CN103860394B - A kind of long-acting mosquitos and flies repellent spray liniment of animal specific and preparation method thereof - Google Patents
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific and preparation method thereof Download PDFInfo
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- CN103860394B CN103860394B CN201210549672.9A CN201210549672A CN103860394B CN 103860394 B CN103860394 B CN 103860394B CN 201210549672 A CN201210549672 A CN 201210549672A CN 103860394 B CN103860394 B CN 103860394B
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Abstract
The invention discloses long-acting mosquitos and flies repellent spray liniment of a kind of animal specific and preparation method thereof, the spray liniment is made up in proportion of Metadelphene, camphor, menthol, eugenol, Permethrin, high molecular polymer, water-soluble organic solvent, its step：1st, water-soluble organic solvent is measured in container, the high molecular polymer weighed is dissolved in water-soluble organic solvent, is stirred, is filtered standby；2nd, camphor, menthol are weighed, is dissolved in 1 step, stirring to camphor, menthol dissolve；3rd, measure Permethrin to be dissolved in 2 step solution, stir；4th, measure eugenol to be dissolved in 3 step solution, stir；5th, measure Metadelphene to be dissolved in 4 step solution, stir；6th, water-soluble organic solvent is added, is stirred, it is filling into container, obtain spray liniment.Easy to operate, evident in efficacy, formula is reasonable, and effect is rapid and lasting.
Description
Technical field
The present invention relates to animal medicine, cultivation field, a kind of long-acting mosquitos and flies repellent spray liniment of animal specific is more particularly to,
Also relate to a kind of preparation method of the long-acting mosquitos and flies repellent spray liniment of animal specific, it is adaptable to reduce hematophagus and domestic animal is made
Into mechanical damage and reduction the insect-borne diseases incidence of disease effective means, auxiliary treatment allergic dermatitis.
Background technology
With Global Temperature raise and natural environment change, the distribution of hematophagus expands, density rise, to herding
The harm that area and domestic animal are caused is increasing.Domestic animal body surface protection is carried out using long-acting mosquitos and flies repellent spray liniment, is to reduce to suck blood
Insect causes the effective means of mechanical damage and the reduction insect-borne diseases incidence of disease to domestic animal.Mosquito is one of important vector, its body
It is interior to carry a variety of pathogenic microorganisms, seriously endanger animal health.Metadelphene (DEET) is widely used insect repellant in the world
Agent, applicating history is up to more than 50 years.Facts have proved Metadelphene is maximally effective wide spectrum repellant.However, mosquito repellent in the market
The actual repelling effect of product typically only 5-6h, it is impossible to which prolonged effectively mosquito repellent protection is provided.In recent years, countries in the world
Government and academia increasingly pay attention to animal welfare, then animal it is mosquito-proof whether our scopes that should considerConsider
To the domestic also repellant without animal specific so far, the mosquito-repellent perfume cost of commercialization is bought and too high, but also not
Preferable effect can be reached, so the research and development application of the sustained release novel form of animal specific repellant is very necessary.We utilize
The suction-operated of high molecular polymer, develops the sustained release spray liniment of Metadelphene.Laboratory repellency test shows, the animal being developed into
Long-acting special mosquitos and flies repellent spray liniment has the features such as duration length, repellent effect are good.
The content of the invention
The purpose of the present invention is to be the provision of a kind of long-acting mosquitos and flies repellent spray liniment of animal specific, and the present invention uses peace
Entirely, easy to operate, evident in efficacy, formula is reasonable, and effect is rapid and lasting.Summer and autumn mosquitos and flies harasses serious pastoral area, cultivation
Field receives good repellent effect using this product.In addition, containing anti-inflammation, antipruritic compositions such as camphor, menthols in this formula,
Have to allergic dermatitis and suppress well and auxiliary therapeutic action.
Another object of the present invention is a kind of preparation for the long-acting mosquitos and flies repellent spray liniment for being the provision of animal specific
Method, easy to implement the method, easy to operate, the spray liniment stable homogeneous of preparation, fragrant odour, it is refrigerant comfortable and to the skin of animal without
Excitant, to a variety of hematophagus repellent effects significantly, and convenient with application, it is adaptable to the characteristics of many animals.
