CN113181075A - Anti-inflammatory repairing antioxidant composition and essence thereof and preparation method - Google Patents
Anti-inflammatory repairing antioxidant composition and essence thereof and preparation method Download PDFInfo
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- CN113181075A CN113181075A CN202110422959.4A CN202110422959A CN113181075A CN 113181075 A CN113181075 A CN 113181075A CN 202110422959 A CN202110422959 A CN 202110422959A CN 113181075 A CN113181075 A CN 113181075A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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Abstract
The invention relates to the technical field of essence, in particular to an anti-inflammatory, repairing and antioxidant composition, which comprises camellia seed oil, tocopherol (vitamin E), phytosphingosine, jojoba seed oil and sunflower seed oil, and also discloses essence containing the anti-inflammatory, repairing and antioxidant composition and a preparation method thereof. The invention aims to overcome the defect that anti-inflammatory repairing efficacy and antioxidant efficacy are mutually inhibited, and provides an anti-inflammatory repairing antioxidant composition.
Description
Technical Field
The invention relates to the technical field of essence, in particular to an anti-inflammatory repairing antioxidant composition, essence thereof and a preparation method thereof.
Background
Skin aging is a very complex physiological process, and external factors such as long-term excessive sun exposure, artificial light irradiation, air pollution, ionizing radiation, and chemistry can cause accelerated skin aging. Skin is chronically subjected to photodamage and Reactive Oxygen Species (ROS) generated on the skin can lead to signs of aging of the skin in tissues and in the clinic. Oxidative stress is accompanied by the production of reactive oxygen species, a process that is the primary weapon of the immune system to fight invading pathogens and to promote tissue repair functions. However, if the active oxygen is excessive, the degree of immune-related oxidative stress is increased, and when the reaction is excessive, the organ is damaged and the function thereof is disordered, obvious allergic and inflammatory reactions are shown, and sensitive muscles are even formed. The long-term bad sleep quality is also related to the internal aging of human body, and can also lead to external skin aging, which gradually weakens the skin barrier.
The defects that most anti-inflammatory repair products in the market have the characteristic of over-strong oxidizability, so that the products need to be compounded by adding other raw materials specially used for oxidation resistance.
Disclosure of Invention
Aiming at the existing problems, the invention aims at overcoming the defect that the anti-inflammatory repair effect and the antioxidant effect are mutually inhibited, and provides an anti-inflammatory repair antioxidant-containing composition.
The technical purpose of the invention is realized by the following technical scheme that the anti-inflammatory repairing antioxidant composition comprises the following components in parts by weight,
camellia seed oil 70-90
Tocopherol (vitamin E)0.1-2.0
Phytosphingosine 0.1-2.0
Jojoba seed oil 0.5-5.0
0.5-10 parts of sunflower seed oil.
An anti-inflammatory, repairing and antioxidant essence comprises the following components in parts by weight,
pure water 100
0.5 to 1.5 percent of preservative
0.7-2.5 parts of thickening agent
Emulsifier 1.6-5
3.5-14 parts of grease
Arginine 0.05-0.25
1.1-11 parts of humectant,
anti-inflammatory, repairing and antioxidant compositions.
Preferably, the preservative is menthone and 1.2 hexanediol.
Preferably, the thickening agent is at least one of xanthan gum, cetearyl alcohol and carbomer.
Preferably, the emulsifier is at least one of hydrogenated lecithin, montanov L and glycerol stearate.
Preferably, the grease is at least one of caprylic/capric triglyceride, polydimethylsiloxane, shea butter, octyl polydimethylsiloxane and bis-PEG-18 methyl ether dimethylsilane.
Further, the humectant is at least one of Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract, glycerol and 1.3 butanediol.
The preparation method of the anti-inflammatory, repairing and antioxidant essence is characterized by comprising the following steps:
s1, adding the humectant, the thickener and a part of pure water into a main emulsifying pot, stirring and heating, heating to 85-95 ℃, homogenizing until the materials are completely dissolved, preserving heat and sterilizing for more than 30 minutes to obtain a first material, and storing the first material in the main emulsifying pot;
s2, heating the oil pan, adding the completely dissolved emulsifier and grease mixture into a main emulsifying pan in which the first material body is stored, stirring and homogenizing until complete emulsification is achieved, obtaining a second material body, and storing the second material body in the main emulsifying pan;
s3, cooling the main emulsifying pot with the second material body to 65-70 ℃, adding a solution of arginine and the other part of pure water, uniformly stirring to obtain a third material body, and storing the third material body in the main emulsifying pot.
