CN106806369A - Pet external application desinsection drops containing natural plant essential oils and its preparation method and application - Google Patents
Pet external application desinsection drops containing natural plant essential oils and its preparation method and application Download PDFInfo
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- CN106806369A CN106806369A CN201710041034.9A CN201710041034A CN106806369A CN 106806369 A CN106806369 A CN 106806369A CN 201710041034 A CN201710041034 A CN 201710041034A CN 106806369 A CN106806369 A CN 106806369A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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Abstract
The invention provides pet external application desinsection drops containing natural plant essential oils and its preparation method and application, the drops is with natural plant essential oils as transdermal penetration enhancer, thus can be while drops action time be improved, additionally it is possible to be effectively improved the smell of drops, the comfort level that raising is used；Drops of the present invention can effectively kill parasite simultaneously, it is thus possible to for the killing of epizoa in pet body.In the of the invention preparation method, with instant component as raw material, and through being further mixed with drops, with preparation method is simple, efficiency high and obtained drops effect is good, the advantages of usage comfort is high.
Description
Technical field
The present invention relates to pet external application field of pesticides, killed in particular to the pet external application containing natural plant essential oils
Worm drops and its preparation method and application.
Background technology
Pet market development is swift and violent, is investigated according to American Pets product association, and the whole America pet industry expenditure is about within 2005
Hundred million U.S. dollar more than 360, it is nearly double by 2015, reach hundred million U.S. dollar more than 600.
Antiparasitic agent is sales quota highest project in pet medication.According to the investigation report of American Pets product association
Accuse, American in 2015 is used for the medical gross expenditure of veterinary drug and is about 30,000,000,000 dollars, and wherein sales volume accounting highest is anti-parasitism
Worm medicine.A survey data show earlier, in 158 veterinary drug new varieties that 2002~2006 years U.S. FDAs are ratified, anti-parasitism
Worm medicine has 32, and proportion is 20.25%, is only second to anti-infective (29.74%), suitable with feed addictive
(21.52%).
Pet external application desinsection drops promotees to ooze due to its special percutaneous absorbtion mechanism, it is necessary to add transdermal in composition is formulated
Agent, at present mostly using the chemical composition such as Laurocapram, but these chemical penetration penetrating agents are using there is its limitation, and
Onset time is relatively long.Meanwhile, the main component of external application desinsection drops is mostly the agricultural chemicals to insect with killing action, agriculture
Medicine and conventional organic solvent are respectively provided with special peculiar smell, and this kind of preparation general recommendations was just being had a bath with latter 24 hours so that
Peculiar smell long-term existence, influence pet, pet are advocated peace the sense organ of user.
In view of this, it is special to propose the present invention.
The content of the invention
The first object of the present invention is to provide a kind of pet external application desinsection drops containing natural plant essential oils, the drops
With natural plant essential oils as transdermal penetration enhancer, thus can be while drops action time is improved, additionally it is possible to it is effectively improved drop
The smell of agent, the comfort level that raising is used.
The second object of the present invention is to provide a kind of described pet external application desinsection drops containing natural plant essential oils
Preparation method, in the method, with instant component as raw material, and through being further mixed with drops, with preparation method it is simple,
Efficiency high and obtained drops effect is good, the advantages of usage comfort is high.
Third object of the present invention is to provide the application of the pet external application desinsection drops containing natural plant essential oils,
Drops of the present invention can effectively kill parasite, it is thus possible to for the killing of epizoa in pet body.
In order to realize above-mentioned purpose of the invention, spy uses following technical scheme：
A kind of pet external application desinsection drops containing natural plant essential oils, the drops is mainly made up of following components：Transdermal
Penetrating agent, effective component, solvent；
Wherein, the transdermal penetration enhancer is natural plant essential oils.
Optionally, in the present invention, the natural plant essential oils are seed oil of Moringa oleigera.
Optionally, in the present invention, the natural plant essential oils also include peppermint oil, eucalyptus oil, citronella oil or lemon
One or more.
