CN107126391A - A kind of anti-inflammatory remediation composition and its application - Google Patents
A kind of anti-inflammatory remediation composition and its application Download PDFInfo
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- CN107126391A CN107126391A CN201710341983.9A CN201710341983A CN107126391A CN 107126391 A CN107126391 A CN 107126391A CN 201710341983 A CN201710341983 A CN 201710341983A CN 107126391 A CN107126391 A CN 107126391A
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- inflammatory
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- remediation composition
- composition
- seed oil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8158—Homopolymers or copolymers of amides or imides, e.g. (meth) acrylamide; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
Abstract
The invention discloses a kind of anti-inflammatory remediation composition and its application, include the composition of following mass percent：Octyl dodecanol 0.1 2%, 'Heijialun ' seed oil 0.1 2%, sunflower seed oil unsaponifiable matter 0.01 2%, sunflower seed oil 0.1 3%, Rosmarinus officinalis extract 0.01 1%, NMF 4.11 21.1%, skin emollient 5.1 24%, emulsifying agent 1.5 4.5%, skin conditioner 3.11 14.1%, preservative 0.3 1%.Skin sensitivity and inflammation can effectively be prevented, alleviate the allergic reaction after bite by mosquitos, while repairing impaired skin, quick to heal, water profit, which is relaxed, to be slided, and the summer for being adapted to sweltering heat uses.
Description
Technical field
The present invention relates to cosmetic field, and in particular to a kind of anti-inflammatory remediation composition and its application.
Background technology
Mosquito is the vector of the other pathogens such as dengue fever, malaria, yellow fever, filariasis, encephalitis B, by mosquito
Many diseases that above-mentioned pathogen triggers may be infected by biting.Most common symptom is：Mosquito bite occur small red pimple,
Local itch；In the case of indivedual, occur stining trace (i.e. smooth, projection, rubescent skin) or hard swelling.Locally produced when serious
The severe reactions such as bleb, hemorrhagic necrosis, therefore, bite by mosquitos are summer dermatology common disease diseases.It is big after by bite by mosquitos
Majority's selection is smeared a floral water and simply got over, and what is had dare not even ignore, and wait it to heal spontaneously, this brings to personal health
Great hidden danger.
Chinese patent application CN200810151319.9 discloses one kind and treats dermatitis and eczema, pruritus due to mosquito bites medicine
Thing and purposes, though belonging to pharmaceutical composition with anti-inflammatory, antibacterial, antipruritic effect, skin sense is poor, is not appropriate in sweltering heat
Summer uses；China applies for a patent CN201410319713.4 and discloses a kind of anti-inflammatory cosmetic composition and preparation method thereof,
Mainly include stevia rebaudianum extract solution and palm leaf extract, can effectively prevent and prevent and treat dermatitis, but can not have after anti-inflammatory
The promotion cytothesis of effect, repairs maintenance skin.
The content of the invention
In view of the above-mentioned problems, the invention discloses a kind of anti-inflammatory remediation composition, can effectively prevent skin sensitivity and inflammation
Disease, alleviates the allergic reaction after bite by mosquitos, while impaired skin is repaired, quick healing, water profit, which is relaxed, to be slided, and is adapted to hot summer
Use.
The present invention is achieved by the following scheme：
A kind of anti-inflammatory remediation composition, includes the composition of following mass percent：Octyl dodecanol 0.1-2%, blackcurrant
Seed oil 0.1-2%, sunflower seed oil unsaponifiable matter 0.01-2%, sunflower seed oil 0.1-3%, Rosmarinus officinalis extract 0.01-
1%.
Further, the anti-inflammatory remediation composition also includes NMF 4.11-21.1%, skin emollient 5.1-
24%, emulsifying agent 1.5-4.5%, skin conditioner 3.11-14.1%, preservative 0.3-1%.
Preferably, the NMF includes the composition of following mass percent：It is butanediol 1-5%, glycerine 1-5%, transparent
Matter acid sodium 0.01-0.1%, glycine betaine 1-5%, double-PEG-18 methyl ethers dimethylsilane 0.1-1%, Butyrospermum parkii fruit fat 1-
5%.
Preferably, the skin emollient includes the composition of following mass percent：Parleam 1-5%, octyl group
Lauryl alcohol myristinate 1-5%, isononyl isononanoate 1-5%, carbonic acid dioctyl ester 1-5%, cetostearyl alcohol ethylhexoate
1-3%, C13-14 isoparaffin 0.1-1%.
Preferably, the emulsifying agent includes the composition of following mass percent：Glyceryl stearate citrate 1-3%,
Stearine 0.5-1.5%.
