CN1401237A - Animal ectoparasite preventing and treating agent - Google Patents
Animal ectoparasite preventing and treating agent Download PDFInfo
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- CN1401237A CN1401237A CN 02139332 CN02139332A CN1401237A CN 1401237 A CN1401237 A CN 1401237A CN 02139332 CN02139332 CN 02139332 CN 02139332 A CN02139332 A CN 02139332A CN 1401237 A CN1401237 A CN 1401237A
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention discloses an animal ectoparasite preventing and treating agent, which is prepared by taking rotenone and abamectin as effective components, adding a solvent, a surfactant and the like, and mixing the components. The agent is composed of biogenic active substances, and has a degradation way in the environment, so the agent has no influence on the environment after being used, and animal ectoparasites are not easy to generate drug resistance to the animal ectoparasites; the pesticide preparation processing means is adopted, so that the preparation is reasonable in dosage form and convenient to use; has high efficiency of killing animal ectoparasites, has little influence on animals, is safe, and is a pollution-free animal ectoparasite control agent.
Description
One, affiliated field
The invention belongs to a kind of desinsection, insect-proof agent in the livestock breeding animal, relate to a kind of control agent, particularly a kind of animal body agent for preventing and controlling ectoparasite.
Two, background technology
Ecotozoa mainly comprises monoids such as mite, tick and lice.Mite, tick and lice of a great variety, widely distributed, very serious to animal is very big to the animal husbandry economy influence.
Mite can endanger ox, sheep, pig, horse, dog, rabbit, fowl and many wildlifes, the positions such as skin, feather and air bag that it parasitizes animal can cause that the animal play itches, illnesss such as depilation and pachyderma, by the animal of mite parasitism, show as and become thin, dysphoria, can not normally take food and rest.Mite also secretes a large amount of toxin in parasitic processes, the digestion and absorption function of animal and the defence capability of body are reduced, and animal skin be full of cracks, hemorrhage secondary infection finally cause death when serious.The mite class can cause multiple infectious disease, and as propagating Richettsia, virus and bacteriosis, mite still is the intermediate host of Anoplocephalidae tapeworm.
Tick claims flat lice or ox louse again, is the epizoa that most of terrestrial vertebrates can both obligate be sucked blood.Comprise three sections: hard tick section, soft ticks section and receive tick section, wherein the most common, harm is hard tick section to the maximum.Tick is sucked host's blood, can cause animal uneasiness, anaemia when a large amount of parasitic, become thin, depauperation, the fur quality reduces and milk production under degradation.And also secrete a kind of neurotoxin in the process of sucking blood, the secondary bacterial infection is the disseminate media and the reservoir host of many pathogene.Can cause multiple piroplasmosis and some infectious disease of domestic animal.Lice to the harm of livestock and poultry not as mite, tick is big but volume also can have a strong impact on growing of livestock and poultry when parasitic, reduces its productivity.
Another kind of epizoa lice, though the harm of livestock and poultry is not had tick, mite is serious, and volume also can have a strong impact on growing of livestock and poultry when parasitic, and when livestock and poultry entered age campaign, a large amount of parasitic of lice can reduce its production capacity.
Because ecotozoa produces influence greatly to livestock breeding, harm is serious.So, be important process during livestock breeding is produced to the verminal control of livestock and poultry.At present, ectoparasiticide thing commonly used both at home and abroad mostly is chemicals, wherein a lot of kinds are big to animal toxicity, use the back that feed, the activity of animal are all had considerable influence, and big to the pollution of environment, the livestock products quality there is harmful effect, and long-term the use, epizoa has produced resistance to various medicaments wherein, suddenly waits to develop the agent for preventing and controlling ectoparasite of efficient, low toxicity, low-residual, solves the ectozoic difficult problem of preventing and treating in the livestock breeding.
Three, summary of the invention
The objective of the invention is to, provide a kind of height is imitated in insect protected, little to animal toxicity, the agent for preventing and controlling ectoparasite of animals of environmentally safe.
The present invention to the epizoa activity research, filters out plant resource material rotenone by multiple biogenic active substance, these two kinds of reactive compounds of microbial source material Avermectin, studies show that, these two kinds of materials are to epizoa preventive effect height, and are little to animal toxicity, environmentally safe.
Rotenone is a contained active component in trifoliate jewelvine, the Baptisia plant, is used for the control of plant insect and mite more, and the report of application is not also arranged in preventing and controlling ectoparasite of animals.Avermectin is to be got by microbial fermentation, and they are many in preventing and controlling ectoparasite of animals to use with the hypodermic injection method, because hypodermic injection is big to the animal influence, after the injection Avermectin, just can slaughter after 3 months, so its application is subjected to certain restriction.