Optionally, in the present invention, the effective component is macrolides；And/or, the effective component is benzimidazole
Class；And/or pyrethroid；And/or, the effective component is organophosphorus insecticides；And/or the effective component is cigarette
Bases；And/or, the effective component is Nylar；And/or, the effective component is Fipronil；And/or, the drug effect into
It is divided into chlorine fragrant new；
Wherein, the macrolides be avermectin, ivermectin, Abamectin, Eprinomectin, Moxidectin,
The mixing of one or more in selamectin, doramectin, milbemycin, Abamectin or acetylamino evericin
Thing；
The benzimidazole is selected from thiabendazolum, cambendazole, Parbendazole, mebendazol, Fenbendazole, Ao Fenda
In azoles, oxibendazole, albendazole, albendazole-sulfoxide, thiophanate, febantel, netobimin or Triclabendazole
The mixture of one or more；
The pyrethroid is effective cypermethrin, cypermethrin, decis, Biphenthrin, fenvalerate, height
One kind in effect cyfloxylate, cyfloxylate, gamma cyhalothrin, lambda-cyhalothrin, phenothrin or Fenpropathrin
Or several mixtures；
The organophosphorus insecticides is the mixture of one or more in chlopyrifos, Hostathion or DDVP；
The nicotinoids are in imidacloprid, Diacloden, clothianidin, Nitenpyram, thiacloprid, MTI-446 or Acetamiprid
Plant or several mixtures.
Optionally, in the present invention, the solvent is alpha-pyrrolidone, ethyl acetate, dimethyl sulfoxide (DMSO), ethanol or third
The mixed solvent of one or more in glycol.
Optionally, in the present invention, the drops is mainly made up of component：Transdermal enhancer 1~10%, effective component 5~
70%, balance of solvent.
Optionally, in the present invention, the drops is mainly made up of component：Transdermal enhancer 3~8%, effective component 8~
60%, balance of solvent.
Meanwhile, present invention also offers the preparation method of the pet external application desinsection drops containing natural plant essential oils, institute
The method of stating comprises the following steps：
1) effective component is dissolved with stirring solvent；
2) to adding transdermal penetration enhancer in resulting solution, and continue stirring mixing, obtain final product described containing natural plant essential oils
Pet external application desinsection drops.
Further, killed in pet body present invention also offers the pet external application desinsection drops containing natural plant essential oils
Application in epizoa.
Compared with prior art, beneficial effects of the present invention are：
In the natural plant essential oils composition of drops of the present invention, containing terpenes active component, make it have it is strong fat-soluble and
Penetrating power, for a common chemical drug transdermal penetration enhancer, the rush effect of oozing of derived essential oil of the present invention is stronger, works more
Hurry up, and side effect is smaller；Meanwhile, the fragrance contained by natural plant essential oils can cover agrochemical medicine and organic molten as aromatic
The distinctive unpleasant peculiar smell of agent, it is possible to increase the sensory-acceptance and user satisfaction of pet and user；Furthermore it is of the invention selected
There is the plants essential oil selected certain parasite of killing to act in itself, and the parasite effect of killing to effective component has collaboration to promote
Effect.
Specific embodiment
Embodiment of the present invention is described in detail below in conjunction with embodiment, but those skilled in the art will
Understand, the following example is merely to illustrate the present invention, and is not construed as limiting the scope of the present invention.It is unreceipted specific in embodiment
Condition person, the condition advised according to normal condition or manufacturer is carried out.Agents useful for same or the unreceipted production firm person of instrument, are
The conventional products that can be obtained by commercially available purchase.
Pet external application desinsection drops containing natural plant essential oils of the present invention, according to percent by weight, by such as the following group
Divide and be made：Transdermal enhancer 3~5%, for example can be, but be not limited to 3,3.5,4,4.5 or 5% etc.；Effective component 8~
60%, for example can be, but be not limited to 8,10,12,15,20,25,30,35,40,50,55 or 60% etc.；Balance of solvent.
Specifically：
In the present invention, the specific composition of the transdermal enhancer is seed oil of Moringa oleigera, peppermint oil, eucalyptus oil, citronella oil or lemon
The natural plant essential oils of one or more of lemon essential oil；
Further, transdermal enhancer of the present invention can be proportionally (1~2) for seed oil of Moringa oleigera and peppermint oil：(1~
2) mixing transdermal enhancer；
Or, the transdermal enhancer can be proportionally (1~2) for seed oil of Moringa oleigera and eucalyptus oil：(1~2) it is mixed
Close transdermal enhancer；
Or, the transdermal enhancer can be proportionally (1~2) for peppermint oil and citronella oil：The mixing of (1~2)
Transdermal enhancer；
Or, the transdermal enhancer can be proportionally (1~2) for eucalyptus oil and lemon：(1~2) it is mixed
Close transdermal enhancer；
Or, the transdermal enhancer can be proportionally (1~2) for seed oil of Moringa oleigera, eucalyptus oil and lemon：
(1~2)：The mixing transdermal enhancer of (1~2)；
Or, the transdermal enhancer can be with seed oil of Moringa oleigera, peppermint oil, eucalyptus oil proportionally for (1~2)：(1~2)：
The mixing transdermal enhancer of (1~2).
