CN101297650A - Agent for preventing and controlling ectoparasite of animals - Google Patents
Agent for preventing and controlling ectoparasite of animals Download PDFInfo
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- CN101297650A CN101297650A CNA2008101501986A CN200810150198A CN101297650A CN 101297650 A CN101297650 A CN 101297650A CN A2008101501986 A CNA2008101501986 A CN A2008101501986A CN 200810150198 A CN200810150198 A CN 200810150198A CN 101297650 A CN101297650 A CN 101297650A
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Abstract
The invention discloses an animal external parasite control agent in emulsifiable solution or water emulsion form, which is prepared by that rotenone and avermectin are used as effective constituents, solvent and surface active agent, etc. are added and the obtained mixture is mixed evenly; the control agent can be made into the emulsifiable solution or the water emulsion, and when in use, water is added so as to form latex used for controlling various parasites such as tick, acarid and lice, etc. which are lived on the body surface of animals such as pigs, cattle, sheep and rabbits, etc. The control agent is formed by biogenic active substances; due to the way of degradation in the environment, the control agent has no influence to the environment after using, and the animal external parasite is not easy to generate resistance to drugs; by adopting processing means of pesticide preparations, the control agent has reasonable preparation formulation and convenient use, high killing rate for the animal external parasite, little influence to the animals, safety and is a non-pollution animal external parasite control agent.
Description
Technical field
The invention belongs to a kind of desinsection, insect-proof agent in the livestock breeding animal, relate to a kind of control agent, particularly a kind of animal body agent for preventing and controlling ectoparasite.
Background technology
Ecotozoa mainly comprises monoids such as mite, tick and lice.Mite, tick and lice of a great variety, widely distributed, very serious to animal is very big to the animal husbandry economy influence.
Mite can endanger ox, sheep, pig, horse, dog, rabbit, fowl and many wildlifes, the positions such as skin, feather and air bag that it parasitizes animal can cause that the animal play itches, illnesss such as depilation and pachyderma, by the animal of mite parasitism, show as and become thin, dysphoria, can not normally take food and rest.Mite also secretes a large amount of toxin in parasitic processes, the digestion and absorption function of animal and the defence capability of body are reduced, and animal skin be full of cracks, hemorrhage secondary infection finally cause death when serious.The mite class can cause multiple infectious disease, and as propagating Richettsia, virus and bacteriosis, mite still is the intermediate host of Anoplocephalidae tapeworm.
Tick claims flat lice or ox louse again, is the epizoa that most of terrestrial vertebrates can both obligate be sucked blood.Comprise three sections: hard tick section, soft ticks section and receive tick section, wherein the most common, harm is hard tick section to the maximum.Tick is sucked host's blood, can cause animal uneasiness, anaemia when a large amount of parasitic, become thin, depauperation, the fur quality reduces and milk production under degradation.And also secrete a kind of neurotoxin in the process of sucking blood, the secondary bacterial infection is the disseminate media and the reservoir host of many pathogene.Can cause multiple piroplasmosis and some infectious disease of domestic animal.Lice to the harm of livestock and poultry not as mite, tick is big but volume also can have a strong impact on growing of livestock and poultry when parasitic, reduces its productivity.
Another kind of epizoa lice, though the harm of livestock and poultry is not had tick, mite is serious, and volume also can have a strong impact on growing of livestock and poultry when parasitic, and when livestock and poultry entered age campaign, a large amount of parasitic of lice can reduce its production capacity.
Because ecotozoa produces influence greatly to livestock breeding, harm is serious.So, be important process during livestock breeding is produced to the verminal control of livestock and poultry.At present, ectoparasiticide thing commonly used both at home and abroad mostly is chemicals, wherein a lot of kinds are big to animal toxicity, use the back that feed, the activity of animal are all had considerable influence, and big to the pollution of environment, the livestock products quality there is harmful effect, and long-term the use, epizoa has produced resistance to various medicaments wherein, suddenly waits to develop the agent for preventing and controlling ectoparasite of efficient, low toxicity, low-residual, solves the ectozoic difficult problem of preventing and treating in the livestock breeding.
Summary of the invention
The objective of the invention is to, provide a kind of height is imitated in insect protected, little to animal toxicity, the agent for preventing and controlling ectoparasite of animals of the missible oil of environmentally safe or aqueous emulsion form.