Rotenone, the Avermectin compound formulation of this research invention are used the be mixed principle of synergy of Pesticidal products, adopt the preparation processing means, make this compound formulation formulation reasonable, easy to use, use the back that feed, the activity of animal are not all had influence.On conceived sheep body, carry out body surface spray, wipe deeply, conceived sheep has no adverse reaction.Show epizoa is killed efficiently, animal is not had influence, the characteristics that environmental pollution is little.
The technical scheme that the present invention takes is: this agent for preventing and controlling ectoparasite of animals, be characterized in, and be effective ingredient with rotenone, Avermectin, add solvent, materials such as surfactant are mixed and form, and the percentage by weight of each component is:
Rotenone 0.1%～99.0%
Avermectin 0.0～2.0%
Solvent 50.0%～80.0%
Surfactant 5.0%～20.0%
This agent can be made into missible oil or aqueous emulsion, and converting water during use becomes emulsion, and spray quinoline or wipe deeply in the infected animal body surface parasitizes the various parasites such as tick, mite, lice of animal body surfaces such as pig, ox, sheep, rabbit with control.
Solvent for use can be water or deionized water or methyl alcohol in the preparation processing, or ethanol, or propyl alcohol, or one or more mixtures in the material known altogether of ethyl acetate or this area staff; Surfactant is a polyoxyethylene nonylphenol ether, or detergent alkylate sulphur phenol calcium, or the alkyl polyoxyethylene ether phosphate, or alkyl polyoxypropylene ether phosphate, or one or more mixtures in the speciality known altogether of polyoxyethylene nonylphenol ether phosphate or this area staff.
The present invention compares with existing agent for preventing and controlling ectoparasite of animals, and following advantage is arranged:
1. this agent is made up of the biogenic active substance, and the approach of its degraded is arranged in environment, so use the back that environment is not had influence, ecotozoa is difficult for should giving birth to pesticide resistance to it;
2. the pesticidal preparations manufacturing process is adopted in this agent, makes preparation formulation reasonable, and is easy to use;
3. this agent is to ecotozoa kill efficiency height, and little to the animal influence, safety is a kind of non-harmful agent for preventing and controlling ectoparasite of animals.
Four, embodiment
For a more clear understanding of the present invention and the drug effect of medicament of the present invention, below the following embodiment that finishes according to technical solution of the present invention that provides by the inventor the present invention is described in further detail, these only are the present invention embodiment preferably, but are not limited to these embodiment.
Embodiment 1: according to technical scheme of the present invention, take by weighing 15% rotenone (below be weight ratio) 25.0g, and polyoxyethylene nonylphenol ether phosphate 10.0g, calcium dodecyl benzene sulfonate 10.0g is dissolved in above three kinds of materials in the isopropyl alcohol; Take by weighing the 55.0g deionized water in homogenizer, the aqueous isopropanol with materials such as rotenone under high-speed stirred is added dropwise in the homogenizer, promptly makes rotenone water emulsion.
Embodiment 2: according to technical scheme of the present invention, take by weighing 15% rotenone 15.0g, 6.5% Avermectin ointment 3.0g (containing pure Avermectin 1.95%), be dissolved in the 72.0g ethanol, under agitation add the 10.0g OPEO, promptly make rotenone A Wei missible oil.
Certainly, adopt the each component in the percentage by weight of the present invention to prepare, can be made into the missible oil or the aqueous emulsion of series, for different animals, as domestic animals, the external various parasites such as mite, tick and lice of bird prevent and treat all is effective, as the span of rotenone between 0.1%～99.0%, Avermectin is between 0～2.0%, solvent is between 50.0%～80.0%, surfactant is between 5.0%～20.0%, the example of above-mentioned preparation can be listed various, and the present invention does not enumerate one by one at this.