Or, the transdermal enhancer can be proportionally (1~2) for peppermint oil, eucalyptus oil and citronella oil：(1~
2)：The mixing transdermal enhancer of (1~2)；
Or, the transdermal enhancer can be with peppermint oil, eucalyptus oil, citronella oil and lemon proportionally for (1
~2)：(1~2)：(1~2)：The mixing transdermal enhancer of (1~2)；
Or, the transdermal enhancer can be pressed with seed oil of Moringa oleigera, peppermint oil, eucalyptus oil, citronella oil and lemon
It is (1~2) according to ratio：(1~2)：(1~2)：(1~2)：The mixing transdermal enhancer of (1~2).
Meanwhile, in the present invention, the specific composition of the effective component can be：Imidacloprid and Permethrin；And/or the medicine
Effect composition is imidacloprid and Nylar；And/or the effective component is Fipronil and Permethrin；And/or the effective component
It is imidacloprid, Nylar and Permethrin；And/or the effective component is Fipronil and Nylar；And/or the effective component
It is acetylamino evericin
Further, in the present invention, the effective component is imidacloprid and Permethrin；Wherein, the quality of imidacloprid is drop
The 8~12% of agent raw material gross mass, for example can be, but be not limited to 9,10 or 11% etc.；The quality of Permethrin is former drops
The 45~50% of material gross mass, for example can be, but be not limited to 48 or 50% etc.；
Or, in the present invention, the effective component is imidacloprid and Nylar；Wherein, the quality of imidacloprid is former drops
The 8~12% of material gross mass, for example can be, but be not limited to 9,10 or 11% etc.；The quality of Nylar is that drops raw material is total
The 0.3~1% of quality, for example can be, but be not limited to 0.4,0.5,0.6,0.7,0.8 or 0.9% etc.；
Or, in the present invention, the effective component is Fipronil and Permethrin；Wherein, the quality of Fipronil is original
The 5~10% of material gross mass, for example can be, but be not limited to 6,7,8 or 9% etc.；The quality of Permethrin is raw material gross mass
45~50%, for example can be, but be not limited to 46,48 or 50% etc.；
Or, in the present invention, the effective component is imidacloprid, Nylar and Permethrin；Wherein, the quality of imidacloprid is
The 6~10% of raw material gross mass, for example can be, but be not limited to 7,8,9 or 10% etc.；The quality of Nylar is the total matter of raw material
The 40~50% of amount, for example can be, but be not limited to 43,44,45,47,48 or 49% etc.；The quality of Permethrin is that raw material is total
The 0.3~0.8% of quality, for example can be, but be not limited to 0.4,0.5,0.6,0.7 or 0.8% etc.；
Or, in the present invention, the effective component is Fipronil and Nylar；Wherein, the quality of Fipronil is original
The 8~12% of material gross mass, for example can be, but be not limited to 9,10 or 11% etc.；The quality of Nylar is raw material gross mass
2~15%, for example can be, but be not limited to 3,5,10 or 12% etc..
Or, in the present invention, the effective component is acetylamino evericin；Wherein, acetylamino evericin
Quality is the 0.1~10% of raw material gross mass, for example, can be, but be not limited to 0.1,0.5,1%, 5% or 10% etc..Together
When, solvent of the present invention is the one kind or several in alpha-pyrrolidone, ethyl acetate, dimethyl sulfoxide (DMSO), ethanol or propane diols
The mixed solvent planted.