In order to realize the purpose of the present invention, the present invention uses following technical measures:
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up of the raw material of following weight parts：
Described water-soluble organic solvent is the one of which in alcohol, tetrahydrofuran；
A kind of described high molecular polymer is its in sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol
Middle one kind.
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up (preferred scope) of the raw material of following weight parts：
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up (preferable scope) of the raw material of following weight parts：
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up (best scope) of the raw material of following weight parts：
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up (optimum value) of the raw material of following weight parts：
A kind of preparation method of the long-acting mosquitos and flies repellent spray liniment of animal specific, its step is：
A. the water-soluble organic solvent of 50 ~ 80 parts by weight is measured in container, by the height of 0.2 ~ 6 parts by weight weighed
Molecularly Imprinted Polymer is dissolved in the water-soluble organic solvent of the above, stir, filter after it is standby；
B. 0.1 ~ 0.5 parts by weight camphor, 0.1 ~ 0.7 parts by weight menthol are weighed, is dissolved in a steps, stirring to camphor, thin
The state that lotus brain is completely dissolved；
C. the Permethrin for measuring 0.2 ~ 3 parts by weight is dissolved in above b step solution, is stirred；
D. the eugenol for measuring 0.5 ~ 5 parts by weight is dissolved in step c solution, stirring；
E. the Metadelphene for measuring 10 ~ 25 parts by weight is dissolved in above Step d solution, is stirred；
F. water-soluble organic solvent of certain part by weight is added, is stirred, it is filling into container, obtain a kind of
The long-acting mosquitos and flies repellent spray liniment of animal specific；F solution is dispensed into small watering can before clinical practice.
The effect of primary raw material in the present invention：
Metadelphene has as a kind of active ingredient of broad spectrum insect repellent to a variety of hematophaguses under various environment
Repellent action, can drive thorn fly, midge, black fly, trombiculid, deerfly, flea, buffalo gnat, horse botfly, mosquito, sand fly, small winged insect, stable fly and flat
Lice, is generally acknowledged best repellant, is used as the standard of repellant.Metadelphene used for thousands of people, and it is gone through
History exceeded 50 years, and annual Metadelphene has used more than 200,000,000 person-times.
Effect of camphor：Orifice opening；Qi stagnation removing；Ward off foul；Desinsection is antipruritic；Swelling and pain relieving, camphorated oil has analgesia, antipruritic
Effect.
Effect of menthol：Outer put on the skin at pruitus has antipruritic, analgesic, anti-corrosion, stimulation, anesthesia, refrigerant and anti-inflammatory to make
With often being shared with camphor, to strengthen antipruritic effect.
Eugenol：With very strong sterilizing power, as Bangesic, and local antisepsis is had concurrently；Available for perfume
Essence and various cosmetic essences and fragrance for detergents formula.
Permethrin：Have it is stronger tag and stomach poison function, with knocking down, power is strong, the fireballing feature of desinsection.It is more steady to light
It is fixed, it is also relatively slow to pest resistance development under equal use condition, it is efficient to lepidopterous larvae.To mosquito, fly, flea, roach
The sanitary insect pests such as dung beetle, louse also have good effect.
High molecular polymer used：There are colloid protective effect, film forming, caking property, hygroscopicity, solubilising or cohesion to make
With but its is most characteristic, thus paid attention to by people is its excellent solubility property and physiological compatibility, tasteless, odorless, several
It is nontoxic, it is non-stimulated to skin and eye, it is only quick to skin, it is safe in a physiologically.Its solubilization, is used for
The water solubility of some materials for being substantially insoluble in water and having pharmacological activity of increase；Peptizaiton, can make coloring matter in solution,
Suspension, emulsion dispersion are uniform and keep stable；Suction-operated, adsorbs at many interfaces and reduces interface table to a certain extent
Face tension force, plays a part of sustained release.
The present invention compared with prior art, with advantages below and effect：
1st, the applicable object of this product is animal, is the hematophagus repellant of animal specific, has no on the market at present similar
Commodity selling；
2nd, the present invention was compared with conventional mosquito-repellent perfume, and effective repellent time is longer, up to more than 12 hours, it is ensured that dynamic
Thing is harassed from mosquitos and flies；
3rd, present invention application is convenient, need to only be fitted into this product in small watering can, even application all may be used in animal body surface；
4th, camphor, menthol are added in the present invention, animal body surface is sprayed onto, has the effect of refrigerant, antipruritic, animal is easy to connect
By.
