CN113350403A - Composition containing poria cocos as well as preparation method and application thereof - Google Patents
Composition containing poria cocos as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of pet medicines, and discloses a composition containing poria cocos, and a preparation method and application thereof. The composition comprises fructus crataegi, Poria, Atractylodis rhizoma, radix Codonopsis, semen Myristicae and Raphani semen. The composition for dogs and cats provided by the invention utilizes Chinese yam, tuckahoe, atractylodes, semen coicis and nutmeg to tonify spleen and stomach; the codonopsis pilosula and the liquorice are added to tonify the spleen and replenish qi, so that the effects of the traditional Chinese medicines on tonifying the spleen and invigorating the stomach are enhanced; the hawthorn and the radish seed are matched to strengthen the stomach and promote digestion so as to eliminate food retention in the stomach. The components have synergistic effect, and can effectively regulate and prevent gastrointestinal diseases of dogs and cats; and the side effect is small, and the feed intake rate of dogs and cats is high.
Description
Technical Field
The invention belongs to the technical field of pet medicines, and particularly relates to a composition containing poria cocos, and a preparation method and application thereof.
Background
Vomiting and diarrhea are the most common abnormalities of pets, accounting for 50% and more of all types of abnormalities. Vomiting and diarrhea in pets are generally directly related to the gastrointestinal status of the pet.
Intestines and stomach are important root of dogs and cats, and unhealthy diet can cause gastrointestinal diseases. Two of them are most typical: the indigestion is caused by overeating greasy food; secondly, the stomach and intestine discomfort caused by eating uncooked and cold food is caused. At present, the conventional treatment mode for the gastrointestinal tract problems of dogs and cats generally adopts western medicine treatment and auxiliary conditioning of prebiotics such as oligosaccharide and the like. But western medicines bring side effects to dogs and cats, and the dogs and cats can be affected by certain medicines; meanwhile, western medicines can only play a temporary role in treatment and cannot achieve the effects of long-term regulation and health care. While the auxiliary conditioning of prebiotics only aims at the disturbance of intestinal flora, and has slow effect and long regulation period.
Therefore, a composition for dogs and cats is needed, which can effectively regulate and prevent gastrointestinal diseases of dogs and cats, has little side effect and high feed intake rate of dogs and cats.
Disclosure of Invention
The present invention is directed to solving at least one of the problems of the prior art described above. Therefore, the composition containing the poria cocos can effectively condition and prevent gastrointestinal diseases of dogs and cats, and is small in side effect and high in feed intake rate of dogs and cats.
In a first aspect, the present invention provides a composition comprising Poria cocos wolf.
Specifically, a composition containing tuckahoe comprises hawthorn, tuckahoe, largehead atractylodes rhizome, pilose asiabell root, nutmeg and radish seed.
Preferably, the composition further comprises yam, licorice and coix seed.
Preferably, the mass ratio of the nutmeg to the codonopsis pilosula to the radish seeds is 1: (1-3): (1-3); further preferably, the mass ratio of the nutmeg to the codonopsis pilosula and the radish seeds is 1: (1.5-2): (1.5-2).
Preferably, the composition comprises the following components in parts by weight:
1-8 parts of hawthorn, 5-12 parts of poria cocos, 5-12 parts of bighead atractylodes rhizome, 5-12 parts of codonopsis pilosula, 1-6 parts of nutmeg, 5-12 parts of radish seed, 1-8 parts of liquorice, 5-12 parts of Chinese yam and 1-6 parts of coix seed.
Further preferably, the composition comprises the following components in parts by weight:
1-5 parts of hawthorn, 5-10 parts of poria cocos, 5-10 parts of bighead atractylodes rhizome, 5-10 parts of codonopsis pilosula, 1-5 parts of nutmeg, 5-10 parts of radish seed, 1-6 parts of liquorice, 5-10 parts of Chinese yam and 1-6 parts of coix seed.
