CN115530164A - In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof - Google Patents

In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof Download PDF

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CN115530164A
CN115530164A CN202211280641.8A CN202211280641A CN115530164A CN 115530164 A CN115530164 A CN 115530164A CN 202211280641 A CN202211280641 A CN 202211280641A CN 115530164 A CN115530164 A CN 115530164A
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solution
drop
fipronil
antioxidant
pets
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宋望成
薛猛
潘康锁
祁会彩
薛芷萱
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Shaanxi Tianzhong Biotechnology Co ltd
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Shaanxi Tianzhong Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/34—Shaped forms, e.g. sheets, not provided for in any other sub-group of this main group
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
    • A01N25/22—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing ingredients stabilising the active ingredients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P17/00—Pest repellants
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01P—BIOCIDAL, PEST REPELLANT, PEST ATTRACTANT OR PLANT GROWTH REGULATORY ACTIVITY OF CHEMICAL COMPOUNDS OR PREPARATIONS
    • A01P7/00—Arthropodicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
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  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Agronomy & Crop Science (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Insects & Arthropods (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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Abstract

The invention provides an in-vitro deodorization and desinsectization drop for pets and a preparation method thereof, wherein the desinsectization drop comprises the following components in percentage by mass: 14-15% of fipronil, 0.2-0.3% of 3-tert-butyl-4-hydroxyanisole, 0.2-0.3% of 2.6 di-tert-butyl p-methylphenol, 67-68% of diethylene glycol monoethyl ether, 1.4-1.5% of lemon essence, 174.7-5.0% of PVPK, 9.5% of 95% ethanol and 1.9-2.0% of purified water. The method comprises the following steps: obtaining fipronil; adding a first antioxidant into fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution; adding a second antioxidant and a stabilizer into the first solution, fully stirring and dissolving, and clarifying to obtain a second solution; adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution; standing, filtering and filling the third solution to obtain the external deodorizing and insect-expelling drop for pets. By adding the essence, the technical effects of effectively expelling and killing ectoparasites and continuously giving out lemon fragrance are achieved.