The present invention to the epizoa activity research, filters out plant resource material rotenone by multiple biogenic active substance, these two kinds of reactive compounds of microbial source material Avermectin, studies show that, these two kinds of materials are to epizoa preventive effect height, and are little to animal toxicity, environmentally safe.
Rotenone is a contained active component in trifoliate jewelvine, the Baptisia plant, is used for the control of plant insect and mite more, and the report of application is not also arranged in preventing and controlling ectoparasite of animals.Avermectin is to be got by microbial fermentation, and they are many in preventing and controlling ectoparasite of animals to use with the hypodermic injection method, because hypodermic injection is big to the animal influence, after the injection Avermectin, just can slaughter after 3 months, so its application is subjected to certain restriction.
Rotenone, the Avermectin compound formulation of this research invention are used the be mixed principle of synergy of Pesticidal products, adopt the preparation processing means, make this compound formulation formulation reasonable, easy to use, use the back that feed, the activity of animal are not all had influence.On conceived sheep body, carry out body surface spray, wipe deeply, conceived sheep has no adverse reaction.Show epizoa is killed efficiently, animal is not had influence, the characteristics that environmental pollution is little.
The technical scheme that the present invention takes is, the agent for preventing and controlling ectoparasite of animals of a kind of missible oil or aqueous emulsion form, it is characterized in that, by rotenone 2.25%～99.0%, Avermectin 1.8%～2%, solvent 50.0%～80.0%, surfactant 5.0%～20.0% is mixed by weight percentage and forms, and the said components summation is 100%.
Converting water when this agent is used becomes emulsion, and spray quinoline or wipe deeply in the infected animal body surface parasitizes the various parasites such as tick, mite, lice of animal body surfaces such as pig, ox, sheep, rabbit with control.
Solvent for use can be water or deionized water or methyl alcohol in the preparation processing, ethanol, propyl alcohol, in the material that ethyl acetate this area is known altogether one or several mixture; Surfactant is a polyoxyethylene nonylphenol ether, or detergent alkylate sulphur phenol calcium, alkyl polyoxyethylene ether phosphate, alkyl polyoxypropylene ether phosphate, wherein one or more mixtures in the speciality that polyoxyethylene nonylphenol ether phosphate, this area are known altogether.
The present invention compares with existing agent for preventing and controlling ectoparasite of animals, and following advantage is arranged:
1. this agent is made up of the biogenic active substance, and the approach of its degraded is arranged in environment, so use the back that environment is not had influence, ecotozoa is difficult for should giving birth to pesticide resistance to it;
2. the pesticidal preparations manufacturing process is adopted in this agent, makes preparation formulation reasonable, and is easy to use;
3. this agent is to ecotozoa kill efficiency height, and little to the animal influence, safety is a kind of non-harmful agent for preventing and controlling ectoparasite of animals.
Four, embodiment
For a more clear understanding of the present invention and the drug effect of medicament of the present invention, below the following embodiment that finishes according to technical solution of the present invention that provides by the inventor the present invention is described in further detail, these only are the present invention embodiment preferably, but are not limited to these embodiment.
Embodiment 1: according to technical scheme of the present invention, take by weighing 15% rotenone (below be weight ratio) 25.0g, and polyoxyethylene nonylphenol ether phosphate 10.0g, calcium dodecyl benzene sulfonate 10.0g is dissolved in above three kinds of materials in the isopropyl alcohol; Take by weighing the 55.0g deionized water in homogenizer, the aqueous isopropanol with materials such as rotenone under high-speed stirred is added dropwise in the homogenizer, promptly makes rotenone water emulsion.
Embodiment 2: according to technical scheme of the present invention, take by weighing 15% rotenone 15.0g, 6.5% Avermectin ointment 3.0g (containing pure Avermectin 1.95%), be dissolved in the 72.0g ethanol, under agitation add the 10.0g OPEO, promptly make rotenone A Wei missible oil.
Certainly, adopt the each component in the percentage by weight of the present invention to prepare, make the missible oil or the aqueous emulsion of series, for different animals, as domestic animals, the external various parasites such as mite, tick and lice of bird prevent and treat all is effective, as the span of rotenone between 0.1%～99.0%, Avermectin is between 0.0%～2%, solvent is between 50.0%～80.0%, surfactant is between 5.0%～20.0%, the example of above-mentioned preparation can be listed various, and the present invention does not enumerate one by one at this.
EXPERIMENTAL EXAMPLE 1: use rotenone water emulsion, rotenone A Wei missible oil has carried out killing the test of haemaphysalis longicornis.Test chorista tickicide and the clinical blood tick of killing are tested.
