CN113382982A - 一种辛波莫德的制备方法 - Google Patents

一种辛波莫德的制备方法 Download PDF

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Publication number
CN113382982A
CN113382982A CN202080011577.6A CN202080011577A CN113382982A CN 113382982 A CN113382982 A CN 113382982A CN 202080011577 A CN202080011577 A CN 202080011577A CN 113382982 A CN113382982 A CN 113382982A
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formula
compound
carbonate
reaction
solvent
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CN113382982B (zh
Inventor
刘诗雨
王仲清
寇景平
林碧悦
刘万慧
刘震
罗忠华
黄芳芳
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Guangdong HEC Pharmaceutical
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Sunshine Lake Pharma Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Abstract

本发明提供了一种辛波莫德的制备方法，属于医药化工领域；本发明所述方法可以3‑溴‑4‑甲基苯乙酮为起始物料，经过溴化、与氮杂环丁烷‑3‑甲酸甲酯或其盐、乙烯三氟硼酸盐反应、烯基还原、水解等步骤后得到辛波莫德，是一种全新的制备辛波莫德的方法，该方法生产得到的产物纯度高，收率高，成本低，方法操作简单，工艺稳定的特点。

Description

PCT国内申请，说明书已公开。

Claims (1)

  1. PCT国内申请，权利要求书已公开。
CN202080011577.6A 2019-02-25 2020-02-19 一种辛波莫德的制备方法 Active CN113382982B (zh)

Applications Claiming Priority (3)

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CN2019101375623 2019-02-25
CN201910137562 2019-02-25
PCT/CN2020/075840 WO2020173346A1 (zh) 2019-02-25 2020-02-19 一种辛波莫德的制备方法

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CN113382982A true CN113382982A (zh) 2021-09-10
CN113382982B CN113382982B (zh) 2023-01-31

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WO (1) WO2020173346A1 (zh)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1791395A (zh) * 2003-05-19 2006-06-21 Irm责任有限公司 免疫抑制剂化合物及组合物
CN102256942A (zh) * 2008-12-18 2011-11-23 诺瓦提斯公司 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的新多晶型物
CN104105687A (zh) * 2012-02-03 2014-10-15 诺华股份有限公司 制备n-(4-环己基-3-三氟甲基-苄氧基)-乙亚氨酸乙酯的方法
WO2017120124A1 (en) * 2016-01-04 2017-07-13 Auspex Pharmaceuticals, Inc. Azetidine modulators of the sphingosine 1-phosphate receptor

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1791395A (zh) * 2003-05-19 2006-06-21 Irm责任有限公司 免疫抑制剂化合物及组合物
CN102256942A (zh) * 2008-12-18 2011-11-23 诺瓦提斯公司 1-(4-{1-[(e)-4-环己基-3-三氟甲基-苄氧基亚氨基]-乙基}-2-乙基-苄基)-氮杂环丁烷-3-甲酸的新多晶型物
CN104105687A (zh) * 2012-02-03 2014-10-15 诺华股份有限公司 制备n-(4-环己基-3-三氟甲基-苄氧基)-乙亚氨酸乙酯的方法
WO2017120124A1 (en) * 2016-01-04 2017-07-13 Auspex Pharmaceuticals, Inc. Azetidine modulators of the sphingosine 1-phosphate receptor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHIFENG PAN等: "Discovery of BAF312 (Siponimod), a Potent and Selective S1P Receptor Modulator.", 《ACS MED. CHEM. LETT.》 *

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WO2020173346A1 (zh) 2020-09-03

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Address after: 523808 No.1, Gongye North Road, Songshanhu Park, Dongguan City, Guangdong Province

Patentee after: Guangdong Dongyangguang Pharmaceutical Co.,Ltd.

Address before: 523808 Songshan Lake Science and Technology Industrial Park, Dongguan City, Guangdong Province

Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd.

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