More preferably, the composition comprises the following components in parts by weight:
3-4 parts of hawthorn, 7-8 parts of poria cocos, 7-8 parts of bighead atractylodes rhizome, 7-8 parts of codonopsis pilosula, 3-4 parts of nutmeg, 7-8 parts of radish seed, 4-5 parts of liquorice, 7-8 parts of Chinese yam and 3-4 parts of coix seed.
In a second aspect, the invention provides a method for preparing a composition containing poria cocos.
Specifically, the preparation method of the composition containing the poria cocos comprises the following steps: weighing the components, crushing and mixing to obtain the composition.
Specifically, fructus crataegi, rhizoma Dioscoreae, Poria, Atractylodis rhizoma, Coicis semen, radix Codonopsis, semen Myristicae, Raphani semen and Glycyrrhrizae radix are oven-dried or naturally air-dried, the water content is controlled below 13%, after micronizing, the powder is made into powder with more than 95% passing through 80 mesh sieve, and mixing. Concentrated powders of the above components are also possible.
In a third aspect, the invention provides a use of a composition comprising poria cocos.
The composition containing Poria can be used for preparing pet food, pet feed, and pet medicine.
In particular to a dog and cat food which comprises the composition.
In particular to a canine cat medicine which comprises the composition.
Preferably, the dog and cat medicine further comprises auxiliary materials, and the auxiliary materials comprise at least one of a flavor regulator, a lubricant, a binder, a wetting agent and a filler.
Preferably, the flavor regulator is at least one of chicken hydrolysate, chicken liver hydrolysate, duck meat hydrolysate, beef hydrolysate or fish hydrolysate. The flavor regulator is matched according to the favor of the odor of dogs and cats, so that the inherent odor of the composition can be covered to a certain degree, the composition is more easily accepted by dogs and cats, and the feed intake rate is improved.
Preferably, the filler is a full cream milk powder. According to the invention, the whole milk powder is preferably selected to replace traditional filler starch, dextrin and the like, so that the tablet is conveniently formed when the tablet is prepared, and the unique odor characteristic formed by the whole milk powder and the fish hydrolysate can enhance the temptation of dogs and cats and improve the palatability.
Further preferably, the auxiliary materials comprise 3-10 parts of flavor modifier, 20-40 parts of whole milk powder, 2-10 parts of microcrystalline cellulose and 1-5 parts of magnesium stearate; more preferably, the auxiliary materials comprise 5-8 parts of flavor modifier, 30-34 parts of whole milk powder, 5-7 parts of microcrystalline cellulose and 1-2 parts of magnesium stearate.
The third aspect of the invention provides a preparation method of a dog or cat medicine.
Specifically, the preparation method of the canine cat medicine comprises the following steps:
mixing the composition with the auxiliary materials, and tabletting to obtain the medicine.
More specifically, the preparation method of the canine cat medicine comprises the following steps:
adding the whole milk powder, fish meat hydrolysate and microcrystalline cellulose into the composition, and mixing; then adding magnesium stearate, mixing and tabletting to obtain the medicine.
Preferably, the preparation method of the fish meat hydrolysate comprises the following steps:
crushing freshwater fish, performing enzymolysis by adopting protease, and drying to obtain the fish hydrolysate.
Specifically, the preparation method of the fish meat hydrolysate comprises the following steps:
crushing freshwater fish, hydrolyzing with protease at 35-45 deg.C for 30-240min, evaporating water at 80-100 deg.C to control water content at 4% -8%, pulverizing to 95% or more, and sieving with 80 mesh sieve.
The fish hydrolysate is freshwater fish which is a raw material and has low allergen, so that the health risk to dogs and cats can be reduced; the method comprises the steps of hydrolyzing freshwater fish protein into peptide and amino acid through a protease catalytic hydrolysis process, and performing Maillard reaction on the peptide and the amino acid through a high-temperature drying process to generate flavor substances which are favored by dogs and cats.
The gastrointestinal physiological structure and the physiological characteristics of dogs and cats are highly similar, the health care and the conditioning of gastrointestinal diseases are common, and both are carnivorous animals and have intersection on the favor of food flavor.
