CN1426811A - Action of litsea citrate oil in killing parasite on human body and animal - Google Patents
Action of litsea citrate oil in killing parasite on human body and animal Download PDFInfo
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Abstract
An application of cubeba oil to kill the parasites on skin of people and animals, such as flea, louse, mite, etc. is disclosed. Its preparation is prepared from cubeba oil (containing citral), liquid carrier (lotion or shampoo), solid carrier (pearlite) and insecticide through proportionally mixing. It also has the killing action to bacteria and fungus.
Description
Technical field the present invention relates to litsea cubeba oil and is killing people and animals' ectozoa, comprises the application of flea, louse, demodicid mite constant pitch main drive thing hematophagus.
The numerous disease of background technology humans and animals is propagated by hematophagus.At present, killing hematophagus both at home and abroad uses comparatively generally, the chemical insecticide that is still with fastest developing speed, normally used chemical insecticide is mainly organic phosphorus compound and pyrethroid, and using these chemical insecticides not only has certain harm to people and animals, and long-term dispensing, insect may develop immunity to drugs, the insecticidal effect of pesticide to be reduced, to have to strengthen the consumption of pesticide in order killing off the insect pests, produced vicious cycle for this reason.
The medicine of U.S. treatment commonly used head louse has Permethrin, Malatklon, Lindane etc.The toxicity of Permethrin is little, hardly by skin absorbs, can be rapidly metabolized to the chemical compound of non-activity and gets rid of from urine, and insecticidal action can continue more than 2 weeks, but along with the prolongation of service time, head louse also increases its drug resistance thereupon; Malatklon is the irreversibility cholinesterase inhibitor, can kill head louse and most of nit rapidly, yet, because this medicine has disagreeable abnormal flavour, be out of favour, now do not re-use; Lindane can be stored in fat and the nervous tissue and kill head louse, but can produce the central nervous system's reaction that comprises epilepsy as excessively use, misuse and absorption, and its drug resistance is also more common.By the explanation of above-mentioned example, except efficient, low toxicity, the development rate of new drug, natural degree and abnormal smells from the patient also are very important for insecticide.
In China, organophosphor product " metrifonate " insecticide uses early and prolongs with till now, and it has a large amount of toxic gas to discharge in building-up process, and is very harmful to human body, and contaminated environment seriously.Operator is easy to poison, stupor even dead.Toxicological experiment shows that also these organophosphor medicines belong to the high toxicity scope, causes the imbalance of human liver renal function.
Chinese medicine is the quintessence of Chinese culture of China, the parasiticidal record of useful medical herbs on the traditional medicine.At present, the Chinese herbal medicine insecticide kind producing and apply of becoming commercialized is few, common mainly contains Pyrethrum, nicotine, Radix seu Caulis Derridis Trifoliatae, calabash, Radix Tripterygii Wilfordii etc.In recent years, 15 kinds of Chinese herbal medicine mixing materials of discovery Cortex Dictamni, Fructus Cnidii, Herba Lobeliae Chinensis and Fructus Zanthoxylis etc. such as Jiang Xiuyun all have killing action to the acarid of 4 genus of fur-bearing animal, can also kill worm's ovum simultaneously.Use Alumen such as Zhang Xinglan, sulfur, Natrii Sulfas, educate Chinese herb compounds such as salt, Fructus Mume, Fructus Chebulae, river nuclear treatment dogs, cat, the rabbit acariasis, good effect, especially to exempting from full evident in efficacy of ear, and to the equal avirulence of people and animals, safe and reliable.But they all are the compound preparations of medical herbs and chemical compound or medical herbs and mineral.
