CN113271977A - 使用艾日布林和选择性cdk4/6抑制剂组合治疗癌症的治疗方案 - Google Patents

使用艾日布林和选择性cdk4/6抑制剂组合治疗癌症的治疗方案 Download PDF

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Publication number
CN113271977A
CN113271977A CN201980088426.8A CN201980088426A CN113271977A CN 113271977 A CN113271977 A CN 113271977A CN 201980088426 A CN201980088426 A CN 201980088426A CN 113271977 A CN113271977 A CN 113271977A
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Prior art keywords
cancer
eribulin
cdk4
inhibitor
acceptable salt
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CN201980088426.8A
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English (en)
Chinese (zh)
Inventor
J·A·索伦蒂诺
P·J·罗伯茨
J·C·斯特鲁姆
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G1 Therapeutics Inc
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G1 Therapeutics Inc
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Publication of CN113271977A publication Critical patent/CN113271977A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/527—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim spiro-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201980088426.8A 2018-11-09 2019-11-12 使用艾日布林和选择性cdk4/6抑制剂组合治疗癌症的治疗方案 Pending CN113271977A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862758388P 2018-11-09 2018-11-09
US62/758,388 2018-11-09
PCT/US2019/061010 WO2020097625A1 (en) 2018-11-09 2019-11-12 Therapeutic regimens for treatment of cancer using eribulin and selective cdk4/6 inhibitor combinations

Publications (1)

Publication Number Publication Date
CN113271977A true CN113271977A (zh) 2021-08-17

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CN201980088426.8A Pending CN113271977A (zh) 2018-11-09 2019-11-12 使用艾日布林和选择性cdk4/6抑制剂组合治疗癌症的治疗方案

Country Status (5)

Country Link
US (1) US20210267986A1 (https=)
EP (1) EP3877422A4 (https=)
JP (1) JP2022506829A (https=)
CN (1) CN113271977A (https=)
WO (1) WO2020097625A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL303038B2 (en) 2016-12-05 2024-08-01 G1 Therapeutics Inc Preservation of immune response during chemotherapy regimens
EP3565558B1 (en) 2017-01-06 2023-12-06 G1 Therapeutics, Inc. Combination therapy with a serd compound and a cdk4/6 inhibitor for the treatment of cancer
ES3048084T3 (en) 2020-05-19 2025-12-09 Pharmacosmos Holding As Cyclin-dependent kinase inhibiting compounds for the treatment of medical disorders
WO2022087018A1 (en) * 2020-10-19 2022-04-28 G1 Therapeutics, Inc. Improved fluorouracil-based multi-agent chemotherapy for treatment of metastatic colorectal cancer
CN114748480B (zh) * 2021-01-08 2023-10-20 轩竹生物科技股份有限公司 一种预防和/或治疗癌症的药物组合物

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429243A (zh) * 2010-10-25 2013-12-04 G1治疗公司 Cdk抑制剂
WO2014087230A1 (en) * 2012-12-04 2014-06-12 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of breast cancer
US20150297606A1 (en) * 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic Lactams for Use in the Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
CN105407889A (zh) * 2013-03-15 2016-03-16 G1治疗公司 针对Rb阳性异常细胞增殖的HSPC节制性治疗
US20160220569A1 (en) * 2015-02-03 2016-08-04 G1 Therapeutics, Inc. CDK4/6 Inhibitor Dosage Formulations For The Protection Of Hematopoietic Stem And Progenitor Cells During Chemotherapy
CN106029070A (zh) * 2014-03-03 2016-10-12 卫材R&D管理有限公司 艾日布林和mTOR抑制剂作为治疗癌症的联合疗法的用途
CN106413705A (zh) * 2014-05-28 2017-02-15 卫材R&D管理有限公司 艾日布林在治疗癌症中的用途
US20170182043A1 (en) * 2014-09-12 2017-06-29 G1 Therapeutics, Inc. Anti-Neoplastic Combinations and Dosing Regimens using CDK4/6 Inhibitor Compounds to Treat RB-Positive Tumors
WO2018005533A1 (en) * 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
WO2018106729A1 (en) * 2016-12-05 2018-06-14 G1 Therapeutics, Inc. Preservation of immune response during chemotherapy regimens
WO2018129387A1 (en) * 2017-01-06 2018-07-12 G1 Therapeutics, Inc. Combination therapy for the treatment of cancer
WO2019017497A1 (en) * 2017-07-21 2019-01-24 Eisai R&D Management Co., Ltd. USE OF CYCLIN-DEPENDENT KINASE ERIBULINE AND INHIBITORS IN THE TREATMENT OF CANCER