Chronic diarrhea, gastroenteritis and gastrointestinal dysfunction of dogs and cats are mostly caused by weakness of the spleen and the stomach, which can cause anorexia, weight loss, mental depression, physical weakness and the like of dogs and cats. The Chinese yam, the tuckahoe, the white atractylodes rhizome, the coix seed and the nutmeg are used for reinforcing spleen and invigorating stomach; the codonopsis pilosula and the liquorice are added to tonify the spleen and replenish qi, so that the effects of the traditional Chinese medicines on tonifying the spleen and invigorating the stomach are enhanced; the hawthorn and the radish seed are matched to strengthen the stomach and promote digestion so as to eliminate food retention in the stomach. The components have synergistic effect, so that the traditional Chinese medicine composition can eliminate surface gastrointestinal symptoms caused by gastrointestinal stagnation, and can also tonify spleen and stomach to fundamentally regulate gastrointestinal tract aiming at the symptoms of spleen and stomach weakness. The composition has small side effect, all the components are homologous to each other, the safety is high, and the effect is not reduced or other physiological diseases are not induced even if the composition is used in an excessive amount.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a composition containing tuckahoe, which utilizes yam, tuckahoe, atractylodes, coix seed and nutmeg to tonify spleen and stomach; the codonopsis pilosula and the liquorice are added to tonify the spleen and replenish qi, so that the effects of the traditional Chinese medicines on tonifying the spleen and invigorating the stomach are enhanced; the hawthorn and the radish seed are matched to strengthen the stomach and promote digestion so as to eliminate food retention in the stomach. The components have synergistic effect, and can effectively regulate and prevent gastrointestinal diseases of dogs and cats; and the side effect is small, and the feed intake rate of dogs and cats is high.
Drawings
Fig. 1 is a sample example graph of stool quality scores.
Detailed Description
In order to make the technical solutions of the present invention more apparent to those skilled in the art, the following examples are given for illustration. It should be noted that the following examples are not intended to limit the scope of the claimed invention.
The starting materials, reagents or apparatuses used in the following examples are conventionally commercially available or can be obtained by conventionally known methods, unless otherwise specified.
Example 1
A composition for dogs and cats comprising the following components: 4 parts of hawthorn, 8 parts of Chinese yam, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome, 4 parts of coix seed, 8 parts of codonopsis pilosula, 4 parts of nutmeg, 8 parts of radish seed and 5 parts of liquorice.
A preparation method of a composition for dogs and cats comprises the following steps: naturally drying fructus crataegi, rhizoma Dioscoreae, Poria, Atractylodis rhizoma, Coicis semen, radix Codonopsis, semen Myristicae, Raphani semen, and Glycyrrhrizae radix to water content below 13%, weighing, micronizing to obtain powder with a content of above 95%, sieving with 80 mesh sieve, and mixing for 30min to obtain the composition.
A medicine for dogs and cats comprises the composition, 6 parts of fish meat hydrolysate, 30 parts of whole milk powder, 5 parts of microcrystalline cellulose and 2 parts of magnesium stearate.
A preparation method of a medicine for dogs and cats comprises the following steps:
(1) preparing fish hydrolysate, purchasing fresh freshwater fish, crushing, performing catalytic hydrolysis with papain (900U/kg) at 40 deg.C for 90 min, evaporating water at 100 deg.C to control water content of the product at 4% -8%, pulverizing to 95% or above, and sieving with 80 mesh sieve.
(2) Adding whole milk powder, fish meat hydrolysate, and microcrystalline cellulose into the above composition, and mixing for 10 min; adding magnesium stearate, and mixing for 5 minutes to obtain powder to be tabletted; the powder to be pressed is molded by a direct tabletting preparation process, and is made into 0.5 g/tablet and round according to the requirement.
Example 2
A composition for dogs and cats comprising the following components: 3 parts of hawthorn, 7 parts of Chinese yam, 7 parts of poria cocos, 7 parts of bighead atractylodes rhizome, 3 parts of coix seed, 8 parts of codonopsis pilosula, 4 parts of nutmeg, 8 parts of radish seed and 5 parts of liquorice.