Preferably, the skin conditioner includes the composition of following mass percent：Creatine 0.01-0.1%, D-sorbite
1-5%, octyl group polymethyl siloxane 1-3%, tocopherol acetate 0.1-1%, niacinamide 1-5%.
Preferably, the preservative includes the composition of following mass percent：Methyl hydroxybenzoate 0.1-0.4%, Phenoxyethanol
0.1-0.4%, Nipasol 0.1-0.2%.
Further, the anti-inflammatory remediation composition also includes the composition of following mass percent：EDETATE SODIUM 0.01-
0.1%th, docosyl alcohol 1-3%, phytosterol isostearate 0.1-1%, polyamide fibre -120.1-1%, PEG-100 stearates
0.5-1.5%, laureth -70.1-1%, vaseline 1-3%, polyacrylamide 0.1-1%, deionized water surplus.
The present invention also provides a kind of application of anti-inflammatory remediation composition in cosmetics are prepared.Described cosmetics can be
Cream, emulsion, aqua, Essence, ointment.It is preferred that, the cosmetics are anti-inflammatory repair cream.
The present invention carries octyl dodecanol, 'Heijialun ' seed oil, sunflower seed oil unsaponifiable matter, sunflower seed oil, rosemary
Thing is taken to combine, obtained anti-inflammatory remediation composition has the advantages that：
1) it is quick to absorb, form protective barrier.Octyl dodecanol in present anti-inflammatory remediation composition can promote flesh
Skin to 'Heijialun ' seed oil, sunflower seed oil unsaponifiable matter, sunflower seed oil, Rosmarinus officinalis extract quick absorption so that Xiang
Seed oil of sunflower unsaponifiable matter, sunflower seed oil are attached to skin surface, and layer protective layer is formed while Glycerin, prevent the external world
Further destruction of the germ to skin, serves good barrier function.
2) anti-inflammatory, reparation skin.In the presence of octyl dodecanol, Rosmarinus officinalis extract and sunflower seed oil unsaponifiable matter
Absorbed by skin rapidly, Rosmarinus officinalis extract promotes the through skin of active ingredient being rich in sunflower seed oil unsaponifiable matter deep
Layer, suppresses the generation of skin inflammation from root, accelerates skin healing, alleviates the skin for repairing bite by mosquitos damage, reduces skin
Vigor.
3) water profit, which is relaxed, slides, and consumer experience degree is high.Moisturizing ingredient is also added in present anti-inflammatory remediation composition, it is transparent
Matter acid sodium can have good transdermal rush absorption, skin cell is had good water imbibition, while in the work of niacinamide
Under, ceramide and free fatty acid levels in skin are maintained, skin water content can also be maintained while moisturizing, promote true
The microcirculation of cortex, glycine betaine then preferably maintains the osmotic pressure of cell, make cell be in one it is permanent and stable moisten
State, simultaneously because the barrier function of sunflower seed oil unsaponifiable matter, sunflower seed oil, moisture is less easy to run off, alleviates skin
Dry sensation, has the easypro sliding skin sense of dampening profit, is particularly suitable for use in the summer of sweltering heat when using present anti-inflammatory remediation composition,
Mitigate scytitis, while repairing impaired skin, improve the comfort level of smearing, make consumer be more willing to receive this anti-inflammatory
Skin care mode, reduce because of bite by mosquitos and caused by potential safety hazard, have more wide market prospects.
Embodiment
In order that those skilled in the art will better understand the technical solution of the present invention, with reference to 1-5 pairs of embodiment
Product of the present invention is described in further detail.
The composition proportion of the embodiment 1-5 anti-inflammatory repair creams of table 1
The preparation method of embodiment 1-5 anti-inflammatory repair cream is as follows：
(1) by Glyceryl stearate citrate, stearine, octyl dodecanol, 'Heijialun ' seed oil, sunflower seed
It is oily unsaponifiable matter, sunflower seed oil, Butyrospermum parkii fruit fat, double-PEG-18 methyl ethers dimethylsilanes, Parleam, pungent
Base lauryl alcohol myristinate, isononyl isononanoate, carbonic acid dioctyl ester, cetostearyl alcohol ethylhexoate, the different alkanes of C13-14
Hydrocarbon, PEG-100 stearates, laureth -7, vaseline, polyacrylamide, which are mixed, constitutes oil phase addition oil phase pot, and stirring adds
Heat waits all components to be incubated after dissolving, A phases is made to 75-85 DEG C；
(2) by creatine, sorb (sugar) alcohol, octyl group polymethyl siloxane, tocopherol acetate, niacinamide, EDETATE SODIUM, mountain
Yu alcohol, phytosterol isostearate, polyamide fibre -12, butanediol, glycerine, deionized water mixing constitute aqueous phase and add aqueous phase pot, stir
Mix and be heated to 70-85 DEG C, insulation 15-30min makes it fully dissolve, and B phases are made；
(3) first B phases are pumped into emulsification pot and add A phases, homogeneous 5-15min, stir speed (S.S.) is 2000-4000r/
Min, then insulated and stirred 15-45min, stir speed (S.S.) is 30-50r/min；40-45 DEG C is cooled to, rosemary is sequentially added and carries
Thing, Sodium Hyaluronate, glycine betaine, methyl hydroxybenzoate, Phenoxyethanol, Nipasol is taken to stir discharging.