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* Cited by examiner, † Cited by third party
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US20160166536A1 (en) * 2014-12-12 2016-06-16 Northwestern University Combination therapy for the treatment of cancer
EP3487492A4 (en) * 2016-07-20 2020-03-11 Eisai R&D Management Co., Ltd. USE OF ERIBULIN AND HISTONE DEACETYLASE INHIBITORS FOR THE TREATMENT OF CANCER
US20180371021A1 (en) * 2017-05-11 2018-12-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103429243A (zh) * 2010-10-25 2013-12-04 G1治疗公司 Cdk抑制剂
WO2014087230A1 (en) * 2012-12-04 2014-06-12 Eisai R&D Management Co., Ltd. Use of eribulin in the treatment of breast cancer
CN105407889A (zh) * 2013-03-15 2016-03-16 G1治疗公司 针对Rb阳性异常细胞增殖的HSPC节制性治疗
CN106029070A (zh) * 2014-03-03 2016-10-12 卫材R&D管理有限公司 艾日布林和mTOR抑制剂作为治疗癌症的联合疗法的用途
US20150297607A1 (en) * 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic Lactams for Use in the Protection of Normal Cells During Chemotherapy
US20150297606A1 (en) * 2014-04-17 2015-10-22 G1 Therapeutics, Inc. Tricyclic Lactams for Use in the Protection of Hematopoietic Stem and Progenitor Cells Against Ionizing Radiation
CN106413705A (zh) * 2014-05-28 2017-02-15 卫材R&D管理有限公司 艾日布林在治疗癌症中的用途
US20170182043A1 (en) * 2014-09-12 2017-06-29 G1 Therapeutics, Inc. Anti-Neoplastic Combinations and Dosing Regimens using CDK4/6 Inhibitor Compounds to Treat RB-Positive Tumors
US20160220569A1 (en) * 2015-02-03 2016-08-04 G1 Therapeutics, Inc. CDK4/6 Inhibitor Dosage Formulations For The Protection Of Hematopoietic Stem And Progenitor Cells During Chemotherapy
WO2018005533A1 (en) * 2016-07-01 2018-01-04 G1 Therapeutics, Inc. Antiproliferative pyrimidine-based compounds
WO2018106729A1 (en) * 2016-12-05 2018-06-14 G1 Therapeutics, Inc. Preservation of immune response during chemotherapy regimens
WO2018129387A1 (en) * 2017-01-06 2018-07-12 G1 Therapeutics, Inc. Combination therapy for the treatment of cancer
WO2019017497A1 (en) * 2017-07-21 2019-01-24 Eisai R&D Management Co., Ltd. USE OF CYCLIN-DEPENDENT KINASE ERIBULINE AND INHIBITORS IN THE TREATMENT OF CANCER

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JOHN E. BISI1等: ""Preclinical Characterization of G1T28: A Novel CDK4/6 Inhibitor for Reduction of Chemotherapy-Induced Myelosuppression"", 《MOLECULAR CANCER THERAPEUTICS》 *
KENICHI NOMOTO等: ""Synergistic anticancer activity of eribulin plus palbociclib inpatient-dervied xenograft (PDX) models of ER+/Her2- human breast cancer"", 《MOL CANCER THER》 *
KENICHI NOMOTO等: "Abstract B191: Synergistic anticancer activity of eribulin plus palbociclib in patient-derived xenograft (PDX) models of ER+/Her2- human breast cancer" *
P.J. ROBERTS等: ""Trilaciclib (G1T28), a CDK4/6 inhibitor, enhances the efficacy of combination chemotherapy and immune checkpoint inhibitor treatment in preclinical models"", 《ANNALS OF ONCOLOGY》 *
P.J. ROBERTS等: "Trilaciclib (G1T28), a CDK4/6 inhibitor, enhances the efficacy of combination chemotherapy and immune checkpoint inhibitor treatment in preclinical models" *
SHREYAS S. RAO等: ""Synergistic effect of eribulin and CDK inhibition for the treatment of triple negative breast cancer"", 《ONCOTARGET》 *
TONGZHENG LIU等: ""CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1"" *

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JP2022506829A (ja) 2022-01-17
EP3877422A4 (en) 2022-08-24
WO2020097625A1 (en) 2020-05-14
EP3877422A1 (en) 2021-09-15
US20210267986A1 (en) 2021-09-02

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