A preparation method of a composition for dogs and cats comprises the following steps: naturally drying fructus crataegi, rhizoma Dioscoreae, Poria, Atractylodis rhizoma, Coicis semen, radix Codonopsis, semen Myristicae, Raphani semen, and Glycyrrhrizae radix to water content below 13%, weighing, micronizing to obtain powder with a content of above 95%, sieving with 80 mesh sieve, and mixing for 30min to obtain the composition.
A medicine for dogs and cats comprises the composition, 7 parts of fish meat hydrolysate, 34 parts of whole milk powder, 6 parts of microcrystalline cellulose and 1 part of magnesium stearate.
A preparation method of a medicine for dogs and cats comprises the following steps:
(1) preparing fish hydrolysate, purchasing fresh freshwater fish, crushing, performing catalytic hydrolysis with papain (900U/kg) at 40 deg.C for 90 min, evaporating water at 100 deg.C to control water content of the product at 4% -8%, pulverizing to 95% or above, and sieving with 80 mesh sieve.
(2) Adding whole milk powder, fish meat hydrolysate, and microcrystalline cellulose into the above composition, and mixing for 10 min; adding magnesium stearate, and mixing for 5 minutes to obtain powder to be tabletted; the powder to be pressed is molded by a direct tabletting preparation process, and is made into 0.5 g/tablet and round according to the requirement.
Example 3
A composition for dogs and cats comprising the following components: 4 parts of hawthorn, 8 parts of Chinese yam, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome, 4 parts of coix seed, 7 parts of codonopsis pilosula, 3 parts of nutmeg, 9 parts of radish seed and 4 parts of liquorice.
A preparation method of a composition for dogs and cats comprises the following steps: naturally drying fructus crataegi, rhizoma Dioscoreae, Poria, Atractylodis rhizoma, Coicis semen, radix Codonopsis, semen Myristicae, Raphani semen, and Glycyrrhrizae radix to water content below 13%, weighing, micronizing to obtain powder with a content of above 95%, sieving with 80 mesh sieve, and mixing for 30min to obtain the composition.
A medicine for dogs and cats comprises the composition, 8 parts of fish meat hydrolysate, 31 parts of whole milk powder, 7 parts of microcrystalline cellulose and 1 part of magnesium stearate.
A preparation method of a medicine for dogs and cats comprises the following steps:
(1) preparing fish hydrolysate, purchasing fresh freshwater fish, crushing, performing catalytic hydrolysis with papain (900U/kg) at 40 deg.C for 90 min, evaporating water at 100 deg.C to control water content of the product at 4% -8%, pulverizing to 95% or above, and sieving with 80 mesh sieve.
(2) Adding whole milk powder, fish meat hydrolysate, and microcrystalline cellulose into the above composition, and mixing for 10 min; adding magnesium stearate, and mixing for 5 minutes to obtain powder to be tabletted; the powder to be pressed is molded by a direct tabletting preparation process, and is made into 0.5 g/tablet and round according to the requirement.
Example 4
A composition for dogs and cats comprising the following components: 4 parts of hawthorn, 8 parts of Chinese yam, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome, 4 parts of coix seed, 3 parts of codonopsis pilosula, 8 parts of nutmeg, 5 parts of radish seed and 4 parts of liquorice.
A preparation method of a composition for dogs and cats comprises the following steps: naturally drying fructus crataegi, rhizoma Dioscoreae, Poria, Atractylodis rhizoma, Coicis semen, radix Codonopsis, semen Myristicae, Raphani semen, and Glycyrrhrizae radix to water content below 13%, weighing, micronizing to obtain powder with a content of above 95%, sieving with 80 mesh sieve, and mixing for 30min to obtain the composition.
A medicine for dogs and cats comprises the composition, 8 parts of fish meat hydrolysate, 31 parts of whole milk powder, 7 parts of microcrystalline cellulose and 1 part of magnesium stearate.