S4, cooling the main emulsifying pot with the third material body to 45-65 ℃, adding the preservative into the main emulsifying pot, uniformly stirring the mixture until the preservative is completely dissolved, and cooling the mixture to below 45 ℃ to obtain the essence.
Further, the solution of arginine and purified water in the step S3 was prepared by completely dissolving arginine and purified water in a mass ratio of 1: 5.
The principle of the present invention is explained,
the phytosphingosine containing sphingosine is a precursor of ceramide naturally existing in synthetic skin, and the phytosphingosine in wheat is very close to skin lipid components, so that the phytosphingosine is easy to absorb without burden, has the functions of keeping moisture and maintaining skin barrier, and further achieves the effect of repairing skin;
the natural tocopherol (vitamin E) has the functions of scavenging free radicals and resisting oxidation, and when the vitamin E is deficient: free radicals generated in the metabolic process of a human body can not only cause lipid peroxidation of a biological membrane, destroy the structure and function of a cell membrane and form lipofuscin; but also denaturalizes protein, inactivates enzyme and hormone, reduces immunity, causes metabolism disorder, and promotes the aging of the organism or causes hemolysis;
the chemical molecular arrangement of the jojoba oil is very similar to that of human sebum, so that the jojoba oil is very easy to be classified and absorbed by skin, pores are unblocked, the pH balance of the skin is adjusted, and skin inflammation and sensitivity are improved;
the sunflower seed oil contains vitamins A, B, D and E, and is rich in unsaturated fatty acids. Can promote the regeneration and growth of human cells and protect the health of skin;
the camellia oil adopts raw materials of Hunan Xixiang sources as basic solvents, and because the camellia oil has high content of unsaturated fatty acid and is easy to oxidize, the camellia oil adopts a pure physical low-temperature cold pressing process, so that the stability is higher, functional components are not easy to damage, and meanwhile, natural tocopherol (vitamin E) and sunflower oil in the composition can well protect the oxidation problem of other natural source plant components, so that the product is more stable, and the function of the functional components is ensured to play.
The invention has the following beneficial effects: the oil and fat of natural ingredients can be reduced or even solved by the specific matching of the compositions, active ingredients are protected from being damaged, and specific anti-inflammatory repairing and antioxidant effects are achieved.
Description of the drawings:
FIG. 1 is a diagram of the original state of skin;
FIG. 2 is a graph of acetone treatment disrupting the skin barrier;
figure 3 is a diagram of the best embodiment for repairing acetone-stimulated skin barriers.
The specific implementation mode is as follows:
the present invention is described in further detail below with reference to examples, which are intended to facilitate the understanding of the present invention and are not intended to limit the present invention in any way. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In case of conflict, the present specification, including definitions, will control.
The term "prepared from …" as used herein is synonymous with "comprising". The terms "comprises," "comprising," "includes," "including," "has," "having," "contains," "containing," or any other variation thereof, as used herein, are intended to cover a non-exclusive inclusion. For example, a composition, process, method, article, or apparatus that comprises a list of elements is not necessarily limited to only those elements but may include other elements not expressly listed or inherent to such composition, process, method, article, or apparatus.
The conjunction "consisting of …" excludes any unspecified elements, steps or components. If used in a claim, the phrase is intended to claim as closed, meaning that it does not contain materials other than those described, except for the conventional impurities associated therewith. When the phrase "consisting of …" appears in a clause of the subject matter of the claims rather than immediately after the subject matter, it defines only the elements described in the clause; other elements are not excluded from the claims as a whole.
When an amount, concentration, or other value or parameter is expressed as a range, preferred range, or as a range of upper preferable values and lower preferable values, this is to be understood as specifically disclosing all ranges formed from any pair of any upper range limit or preferred value and any lower range limit or preferred value, regardless of whether ranges are separately disclosed. For example, when a range of "1 to 5" is disclosed, the described range should be interpreted to include the ranges "1 to 4", "1 to 3", "1 to 2 and 4 to 5", "1 to 3 and 5", and the like. When a range of values is described herein, unless otherwise stated, the range is intended to include the endpoints thereof and all integers and fractions within the range.
Although the anti-inflammatory, repairing and antioxidant composition can be used alone to exert its effects, it is difficult to embody the effects of the composition only by the embodiment, and therefore, the present application is exemplified by the essence containing the anti-inflammatory, repairing and antioxidant composition as follows.