EXPERIMENTAL EXAMPLE 1: use rotenone water emulsion, rotenone A Wei missible oil has carried out killing the test of haemaphysalis longicornis.Test chorista tickicide and the clinical blood tick of killing are tested.1.1 experimental animal
Selection Baoji boolean mutton sheep breeding is all raised the boolean mutton sheep of herding naturally in two districts 35 (no lambs) and is tested as the clinical medicine tickicide.Record overbit before the test, and by an infection intensity of statistics body surface tick.1.2 test method: the 1.2.1 tickicide test method that exsomatizes
The plate medicine embrane method is adopted in the tickicide test of exsomatizing.The tick (one-tenth tick) of living is taked from the sheep body in the scene before the test, selects the strong person of vigor to use.Each chemicals treatment with 20 ticks (
: ♀=3: 2), with the exsomatize tickicide test of plate medicine embrane method, other establishes the plate moisture film and organizes in contrast.Every the death condition that 8h observes a tick, record 24h respectively tests the death toll of tick, and calculates its tickicide rate.1.2.2 the clinical tickicide test of pesticide effectiveness
The clinical rotenone water emulsion of establishing, two processing of rotenone A Wei missible oil.Rotenone water emulsion is diluted to contain rotenone be 0.075%; Rotenone A Wei missible oil is diluted to and contains trifoliate jewelvine 0.0375%.Every drug test group infects sheep with 5 and carries out the body surface spraying.During spraying tick is stung the bigger position spraying of attached density and strengthen, thoughtful to the spraying that chest, abdomen, four limbs inboard etc. are located.With the clear water processed group is contrast.
At random carry out the observation of sheep body tick by experimental group every day after the medication, checks clinical symptoms, observes, writes down the drinking-water, appetite, spirit of sheep etc. simultaneously, judges the safety of sheep after the medication and non-toxic reaction is arranged with this.Till infecting new tick again.1.2.3 medicament is killed the calculating of rate to tick
72h after the medication by the whole ticks on each experimental group collection sheep body, judges death condition, calculates the kill rate of medicament to tick with following formula.
The tickicide test of pesticide effectiveness 1.3 result of the test 1.3.1 exsomatizes
Rotenone water emulsion, the stripped tickicide result of the test of rotenone A Wei missible oil variable concentrations processing etc. sees Table 1.
Two kinds of medicaments of table 1 tickicide result of the test (plate medicine embrane method) that exsomatizes
| Medicament | Concentration (containing rotenone) % | Death toll | Killing rate % |
| Rotenone water emulsion | 0.01 | 8 | 40.0 |
| 0.02 | 12 | 60.0 | |
| 0.04 | 14 | 70.0 | |
| 0.08 | 18 | 90.0 | |
| Rotenone A Wei missible oil | 0.01 | 12 | 60.0 |
| 0.02 | 16 | 80.0 | |
| 0.04 | 20 | 100.0 |
Result of the test shows that two kinds of medicaments of the present invention have very high killing rate to tick under isolated condition.1.3.2 the clinical tickicide test of pesticide effectiveness
The clinical tickicide drug effect result of the test of medicament sees Table 2.
The clinical tickicide result of the test of two kinds of medicaments of table 2
Medicine was observed the repellent phase of tick: observe by clinical trail, find two kinds of medicaments under above-mentioned two kinds of concentration are handled, the processed group sheep infects the time of tick again at 20-30 days, and drug effect is better.Sheep is only spiritual in the process of the test, appetite, all no abnormal reaction of defecation, and pregnant ewe also has no adverse reaction.
| Medicament | Concentration (containing rotenone) % | The average infection intensity of group before the medication (only/sheep) | 72h sheep body surface tick cell mean alive after the medication (only/sheep) | Kill rate % |
| Rotenone water emulsion | ????0.0750 | ????127 | ??12.0 | ??90.55 |
| Rotenone A Wei missible oil | ????0.0375 | ????141 | ??12.0 | ??91.49 |
Experimental example 2: medicament is killed Sarcoptes suis and is tested 2.1 experimental animals
The typical stock boar of symptom and the breeding sow of psoroptic mange suffered from kind pig farm, Xibei Univ. of Agricultural ﹠ Forest Science ﹠ Technology herding station, and totally 5, this pig had inoculated escherichia coli seedling before the test.2.2 experimental design
Three groups are set up in experiment separately, treat one group with rotenone water emulsion of the present invention; Treat one group with rotenone A Wei missible oil of the present invention; The 3rd group of pig do not do any processing.Except that rotenone A Wei missible oil treatment group be two pigs (one 8 age boar, one 24 the monthly age farrowing sow) all the other two treatment groups be one 24 the monthly age boar.2.3 experimental implementation
Except that control group, every group of pig medication secondary, it is spaced apart 7 days.Rotenone water emulsion treatment group: medicine is sprayed on the pig surface by 1: 1000 dilution back with watering can, embrocates evenly with shoe brush simultaneously, do not stay the dead angle; Rotenone A Wei missible oil treatment group: the medicine for preparing is sprayed on the pig surface by 1: 1000 dilution back with watering can, embrocates evenly with shoe brush simultaneously, do not stay the dead angle; The 3rd group: do not do any processing.Pig after the medication only all divides circle to raise, and regularly to pig symptom only, record is observed and carried out in clinical manifestation.2.4 the pig body kills the clinical manifestation before the mite result of the test 2.4.1 medication
