KR100533239B1 - Long lasting aromatic and antibacterial insecticide for pets - Google Patents

Abstract

The present invention relates to a sustained aroma antimicrobial insect repellent for pets containing the microencapsulated antimicrobial, insect repellent, pest repellent and fragrance to sustain the effect. The antimicrobial insecticide is characterized in that the styrene-maleic anhydride and the methol melamine component as a wall and microencapsulated by the insect repellent, the antimicrobial agent and the fragrance as an inner phase. On the other hand, the insect repellent is preferably one or two or more selected from pyrethroid pest repellents and diethyltoluamide pest repellents such as hydroxy alkylated cyclodextrin, fermethrin, cipermethrin and alletrin. . In addition, natural essential oils are suitable as antibacterial agents. The natural essential oil is preferably selected from the group consisting of tea tree oil, citronella oil, eucalyptus oil and geranium oil. In addition, a preferred antimicrobial agent is trichromic acid. Long-acting aroma antibacterial insect repellent for pets having the above configuration, by forming a film on the surface of the internal material to control the release of the internal material by microcapsules manufactured to exert the antibacterial, deodorant, aroma and insect repellent function at a desired time It has antimicrobial effect on fungus, fungus, etc. which inhabit pet's hair and skin, and has the function of avoiding pests against mosquitoes, and it reduces antibacterial, insect repellent and fragrance by physical touch. It can provide various effects.

Description

Long lasting aromatic and antibacterial insecticide for pets}

The present invention relates to a long-acting aromatic antimicrobial insect repellent for pets containing a microencapsulated antimicrobial, insect repellent, pest repellent and aroma substance, and more particularly, to form a film on the surface of the internal material to It is a microcapsule manufactured to exert antibacterial, deodorant, aroma and insect repellent functions at a desired time by controlling the release at random. It has antibacterial effect on the hair, skin and fungus and fungi of pets. The present invention relates to a long-acting aromatic antimicrobial insect repellent for pets that reduces the body's body odor by releasing antibacterial, insect repellent, and fragrance substances by physical touches.

In general, fungi and fungi, which are parasitic on the skin or hair of a pet, can cause disease on the pet's skin or body, can cause allergies to those who are sensitive to them, and headaches due to the peculiar body odor of the pet. It can also cause back and / or unpleasant smells in the fibers or home. In addition, when infected with dog heartworms transmitted by mosquitoes, there are reports that dogs can cause various diseases in the heart, lungs, liver, kidneys, etc., and even humans.

On the other hand, among the antibacterial insect repellents for pets, antimicrobial agents are representative of inorganic metals, organometallics, quaternary ammonium salts, amphoteric and nonionic surfactants, alcohols, nitrile, iodine, fluorine, etc. If used, the effects of hazard and persistence are small.

Diethyltoluamide (DEET), a synthetic insect repellent as an insect repellent, has an unpleasant odor and a high penetration into the skin, which is harmful to humans or animals when used excessively to increase the effect. In addition, it is reported that overuse causes skin itching, headache, and carcinogenicity to permethrin and cipermethrin.

In addition, when less diethyltoluamide (DEET) or pyrethroid pest repellent is used, the pest repelling effect and the insect repellent effect are not sustained. In addition, the study related to the antibacterial insect repellent for pets to increase the persistence, the study to maintain a stable insect repellent effect for a long time at low concentration by using a microcapsules containing pyrethroid insect repellent, which is a botanical extract system {related application PCT / JP92 / 00701 (filed May 29, 1992)}, but this is a secondary method for the insect repellent to exert the insect repellent effect from the capsule, but only by miniaturizing the insect repellent and encapsulating it in the capsule for a long time. There is a lack of measures, and the study of spray repellents (Korean Patent Application No. 1994-0016196) only introduces a simple technique of microemulsification of insect repellents, which is difficult to properly control the amount of spraying when spraying insect repellents. Since the concentration is not controlled, there is a problem that it is easy to cause irritation or side effects of the contact material.

Accordingly, the present inventors have repeatedly studied to solve the above problems, by using a microcapsule formulation, the aromatic antimicrobial pest repellent is released appropriately, each function and complex functions are suitable, so it is safe for the skin of pets or zookeepers. In addition, it has developed a long-acting aroma antibacterial insect repellent for pets that releases antibacterial insect repellent when needed by physical touch.

Accordingly, an object of the present invention is to provide a sustained fragrance antibacterial insect repellent for pets having a variety of advantages, as well as a safe smell to the breeder's skin and pets because the effect is continuous compared to the existing temporary fragrance antibacterial insect repellent effect It is.