Fructus Litseae has another name called cubeb litsen tree, and [Litsesa cubeba (Lours.) Pers is Lauraceae Litsea plant, the volatile oil that litsea cubeba oil system extracts from Fructus Litseae fruit, root, leaf.Litsea cubeba oil is the flavorant that China GB2760-86 regulation allows use, has natural faint scent.Since the seventies, China is to the chemical constituent of litsea cubeba oil, a series of researchs have been carried out in pharmacological action, find wherein to contain tens of kinds of chemical constituents, have certain relieving asthma, effects such as antiallergic, antithrombotic, arrhythmia, antimicrobial and trichomonas vaginitis, anti-plant insecticide, aflatoxin degradation.Use aspects such as litsea cubeba oil treatment chronic bronchitis, cerebral thrombosis, burn infection clinically, obtained certain curative effect, but never useful litsea cubeba oil is killed people and animals' ectozoa, report as louse, demodicid mite, flea, we use litsea cubeba oil to carry out exsomatizing and body kill louse, demodicid mite, flea experiment and acute toxicity testing, stimulation test, all obtained satisfied result.Confirm that litsea cubeba oil is to possess that environmental protection, efficient, low toxicity, abnormal smells from the patient are pure and fresh, polypide does not produce chemical sproof new type natural insecticidal materials as yet.
Provide the application litsea cubeba oil to kill people and animals' ectozoa for this reason, comprise that the application process of killing louse, demodicid mite, flea is particularly necessary.
Summary of the invention the objective of the invention is at above-mentioned present situation, aims to provide a kind of Fructus Litseae essential oil and is killing people and animals' vermin, comprises the application process of killing louse, demodicid mite, flea.
The implementation of purpose of the present invention is, litsea cubeba oil stock solution or litsea cubeba oil mixed being used in people and animals' body surface with liquid-carrier, solid carrier or insecticide.Percentage by weight between litsea cubeba oil and liquid-carrier, solid carrier or insecticide is 2.25%-18%, 100%-200% or 2.25%-18%.
The used litsea cubeba oil of the present invention contains＞65% citral; Liquid-carrier includes bath lotion or shampoo; Solid carrier comprises perlite class solid matter.Litsea cubeba oil and bath lotion or shampoo are made into parasite killing bath lotion or shampoo; With the absorption of perlite class solid matter, be made into the anthelmintic necklace, the anthelmintic necklace is worn over the animal cervical region, its ectozoa is prevented or killed.Insecticide comprises the Radix Stemonae, Stellera chamaejasme L., Radix Sophorae Flavescentis class plant extract.
As content＜65% of citral in the litsea cubeba oil, then in proportioning, need to strengthen the content of litsea cubeba oil.
Insecticidal solution that is made into litsea cubeba oil or the anthelmintic necklace of making do not have stimulation, damaged skin is had slight stimulation intact skin and eye, can recover automatically after stopping using, and be safe in utilization, toxicity is low, do not have bad abnormal smells from the patient.
The raw material Fructus Litseae source of litsea cubeba oil is abundant, fragrance uniqueness, simple, easy to use, the environmentally safe of preparation method.Litsea cubeba oil mixes with liquid-carrier or solid carrier and is used in people and animals' body surface, and body surface parasitic mite, louse, flea are had stronger killing action, and body surface antibacterial, mycete are also had certain inhibition and killing effect.Because be natural prodcuts, and the use of still not going public, polypide does not produce drug resistance to this.
