CN113260607A - 改性的胺脂质 - Google Patents
改性的胺脂质 Download PDFInfo
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- CN113260607A CN113260607A CN201980086265.9A CN201980086265A CN113260607A CN 113260607 A CN113260607 A CN 113260607A CN 201980086265 A CN201980086265 A CN 201980086265A CN 113260607 A CN113260607 A CN 113260607A
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- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
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- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/16—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by an inorganic acid or a derivative thereof
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- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
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- C07C229/12—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of acyclic carbon skeletons
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- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
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- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202410977955.6A CN119285480A (zh) | 2018-12-05 | 2019-12-05 | 改性的胺脂质 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114213346A (zh) * | 2022-02-22 | 2022-03-22 | 中国科学院基础医学与肿瘤研究所(筹) | 一种双价可电离脂质化合物、组合物及其应用 |
| CN114213347A (zh) * | 2022-02-22 | 2022-03-22 | 中国科学院基础医学与肿瘤研究所(筹) | 一种双价可电离脂质化合物、组合物及其应用 |
| CN116354836A (zh) * | 2022-03-25 | 2023-06-30 | 深圳市新合生物医疗科技有限公司 | 阳离子脂质化合物及其制备方法和应用、以及mRNA递送系统 |
| WO2023179463A1 (zh) * | 2022-03-25 | 2023-09-28 | 深圳新合睿恩生物医疗科技有限公司 | 阳离子脂质化合物及其制备方法和应用、以及mRNA递送系统 |
| WO2024251108A1 (zh) * | 2023-06-07 | 2024-12-12 | 北京因诺惟康医药科技有限公司 | 可电离脂质化合物、包含其的脂质载体及应用 |
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| BR112021010853A2 (pt) | 2021-08-31 |
| US12077483B2 (en) | 2024-09-03 |
| IL314386A (en) | 2024-09-01 |
| PH12021551279A1 (en) | 2021-12-06 |
| CO2021008838A2 (es) | 2021-10-29 |
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| MX2021006150A (es) | 2021-11-12 |
| CA3121621A1 (en) | 2020-06-11 |
| TW202504886A (zh) | 2025-02-01 |
| EP3891127A1 (en) | 2021-10-13 |
| CN119285480A (zh) | 2025-01-10 |
| MA54385A (fr) | 2021-10-13 |
| IL283622B1 (en) | 2024-09-01 |
| IL283622B2 (en) | 2025-01-01 |
| JP2024167309A (ja) | 2024-12-03 |
| KR20210108969A (ko) | 2021-09-03 |
| AU2019392673A1 (en) | 2021-06-10 |
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