CN113382986A - 酪氨酸激酶抑制剂组合物、其制备方法和使用方法 - Google Patents

酪氨酸激酶抑制剂组合物、其制备方法和使用方法 Download PDF

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CN113382986A
CN113382986A CN201980077292.XA CN201980077292A CN113382986A CN 113382986 A CN113382986 A CN 113382986A CN 201980077292 A CN201980077292 A CN 201980077292A CN 113382986 A CN113382986 A CN 113382986A
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A·弗洛尔
A·梅威格
G·特雷纳
D·M·爱普斯坦
M·奥康纳
E·巴克
L·阿里斯塔
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Black Diamond Treatment Co
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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  • Chemical & Material Sciences (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980077292.XA 2018-09-25 2019-09-24 酪氨酸激酶抑制剂组合物、其制备方法和使用方法 Pending CN113382986A (zh)

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US201862736293P 2018-09-25 2018-09-25
US62/736293 2018-09-25
US201962903592P 2019-09-20 2019-09-20
US62/903592 2019-09-20
PCT/US2019/052784 WO2020068867A1 (en) 2018-09-25 2019-09-24 Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use

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AU (1) AU2019346550A1 (https=)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114787150A (zh) * 2019-08-15 2022-07-22 黑钻治疗公司 炔基喹唑啉化合物
CN116655599A (zh) * 2023-05-17 2023-08-29 江南大学 一类egfr别构抑制剂的合成及其用途
CN118084767A (zh) * 2024-04-02 2024-05-28 康龙化成手性医药技术(宁波)有限公司 一种外型-6-氟甲基-3-氮杂双环[3,1,0]己烷盐酸盐及其衍生物的合成方法
CN118652239A (zh) * 2024-05-29 2024-09-17 江南大学 一类egfr别构抑制剂的合成及其用途

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* Cited by examiner, † Cited by third party
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AU2019346550A1 (en) 2018-09-25 2021-04-22 Black Diamond Therapeutics, Inc. Quinazoline derivatives as tyrosine kinase inhibitor, compositions, methods of making them and their use
WO2021195206A1 (en) * 2020-03-24 2021-09-30 Black Diamond Therapeutics, Inc. Polymorphic forms and related uses
AR122450A1 (es) * 2020-05-08 2022-09-14 Lilly Co Eli Compuestos de (trifluorometil)pirimidin-2-amina
US20230265098A1 (en) * 2020-07-02 2023-08-24 Enliven Therapeutics, Inc. Alkyne quinazoline derivatives as inhibitors of erbb2
US20230271936A1 (en) * 2020-08-10 2023-08-31 Abbisko Therapeutics Co., Ltd Efgr inhibitor, preparation method therefor and application thereof
WO2022040377A1 (en) 2020-08-20 2022-02-24 Black Diamond Therapeutics, Inc. Methods for preparing quinazoline derivatives
AU2021347232A1 (en) 2020-09-23 2023-04-27 Erasca, Inc. Tricyclic pyridones and pyrimidones
WO2022076671A1 (en) * 2020-10-08 2022-04-14 Black Diamond Therapeutics, Inc. Method of treating cancers using quinazoline derivatives
CN116710096A (zh) * 2020-11-02 2023-09-05 黑钻治疗公司 用炔取代的喹唑啉衍生物治疗癌症的方法
US20240075042A1 (en) * 2020-11-02 2024-03-07 Black Diamond Therapeutics, Inc. Method of treating cancers with alkyne substituted quinazoline derivatives
WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
EP4323356A1 (en) 2021-04-13 2024-02-21 Nuvalent, Inc. Amino-substituted heterocycles for treating cancers with egfr mutations
EP4724436A1 (en) * 2023-06-12 2026-04-15 Remix Therapeutics Inc. Compounds and methods for modulating splicing
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