The specific embodiment:
Killing the organism epizoa for the proof litsea cubeba oil, comprising the application of killing in louse, demodicid mite, the flea, the applicant has done a large amount of experiments, now is listed below:
1, Hua Zhong Agriculture University's animal medicine institute has made stripped effect experiment
Use contains the litsea cubeba oil of citral 65% to the (test of the insecticidal effect that sarcoptes canis (S.scabiei var canis) and Sarcoptes suis (S.ccabiei var.suis), the colored shape flea (Vermipsylla alacurt) that wriggles, Canis familiaris L. louse (Haematopinus canis) are exsomatized of epizoa arthropod.Maximum concentration: directly adopt not with the stock solution of dilution, other adds bath lotion, allots concentration and is respectively 18%, 9%, 4.5%, 2.25% insecticidal solution.Medication, the different worm kinds of living of picking, every kind of 25-28 only is put in the wide mouthed bottle, sprays administration with micro-sprayer, and each dosage (keeps unit spray area dose unanimity, about 0.05ml/cm with the substantially moistening degree of being of polypide table
2).Observe the polypide death time under the various dose condition, the result confirms the litsea cubeba oil diluent to colonizing in the common parasite of animal body surface, has killing action as the adult of arthropod louse, flea and acarid.Insecticidal effect and drug level present tangible dose-effect relationship: under 2.25% concentration, be 3～5min to the parasite killing required time of acarid, flea and louse, wherein acarid is the most responsive, and flea takes second place, and louse takes second place again.Though the stock solution with dilution does not have certain inhibitory or killing effect to three kinds of polypides, the time spent needs 15min-30min, and the concentration parasite killing time 3～5min than 2.25% will grow.
2, Hubei Province's Experimental Animal Center has been done acute toxicity test
With litsea cubeba oil stock solution that contains citral 65% or concentration is that 4.5% parasite killing bath lotion irritates stomach for SPF level kunming mice, calculates half lethal dose (LD with the Bliss method
50) and 95% fiducial limit scope, result: LD
50Be 3458.4 ± 558.7 (2939.7～4057.0) mg/kg, regression equation Y=5.72*X-15.24; The LD of parasite killing bath lotion
50Be 20573.3 ± 2465.7 (18289.6～23220.9) mg/kg, regression equation Y=9.88*X-37.61.Prove that thus the parasite killing bath lotion is a low toxicity, reality is No Poison.
3, litsea cubeba oil is to the skin irritation test of Cavia porcellus
Yichun Prefecture foreign trade corporation is that each 0.5ml of 92% litsea cubeba oil smears at guinea pig back respectively with three grades of product litsea cubeba oil with containing citral, once a day, totally 12 times, drug withdrawal midway a day.Both all have certain stimulation to guinea pig skin as a result, do not see in whole experiment that litsea cubeba oil and citral cause skin histology to fester or downright bad phenomenon, and histological observation does not also see that it has tangible influence and untoward reaction to the appendages of skin.But both can cause the aseptic inflammation reflection of skin histology, so clinical practice is to consider to reduce drug concentrations or dosage, to reduce or eliminate this stimulation.
4, Hubei Province's Experimental Animal Center has been done the single-dose skin irritation of rabbit is tested with the parasite killing bath lotion of variable concentrations
The concentration of parasite killing bath lotion is respectively 18%, 9%, 4.5%, Japan large ear rabbit is carried out the single skin irritation test of complete sum damaged skin.The result: four medication zones that 4 of intact skin group are tried rabbit all do not have erythema and edema occurs, and illustrate that this parasite killing bath lotion is to experimental rabbit intact skin nonirritant.2 of damaged skin group are tried four medication districts of rabbit after medication finishes, and 1, inadequate visible erythema is all arranged during 24h, but do not have edema; Have 1 to still have erythema behind the 48h, it is normal that 72h recovers, illustrate this parasite killing bath lotion to the experimental rabbit damaged skin with remove 1 after being tried thing, 24h has slight zest, finish back 48h in medication and recover normally.
5, Experimental Animal Center concentration in Hubei Province's is the eye irritant test that 4.5% parasite killing shampoo is done rabbit
With 0.1m parasite killing shampoo eye drip, behind eye drip 6,24,48,72h and 4d, 7d observe damage and the recovery situation that is tried tame lagophthalmos conjunctiva, iris and cornea.As a result, all do not find the damage of cornea and iris in the observation period, conjunctiva had irritant reaction such as hyperemia, edema, secretions at 6,24 hours, but eye stimulates compound average all less than 3.9.Conclusion: this parasite killing shampoo does not have tangible stimulation to tame lagophthalmos.