The hard of hearing portion of pig of the suffering from psoroptic mange thick crust of 1cm of having an appointment, skin is full split hemorrhage, the coarse hardening of touching, there is the canescence crust head, eye, cheek, there are a large amount of white crusts at the back, some is full split hemorrhage, the coarse hardening of touching, trunk both sides canescence crust, rubefaction, there is the canescence crust four limbs and oxter, and there is the big bronzing scab of grain of rice piece two forelimbs and oxter, about the about 2mm of thickness, that touches is hard slightly.The pars affecta skin dorsal body setae comes off, and the pig gargalesthesia is violent, rubs on the circle wall every now and then, rubs forelimb and oxter with hind leg sometimes, and sick pig becomes thin, spirit difference and irritated.2.4.2 the clinical manifestation after the medication
After medication the 7th day, respectively medication group pig is gathered pathological material of disease, put into plate separately after the numbering, add a cover, put into 40 ℃ of water-bath 30min after, examining under a microscope does not all have mite alive and climbs out of.Each medication group pig back crust begins to soften, crust around the pig ear of rotenone A Wei preparation group comes off, back some places crust also comes off, ear middle part scab piece is dry and cracked, stopped bleeding and incrustation, and medication group pig is obviously than quiet before the medication, and control group pig back canescence crust obviously thickens, and the some places be full of cracks is hemorrhage serious, and ear's crust thickens, and the oxter crust thickens.After medication the 14th day, the rotenone water emulsion group had a little crust except that the ear middle part of pig, and all the other all come off, and expose pink skin.After medication the 21st day, rotenone water emulsion and the complete obiteration of rotenone A Wei preparation group Sarcoptes suis disease symptoms, affected part grows virgin wool, and the pig state of mind is good.Control group pig crust is thicker, and the skin be full of cracks is hemorrhage serious, and the gargalesthesia aggravation is become thin, and the pig state of mind is very poor.
Experimental example 3: medicament is killed the rabbit mite and is tested 3.1 experimental animals:
The common rabbit (part is bought healthy rabbits and duplicated case with artificial infection's method from the fairground, a part is directly purchased the rabbit that suffers from acariasis) that suffers from acariasis.Every rabbit all inoculates rabbit Pasteurella, rabbit pest, clostridieum welchii triple vaccine before testing.3.2 test operation
Rotenone water emulsion (1000 accompany dilution), rotenone A Wei preparation (1500 accompany dilution) and clear water contrast are established in test.Except that control group, medicine was wiped 3 days continuously, guaranteed not stay the dead angle every day 1 time at every turn, and the affected part crust is left intact when handle handling, and three groups of rabbit groupings are raised after the medication, after the medication to rabbit symptom, clinical manifestation observe, record.2.3 the rabbit body kills clinical manifestation and symptom before the mite result of the test 2.3.1 medication
The rabbit fore paw of suffering from chorioptic mange is come off by hair, and nail is exposed, and preceding claw covers the linen thick scab of one deck, touches hardly, and rabbit has the action of shaking claw frequently; Forming a scab fully, harden in the hind leg landing part, is come off by hair, has when rabbit reposes and do not stop the performance that the change of feet lands, and around the nose of rabbit, the lip tangible incrustation arranged all, and the action of shaking forelimb is arranged.
Suffer from the rabbit of otoacariasis, show as the yellow-white crust that has filled up numb pattern in the duct, ear is sagging, and the performance of shaking the head is arranged frequently, and hard of hearing blood vessel is obviously congested.
Suffer from chorioptic mange and the rabbit that suffers from otoacariasis all show spirit depressed, become thin, search for food, having a rest is greatly affected.2.3.2 clinical manifestation after the medication and symptom
After medication the 7th day, respectively each group rabbit is gathered pathological material of disease, the plate of putting into after the numbering is separately added a cover, put into 40 ℃ of water-bath 30min after, examining under a microscope does not all have mite alive and climbs out of.The crust that examination is respectively organized on the rabbit four limbs is obviously softening, and the crust around the rabbit lip of chemicals treatment group comes off, and crust is dry and cracked in the external auditory meatus, respectively organizes rabbit simultaneously obviously than quiet before the medication, and feed intake also increases to some extent.Linen crust obviously thickens around the control group rabbit lip, and front foot is come off fully by hair, and numb pattern yellowish-brown crust thickens in the ear.