Description

In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof
Technical Field
The invention relates to the technical field of in-vitro pet insect expelling, and in particular relates to an in-vitro deodorizing insect expelling drop for pets and a preparation method thereof.
Background
Pets such as dogs, cats and the like are easy to grow parasites such as fleas, lice, ticks and the like because of long-term contact with the ground and longer and thicker hair, so that it is very important to periodically repel insects outside the body of the pet.
At present, most of the in vitro anthelmintics in the market are mainly fipronil, which is a broad-spectrum pesticide with excellent control effect on various pests. The insecticidal mechanism is that the insecticidal composition can be combined with gamma-aminobutyric acid receptors on central nervous cell membranes of insects to block chloride ion channels of nerve cells, so that normal functions of the central nervous system are interfered, and the insects die. Fipronil mainly acts through stomach toxicity and contact killing, has certain systemic conduction effect, is mainly used for preventing and treating fleas, dog ticks and other epizoon of dogs and cats, and has killing effect on more than 480 kinds of insects.
However, in the process of implementing the technical solution of the embodiment of the present application, the inventor of the present application finds that the above prior art has at least the following technical problems:
most of the in-vitro anthelmintic in the prior art is mainly fipronil, and the odor of the in-vitro anthelmintic is particularly smelly, so that the technical problem that the pet continuously emits odor after dripping the insecticide is solved.
Disclosure of Invention
The embodiment of the invention provides an in-vitro deodorization and parasite expelling drop for pets and a preparation method thereof, which are used for solving the technical problem that most of in-vitro repellent in the prior art is mainly fipronil, and the pet continuously smells after dropping the in-vitro repellent because the odor of the in-vitro repellent is particularly smelly. By adding the essence, the technical effects of effectively expelling and killing ectoparasites and continuously giving out lemon fragrance are achieved.
In view of the above problems, the present invention provides an external deodorant and insect-repellent drop for pets, which comprises the following components by mass: 14-15% of fipronil, 0.2-0.3% of 3-tert-butyl-4-hydroxyanisole, 0.2-0.3% of 2.6 di-tert-butyl p-methylphenol, 67-68% of diethylene glycol monoethyl ether, 1.4-1.5% of lemon essence, 4.7-5.0% of PVPK-17, 9.5% of 95% ethanol and 1.9-2.0% of purified water.
In another aspect, the present invention provides a method for preparing an in vitro deodorant and insect-repellent drop for pets, comprising: obtaining fipronil; adding a first antioxidant into the fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution; adding a second antioxidant and a stabilizer into the first solution, fully stirring for dissolving, and clarifying to obtain a second solution; adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution; standing the third solution; and filtering and filling the third solution after standing to obtain the external deodorizing and insect-expelling drop for the pet.
Preferably, the obtaining fipronil comprises: obtaining the prescription amount of the insect repellent drop according to the mass percentage composition of the in-vitro deodorizing insect repellent drop for the pets; obtaining the weight of the fipronil according to the prescribed amount of the vermifuge.
Preferably, the first antioxidant is diethylene glycol monoethyl ether, and the second antioxidant is 3-tert-butyl-4-hydroxyanisole.
Preferably, the stabilizer is 2.6 di-tert-butyl-p-methylphenol.
Preferably, the standing time of the third solution is 2 to 4 hours.
Preferably, when the third solution is free from precipitation and discoloration, the third solution does not need to be rested.
One or more technical solutions in the embodiments of the present application have at least one or more of the following technical effects:
the embodiment of the invention provides an in-vitro deodorizing and insect-repelling drop for pets and a preparation method thereof, wherein the method comprises the following steps: obtaining fipronil; adding a first antioxidant into the fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution; adding a second antioxidant and a stabilizer into the first solution, fully stirring for dissolving, and clarifying to obtain a second solution; adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution; standing the third solution; and filtering and filling the third solution after standing to obtain the external deodorizing and insect-expelling drop for the pet. Solves the technical problem that most of the in-vitro anthelmintics in the prior art are mainly fipronil and cause pets to continuously emit odor after dripping the insecticide due to the peculiar odor of the in-vitro anthelmintics. By adding the essence, the technical effects of effectively repelling and killing ectoparasites and continuously giving out lemon fragrance are achieved.
The foregoing description is only an overview of the technical solutions of the present invention, and the embodiments of the present invention are described below in order to make the technical means of the present invention more clearly understood and to make the above and other objects, features, and advantages of the present invention more clearly understandable.
Drawings
Fig. 1 is a schematic flow chart of a preparation method of the in-vitro deodorizing and insect-repellent drop for pets, which is provided by the embodiment of the invention.
Detailed Description
The embodiment of the invention provides an in-vitro deodorization and parasite expelling drop for pets and a preparation method thereof, which solve the technical problem that most of in-vitro repellent medicines in the prior art are mainly fipronil, and the pet continuously emits odor after dropping the medicines because the odor of the in-vitro repellent medicines is particularly smelly.
The technical scheme provided by the invention has the following general idea: obtaining fipronil; adding a first antioxidant into the fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution; adding a second antioxidant and a stabilizer into the first solution, fully stirring and dissolving, and clarifying to obtain a second solution; adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution; standing the third solution; and filtering and filling the third solution after standing to obtain the external deodorizing and insect-expelling drop for the pet. By adding the essence, the technical effects of effectively expelling and killing ectoparasites and continuously giving out lemon fragrance are achieved.
The technical solutions of the present invention are described in detail below with reference to the accompanying drawings and specific embodiments, and it should be understood that the specific features in the embodiments and examples are described in detail in the technical solutions of the present invention, but not limited to the technical solutions of the present invention, and the technical features in the embodiments and examples may be combined with each other without conflict.
The term "and/or" herein is merely an association describing an associated object, meaning that three relationships may exist, e.g., a and/or B, may mean: a exists alone, A and B exist simultaneously, and B exists alone. In addition, the character "/" herein generally indicates that the former and latter associated objects are in an "or" relationship.