6, Hua Zhong Agriculture University's animal medicine institute is that 4.5% parasite killing bath lotion is made the ectozoal anthelmintic test of pesticide effectiveness of Canis familiaris L. with concentration
Being 4.5% parasite killing bath lotion with concentration carries out clinical experiment to the dog of natural infection demodicid mite, flea, louse.20-30ml/ dosage medication only as a result has good effect to flea, the louse epizoa disease of control Canis familiaris L., can reach 100% the clean rate effect of driving behind the single administration.To epizoa effect persistency effects is 5-7 days, belongs to long-acting external parasite resistance medicine.Use 20-30ml/ dosage only that the acaricide of Canis familiaris L. is also had significant curative effect, medication in per 7 days is once used three times continuously, can reach 100% effect to the clean rate of driving of acarid.After the use, do not find any local skin irritative response and systemic adverse reactions symptom, safe in utilization.Prove that this parasite killing bath lotion is the good pharmaceutical preparation of anti-animal (dog) ectozoa (arthropod).
The drug effect protracted test is observed and to be shown, after medication, will drive clean rate to flea and reach 100% Canis familiaris L. and be put back in the environment that cause of disease pollutes again and observe, and in 5-7 days, animal does not take place to infect again, proves that duration of efficacy is 5-7 days.After giving the medication of animal dog, the appetite of dog, drink are desired normal, and spirit is good, does not see the clinical adverse symptom.Press 30ml/ administration, skin is not had inflammatory stimulus reaction such as red, swollen, hot, pain take place, prove safe in utilization.
7, Hua Zhong Agriculture University's animal medicine institute is that the anthelmintic necklace of content has been made the anthelmintic test of pesticide effectiveness to Canis familiaris L. vermin arthropod with litsea cubeba oil and perlite mixture
The anthelmintic necklace is worn over the cervical region that infects the dog that flea and louse are arranged, continuous 6 weeks; The blank group is not used the anthelmintic necklace, does not use any anthelmintic drug, observes for 6 weeks.
Wear the clean rate of driving in second week of anthelmintic necklace and drive clean rate up to 100%, prove that the anthelmintic necklace has anthelminthic effect preferably to dog ectozoa flea and louse up to 93.3%, the three week.If cooperate parasite killing bathing agent medication once to get final product, reach 100% the clean rate effect of driving.Wear the anthelmintic necklace and can keep effective drug duration more than 6 weeks.The test dog is wearing the anthelmintic necklace in period, and the skin of neck part is irritative responses such as show, swollen, heat, pain not, and the while is not found appetite decline, untoward reaction symptoms such as lassitude yet.The evidence dog wears the anthelmintic of anthelmintic necklace, and is safe and effective.
The used litsea cubeba oil of the present invention is that national GB276-86 regulation allows the flavorant of use not only extremely low to the person poultry toxicity, its preparation process environmentally safe, and the fragrance pleasant of natural uniqueness.Be used for people and animals' ectozoa, as demodicid mite, flea, louse arthropod, have good killing action, effect is remarkable, and environmentally safe.Killing the ectozoal while, body surface antibacterial, mycete also there are certain inhibition and killing effect.
Litsea cubeba oil and shampoo or body lotion are fully emulsified, can make parasite killing shampoo or body lotion that people or pet animals are used; Behind perlite absorption litsea cubeba oil, can be made into the parasite killing necklace and be enclosed within on the neck of animal, can prevent or kill animal body surface louse, flea Huo ?; Also compressiblely cannedly in spray bottle or aerosol jar, make spray and aerosol, be used for spraying the parasite of people and animals' body surface or handle worm and dye clothing cotton-padded mattress, environment; Make the parasite killing carding agent of house pet, also can be used for parasite killing with mao animal body surface.
Claims (5)
1, litsea cubeba oil is being killed the ectozoal effect of people and animals, it is characterized in that litsea cubeba oil stock solution or litsea cubeba oil mixed with liquid-carrier, solid carrier or insecticide being used in people and animals' body surface, the percentage by weight between litsea cubeba oil and liquid-carrier, solid carrier or insecticide is 2.25%-18%, 100%-200% or 2.25%-18%.