Comparative example 1
It is with the difference of implementation 2, is not added with octyl dodecanol.
Comparative example 2
It is with the difference of implementation 2, is not added with 'Heijialun ' seed oil.
Comparative example 3
It is with the difference of implementation 2, is not added with sunflower seed oil unsaponifiable matter.
Comparative example 4
It is with the difference of implementation 2, is not added with sunflower seed oil.
Comparative example 5
It is with the difference of implementation 2, is not added with Rosmarinus officinalis extract.
Comparative example 6
With implement 2 difference be, be not added with octyl dodecanol, 'Heijialun ' seed oil, sunflower seed oil unsaponifiable matter,
Sunflower seed oil, Rosmarinus officinalis extract.
Repair skin barrier efficacy validation
Experimental subjects：Choose the mouse of 100 12 to 13 week old.
Test method：All mouse are shaved off into back dorsal body setae, exposure about 2cm × 3cm skin, Ran Housui with shaver
Machine is divided into 12 groups, using butanediol solution as blank control, and 10 components are embodiment 1-5, comparative example 1-6 and control group.Will be each
Group anti-inflammatory repair cream is applied to the baring skin of mouse, and control group smears butanediol, then is placed under dehumidifier environment by mouse
Row exposure, exposure 6 hours, continue 15 days daily：Then mouse back baring skin moisture determination is carried out, is removed with card punch
Skin histology 0.5g after depilation, precision claims skin weight in wet base, is put into 48h in 80 DEG C of drying boxes, claims skin dry weight.And by following equation
Measure the skin percentage of moisture：
The skin percentage of moisture=(skin weight in wet base-skin dry weight)/weight in wet base × 100%
Experimental result see the table below 2：
Table 2
The skin percentage of moisture average value of the corresponding experiment mices of embodiment 1-5 is more than 72.82% as shown in Table 2,
Far above comparative example 1-6, it can be seen that although comparative example 1-6 is compared with embodiment 1-5, only the presence or absence of individual components change
Become, just generate more significant moistening effect difference, side proves the reasonable science of formula of present anti-inflammatory repair cream, respectively into
Divide Synergistic, it is indispensable.
Using effect is tested
In order to assess effect of present anti-inflammatory repair cream, by product made from embodiment 1-5 and comparative example 1-6 in will
Tested with hope person, every group of 30 people, continuous to use 4 weeks, observation uses result, as shown in table 4：
Table 4
Anti-inflammatory repair cream of the invention, can effectively suppress scytitis as can be seen here, repair damaged cell, and the easypro cunning of water profit has
Good skin sense.
Embodiment described above only expresses the several embodiments of the present invention, and it describes more specific and detailed, but simultaneously
Therefore the limitation to the scope of the claims of the present invention can not be interpreted as.It should be pointed out that for one of ordinary skill in the art
For, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to the guarantor of the present invention
Protect scope.
Claims (10)
1. a kind of anti-inflammatory remediation composition, it is characterised in that the anti-inflammatory remediation composition include following mass percent into
Point：Octyl dodecanol 0.1-2%, 'Heijialun ' seed oil 0.1-2%, sunflower seed oil unsaponifiable matter 0.01-2%, sunflower seed oil 0.1-
3%, Rosmarinus officinalis extract 0.01-1%.
2. anti-inflammatory remediation composition according to claim 1, it is characterised in that the anti-inflammatory remediation composition also includes protecting
Humectant 4.11-21.1%, skin emollient 5.1-24%, emulsifying agent 1.5-4.5%, skin conditioner 3.11-14.1%, preservative
0.3-1%。
3. anti-inflammatory remediation composition according to claim 2, it is characterised in that the NMF includes following quality percentage
The composition of ratio：Butanediol 1-5%, glycerine 1-5%, Sodium Hyaluronate 0.01-0.1%, glycine betaine 1-5%, double-PEG-18 methyl ethers
Dimethylsilane 0.1-1%, Butyrospermum parkii fruit fat 1-5%.