The essence containing the anti-inflammatory, repairing and antioxidant composition is 100 parts of pure water, 0.5-1.5 parts of preservative, 0.7-2.5 parts of thickening agent, 1.6-5 parts of emulsifier, 3.5-14 parts of grease, 0.05-0.25 part of arginine, 1.1-11 parts of humectant and 4-6 parts of anti-inflammatory, repairing and antioxidant composition.
Wherein the anti-inflammatory, repairing and antioxidant composition comprises camellia seed oil 70-90, tocopherol (vitamin E)0.1-2.0, phytosphingosine 0.1-2.0, jojoba seed oil 0.5-5.0, and sunflower seed oil 0.5-10.
Explanation of the respective raw materials:
arginine as a neutralizing agent;
the antiseptic is menthone and 1.2 hexanediol;
the thickener is at least one of xanthan gum, cetearyl alcohol and carbomer.
The emulsifier is at least one of hydrogenated lecithin, montanov L and glycerol stearate.
The oil and fat is at least one of caprylic/capric triglyceride, polydimethylsiloxane, shea butter, octyl polydimethylsiloxane, and bis-PEG-18 methyl ether dimethylsilane.
The humectant is at least one of Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract, glycerol, and 1.3 butanediol.
The inventive examples 1-2, the most preferred examples and the blank examples were compared, and the contents of the respective components are shown in the following table 1,
TABLE 1 statistical table of raw material component contents of each example
The "/" part above indicates that this material was not added.
The contents of the components of the anti-inflammatory, repairing and antioxidant composition are shown in the following table 2,
TABLE 2 statistical table of anti-inflammatory, repairing and antioxidant composition component content
| Components | Example 1 | Example 2 | Best mode for carrying out the invention |
| Camellia JAPONICA (Camellia JAPONICA) seed oil | 70 | 90 | 80 |
| Tocopherol (vitamin E) | 2.0 | 0.1 | 1.0 |
| Phytosphingosine | 2.0 | 0.1 | 1.0 |
| Jojoba seed oil | 5 | 0.5 | 3.0 |
| Sunflower seed oil | 10 | 0.5 | 4.8 |
The preparation method of the anti-inflammatory repairing antioxidant composition comprises the following steps: the components in the amounts according to Table 2 were mixed and stirred homogeneously, it being essential that the entire preparation process be inhibited from any temperature increase.
The above examples 1-2, the most preferred examples and the blank examples were prepared as follows,
s1, adding the humectant, the thickener and a part of pure water into a main emulsifying pot, stirring and heating, heating to 85-95 ℃, homogenizing until the materials are completely dissolved, preserving heat and sterilizing for 30 minutes to obtain a first material, and storing the first material in the main emulsifying pot;
s2, heating the oil pan, adding the completely dissolved emulsifier and grease mixture into a main emulsifying pan in which the first material body is stored, stirring and homogenizing until complete emulsification is achieved, obtaining a second material body, and storing the second material body in the main emulsifying pan;
s3, cooling the main emulsifying pot with the second material body to 65-70 ℃, adding a solution of arginine and the other part of pure water, uniformly stirring to obtain a third material body, and storing the third material body in the main emulsifying pot.
Wherein the solution of arginine and pure water is prepared by completely dissolving arginine and pure water in a mass ratio of 1: 5.
S4, cooling the main emulsifying pot with the third material body to 45-65 ℃, adding the preservative into the main emulsifying pot, uniformly stirring the mixture until the preservative is completely dissolved, and cooling the mixture to below 45 ℃ to obtain the essence.
Examples 1-2 and the best example can prepare essence containing anti-inflammatory, repairing and antioxidant composition, and the best example and the blank example are compared for effects.
Comparison of first, repair action
1) The test method comprises the following steps: both the most preferred and blank examples were tested using human skin ex vivo testing using immunohistochemical methods using anti-filaggrin antibodies.
2) And (3) testing results: referring to fig. 1-3, wherein fig. 1 is a diagram of the skin in its original state, fig. 2 is a diagram of the acetone treatment for disrupting the skin barrier, fig. 3 is a diagram of the preferred embodiment for repairing the acetone-stimulated skin barrier,
as an illustration, the blank example is used to repair the acetone-stimulated skin barrier map is nearly identical to that of FIG. 2, and therefore, the effect map is omitted.
3) And (4) experimental conclusion: in the case of using acetone to destroy the skin barrier, it is apparent that the most preferred embodiment has a function of efficiently repairing the skin barrier when compared with the blank embodiment and the most preferred embodiment of the additive composition, while the blank embodiment has substantially no change before and after the repair.