1.1 experimental animal
Selection Baoji boolean mutton sheep breeding is all raised the boolean mutton sheep of herding naturally in two districts 35 (no lambs) and is tested as the clinical medicine tickicide.Record overbit before the test, and by an infection intensity of statistics body surface tick.
1.2 test method:
The tickicide test method 1.2.1 exsomatize
The plate medicine embrane method is adopted in the tickicide test of exsomatizing.The tick (one-tenth tick) of living is taked from the sheep body in the scene before the test, selects the strong person of vigor to use.Each chemicals treatment with 20 ticks (
), with the exsomatize tickicide test of plate medicine embrane method, other establishes the plate moisture film and organizes in contrast.Every the death condition that 8h observes a tick, record 24h respectively tests the death toll of tick, and calculates its tickicide rate.
1.2.2 the clinical tickicide test of pesticide effectiveness
The clinical rotenone water emulsion of establishing, two processing of rotenone A Wei missible oil.Rotenone water emulsion is diluted to contain rotenone be 0.075%; Rotenone A Wei missible oil is diluted to and contains trifoliate jewelvine 0.0375%.Every drug test group infects sheep with 5 and carries out the body surface spraying.During spraying tick is stung the bigger position spraying of attached density and strengthen, thoughtful to the spraying that chest, abdomen, four limbs inboard etc. are located.With the clear water processed group is contrast.
At random carry out the observation of sheep body tick by experimental group every day after the medication, checks clinical symptoms, observes, writes down the drinking-water, appetite, spirit of sheep etc. simultaneously, judges the safety of sheep after the medication and non-toxic reaction is arranged with this.Till infecting new tick again.
1.2.3 medicament is killed the calculating of rate to tick
72h after the medication by the whole ticks on each experimental group collection sheep body, judges death condition, calculates the kill rate of medicament to tick with following formula.
1.3 result of the test
The tickicide test of pesticide effectiveness 1.3.1 exsomatize
Rotenone water emulsion, the stripped tickicide result of the test of rotenone A Wei missible oil variable concentrations processing etc. sees Table 1.
Two kinds of medicaments of table 1 tickicide result of the test (plate medicine embrane method) that exsomatizes
1.2 test method:
The tickicide test method 1.2.1 exsomatize
The plate medicine embrane method is adopted in the tickicide test of exsomatizing.The tick (one-tenth tick) of living is taked from the sheep body in the scene before the test, selects the strong person of vigor to use.Each chemicals treatment with 20 ticks (
), with the exsomatize tickicide test of plate medicine embrane method, other establishes the plate moisture film and organizes in contrast.Every the death condition that 8h observes a tick, record 24h respectively tests the death toll of tick, and calculates its tickicide rate.
1.2.2 the clinical tickicide test of pesticide effectiveness
The clinical rotenone water emulsion of establishing, two processing of rotenone A Wei missible oil.Rotenone water emulsion is diluted to contain rotenone be 0.075%; Rotenone A Wei missible oil is diluted to and contains trifoliate jewelvine 0.0375%.Every drug test group infects sheep with 5 and carries out the body surface spraying.During spraying tick is stung the bigger position spraying of attached density and strengthen, thoughtful to the spraying that chest, abdomen, four limbs inboard etc. are located.With the clear water processed group is contrast.
At random carry out the observation of sheep body tick by experimental group every day after the medication, checks clinical symptoms, observes, writes down the drinking-water, appetite, spirit of sheep etc. simultaneously, judges the safety of sheep after the medication and non-toxic reaction is arranged with this.Till infecting new tick again.
1.2.3 medicament is killed the calculating of rate to tick
72h after the medication by the whole ticks on each experimental group collection sheep body, judges death condition, calculates the kill rate of medicament to tick with following formula.
1.3 result of the test
The tickicide test of pesticide effectiveness 1.3.1 exsomatize
Rotenone water emulsion, the stripped tickicide result of the test of rotenone A Wei missible oil variable concentrations processing etc. sees Table 1.
Two kinds of medicaments of table 1 tickicide result of the test (plate medicine embrane method) that exsomatizes
Pig outer (one 8 age boar, one 24 the monthly age farrowing sow) all the other two treatment groups be one 24 the monthly age boar.