2, litsea cubeba oil according to claim 1 is being killed the ectozoal effect of people and animals, it is characterized in that litsea cubeba oil is the litsea cubeba oil that contains citral＞65%.
3, litsea cubeba oil according to claim 1 is being killed the ectozoal effect of people and animals, it is characterized in that liquid-carrier includes bath lotion or shampoo.
4, litsea cubeba oil according to claim 1 is being killed the ectozoal effect of people and animals, it is characterized in that insecticide comprises the Radix Stemonae, Stellera chamaejasme L., Radix Sophorae Flavescentis class plant extract.
5, litsea cubeba oil according to claim 1 is being killed the ectozoal effect of people and animals, it is characterized in that solid carrier comprises perlite class solid matter.
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| CN 02147862 CN1201777C (en) | 2002-12-17 | 2002-12-17 | Action of litsea citrate oil in killing parasite on human body and animal |
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| CN 02147862 CN1201777C (en) | 2002-12-17 | 2002-12-17 | Action of litsea citrate oil in killing parasite on human body and animal |
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| CN1426811A true CN1426811A (en) | 2003-07-02 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103417630A (en) * | 2012-05-16 | 2013-12-04 | 中国人民解放军第二军医大学 | Extract of litsea citrata root and applications thereof |
| CN105475373A (en) * | 2015-11-06 | 2016-04-13 | 台州学院 | Preparation method for neolitsea-sericea-essential-oil miticide |
| CN107468571A (en) * | 2017-08-25 | 2017-12-15 | 广西和桂集团有限公司 | Shampoo containing Chinese herbal medicines and preparation method thereof |
| CN107982104A (en) * | 2017-12-20 | 2018-05-04 | 佛山市洛克威特科技有限公司 | A kind of anti-dandruff conditioner shampoo |
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| CN109893619A (en) * | 2019-04-16 | 2019-06-18 | 钟桂寿 | A kind of Chinese medicine composition for treating parasite of human |
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- 2002-12-17 CN CN 02147862 patent/CN1201777C/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103417630A (en) * | 2012-05-16 | 2013-12-04 | 中国人民解放军第二军医大学 | Extract of litsea citrata root and applications thereof |
| CN103417630B (en) * | 2012-05-16 | 2015-05-20 | 中国人民解放军第二军医大学 | Extract of litsea citrata root and applications thereof |
| CN105475373A (en) * | 2015-11-06 | 2016-04-13 | 台州学院 | Preparation method for neolitsea-sericea-essential-oil miticide |
| CN107468571A (en) * | 2017-08-25 | 2017-12-15 | 广西和桂集团有限公司 | Shampoo containing Chinese herbal medicines and preparation method thereof |
| CN107982104A (en) * | 2017-12-20 | 2018-05-04 | 佛山市洛克威特科技有限公司 | A kind of anti-dandruff conditioner shampoo |
| CN109985090A (en) * | 2017-12-29 | 2019-07-09 | 瑞普（天津）生物药业有限公司 | A kind of Compound Resisting vermin composition and preparation method thereof |
| CN108403536A (en) * | 2018-06-11 | 2018-08-17 | 广州三亮科技有限公司 | Pet shower cream and preparation method thereof |
| CN109893619A (en) * | 2019-04-16 | 2019-06-18 | 钟桂寿 | A kind of Chinese medicine composition for treating parasite of human |
| CN111494461A (en) * | 2020-04-26 | 2020-08-07 | 咸阳职业技术学院 | Nanoemulsion for preventing and treating canine skin diseases and preparation method thereof |
| CN111991445A (en) * | 2020-09-21 | 2020-11-27 | 莫兆钦 | Application and preparation of traditional Chinese medicine preparation for treating cardiovascular and cerebrovascular diseases by external treatment of internal diseases |
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| CN1201777C (en) | 2005-05-18 |
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