First it is that effective component is dissolved with solvent in preparation method of the present invention；
Specifically, effective component can simultaneously be added solvent dissolved, or by effective component step-wise dissolution in molten
In agent；
It is further preferred：When the effective component be imidacloprid and Permethrin when, can first by imidacloprid be dissolved in α-
In pyrrolidones, the further stirring and dissolving of Permethrin is then added；
When the effective component is imidacloprid and Nylar, first imidacloprid can be dissolved in alpha-pyrrolidone, then
Add the further stirring and dissolving of Nylar；
When the effective component is Fipronil and Permethrin, first Fipronil can be dissolved in alpha-pyrrolidone,
Then the further stirring and dissolving of Permethrin is added；
When the effective component is imidacloprid, Nylar and Permethrin, imidacloprid first can be dissolved in alpha-pyrrolidone
In, then add Nylar and the further stirring and dissolving of Permethrin；
When the effective component is Fipronil and Nylar, first Fipronil can be dissolved in alpha-pyrrolidone,
Then the further stirring and dissolving of Nylar is added；
Then, be by transdermal penetration enhancer add solution in, and continue stirring mixing；
Finally, will continue to stir mixing resulting solution with filtered through gauze, drops as of the present invention；After qualified after testing, can
To be packed or be dispensed.
Drops of the present invention can be used for the inside and outside desinsection of the pets such as cat, dog, and can effectively kill pet inside and outside
Parasite.
Embodiment 1
According to mass percent, 10% imidacloprid, 50% Permethrin, 2% peppermint oil, 3% seed oil of Moringa oleigera, and surplus
Alpha-pyrrolidone, weighs appropriate each raw material respectively；
Then, the pet external application desinsection drops containing natural plant essential oils is prepared according to methods described below；
1) imidacloprid is dissolved with alpha-pyrrolidone；
2) to step 1) Permethrin is added in resulting solution, and continue stirring and dissolving；
3) to step 2) peppermint oil and seed oil of Moringa oleigera are added in resulting solution, and stir 20min；
Then, by gained mixed solution with filtered through gauze, the pet external application containing natural plant essential oils for obtaining final product embodiment 1 is killed
Worm drops.
Embodiment 2
According to mass percent, 9.1% imidacloprid, 0.46% Nylar, 2% seed oil of Moringa oleigera, 2% eucalyptus oil, 1% lemon
The alpha-pyrrolidone of essential oil and surplus, weighs appropriate each raw material respectively；
Then, the pet external application desinsection drops containing natural plant essential oils is prepared according to methods described below；
1) imidacloprid is dissolved with most of alpha-pyrrolidone；
2) to step 1) Nylar is added in resulting solution, and continue stirring and dissolving；
3) to step 2) seed oil of Moringa oleigera, eucalyptus oil and lemon are added in resulting solution, and stir 20min；
4) and then, by gained mixed solution with filtered through gauze, obtain final product the pet external application containing natural plant essential oils of embodiment 2
Desinsection drops.
Embodiment 3
According to mass percent, 6.8% Fipronil, 0.46% Permethrin, 3% seed oil of Moringa oleigera, 2% citronella oil and remaining
The alpha-pyrrolidone of amount, weighs appropriate each raw material respectively；
Then, the pet external application desinsection drops containing natural plant essential oils is prepared according to methods described below；
1) Fipronil alpha-pyrrolidone is dissolved；
2) to step 1) Permethrin is added in resulting solution, and continue stirring and dissolving；
3) to step 2) seed oil of Moringa oleigera and citronella oil are added in resulting solution, and stir 20min；
4) and then, by gained mixed solution with filtered through gauze, obtain final product the pet external application containing natural plant essential oils of embodiment 3
Desinsection drops.
Embodiment 4
According to mass percent, 8.8% imidacloprid, 44% Nylar, 0.44% Permethrin, 1% peppermint oil, 1% Moringa
The alpha-pyrrolidone of seed oil, 1% eucalyptus oil, 2% citronella oil and surplus, weighs appropriate each raw material respectively；
Then, the pet external application desinsection drops containing natural plant essential oils is prepared according to methods described below；
1) imidacloprid is dissolved with alpha-pyrrolidone；
2) to step 1) Nylar and Permethrin are added in resulting solution, and continue stirring and dissolving；
3) to step 2) peppermint oil, seed oil of Moringa oleigera, eucalyptus oil and citronella oil are added in resulting solution, and stir
20min；
4) and then, by gained mixed solution with filtered through gauze, obtain final product the pet external application containing natural plant essential oils of embodiment 4
Desinsection drops.