Example one
The embodiment of the invention provides an external deodorization and insect repellent drop for pets, which comprises the following components in percentage by mass: 14-15% of fipronil, 0.2-0.3% of 3-tert-butyl-4-hydroxyanisole, 0.2-0.3% of 2.6 di-tert-butyl p-methylphenol, 67-68% of diethylene glycol monoethyl ether, 1.4-1.5% of lemon essence, 4.7-5.0% of PVPK-17, 9.5% of 95% ethanol and 1.9-2.0% of purified water.
Specifically, fipronil is a broad-spectrum insecticide with excellent control effect on various pests, is mainly used for controlling fleas, dog ticks and other epizoons of dogs and cats, and has killing effect on more than 480 insects. The insecticidal mechanism is that the insecticidal composition can be combined with gamma-aminobutyric acid receptors on central nervous cell membranes of insects to block chloride ion channels of nerve cells, so that normal functions of the central nervous system are interfered, and the insects die.
Fipronil mainly acts through stomach toxicity and contact killing, also has a certain systemic conduction effect, has the activity 100 times that of organic phosphate and carbamate, and also has extremely strong repelling and killing effects on insects with drug resistance to pyrethroid and carbamate. The residual effective period is 2-4 weeks generally, and the maximum period can reach 6 weeks.
According to the application embodiment of the invention, the lemon essence is added into the in-vitro anthelmintic, so that the technical effects of being rich in effective anthelmintic ingredients and being capable of achieving a deodorizing effect after pets expel insects are further achieved.
Example two
Fig. 1 is a schematic flow chart of a preparation method of the in-vitro deodorizing and insect-repellent drop for pets in the embodiment of the invention. As shown in fig. 1, the embodiment of the present invention provides a method for preparing an in vitro deodorizing and insect-repellent drop for pets, the method comprising:
step S110: obtaining fipronil;
further, the obtaining fipronil comprises: obtaining the prescription amount of the insect repellent drop according to the mass percentage composition of the in-vitro deodorizing insect repellent drop for the pets; obtaining the weight of the fipronil according to the prescribed amount of the vermifuge.
Specifically, according to the mass percentage composition of the in-vitro deodorization and desinsection drop for the pet, the prescription amount of the desinsection drop is obtained by combining the actual dosage, so that the prescription amount of each component in the desinsection drop can be obtained, and the weight of fipronil can be further obtained.
Step S120: adding a first antioxidant into the fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution;
step S130: adding a second antioxidant and a stabilizer into the first solution, fully stirring and dissolving, and clarifying to obtain a second solution;
further, the first antioxidant is diethylene glycol monoethyl ether, and the second antioxidant is 3-tert-butyl-4-hydroxyanisole.
Further, the stabilizer is 2.6 di-tert-butyl-p-methylphenol.
Specifically, diethylene glycol monoethyl ether is added into the fipronil, the mixture is fully stirred for 20-30 min until the mixture is completely dissolved, so that a first solution is obtained, then 3-tert-butyl-4-hydroxyanisole and 2.6-di-tert-butyl-p-methylphenol are sequentially added into the first solution, the mixture is fully stirred for 20-30 min to be dissolved and then clarified, and a second solution is further formed, wherein the diethylene glycol monoethyl ether and the 3-tert-butyl-4-hydroxyanisole are antioxidants, the oxidation reaction of the fipronil is effectively avoided, and the 2.6-di-tert-butyl-p-methylphenol is a stabilizer, so that the stability of a second solution system is ensured.
Step S140: adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution;
specifically, 95% ethanol, PVPK-17 and lemon essence are sequentially added into the second solution, and after the second solution is fully dissolved, purified water is added to form a third solution. The lemon essence is added into the insect repellent drops, so that the insect repellent drops are rich in lemon fragrance, and the problem of bad smell of the insect repellent is solved, wherein the 95% ethanol is used as a solvent and is beneficial to fully dissolving the solution, and the PVPK-17 is used as a film forming agent and can play a role in glue protection.
Step S150: standing the third solution;
further, the standing time of the third solution is 2-4 h.
Further, when the third solution is free from precipitation and discoloration, the third solution does not need to be stood again.
Step S160: and filtering the third solution after standing, and filling to obtain the external deodorizing and insect repellent drop for pets.
Specifically, after the lemon essence is added, standing is carried out on the third solution for 2-4 hours, a lot of precipitates can be generated in the standing process of the third solution, when the third solution is clear, free of precipitates and free of color change, standing is not needed, then a lot of precipitates generated in the third solution are filtered and filled, and therefore the external deodorizing and insect repelling drop for pets is obtained, and the technical effects that the external parasites can be effectively repelled and can continuously emit lemon fragrance are further achieved.
One or more technical solutions in the embodiments of the present application have at least one or more of the following technical effects:
the embodiment of the invention provides an in-vitro deodorizing and insect-repelling drop for pets and a preparation method thereof, wherein the method comprises the following steps: obtaining fipronil; adding a first antioxidant into the fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution; adding a second antioxidant and a stabilizer into the first solution, fully stirring for dissolving, and clarifying to obtain a second solution; adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution; standing the third solution; and filtering and filling the third solution after standing to obtain the external deodorizing and insect-expelling drop for the pet. Solves the technical problem that most of the in-vitro anthelmintics in the prior art are mainly fipronil and cause pets to continuously emit odor after dripping the insecticide because the odor of the in-vitro anthelmintic is particularly odorous. By adding the essence, the technical effects of effectively expelling and killing ectoparasites and continuously giving out lemon fragrance are achieved.
While preferred embodiments of the present invention have been described, additional variations and modifications in those embodiments may occur to those skilled in the art once they learn of the basic inventive concepts. Therefore, it is intended that the appended claims be interpreted as including preferred embodiments and all such alterations and modifications as fall within the scope of the invention.
It will be apparent to those skilled in the art that various modifications and variations can be made in the embodiments of the present invention without departing from the spirit or scope of the embodiments of the invention. Thus, if such modifications and variations of the embodiments of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to encompass such modifications and variations.