2.3 experimental implementation
Except that control group, every group of pig medication secondary, it is spaced apart 7 days.Rotenone water emulsion treatment group: medicine is sprayed on the pig surface by 1: 1000 dilution back with watering can, embrocates evenly with shoe brush simultaneously, do not stay the dead angle; Rotenone A Wei missible oil treatment group: the medicine for preparing is sprayed on the pig surface by 1: 1000 dilution back with watering can, embrocates evenly with shoe brush simultaneously, do not stay the dead angle; The 3rd group: do not do any processing.Pig after the medication only all divides circle to raise, and regularly to pig symptom only, record is observed and carried out in clinical manifestation.
2.4 the pig body kills the mite result of the test
2.4.1 the clinical manifestation before the medication
The hard of hearing portion of pig of the suffering from psoroptic mange thick crust of 1cm of having an appointment, skin is full split hemorrhage, the coarse hardening of touching, there is the canescence crust head, eye, cheek, there are a large amount of white crusts at the back, some is full split hemorrhage, the coarse hardening of touching, trunk both sides canescence crust, rubefaction, there is the canescence crust four limbs and oxter, and there is the big bronzing scab of grain of rice piece two forelimbs and oxter, about the about 2mm of thickness, that touches is hard slightly.The pars affecta skin dorsal body setae comes off, and the pig gargalesthesia is violent, rubs on the circle wall every now and then, rubs forelimb and oxter with hind leg sometimes, and sick pig becomes thin, spirit difference and irritated.
2.4.2 the clinical manifestation after the medication
After medication the 7th day, respectively medication group pig is gathered pathological material of disease, put into plate separately after the numbering, add a cover, put into 40 ℃ of water-bath 3Omin after, examining under a microscope does not all have mite alive and climbs out of.Each medication group pig back crust begins to soften, crust around the pig ear of rotenone A Wei preparation group comes off, back some places crust also comes off, ear middle part scab piece is dry and cracked, stopped bleeding and incrustation, and medication group pig is obviously than quiet before the medication, and control group pig back canescence crust obviously thickens, and the some places be full of cracks is hemorrhage serious, and ear's crust thickens, and the oxter crust thickens.After medication the 14th day, the rotenone water emulsion group had a little crust except that the ear middle part of pig, and all the other all come off, and expose pink skin.After medication the 21st day, rotenone water emulsion and the complete obiteration of rotenone A Wei preparation group Sarcoptes suis disease symptoms, affected part grows virgin wool, and the pig state of mind is good.Control group pig crust is thicker, and the skin be full of cracks is hemorrhage serious, and the gargalesthesia aggravation is become thin, and the pig state of mind is very poor.
Experimental example 3: medicament is killed the test of rabbit mite
3.1 experimental animal:
The common rabbit (part is bought healthy rabbits and duplicated case with artificial infection's method from the fairground, a part is directly purchased the rabbit that suffers from acariasis) that suffers from acariasis.Every rabbit all inoculates rabbit Pasteurella, rabbit pest, clostridieum welchii triple vaccine before testing.
3.2 test operation
Rotenone water emulsion (1000 accompany dilution), rotenone A Wei preparation (1500 accompany dilution) and clear water contrast are established in test.Except that control group, medicine was wiped 3 days continuously, guaranteed not stay the dead angle every day 1 time at every turn, and the affected part crust is left intact when handle handling, and three groups of rabbit groupings are raised after the medication, after the medication to rabbit symptom, clinical manifestation observe, record.
2.3 the rabbit body kills the mite result of the test
2.3.1 clinical manifestation and symptom before the medication
The rabbit fore paw of suffering from chorioptic mange is come off by hair, and nail is exposed, and preceding claw covers the linen thick scab of one deck, touches hardly, and rabbit has the action of shaking claw frequently; Forming a scab fully, harden in the hind leg landing part, is come off by hair, has when rabbit reposes and do not stop the performance that the change of feet lands, and around the nose of rabbit, the lip tangible incrustation arranged all, and the action of shaking forelimb is arranged.
Suffer from the rabbit of otoacariasis, show as the yellow-white crust that has filled up numb pattern in the duct, ear is sagging, and the performance of shaking the head is arranged frequently, and hard of hearing blood vessel is obviously congested.
Suffer from chorioptic mange and the rabbit that suffers from otoacariasis all show spirit depressed, become thin, search for food, having a rest is greatly affected.