Embodiment 5
According to mass percent, 10% Fipronil, 30% Nylar, 2% seed oil of Moringa oleigera, 3% lemon and remaining
The alpha-pyrrolidone of amount, weighs appropriate each raw material respectively；
Then, the pet external application desinsection drops containing natural plant essential oils is prepared according to methods described below；
1) Fipronil is dissolved with alpha-pyrrolidone；
2) to step 1) Nylar is added in resulting solution, and continue stirring and dissolving；
3) to step 2) seed oil of Moringa oleigera and lemon are added in resulting solution, and stir 20min；
4) and then, by gained mixed solution with filtered through gauze, obtain final product the pet external application containing natural plant essential oils of embodiment 5
Desinsection drops.
Embodiment 6
According to mass percent, 10% Fipronil, 10% Nylar, 2% seed oil of Moringa oleigera, 3% lemon and remaining
The alpha-pyrrolidone of amount, weighs appropriate each raw material respectively；
Then, the pet external application desinsection containing natural plant essential oils for embodiment 6 being obtained according to the methods described of embodiment 5 drips
Agent.
The ill dog therapeutic effect of experimental example 1
The suitable ill dog 30 of pet selection medical history, the state of an illness, is by parasitic infection, more serious scabies occurs
Itch, the dog of hair loss, skin injury or scytitis only, be randomly divided into 3 groups, respectively test group 1, test group 2 and control group, often
Group 10.Test group 1 gives the embodiment of the present invention 1, and 1ml is given by every 5kg body weight, drips between dog dorsal scapular bone, medication 1
It is secondary, observe Cure；Test group 2 gives the embodiment of the present invention 3, and 1ml is given by every 5kg body weight, drips in dog dorsal scapular bone
Between, daily medication 1 time, continuous use 3 days observes Cure；Control group dog not medication, the sick heat condition of observation.Observation refers to
It is marked with and suffers from dog and scratch frequency, depilation situation, scytitis situation.
Result shows that after the sick dog medication of test group 1, test group 2, symptom is clearly better within the 2nd day, or worm is reduced, and is suffered from dog and is grabbed
Number of times of itching is significantly reduced, and depilation stops, and skin color is switched to pink, inflammatory symptom mitigation by flush, and frass reduces the 4th day within 3 days
Dermatitis disappears substantially, starts to grow virgin wool, and without the phenomenon that scratches, after the 7th day, skin color switchs to normally, without breakage, and control group
Suffer from the daily symptom of dog symptom to be not improved, develop in the state of exacerbation.
The transdermal experiment of experimental example 2
Defrosting skin carries out Transdermal Absorption experiment under normal temperature, and releasing agent is the drops of embodiment 3, and consumption is 2ml；Receive
Liquid is blank alpha-pyrrolidone solvent；Experimental temperature is 37 DEG C, and vibration velocity is 150r/min.
5.0ml acceptable solutions are taken respectively at the 1st, 2,4,6,8,10,12h time points, while supplementing equivalent acceptable solution, and are utilized
Gas chromatography and UV-visible absorbance method determine Fipronil content, and calculate different time points Fipronil unit
Area infiltration capacity.Result is as follows：
| Time (h) | |
| 1 | 70.13 |
| 2 | 99.66 |
| 4 | 145.59 |
| 6 | 193.26 |
| 8 | 264.03 |
| 10 | 341.22 |
| 12 | 353.17 |
Then, the transdermal enhancer in the drops of embodiment 3 is replaced with into equivalent Laurocapram, and in same experimental conditions
Under carry out transdermal experiment, as a result show, the accumulative infiltration capacity of the unit area of 12h is 273.16 μ g/cm2。
As can be seen here, drops of the present invention has good osmotic effect.
Experimental example 3
1) dog insecticidal effect
In certain plant, 30 harriers at 12~24 physically fit monthly ages are chosen, be randomly divided into 3 groups, respectively
Test 1 group, experiment 2 groups and observation group, every group 10；
After being cleaned to harrier body surface, the anterior part of chest in every harrier infects the dog flea of 100 or so respectively；
Then, after 1d is infected, dipping treatment is carried out with the drops of embodiment 5,6 respectively to 2 groups of 1 group of experiment and experiment, observation group is not
Receive treatment；
Dipping treatment method is as follows：By the drops of the 4g embodiment of the present invention according to 1：100 ratio mixes with water, Ran Hou
Infecting position and peripheral part carries out dipping drug treatment；
It is harrier carding after treatment 1d, to remove dog flea, calculates the dog flea collected, and evaluate the dog flea death rate.