A feature of the present invention for achieving the above object is a microcapsule type insect repellent in which a styrene-maleic anhydride and a methiol melamine component are used as a wall and a pyrethroid insect repellent is injured. In the styrene-maleic anhydride 0.5 to 1% by weight of the total weight, metholol melamine is composed of 0.5 to 1% by weight of the total weight of the wall, natural essential oils tea tree oil, citronella One or two of the oil, eucalyptus oil and geranium oil groups and triclosan may be achieved by a sustained aromatic antimicrobial insect repellent for pets, characterized in that it is injured as an antimicrobial agent.

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Hereinafter, the configuration and action of the long-acting antibacterial insect repellent for pets of the present invention will be described in more detail.

The long-acting aromatic antibacterial insect repellent for pets of the present invention is characterized in that the capsule is formed of styrene-maleic anhydride and methol melamine components and microencapsulated with an insect repellent, an antibacterial agent, and an aromatic substance as an injection.

That is, the present invention is first prepared so as to contain microcapsules made by styrene-maleic anhydride and methiol melamine as the wall material and one or two or more natural essential oils as the core material of the aromatic antibacterial function.

At this time, the styrene-maleic anhydride is 0.5 to 1% by weight of the total weight of the antimicrobial deodorant, it is preferable to maintain 0.5 to 1% by weight of the total weight of methol melamine.

Then, insecticides, antimicrobials and insect repellents, antimicrobial agents and fragrances as an internal wound to microencapsulate the persistent aromatic antibacterial insect repellent for pets of the present invention.

The insect repellent is preferably one or two or more selected from pyrethroid pest repellents and diethyltoluamide pest repellents consisting of hydroxy alkylated cyclodextrins, fermethrins, cipermethrins, and allethrins. Pyrethloy insect repellents, manned insect repellents, pest repellents, etc. may use those specified in the "Pesticide Ingredient Content Standard of Pharmaceuticals and Non-Medicinal Products" of the Korean Pharmaceutical Affairs Act.

As the antimicrobial agent, natural essential oils are preferred. Natural essential oils are selected from the group consisting of tea tree oil, citronella oil, eucalyptus oil and geranium oil. In addition, as a preferred antimicrobial agent, triclosan may be used.

Hereinafter, the present invention will be described in more detail with reference to the following Examples and Experimental Examples, but these Examples and Experimental Examples are only intended to assist the understanding of the present invention, and the scope of the present invention in any sense is limited thereto. It is not.

Examples 1 to 3

According to the composition as shown in Table 1, Example 1, which does not contain the aromatic antibacterial pest repellent and Example 2, which is not microencapsulated, and the surfactant, styrene-maleic anhydride, teatrio which is an aromatic antibacterial substance in the oil phase Work, the pest repellents citronella oil, diphenotrin and trichromic acid are dissolved well with each other, and gradually mixed into a water phase in which the methiol melamine and propylene glycol well dissolved, mixed with a mixer to make the oil phase finely in the water phase After the dispersion, the sustained-directional antimicrobial insecticide composition of Example 3 was prepared by gradually raising the temperature to harden the wall material.

division Name Example 1 Example 2 Example 3 Yu Sang Styrene-maleic anhydride 1.0 0 1.0 Triclosan 0 0.05 0.05 Tea Tree Oil 0 1.0 1.0 Citronella Oil 0 1.0 1.0 Sorbitan sesquiisostearate 1.5 1.5 1.5 Di-phenotrine 0.1 0.1 0.1 Water Department Propylene glycol 5.0 5.0 5.0 Methiol Melamine 0 0 1.0 Polysorbate 60 0.3 0.3 0.3 Purified water 92.1 91.05 89.05

Note) Unit: weight%

In this experiment, two rats were fixed with a gold mesh in the center of a 50cm × 50cm × 50cm, and 50 culex pipiens, which were not exposed to pest repellents, were released in the center of the box, and then compared with the comparative example and experiment for 1 hour. The number of mosquitoes flying in the mice was measured. Experimental environment was carried out under the conditions of temperature 27 ± 3 ℃, relative humidity 70 ± 10%. Pest evasion rate was calculated as follows.

                Mosquitoes Fly in Comparative Example-Mosquitoes Fly in Example

Insect Evasion (%) = ------------------------------------------- --- × 100

                           Mosquitoes flying in Comparative Example

Experimental Example 1: Insect Evasion Evaluation Experiment

0.5 g of each of Examples 1 to 3 were applied and lightly rubbed with a mouse, and the rat of the comparative example (blank) was fixed inside the box, and the number of mosquitoes was measured under the above-described conditions.

