CN113271940A - Tyk2抑制剂和其用途 - Google Patents

Tyk2抑制剂和其用途 Download PDF

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Publication number
CN113271940A
CN113271940A CN201980079011.4A CN201980079011A CN113271940A CN 113271940 A CN113271940 A CN 113271940A CN 201980079011 A CN201980079011 A CN 201980079011A CN 113271940 A CN113271940 A CN 113271940A
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China
Prior art keywords
nitrogen
sulfur
oxygen
independently selected
heteroatoms independently
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CN201980079011.4A
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English (en)
Chinese (zh)
Inventor
C·E·玛斯
J·R·葛林伍德
S·蒙达尔
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Takeda Pharmaceutical Co Ltd
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Nimbus Lakshmi Inc
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Publication of CN113271940A publication Critical patent/CN113271940A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980079011.4A 2018-10-15 2019-10-15 Tyk2抑制剂和其用途 Pending CN113271940A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862745642P 2018-10-15 2018-10-15
US62/745,642 2018-10-15
US201962795869P 2019-01-23 2019-01-23
US62/795,869 2019-01-23
US201962820509P 2019-03-19 2019-03-19
US62/820,509 2019-03-19
PCT/US2019/056230 WO2020081508A1 (en) 2018-10-15 2019-10-15 Tyk2 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CN113271940A true CN113271940A (zh) 2021-08-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980079011.4A Pending CN113271940A (zh) 2018-10-15 2019-10-15 Tyk2抑制剂和其用途

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US (2) US11414431B2 (https=)
EP (1) EP3866789A4 (https=)
JP (2) JP7619951B2 (https=)
CN (1) CN113271940A (https=)
AU (2) AU2019360941B2 (https=)
CA (1) CA3115088A1 (https=)
IL (2) IL282090B2 (https=)
WO (1) WO2020081508A1 (https=)

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WO2026037386A1 (zh) * 2024-08-15 2026-02-19 成都肯迪特生物医药科技有限公司 一种具有tyk2抑制作用的化合物及其制备方法和用途

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JP2022519696A (ja) * 2019-02-07 2022-03-24 ベンティックス バイオサイエンシーズ，インク． Ｔｙｋ２偽キナーゼリガンド
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JP7635228B2 (ja) 2019-11-08 2025-02-25 ベンティックス バイオサイエンシーズ，インク． Ｔｙｋ２偽キナーゼリガンド
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CN113943294A (zh) * 2020-07-15 2022-01-18 成都海博为药业有限公司 一种作为btk抑制剂的化合物及其制备方法与用途
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EP4423086A1 (en) 2021-10-25 2024-09-04 Kymera Therapeutics, Inc. Tyk2 degraders and uses thereof
US20250213572A1 (en) * 2022-03-25 2025-07-03 Takeda Pharmaceutical Company Limited Tyk2 inhibitors and uses thereof
AR128868A1 (es) * 2022-03-25 2024-06-19 Nimbus Lakshmi Inc Formulaciones de inhibidor de tyk2 y métodos para elaborarlas
US20240158394A1 (en) 2022-09-14 2024-05-16 Halia Therapeutics, Inc. Nek7 inhibitors
WO2026033474A1 (en) 2024-08-08 2026-02-12 Takeda Pharmaceutical Company Limited Deuterated compounds and uses thereof

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IL324623A (en) 2026-01-01
CA3115088A1 (en) 2020-04-23
US11414431B2 (en) 2022-08-16
IL282090B2 (en) 2026-04-01
EP3866789A1 (en) 2021-08-25
WO2020081508A1 (en) 2020-04-23
JP7619951B2 (ja) 2025-01-22
JP2022502515A (ja) 2022-01-11
IL282090B1 (en) 2025-12-01
AU2019360941A1 (en) 2021-04-29
JP2025061147A (ja) 2025-04-10
AU2019360941B2 (en) 2025-02-27
US20230110996A1 (en) 2023-04-13
AU2025203926A1 (en) 2025-06-19
EP3866789A4 (en) 2022-07-06
IL282090A (en) 2021-05-31
US20200131201A1 (en) 2020-04-30
US12221453B2 (en) 2025-02-11

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