A preparation method of a medicine for dogs and cats comprises the following steps:
(1) preparing fish hydrolysate, purchasing fresh freshwater fish, crushing, performing catalytic hydrolysis with papain (900U/kg) at 40 deg.C for 90 min, evaporating water at 100 deg.C to control water content of the product at 4% -8%, pulverizing to 95% or above, and sieving with 80 mesh sieve.
(2) Adding whole milk powder, fish meat hydrolysate, and microcrystalline cellulose into the above composition, and mixing for 10 min; adding magnesium stearate, and mixing for 5 minutes to obtain powder to be tabletted; the powder to be pressed is molded by a direct tabletting preparation process, and is made into 0.5 g/tablet and round according to the requirement.
Example 5
A composition for dogs and cats comprising the following components: 4 parts of hawthorn, 8 parts of Chinese yam, 8 parts of poria cocos, 8 parts of bighead atractylodes rhizome, 4 parts of coix seed, 7 parts of codonopsis pilosula, 3 parts of nutmeg, 9 parts of radish seed and 4 parts of liquorice.
A preparation method of a composition for dogs and cats comprises the following steps: naturally drying fructus crataegi, rhizoma Dioscoreae, Poria, Atractylodis rhizoma, Coicis semen, radix Codonopsis, semen Myristicae, Raphani semen, and Glycyrrhrizae radix to water content below 13%, weighing, micronizing to obtain powder with a content of above 95%, sieving with 80 mesh sieve, and mixing for 30min to obtain the composition.
A medicine for dogs and cats comprises the composition, 8 parts of chicken hydrolysate, 31 parts of whole milk powder, 7 parts of microcrystalline cellulose and 1 part of magnesium stearate.
A preparation method of a medicine for dogs and cats comprises the following steps:
(1) preparing chicken hydrolysate, purchasing chicken, crushing, performing catalytic hydrolysis with papain (900U/kg) at 40 deg.C for 90 min, evaporating water at 100 deg.C, controlling water content at 4% -8%, pulverizing to 95% or above, and sieving with 80 mesh sieve.
(2) Adding whole milk powder, chicken hydrolysate and microcrystalline cellulose into the prepared composition, and mixing for 10 minutes; adding magnesium stearate, and mixing for 5 minutes to obtain powder to be tabletted; the powder to be pressed is molded by a direct tabletting preparation process, and is made into 0.5 g/tablet and round according to the requirement.
Example 6
Example 6 differs from example 3 in that example 6 does not contain fish meat hydrolysate and the remaining raw materials and preparation method are the same as example 3.
Comparative example 1
The difference between the comparative example 1 and the example 1 is that in the comparative example 1, nutmeg is replaced by the same amount of amomum cardamomum, codonopsis pilosula is replaced by the same amount of ginseng, and the rest raw materials and the preparation method are the same as the example 1.
Comparative example 2
The difference between the comparative example 2 and the example 1 is that the hawthorn in the comparative example 2 is replaced by the same amount of medicated leaven which also has the effects of strengthening the stomach and promoting digestion, and the rest raw materials and the preparation method are the same as the example 1.
Comparative example 3
Comparative example 3 is different from example 1 in that in comparative example 3, the largehead atractylodes rhizome is removed, and the rest of the raw materials and the preparation method are the same as those in example 1.
Product effectiveness testing
(1) 80 poodle dogs which are 1-3 years old, 6-8kg in weight and half of male dogs and female dogs respectively, have gastrointestinal discomfort symptoms, are generally soft stools, and are rarely diarrhea or vomit are randomly divided into 8 groups, and 10 test dogs are selected in each group. Feeding the same amount of commodity ration for dog and the medicines for dog and cat prepared in examples 1-6 and comparative examples 1-3 (which are administered according to the amount of 0.3g/kg and are used for 2 times/day) respectively for each group, observing the ingestion condition and health condition of the dog during the feeding process after continuously feeding for 10 days, and stopping feeding the products of the patent examples when the dog has normally ingested and feces have good formation and no vomit; feeding for 10 days without recovery.