Pest control evaluation result Example 1 Example 2 Example 3 Blank Sample Blank Sample Blank Sample Mosquitoes 83 87 67 3 79 6 Pest evasion rate <0% 96% 96%

Experimental Example 2: Insect pest persistence evaluation experiment

0.5 g of the samples of each of Examples 1 to 3 were applied to each rat, insulated for 7 days under the same conditions, and reared, and then gently rubbed by hand, and the number of mosquitoes in the comparative example and the above-described conditions were determined. Measured.

Result of evaluation of persistence of pest attack Example 1 Example 2 Example 3 Blank Sample Blank Sample Blank Sample Mosquitoes 94 91 72 51 81 9 Pest evasion rate 3% 29% 89%

The results of Experiment 1 showed that there was no pest avoiding effect in Experiment 1 without pest repellent, and microencapsulation with the wall of Example 2 made of a general emulsion and styrene-maleic anhydride and methiol melamine The pest evasion rate of Example 3 was found to be about the same level.

In addition, the pest repelling force of Example 2 emulsified with the emulsion was significantly reduced after 7 days from the results of Experimental Example 2, while in the microencapsulated Example 3 with the pest repellent as an internal wound, the encapsulated pest repellent burst as the capsule collapsed. It was found that the insect repellent effect.

Experimental Example 3

Escherichia coli and Staphylococcus were cultured in a blank and a sample petri dish, and 0.5 g of the antimicrobial capsule of Example 3 was added to the sample, and the heart was discharged at an appropriate pressure.

E. coli reduction results of Experimental Example 3 E. coli reduction Test Items unit Early 24 hours later % Reduction Experimental Example 3 Blank Bacteria count / ml 1.4 × 10 ⁵ 6.7 × 10 ⁶ - Escherichia coli Bacteria count / ml 1.4 × 10 ⁵ <10 99.9

Bacteria Reduction Results of Experimental Example 3 Staphylococcus reduction Test Items unit Early 24 hours later % Reduction Experimental Example 3 Blank Bacteria count / ml 1.3 × 10 ⁵ 6.0 × 10 ⁶ - Staphylococcus Bacteria count / ml 1.3 × 10 ⁵ <10 99.9

Experimental Example 4

Procedure 1) The antimicrobial capsules of Example 3 were stored for 1 day and 7 days at room temperature.

Step 2) A sample prepared by adding a blank and 0.5 g of the capsule of Example 3 to a petri dish of Escherichia coli cultured in each tank 2 was prepared.

Step 3) After pressurizing the capsule by hand to release the internal substance, it was left to stand for 24 hours to confirm the reduction of bacteria.

Antibacterial persistence test results of Escherichia coli 1 Daily Storage Example 3 Capsules 7 Day Storage Example 3 Capsules Initial bacterial count [bacterial count / ml] 1.4 × 10 ⁵ 1.4 × 10 ⁵ Blank [bacterial number / ml] 6.7 × 10 ⁶ 6.7 × 10 ⁶ Escherichia coli [Bacteria / ml] <10 <10 % Reduction 99.9 99.9

Bacterial antimicrobial persistence test result 2 Daily Storage Example 3 Capsules 7 Day Storage Example 3 Capsules Initial bacterial count [bacterial count / ml] 1.3 × 10 ⁵ 1.3 × 10 ⁵ Blank [bacterial number / ml] 6.0 × 10 ⁵ 6.0 × 10 ⁵ Staphylococcus [bacteria bacteria / ml] <10 <10 % Reduction 99.9 99.9

In Example 3 microencapsulated from the results of Experimental Example 3 to Experimental Example 4 it can be seen that the antimicrobial effect lasts even after 7 days.

In particular, when the physical force was applied from the results of Experimental Example 4, it was found that the antimicrobial agent contained in the bursting of the capsules of Example 3 burst, and the antimicrobial effect of the initial and seven days after the sustained and equivalent degree.

As described above in the above description, the long-acting aroma antimicrobial insect repellent for pets of the present invention exhibits an antimicrobial insect repellent effect immediately after application as well as a long-term aroma antimicrobial insect repellent effect when physical force is applied. It is expected that it can be preferably used as a composition.

Claims (5)

delete delete delete delete In the microcapsule type insect repellent in which a styrene-maleic anhydride and a methol melamine component are used as the wall material and the pyrethroid insect repellent is injured, The styrene-maleic anhydride is 0.5 to 1% by weight of the total weight, methol melamine is 0.5 to 1% by weight of the total weight constitutes the wall material, tea tree oil, citronella oil, eucalyptus, which is a natural essential oil Long lasting fragrance antibacterial insect repellent for pets, characterized in that one or two of the tooth oil and geranium oil group and triclosan selected from the group.