2.3.2 clinical manifestation after the medication and symptom
After medication the 7th day, respectively each group rabbit is gathered pathological material of disease, the plate of putting into after the numbering is separately added a cover, put into 40 ℃ of water-bath 30min after, examining under a microscope does not all have mite alive and climbs out of.The crust that examination is respectively organized on the rabbit four limbs is obviously softening, and the crust around the rabbit lip of chemicals treatment group comes off, and crust is dry and cracked in the external auditory meatus, respectively organizes rabbit simultaneously obviously than quiet before the medication, and feed intake also increases to some extent.Linen crust obviously thickens around the control group rabbit lip, and front foot is come off fully by hair, and numb pattern yellowish-brown crust thickens in the ear.
After medication the 14th day, the symptom of chemicals treatment group was similar to the 7th day, and rabbit limb portion only leaves the crust of pin front portion, and the remainder crust all comes off, and forelimb is similar to hind leg.Control group rabbit spirit is depressed, poor appetite, ear and the foot symptom is bright increases the weight of.
After medication the 14th day, the symptom complete obiteration of rotenone water emulsion (1000 accompany dilution), rotenone A Wei preparation (1500 accompany dilution) processed group rabbit acariasis.Affected part has grown virgin wool, and ear is upright.This moment, the control group rabbit was only surplus 1.This rabbit skeletonize, appetite is useless exhausted, in 24h death.The control group rabbit is after death cutd open inspection and is not all found obvious pathological change, rabbit stomach inanition.
Prove by above test examples, agent for preventing and controlling ectoparasite of animals of the present invention, to ecotozoa kill efficiency height, little to the animal influence, safety is a kind of non-harmful agent for preventing and controlling ectoparasite of animals.
Claims (3)
1. the agent for preventing and controlling ectoparasite of animals of missible oil or aqueous emulsion form, it is characterized in that, this parasite control agent is mixed by following compositions in weight percentage and forms: rotenone 2.25%～99.0%, Avermectin 1.8%～2%, solvent 50.0%～80.0%, surfactant 5.0%～20.0%, said components summation are 100%.
2. agent for preventing and controlling ectoparasite of animals as claimed in claim 1 is characterized in that, described solvent be in the vehicle substance known altogether of water, deionized water, methyl alcohol, ethanol, propyl alcohol, ethyl acetate, this area one or several mixture.
3. agent for preventing and controlling ectoparasite of animals as claimed in claim 1, it is characterized in that, described surfactant be in the surfactant materials known altogether of polyoxyethylene nonylphenol ether or detergent alkylate sulphur phenol calcium or alkyl polyoxyethylene ether phosphate or alkyl polyoxypropylene ether phosphate or polyoxyethylene nonylphenol ether phosphate or this area one or several mixture.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101501986A CN101297650A (en) | 2008-06-30 | 2008-06-30 | Agent for preventing and controlling ectoparasite of animals |
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| Application Number | Priority Date | Filing Date | Title |
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| CNA2008101501986A CN101297650A (en) | 2008-06-30 | 2008-06-30 | Agent for preventing and controlling ectoparasite of animals |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657712A (en) * | 2012-05-30 | 2012-09-12 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method for adonis coerulea maxim extract and application thereof |
| CN107227641A (en) * | 2017-07-21 | 2017-10-03 | 广州市鸿嘉鞋业有限公司 | The preparation method of light blue cladding modelled after an antique |
| CN108096564A (en) * | 2017-12-29 | 2018-06-01 | 塔里木大学 | A kind of externally applied drug for preventing livestock and poultry vermin |
| CN109223857A (en) * | 2018-11-23 | 2019-01-18 | 句容市茅山风景区鼎源畜禽养殖场 | A kind of knob raising goat preventing and treating verminosis medicament and preparation method thereof |
-
2008
- 2008-06-30 CN CNA2008101501986A patent/CN101297650A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102657712A (en) * | 2012-05-30 | 2012-09-12 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method for adonis coerulea maxim extract and application thereof |
| CN107227641A (en) * | 2017-07-21 | 2017-10-03 | 广州市鸿嘉鞋业有限公司 | The preparation method of light blue cladding modelled after an antique |
| CN108096564A (en) * | 2017-12-29 | 2018-06-01 | 塔里木大学 | A kind of externally applied drug for preventing livestock and poultry vermin |
| CN109223857A (en) * | 2018-11-23 | 2019-01-18 | 句容市茅山风景区鼎源畜禽养殖场 | A kind of knob raising goat preventing and treating verminosis medicament and preparation method thereof |
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Open date: 20081105 |