4. anti-inflammatory remediation composition according to claim 2, it is characterised in that the skin emollient includes following quality
The composition of percentage：Parleam 1-5%, octyl dodecanol myristinate 1-5%, isononyl isononanoate 1-5%, carbonic acid
Dioctyl ester 1-5%, cetostearyl alcohol ethylhexoate 1-3%, C13-14 isoparaffin 0.1-1%.
5. anti-inflammatory remediation composition according to claim 2, it is characterised in that the emulsifying agent includes following quality percentage
The composition of ratio：Glyceryl stearate citrate 1-3%, stearine 0.5-1.5%.
6. anti-inflammatory remediation composition according to claim 2, it is characterised in that the skin conditioner includes following quality
The composition of percentage：Creatine 0.01-0.1%, D-sorbite 1-5%, octyl group polymethyl siloxane 1-3%, tocopherol acetate
0.1-1%, niacinamide 1-5%.
7. anti-inflammatory remediation composition according to claim 2, it is characterised in that the preservative includes following quality percentage
The composition of ratio：Methyl hydroxybenzoate 0.1-0.4%, Phenoxyethanol 0.1-0.4%, Nipasol 0.1-0.2%.
8. anti-inflammatory remediation composition according to claim 1, it is characterised in that the anti-inflammatory remediation composition also include with
The composition of lower mass percent：EDTA disodiums 0.01-0.1%, docosyl alcohol 1-3%, phytosterol isostearate 0.1-1%, brocade
Synthetic fibre -12 0.1-1%, PEG-100 stearate 0.5-1.5%, the 0.1-1% of laureth -7, vaseline 1-3%, polyacrylamide
Amine 0.1-1%, deionized water surplus.
9. application of the anti-inflammatory remediation composition according to claim any one of 1-8 in cosmetics are prepared.
10. application according to claim 9, it is characterised in that the cosmetics are anti-inflammatory repair cream.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710341983.9A CN107126391A (en) | 2017-05-13 | 2017-05-13 | A kind of anti-inflammatory remediation composition and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710341983.9A CN107126391A (en) | 2017-05-13 | 2017-05-13 | A kind of anti-inflammatory remediation composition and its application |
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| Publication Number | Publication Date |
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| CN107126391A true CN107126391A (en) | 2017-09-05 |
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ID=59732245
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710341983.9A Pending CN107126391A (en) | 2017-05-13 | 2017-05-13 | A kind of anti-inflammatory remediation composition and its application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511216A (en) * | 2016-12-28 | 2017-03-22 | 广州市聚吉科绿色化学共性技术研究院有限公司 | Moisturizing cosmetic composition and application thereof |
| CN113181075A (en) * | 2021-04-20 | 2021-07-30 | 东晟源研究院(广州)有限公司 | Anti-inflammatory repairing antioxidant composition and essence thereof and preparation method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769666A (en) * | 2016-03-18 | 2016-07-20 | 广州市索柔生物科技有限公司 | Composition and skin care product containing same |
| CN106580798A (en) * | 2016-12-30 | 2017-04-26 | 广州科盈化妆品有限公司 | All-in-one eye cream and preparation method |
-
2017
- 2017-05-13 CN CN201710341983.9A patent/CN107126391A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105769666A (en) * | 2016-03-18 | 2016-07-20 | 广州市索柔生物科技有限公司 | Composition and skin care product containing same |
| CN106580798A (en) * | 2016-12-30 | 2017-04-26 | 广州科盈化妆品有限公司 | All-in-one eye cream and preparation method |
Non-Patent Citations (1)
| Title |
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| 嘉文丽（福建）化妆品有限公司: "黛昂丝润颜修护精华油", 《国产非特殊用途化妆品备案，闽G妆网备字2016002103》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106511216A (en) * | 2016-12-28 | 2017-03-22 | 广州市聚吉科绿色化学共性技术研究院有限公司 | Moisturizing cosmetic composition and application thereof |
| CN113181075A (en) * | 2021-04-20 | 2021-07-30 | 东晟源研究院(广州)有限公司 | Anti-inflammatory repairing antioxidant composition and essence thereof and preparation method |
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Effective date of registration: 20190329 Address after: Room 01-08, 05th floor, Baiyun Electrical Science and Technology Building, Guangzhou Private Science and Technology Park, No. 1633 Beitai Road, Baiyun District, Guangzhou, Guangdong 510000 Applicant after: Guangdong Chuangmei Anti-aging Research Co., Ltd. Address before: Room 202-092, second floor, 32 Jianhua Factory, No. 11 Heping Road, Chancheng District, Foshan City, Guangdong Province Applicant before: Foshan Vincent Intellectual Property Service Co., Ltd. |
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