Embodiment
The present invention is described in further detail with reference to embodiments, but not limitation of the present invention, it is all according to
The equivalent substitution of any this area that the disclosure of invention is made, belongs to protection scope of the present invention.
Embodiment 1:
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up of the raw material of following weight parts：
A kind of preparation method of the long-acting mosquitos and flies repellent spray liniment of animal specific, its step is：
A, the water-soluble organic solvent of certain part by weight is measured in container, by the high score of the certain part by weight weighed
Sub- polymer is dissolved in the water-soluble organic solvent of the above, stir, filter after it is standby；
B, the camphor for weighing certain part by weight, the menthol of certain part by weight, are dissolved in a steps, stirring to camphor, peppermint
The state that brain is completely dissolved；
C, the Permethrin for measuring certain part by weight are dissolved in above b step solution, are stirred；
D, the eugenol for measuring certain part by weight are dissolved in step c solution, stirring；
E, the Metadelphene for measuring certain part by weight are dissolved in above Step d solution, are stirred；
F, the water-soluble organic solvent for adding certain part by weight, stir, filling into container, obtain a kind of
The long-acting mosquitos and flies repellent spray liniment of animal specific；The present invention verifies that effect is gratifying through zoopery：
Embodiment 2-7：
A kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up of the raw material of following weight parts：
Its preparation process is same as Example 1.
In August, 2012, certain yak group, because mosquitos and flies of sucking blood is too many, seriously harasses yak, and there being consumption ox when light hides, kicks and kick, get rid of
The reaction such as tail, even causing seriously is bolted, and is influenceed its feeding, is fattened, more even influences growing and productivity for ox
Can, huge economic loss is caused to Animal husbandry production.We learn this afterwards, have chosen 6 yaks and are coated before herding
After the present invention, spraying ox only without it is terrified, dodge, lick and the uncomfortable reaction such as lick.When herding, we, which observe ox, quiet to search for food,
From mosquitos and flies harassing and wrecking, and the cows for not spraying the present invention are still as usual, shake the head, whipping, kick and kick or even bolt, serious shadow
Feeding is rung.
In August, 2012, certain ox environment is poor, and fly is horizontal to fly, and is seen everywhere.The portions such as Niu Jing, the back of the body, chest, abdomen and four limbs
Position stops falling a large amount of flies, averagely has 28 flies to stop falling in ox body surface, has 48 flies while falling within ox when at dusk at most
Body surface, ox only does not stop to drive fly, has had a strong impact on feeding and has rested.We first have chosen 2 ox spraying present invention, 1 ox
Spraying distilled water was compareed, every 8 hours, is calculated ox body surface in 1 minute and is stopped falling the sum of fly.Result of the test is as follows：Spraying
Two ox 0 of the present invention, observe after 8,16,24 hours, average body surface fly sum is 30,2,4,5, and the ox of control group
Only 0,8,16, observed after 24 hours, average body surface fly sum is 28,26,25,27.Illustrate that the present invention is walked quickly and kept away to fly
Effect, effective repellent time was up to more than 12 hours.
In September, 2012, certain stud-farm skin disease is popular, it is reported that, the disease annual late spring occurs, and summer and autumn are serious, winter
Disappear, just being dispersed in property papule occurs to disease in affected part, and followed by due to affected part itching, sick horse bites or dawdled with strength, causes local hair
Fall light, fester, ooze out, finally knot is silly comes off, and leaves bald hair spot.The case of especially severe, bald hair spot can be merged in flakes；Animal doctor examines
Break as allergic dermatitis, the sick arch-criminal is the Storehouse midge and mosquito sucked blood.We have chosen 4 wherein serious dry goods and coat
Horses react without discomfort after the present invention, spraying, quiet vertical rest or peace and quiet can be pastured against mosquito midges bite.Adhere to spray daily
Apply, with reference to partial smearing PINGYANPING RUANGAO, after one week, affected part starts incrustation, scurf increases, drops to and gradually grows virgin wool, it
Skin disease never has recurrence afterwards, and horses can quietly rest in stable.Without spraying other horses of the present invention then
Show as getting rid of head again and again, wagging the tail, plane the ground etc. driveing action, seriously then rub wall, agree to sting.By this example, further illustrate
The present invention has good avoidance effect to hematophaguses such as mosquito, midges, but also can prevent and auxiliary treatment allergic dermatitis, fits
For many animals.