Result shows that 1 group of average mortality of dog flea of experiment can reach 93%, and the death rate for testing 2 groups of dog fleas is
85%, the death rate of observation group dog flea is 0.
Meanwhile, over the course for the treatment of with treatment after, harrier drinking water diet is normal, any abnormal conditions does not occur；
During medication, find drops of the present invention has no agricultural chemicals peculiar smell, and sense organ is good.
2) pet cat insecticidal effect
In certain pet market, 20 pet cats are chosen, be randomly divided into 2 groups, respectively test 1 group and 2 groups, every group 10 of experiment
Only；
After being cleaned to pet cat body surface, the anterior part of chest in every pet cat infects the cat flea of 100 or so respectively；
Then, after 1d is infected, dipping treatment is carried out with the drops of embodiment 5,6 respectively to 2 groups of 1 group of experiment and experiment；
Dipping treatment method is as follows：By the drops of the 3g embodiment of the present invention according to 1：100 ratio mixes with water, Ran Hou
Infecting position and peripheral part carries out dipping treatment.
It is pet cat carding after treatment 1d, to remove dog flea, calculates the cat flea collected, and evaluate the cat flea death rate.
Result shows that 1 group of average mortality of cat flea of experiment can reach 86%, and the death rate for testing 2 groups of cat fleas is
92%.
Although illustrate and describing the present invention with specific embodiment, but will be appreciated that without departing substantially from of the invention
Many other changes and modification can be made in the case of spirit and scope.It is, therefore, intended that in the following claims
Including belonging to all such changes and modifications in the scope of the invention.
Claims (9)
1. a kind of pet external application desinsection drops containing natural plant essential oils, it is characterised in that the drops is main by following components
It is made：Transdermal penetration enhancer, effective component, solvent；
Wherein, the transdermal penetration enhancer is natural plant essential oils.
2. the pet external application desinsection drops containing natural plant essential oils according to claim 1, it is characterised in that described natural
Plants essential oil is seed oil of Moringa oleigera.
3. the pet external application desinsection drops containing natural plant essential oils according to claim 1 and 2, it is characterised in that described
Also one or more including peppermint oil, eucalyptus oil, citronella oil or lemon of natural plant essential oils.
4. the pet external application desinsection drops containing natural plant essential oils according to claim 1, it is characterised in that the drug effect
Composition is macrolides；And/or, the effective component is benzimidazole；And/or pyrethroid；And/or, it is described
Effective component is organophosphorus insecticides；And/or the effective component is nicotinoids；And/or, the effective component is pyrrole third
Ether；And/or, the effective component is Fipronil；And/or, the effective component is fragrant new chlorine；
Wherein, the macrolides is avermectin, ivermectin, Abamectin, Eprinomectin, Moxidectin, department's drawing
The mixture of one or more in gram fourth, doramectin, milbemycin, Abamectin or acetylamino evericin；
The benzimidazole be selected from thiabendazolum, cambendazole, Parbendazole, mebendazol, Fenbendazole, oxfendazole,
One kind in oxibendazole, albendazole, albendazole-sulfoxide, thiophanate, febantel, netobimin or Triclabendazole
Or several mixtures；
The pyrethroid is effective cypermethrin, cypermethrin, decis, Biphenthrin, fenvalerate, efficient fluorine
One kind or several in cypermethrin, cyfloxylate, gamma cyhalothrin, lambda-cyhalothrin, phenothrin or Fenpropathrin
The mixture planted；
The organophosphorus insecticides is the mixture of one or more in chlopyrifos, Hostathion or DDVP；
The nicotinoids be imidacloprid, Diacloden, clothianidin, Nitenpyram, thiacloprid, MTI-446 or Acetamiprid in one kind or
Several mixtures.
5. the pet external application desinsection drops containing natural plant essential oils according to claim 1, it is characterised in that the solvent
It is the mixed solvent of one or more in alpha-pyrrolidone, ethyl acetate, dimethyl sulfoxide (DMSO), ethanol or propane diols.
