CN113171371A - 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 - Google Patents
一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 Download PDFInfo
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- CN113171371A CN113171371A CN202110394458.XA CN202110394458A CN113171371A CN 113171371 A CN113171371 A CN 113171371A CN 202110394458 A CN202110394458 A CN 202110394458A CN 113171371 A CN113171371 A CN 113171371A
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Abstract
Description
R<sub>1</sub>代码 | RNA抑制剂代码 | R<sub>1</sub>结构 |
R1-1 | Ky-22 | -NH(CH<sub>2</sub>)<sub>6</sub>O- |
R1-2 | Ky-22-R1-1 | -O(CH<sub>2</sub>)<sub>6</sub>O- |
R1-3 | Ky-22-R1-2 | -S(CH<sub>2</sub>)<sub>6</sub>O- |
R1-4 | Ky-22-R1-3 | -NH(CH<sub>2</sub>)<sub>8</sub>O- |
R1-5 | Ky-22-R1-4 | -NH(CH<sub>2</sub>)<sub>5</sub>CH(CH<sub>2</sub>CH<sub>3</sub>)O- |
R1-6 | Ky-22-R1-5 | -S(CH<sub>2</sub>)<sub>4</sub>CH(CH<sub>3</sub>)O- |
Claims (12)
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CN202110394458.XA CN113171371B (zh) | 2021-04-13 | 2021-04-13 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
CN202210253554.7A CN114621954B (zh) | 2021-04-13 | 2021-04-13 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
JP2023562671A JP2024511894A (ja) | 2021-04-13 | 2022-03-31 | B型肝炎ウイルス遺伝子発現を抑制するrna阻害剤及びその適用 |
PCT/CN2022/084381 WO2022218163A1 (zh) | 2021-04-13 | 2022-03-31 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
EP22787390.8A EP4324923A1 (en) | 2021-04-13 | 2022-03-31 | Rna inhibitor for inhibiting hepatitis b virus gene expression and application thereof |
CN202280028156.3A CN117597443A (zh) | 2021-04-13 | 2022-03-31 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
AU2022256594A AU2022256594A1 (en) | 2021-04-13 | 2022-03-31 | Rna inhibitor for inhibiting hepatitis b virus gene expression and application thereof |
KR1020237038959A KR20240004506A (ko) | 2021-04-13 | 2022-03-31 | B형 간염 바이러스 유전자 발현을 억제하는 rna억제제 및 그 응용 |
TW111113731A TWI835116B (zh) | 2021-04-13 | 2022-04-11 | 一種抑制b型肝炎病毒基因表達的rna抑制劑及其應用 |
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CN202210255255.7A Division CN114940991B (zh) | 2021-04-13 | 2021-04-13 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
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AU (1) | AU2022256594A1 (zh) |
WO (1) | WO2022218163A1 (zh) |
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CN113862268A (zh) * | 2021-10-20 | 2021-12-31 | 厦门甘宝利生物医药有限公司 | Agt抑制剂及其用途 |
WO2022218163A1 (zh) * | 2021-04-13 | 2022-10-20 | 厦门甘宝利生物医药有限公司 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
WO2023169548A1 (zh) * | 2022-03-11 | 2023-09-14 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024027809A1 (zh) * | 2022-08-05 | 2024-02-08 | 厦门甘宝利生物医药有限公司 | 一种抑制apoc3基因表达的rna抑制剂及其应用 |
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CN117342983B (zh) * | 2023-12-05 | 2024-02-06 | 康羽生命科学技术(苏州)有限公司 | 过乙酰化GalNAc-L96合成方法 |
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CN109331185A (zh) * | 2017-12-01 | 2019-02-15 | 厦门甘宝利生物医药有限公司 | 含有肝靶向特异性配体和甲状腺素受体激动剂的药物 |
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CN103333890B (zh) * | 2012-12-21 | 2015-04-15 | 厦门成坤生物技术有限公司 | 治疗乙型病毒性肝炎的rna干扰制剂 |
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CN113171371B (zh) * | 2021-04-13 | 2022-01-25 | 厦门甘宝利生物医药有限公司 | 一种抑制乙型肝炎病毒基因表达的rna抑制剂及其应用 |
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WO2023066236A1 (zh) * | 2021-10-20 | 2023-04-27 | 厦门甘宝利生物医药有限公司 | Agt抑制剂及其用途 |
WO2023169548A1 (zh) * | 2022-03-11 | 2023-09-14 | 厦门甘宝利生物医药有限公司 | Lpa抑制剂及其用途 |
WO2024027809A1 (zh) * | 2022-08-05 | 2024-02-08 | 厦门甘宝利生物医药有限公司 | 一种抑制apoc3基因表达的rna抑制剂及其应用 |
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