Claims (10)
1. a kind of long-acting mosquitos and flies repellent spray liniment of animal specific, it is made up of the raw material of following weight parts：
Described high molecular polymer is the one of which in sodium carboxymethylcellulose, polyvinylpyrrolidone, polyvinyl alcohol.
2. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
3. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
4. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
5. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
6. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
7. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
8. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
9. the long-acting mosquitos and flies repellent spray liniment of a kind of animal specific described in claim 1, it is characterised in that：
10. a kind of preparation method of the long-acting mosquitos and flies repellent spray liniment of animal specific as claimed in claim 1, its step is：
A, tetrahydrofuran is measured in container, the high molecular polymer weighed is dissolved in above tetrahydrofuran, stir,
It is standby after filtering；
B, camphor, menthol are weighed, be dissolved in step A solution, stirring to camphor, menthol dissolve；
C, measure Permethrin and be dissolved in step B solution, stir；
D, measure eugenol and be dissolved in step C solution, stir；
E, measure Metadelphene and be dissolved in D step solution, stir；
F, tetrahydrofuran is added, stirred, it is filling into container, obtain a kind of long-acting mosquitos and flies repellent spraying of animal specific
Agent.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210549672.9A CN103860394B (en) | 2012-12-17 | 2012-12-17 | A kind of long-acting mosquitos and flies repellent spray liniment of animal specific and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210549672.9A CN103860394B (en) | 2012-12-17 | 2012-12-17 | A kind of long-acting mosquitos and flies repellent spray liniment of animal specific and preparation method thereof |
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| CN103860394A CN103860394A (en) | 2014-06-18 |
| CN103860394B true CN103860394B (en) | 2017-09-05 |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104872202A (en) * | 2015-05-08 | 2015-09-02 | 滕腾 | Domestic environment-friendly insecticide |
| CN106265290A (en) * | 2016-08-31 | 2017-01-04 | 何宗彦 | Multifunctional mosquito-proof coating material and the method preventing mosquito bite |
| CN110897917B (en) * | 2019-12-31 | 2023-09-15 | 河南安进生物技术股份有限公司 | Long-acting mosquito repellent of mosquito repellent ester and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088731A (en) * | 1992-12-30 | 1994-07-06 | 杨之明 | Multi-effect mosquito repellent |
| CN1237347A (en) * | 1998-05-28 | 1999-12-08 | 华健医药科技股份有限公司 | Composite for expelling mosquito and paster made of said composite |
| CN101926746A (en) * | 2010-08-25 | 2010-12-29 | 邱日辉 | Polymer controlled release long-acting mosquito repellent product and preparation method thereof |
-
2012
- 2012-12-17 CN CN201210549672.9A patent/CN103860394B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1088731A (en) * | 1992-12-30 | 1994-07-06 | 杨之明 | Multi-effect mosquito repellent |
| CN1237347A (en) * | 1998-05-28 | 1999-12-08 | 华健医药科技股份有限公司 | Composite for expelling mosquito and paster made of said composite |
| CN101926746A (en) * | 2010-08-25 | 2010-12-29 | 邱日辉 | Polymer controlled release long-acting mosquito repellent product and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 蚊虫驱避剂的研究概况;吴刚等;《寄生虫与医学昆虫学报》;20041231;第11卷(第4期);第253-256页 * |
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Effective date of registration: 20170731 Address after: 430070 Wuhan, Hongshan Province, lion street, No. 1 District, No. Applicant after: Huazhong Agricultural University Applicant after: Tibet Agricultural and Animal Husbandry College Address before: 430070 Wuhan, Hongshan Province, lion street, No. 1 District, No. Applicant before: Huazhong Agricultural University |
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