After medication the 14th day, the symptom of chemicals treatment group was similar to the 7th day, and rabbit limb portion only leaves the crust of pin front portion, and the remainder crust all comes off, and forelimb is similar to hind leg.Control group rabbit spirit is depressed, poor appetite, ear and the foot symptom is bright increases the weight of.
After medication the 14th day, the symptom complete obiteration of rotenone water emulsion (1000 accompany dilution), rotenone A Wei preparation (1500 accompany dilution) processed group rabbit acariasis.Affected part has grown virgin wool, and ear is upright.This moment, the control group rabbit was only surplus 1.This rabbit skeletonize, appetite is useless exhausted, in 24h death.The control group rabbit is after death cutd open inspection and is not all found obvious pathological change, rabbit stomach inanition.
Prove by above test examples, agent for preventing and controlling ectoparasite of animals of the present invention, to ecotozoa kill efficiency height, little to the animal influence, safety is a kind of non-harmful agent for preventing and controlling ectoparasite of animals.
Claims (4)
1. an agent for preventing and controlling ectoparasite of animals is characterized in that, this agent for preventing and controlling ectoparasite of animals is to be effective ingredient with rotenone, Avermectin, adds solvent, and materials such as surfactant are mixed and form, and the percentage by weight of each component is:
Rotenone 0.1%～99.0%
Avermectin 0.0～2.0%
Solvent 50.0%～80.0%
Surfactant 5.0%～20.0%
2. agent for preventing and controlling ectoparasite of animals as claimed in claim 1 is characterized in that this agent can be made into missible oil or aqueous emulsion, and converting water during use becomes emulsion.
3. agent for preventing and controlling ectoparasite of animals as claimed in claim 1 is characterized in that, described solvent can be a water, or deionized water, or methyl alcohol, or ethanol, or propyl alcohol, or ethyl acetate, or one or more mixtures in the vehicle substance known altogether of this area staff.
4. agent for preventing and controlling ectoparasite of animals as claimed in claim 1, it is characterized in that, described surfactant is a polyoxyethylene nonylphenol ether, or detergent alkylate sulphur phenol calcium, or alkyl polyoxyethylene ether phosphate, or alkyl polyoxypropylene ether phosphate, or polyoxyethylene nonylphenol ether phosphate, or one or more mixtures in the surfactant materials known altogether of this area staff.
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| CN 02139332 CN1401237A (en) | 2002-08-05 | 2002-08-05 | Animal ectoparasite preventing and treating agent |
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| CN 02139332 CN1401237A (en) | 2002-08-05 | 2002-08-05 | Animal ectoparasite preventing and treating agent |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100397989C (en) * | 2005-11-21 | 2008-07-02 | 河北威远生物化工股份有限公司 | Disinsection emulsion in water containing avermectin |
| CN1985594B (en) * | 2006-12-04 | 2010-08-18 | 上海农乐生物制品股份有限公司 | Preparing process of rotenone water emulsion |
| CN101991522A (en) * | 2010-11-03 | 2011-03-30 | 华南理工大学 | Tick repellent toilet water and preparation method thereof |
| CN102037979A (en) * | 2010-10-26 | 2011-05-04 | 张炳泉 | Pesticide preparation for prevention and control of ticks |
| CN102657712A (en) * | 2012-05-30 | 2012-09-12 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method for adonis coerulea maxim extract and application thereof |
-
2002
- 2002-08-05 CN CN 02139332 patent/CN1401237A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100397989C (en) * | 2005-11-21 | 2008-07-02 | 河北威远生物化工股份有限公司 | Disinsection emulsion in water containing avermectin |
| CN1985594B (en) * | 2006-12-04 | 2010-08-18 | 上海农乐生物制品股份有限公司 | Preparing process of rotenone water emulsion |
| CN102037979A (en) * | 2010-10-26 | 2011-05-04 | 张炳泉 | Pesticide preparation for prevention and control of ticks |
| CN101991522A (en) * | 2010-11-03 | 2011-03-30 | 华南理工大学 | Tick repellent toilet water and preparation method thereof |
| CN101991522B (en) * | 2010-11-03 | 2012-08-22 | 华南理工大学 | Tick repellent toilet water and preparation method thereof |
| CN102657712A (en) * | 2012-05-30 | 2012-09-12 | 中国农业科学院兰州畜牧与兽药研究所 | Preparation method for adonis coerulea maxim extract and application thereof |
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