The degree of improvement in gastrointestinal function is mainly reflected in stool quality. Stool quality scores are used in the test, and the stool quality is evaluated by scores, and specific scoring standards are shown in table 1 and fig. 1 (fig. 1 is an example graph of scores and samples): (1 is classified as dry stool, 2-3 is classified as normal stool, 4-5 is classified as soft stool, and 6-7 is classified as diarrhea).
TABLE 1
The results of the tests are shown in Table 2.
TABLE 2
As is clear from Table 2, the dogs were able to recover within 4 to 7 days after taking the drugs prepared in examples 1 to 6, and had good stool formation and no vomiting after use. Some dogs still have the phenomena of loose stool, slight vomiting or diarrhea after taking the medicine prepared by the comparative example. The medicine for dogs and cats provided by the embodiment of the invention is obviously better than the comparative example in regulating the intestines and stomach of dogs.
(2) Selecting 80 cats with age of 1-3 years, weight of 3.5-4.5 kg, half British short-haired cats and half American short-haired cats, half male cats and half female cats, gastrointestinal discomfort symptoms, general soft stool, few diarrhea or few vomiting, randomly dividing the cats into 8 groups, and 10 cats in each group. The same amount of cat food and the medicines for dogs and cats prepared in examples 1-6 and comparative examples 1-3 (administered in an amount of 0.3g/kg, 2 times/day) were fed to each group, and after feeding for 10 days continuously, the feeding condition and health condition of dogs were observed during feeding, and the feeding of the product of the example patent was stopped when cats had normally fed the feed and had good stool formation and no vomiting; the administration is continued for 10 days without recovery. Test results are shown in Table 2.
The degree of improvement in gastrointestinal function is mainly reflected in stool quality. The stool quality scores are used in the test, and the stool quality is evaluated by the scores, and specific scoring standards are shown in table 1 and figure 1.
The results of the tests are shown in Table 3.
TABLE 3
As is clear from Table 3, cats could be healed within 4-7 days by taking the drugs prepared in examples 1-6, and the feces formed well after use without vomiting. After taking the medicine prepared by the comparative example, some cats still have the phenomena of soft stool, slight vomit or diarrhea. The medicine for dogs and cats provided by the embodiment of the invention is obviously better than the comparative example in conditioning the intestines and stomach of cats.
Claims (10)
1. A composition containing Poria is characterized by comprising fructus crataegi, Poria, Atractylodis rhizoma, radix Codonopsis, semen Myristicae and Raphani semen.
2. The composition of claim 1, further comprising yam, licorice, and coix seed.
3. The composition of claim 1, wherein the mass ratio of nutmeg to codonopsis pilosula to radish seed is 1: (1-3): (1-3).
4. The composition according to claim 2, wherein the composition comprises the following components in parts by weight: 1-8 parts of hawthorn, 5-12 parts of poria cocos, 5-12 parts of bighead atractylodes rhizome, 5-12 parts of codonopsis pilosula, 1-6 parts of nutmeg, 5-12 parts of radish seed, 1-8 parts of liquorice, 5-12 parts of Chinese yam and 1-6 parts of coix seed.
5. A process for preparing the composition of any one of claims 1 to 4, comprising the steps of: weighing the components, crushing and mixing to obtain the composition.
6. Use of a composition according to any one of claims 1 to 4 for the preparation of a pet food, a pet feed, a pet pharmaceutical.
7. A canine or feline food comprising the composition of any one of claims 1-4.
8. A canine or feline pharmaceutical product comprising the composition of any one of claims 1-4.
9. The canine or feline pharmaceutical product of claim 8, further comprising an adjuvant comprising at least one of a flavor modulator, a lubricant, a binder, a humectant, a filler.
10. The canine or feline pharmaceutical product of claim 9, wherein the flavor modifier is at least one of a chicken hydrolysate, a chicken liver hydrolysate, a duck meat hydrolysate, a beef hydrolysate, or a fish hydrolysate.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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Application publication date: 20210907 |