CN113286807A - 一种卡泊芬净的合成方法及其中间体 - Google Patents

一种卡泊芬净的合成方法及其中间体 Download PDF

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Publication number
CN113286807A
CN113286807A CN201980072867.9A CN201980072867A CN113286807A CN 113286807 A CN113286807 A CN 113286807A CN 201980072867 A CN201980072867 A CN 201980072867A CN 113286807 A CN113286807 A CN 113286807A
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acid
caspofungin
reaction
water
intermediate iii
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CN201980072867.9A
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CN113286807B (zh
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陈迎会
朱兵峰
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Lunan Better Pharmaceutical Co ltd
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Lunan Better Pharmaceutical Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid

Abstract

一种卡泊芬净的合成方法及其中间体化合物，其中合成方法以纽莫康定B0为起始物，丙酮叉保护得到卡泊芬净中间体Ⅲ化合物，进而与乙二胺反应得到卡泊芬净中间体IV，再进一步还原得到卡泊芬净。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980072867.9A 2019-10-20 2019-10-20 一种卡泊芬净的合成方法及其中间体 Active CN113286807B (zh)

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PCT/CN2019/112067 WO2021077242A1 (zh) 2019-10-20 2019-10-20 一种卡泊芬净的合成方法及其中间体

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CN113286807A true CN113286807A (zh) 2021-08-20
CN113286807B CN113286807B (zh) 2022-09-30

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CN (1) CN113286807B (zh)
WO (1) WO2021077242A1 (zh)

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06192292A (ja) * 1992-09-09 1994-07-12 Fujisawa Pharmaceut Co Ltd 新規ポリペプチド化合物及びその塩
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
WO2012047762A2 (en) * 2010-10-08 2012-04-12 Amplyx Pharmaceuticals, Inc. Antifungal agents
CN105481952A (zh) * 2014-12-24 2016-04-13 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
CN106478781A (zh) * 2015-09-02 2017-03-08 正大天晴药业集团股份有限公司 卡泊芬净的制备方法
CN109721640A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种卡泊芬净中间体及其合成方法
CN109721641A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种卡泊芬净的合成方法

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06192292A (ja) * 1992-09-09 1994-07-12 Fujisawa Pharmaceut Co Ltd 新規ポリペプチド化合物及びその塩
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
WO2012047762A2 (en) * 2010-10-08 2012-04-12 Amplyx Pharmaceuticals, Inc. Antifungal agents
CN105481952A (zh) * 2014-12-24 2016-04-13 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
CN106478781A (zh) * 2015-09-02 2017-03-08 正大天晴药业集团股份有限公司 卡泊芬净的制备方法
CN109721640A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种卡泊芬净中间体及其合成方法
CN109721641A (zh) * 2017-10-31 2019-05-07 鲁南制药集团股份有限公司 一种卡泊芬净的合成方法

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CN113286807B (zh) 2022-09-30
WO2021077242A1 (zh) 2021-04-29

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