6. the pet external application desinsection drops containing natural plant essential oils according to claim 1, it is characterised in that according to weight
Percentage meter, the drops is mainly made up of component：Transdermal enhancer 1~10%, effective component 5~70%, balance of solvent.
7. the pet external application desinsection drops containing natural plant essential oils according to claim 1, it is characterised in that according to weight
Percentage meter, the drops is mainly made up of component：Transdermal enhancer 3~8%, effective component 8~60%, balance of solvent.
8. the preparation method of the pet external application desinsection drops of natural plant essential oils is contained any one of claim 1-7, and it is special
Levy and be, methods described comprises the following steps：
1) effective component is dissolved with stirring solvent；
2) to adding transdermal penetration enhancer in resulting solution, and continue stirring mixing, obtain final product the pet containing natural plant essential oils
External application desinsection drops.
9. the pet external application desinsection drops containing natural plant essential oils any one of claim 1-7 is killing pet body
Application in interior epizoa.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108743946A (en) * | 2018-07-02 | 2018-11-06 | 佛山市南海东方澳龙制药有限公司 | Compound Fipronil pet external application expelling parasite drops and its preparation method and application |
| CN108785679A (en) * | 2018-06-29 | 2018-11-13 | 佛山市南海东方澳龙制药有限公司 | The application of Fipronil and insect growth regulator, IGR, the animal compound external-use preparation of antibody epizoa and preparation method thereof |
| CN112315998A (en) * | 2020-12-02 | 2021-02-05 | 山东省寄生虫病防治研究所 | Broad-spectrum antiparasitic composite preparation and preparation method thereof |
| CN114712408A (en) * | 2022-05-12 | 2022-07-08 | 镇江威特药业有限责任公司 | Compound phoxim pour-on agent and preparation method thereof |
| CN114917221A (en) * | 2022-05-27 | 2022-08-19 | 吉林吉力生物技术研究有限公司 | Veterinary albendazole sulfoxide composition as well as preparation method and application thereof |
| CN115530164A (en) * | 2022-10-19 | 2022-12-30 | 陕西天宠生物科技有限公司 | In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006785A (en) * | 2012-12-19 | 2013-04-03 | 成都乾坤动物药业有限公司 | Chinese and western medicine compound transdermal solution and preparation method thereof |
| CN106212551A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪（厦门）生物科技有限公司 | A kind of daily non-stimulated disinfectant and preparation method thereof |
-
2017
- 2017-01-18 CN CN201710041034.9A patent/CN106806369B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103006785A (en) * | 2012-12-19 | 2013-04-03 | 成都乾坤动物药业有限公司 | Chinese and western medicine compound transdermal solution and preparation method thereof |
| CN106212551A (en) * | 2016-07-29 | 2016-12-14 | 腾科宝迪（厦门）生物科技有限公司 | A kind of daily non-stimulated disinfectant and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 李威等: "《药剂学》", 28 February 2014, 湖北科学技术出版社 * |
| 汪明: "《兽医寄生虫学》", 31 January 2004, 中国农业出版社 * |
| 黄素青等: "植物精油的生物活性及其在有害生物控制上的应用", 《农药》 * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108785679A (en) * | 2018-06-29 | 2018-11-13 | 佛山市南海东方澳龙制药有限公司 | The application of Fipronil and insect growth regulator, IGR, the animal compound external-use preparation of antibody epizoa and preparation method thereof |
| CN108743946A (en) * | 2018-07-02 | 2018-11-06 | 佛山市南海东方澳龙制药有限公司 | Compound Fipronil pet external application expelling parasite drops and its preparation method and application |
| CN112315998A (en) * | 2020-12-02 | 2021-02-05 | 山东省寄生虫病防治研究所 | Broad-spectrum antiparasitic composite preparation and preparation method thereof |
| CN114712408A (en) * | 2022-05-12 | 2022-07-08 | 镇江威特药业有限责任公司 | Compound phoxim pour-on agent and preparation method thereof |
| CN114917221A (en) * | 2022-05-27 | 2022-08-19 | 吉林吉力生物技术研究有限公司 | Veterinary albendazole sulfoxide composition as well as preparation method and application thereof |
| CN115530164A (en) * | 2022-10-19 | 2022-12-30 | 陕西天宠生物科技有限公司 | In-vitro deodorizing and parasite-expelling drop for pets and preparation method thereof |
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