Comparison of antioxidant action
1) The test method comprises the following steps: the empty and best examples were placed in the same clear glass and observed after 24 hours.
2) And (3) testing results: the blank embodiment is darker than the preferred embodiment.
3) And (4) experimental conclusion: the blank examples are more oxidized, and the reverse derivation shows that the essence of the optimal example has oxidation resistance.
The foregoing examples are merely illustrative and serve to explain some of the features of the method of the present invention. The appended claims are intended to claim as broad a scope as is conceivable, and the examples presented herein demonstrate the results of applicants' actual experiments. Accordingly, it is applicants' intention that the appended claims are not to be limited by the choice of examples illustrating features of the invention. Also, where numerical ranges are used in the claims, subranges therein are included, and variations in these ranges are also to be construed as possible being covered by the appended claims.
Claims (9)
1. The anti-inflammatory repairing antioxidant composition is characterized by comprising a humectant, an anti-inflammatory repairing antioxidant composition, a humectant and a antioxidant composition, wherein the anti-inflammatory repairing antioxidant composition comprises the following components in parts by weight,
camellia seed oil 70-90
Tocopherol (vitamin E)0.1-2.0
Phytosphingosine 0.1-2.0
Jojoba seed oil 0.5-5.0
0.5-10 parts of sunflower seed oil.
2. An anti-inflammatory repairing antioxidant essence is characterized by comprising the following components in parts by weight,
pure water 100
0.5 to 1.5 percent of preservative
0.7-2.5 parts of thickening agent
Emulsifier 1.6-5
3.5-14 parts of grease
Arginine 0.05-0.25
1.1-11 parts of humectant,
anti-inflammatory, repairing and antioxidant compositions.
3. The anti-inflammatory, repairing and antioxidant essence of claim 2 wherein the preservative is menthone and 1.2 hexanediol.
4. The anti-inflammatory, repairing and antioxidant essence of claim 2, wherein the thickener is at least one of xanthan gum, cetearyl alcohol and carbomer.
5. The anti-inflammatory, repairing and antioxidant essence according to claim 2, wherein the emulsifier is at least one of hydrogenated lecithin, montanov L, and glyceryl stearate.
6. The anti-inflammatory, repairing and antioxidant essence of claim 2, wherein the oil is at least one of caprylic/capric triglyceride, dimethicone, shea butter, octyl dimethicone, bis-PEG-18 methyl ether dimethylsilane.
7. The anti-inflammatory, repairing and antioxidant essence as claimed in claim 2, wherein the humectant is at least one of Tremella FUCIFORMIS (Tremella FUCIFORMIS) fruiting body extract, glycerin, and 1.3 butylene glycol.
8. The preparation method of the anti-inflammatory repairing antioxidant essence is characterized by comprising the following steps of:
s1, adding the humectant, the thickener and a part of pure water into a main emulsifying pot, stirring and heating, heating to 85-95 ℃, homogenizing until the materials are completely dissolved, preserving heat and sterilizing for more than 30 minutes to obtain a first material, and storing the first material in the main emulsifying pot;
s2, heating the oil pan, adding the completely dissolved emulsifier and grease mixture into a main emulsifying pan in which the first material body is stored, stirring and homogenizing until complete emulsification is achieved, obtaining a second material body, and storing the second material body in the main emulsifying pan;
s3, cooling the main emulsifying pot in which the second material body is stored to 65-70 ℃, adding a solution of arginine and the other part of pure water, uniformly stirring to obtain a third material body, and storing the third material body in the main emulsifying pot;
s4, cooling the main emulsifying pot with the third material body to 45-65 ℃, adding the preservative into the main emulsifying pot, uniformly stirring the mixture until the preservative is completely dissolved, and cooling the mixture to below 45 ℃ to obtain the essence.
9. The method for preparing the essence containing anti-inflammatory, repairing and antioxidant effects of claim 8, wherein the solution of arginine and purified water at step S3 is prepared by completely dissolving arginine and purified water at a mass ratio of 1: 5.
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2021
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Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20130323332A1 (en) * | 2012-05-31 | 2013-12-05 | Sherry May Raymond-Coblantz | Hand and body moisturizing serum |
| CN110402134A (en) * | 2017-03-01 | 2019-11-01 | 布茨公司 | Cosmetic skin care composition |
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Application publication date: 20210730 |