Claims (7)

1. The in-vitro deodorization and parasite expelling drop for the pets is characterized by comprising the following components in percentage by mass: 14-15% of fipronil, 0.2-0.3% of 3-tert-butyl-4-hydroxyanisole, 0.2-0.3% of 2.6 di-tert-butyl p-methylphenol, 67-68% of diethylene glycol monoethyl ether, 1.4-1.5% of lemon essence, 4.7-5.0% of PVPK-17, 9.5% of 95% ethanol and 1.9-2.0% of purified water.
2. A method for preparing an in vitro deodorant insect repellent drop for pets, which comprises:
obtaining fipronil;
adding a first antioxidant into the fipronil, and fully stirring until the first antioxidant is completely dissolved to obtain a first solution;
adding a second antioxidant and a stabilizer into the first solution, fully stirring for dissolving, and clarifying to obtain a second solution;
adding 95% ethanol, PVPK-17 and lemon essence into the second solution in sequence, fully dissolving, and adding purified water to obtain a third solution;
standing the third solution;
and filtering the third solution after standing, and filling to obtain the external deodorizing and insect repellent drop for pets.
3. The method of preparation of claim 2, wherein the obtaining fipronil comprises:
obtaining the prescription amount of the insect repellent drop according to the mass percentage composition of the in-vitro deodorizing insect repellent drop for the pets;
obtaining the weight of the fipronil according to the prescribed amount of the vermifuge.
4. The method of claim 2, wherein the first antioxidant is diethylene glycol monoethyl ether and the second antioxidant is 3-tert-butyl-4-hydroxyanisole.
5. The method of claim 2, wherein the stabilizer is 2.6 di-tert-butyl-p-methylphenol.
6. The method according to claim 2, wherein the third solution is allowed to stand for 2 to 4 hours.
7. The method of claim 6, wherein when the third solution is free of precipitate and discoloration, there is no need to stand.
CN202211280641.8A 2022-10-19 2022-10-19 In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof Pending CN115530164A (en)

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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106806369A (en) * 2017-01-18 2017-06-09 佛山市南海东方澳龙制药有限公司 Pet external application desinsection drops containing natural plant essential oils and its preparation method and application
CN108743946A (en) * 2018-07-02 2018-11-06 佛山市南海东方澳龙制药有限公司 Compound Fipronil pet external application expelling parasite drops and its preparation method and application
CN108785679A (en) * 2018-06-29 2018-11-13 佛山市南海东方澳龙制药有限公司 The application of Fipronil and insect growth regulator, IGR, the animal compound external-use preparation of antibody epizoa and preparation method thereof
CN109985090A (en) * 2017-12-29 2019-07-09 瑞普（天津）生物药业有限公司 A kind of Compound Resisting vermin composition and preparation method thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106806369A (en) * 2017-01-18 2017-06-09 佛山市南海东方澳龙制药有限公司 Pet external application desinsection drops containing natural plant essential oils and its preparation method and application
CN109985090A (en) * 2017-12-29 2019-07-09 瑞普（天津）生物药业有限公司 A kind of Compound Resisting vermin composition and preparation method thereof
CN108785679A (en) * 2018-06-29 2018-11-13 佛山市南海东方澳龙制药有限公司 The application of Fipronil and insect growth regulator, IGR, the animal compound external-use preparation of antibody epizoa and preparation method thereof
CN108743946A (en) * 2018-07-02 2018-11-06 佛山市南海东方澳龙制药有限公司 Compound Fipronil pet external application expelling parasite drops and its preparation method and application

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