the ratio of described Fipronil and methoprene is in the scope of 10:8 to 10:9, it is preferred to 10:9。
3. pharmaceutical composition according to claim 1 and 2, it is characterised in that described emollient is lanonol and/or acetylated lanolin。
4. the pharmaceutical composition according to any one in claim 1-3, it is characterised in that described emollient ratio is 2-5%。
5. the pharmaceutical composition according to any one in claim 1-4, it is characterised in that described pharmaceutical composition is the pharmaceutical composition of drop form。
6. the pharmaceutical composition according to any one in claim 1-4, it is characterised in that described pharmaceutically can carrier be solvent, described solvent preferably includes one or more in tween 80, ethanol, water, diethylene glycol monoethyl ether。
7. the preparation method of the pharmaceutical composition according to any one in claim 1-6, described preparation method comprises the following steps:
I) each component is weighed respectively according to the component of the pharmaceutical composition according to any one in claim 1-6 and content thereof；
Ii) first emollient is dissolved in solvent, is then sequentially added into Fipronil and methoprene, stirring and dissolving, finally add solvent to full dose。
8. the pharmaceutical composition according to any one in claim 1-6 is being prepared for driving away and/or killing the application on ectozoal medicine, particularly in preparing the application on the medicine driving away and/or killing flea and/or Ticks。
9. the pharmaceutical composition according to any one in claim 1-6 is being prepared for driving away and/or killing the application on the ectozoal medicine of house pet, particularly in preparation for driving away and/or kill the application on dog and/or the ectozoal medicine of cat, wherein said ectozoa is preferably flea and/or Ticks。
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727981A (en) * | 2017-02-16 | 2017-05-31 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for killing livestock and poultry vermin and its preparation method and application |
| CN109985090A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of Compound Resisting vermin composition and preparation method thereof |
| CN110664806A (en) * | 2019-10-17 | 2020-01-10 | 广东省农业科学院动物卫生研究所 | Fipronil and methoprene glycol plastid and preparation method and application thereof |
| CN116173017A (en) * | 2022-12-01 | 2023-05-30 | 浙江科瑞特生物科技有限公司 | Safe and efficient general-purpose external insect repellent for non-prednisone Luo Niquan cats and preparation method |
| CN116211800A (en) * | 2023-05-09 | 2023-06-06 | 济南广盛源生物科技有限公司 | Non-prednisone drop and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106727981A (en) * | 2017-02-16 | 2017-05-31 | 中国农业科学院兰州畜牧与兽药研究所 | A kind of Chinese medicine composition for killing livestock and poultry vermin and its preparation method and application |
| CN106727981B (en) * | 2017-02-16 | 2020-12-29 | 中国农业科学院兰州畜牧与兽药研究所 | Traditional Chinese medicine composition for killing ectoparasites of livestock and poultry as well as preparation method and application thereof |
| CN109985090A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of Compound Resisting vermin composition and preparation method thereof |
| CN110664806A (en) * | 2019-10-17 | 2020-01-10 | 广东省农业科学院动物卫生研究所 | Fipronil and methoprene glycol plastid and preparation method and application thereof |
| CN110664806B (en) * | 2019-10-17 | 2023-02-28 | 广东省农业科学院动物卫生研究所 | Fipronil and methoprene dihydric alcohol plastid and preparation method and application thereof |
| CN116173017A (en) * | 2022-12-01 | 2023-05-30 | 浙江科瑞特生物科技有限公司 | Safe and efficient general-purpose external insect repellent for non-prednisone Luo Niquan cats and preparation method |
| CN116211800A (en) * | 2023-05-09 | 2023-06-06 | 济南广盛源生物科技有限公司 | Non-prednisone drop and preparation method and application thereof |
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