CN113166188A - 两性霉素b肽衍生物 - Google Patents

两性霉素b肽衍生物 Download PDF

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Publication number
CN113166188A
CN113166188A CN201980079769.8A CN201980079769A CN113166188A CN 113166188 A CN113166188 A CN 113166188A CN 201980079769 A CN201980079769 A CN 201980079769A CN 113166188 A CN113166188 A CN 113166188A
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China
Prior art keywords
gly
aeeac
pharmaceutically acceptable
acceptable salt
compound
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CN201980079769.8A
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English (en)
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CN113166188B (zh
Inventor
东圆珍
冯军
张喜全
张金华
赵文杰
朱冰
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Shanghai Duomirui Biotechnology Co ltd
Shanghai Institute of Pharmaceutical Industry
Chia Tai Tianqing Pharmaceutical Group Co Ltd
Original Assignee
Shanghai Duomirui Biotechnology Co ltd
Shanghai Institute of Pharmaceutical Industry
Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Publication of CN113166188A publication Critical patent/CN113166188A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

属于医药领域，具体涉及两性霉素B肽衍生物及其制备方法。所述两性霉素B肽衍生物对耐药细菌、真菌具有广谱、高效的杀菌效果。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980079769.8A 2018-12-13 2019-12-13 两性霉素b肽衍生物 Active CN113166188B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201811521926X 2018-12-13
CN201811521926 2018-12-13
PCT/CN2019/124970 WO2020119773A1 (zh) 2018-12-13 2019-12-13 两性霉素b肽衍生物

Publications (2)

Publication Number Publication Date
CN113166188A true CN113166188A (zh) 2021-07-23
CN113166188B CN113166188B (zh) 2023-06-20

Family

ID=71076256

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980079769.8A Active CN113166188B (zh) 2018-12-13 2019-12-13 两性霉素b肽衍生物

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Country Link
CN (1) CN113166188B (zh)
WO (1) WO2020119773A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114133428A (zh) * 2021-12-09 2022-03-04 华东理工大学 两性霉素b亲水性多肽衍生物及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010297A1 (en) * 1978-10-23 1980-04-30 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
US4272525A (en) * 1978-10-23 1981-06-09 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
CA2394833A1 (en) * 2000-01-14 2001-07-19 Binh T. Dang Derivatives of polyene macrolides and preparation and use thereof
CN104520309A (zh) * 2012-06-15 2015-04-15 布里特股份公司 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用
US20170043029A1 (en) * 2015-08-13 2017-02-16 Ramot At Tel-Aviv University Ltd. Amphotericin b derivatives
CN107375939A (zh) * 2017-07-19 2017-11-24 中国药科大学 用于治疗真菌感染的两性霉素b多肽类水凝胶载药体系

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10129369C1 (de) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
CN108714151B (zh) * 2018-06-15 2021-01-08 中国科学院长春应用化学研究所 一种两性霉素b抗真菌纳米药物及其制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010297A1 (en) * 1978-10-23 1980-04-30 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
US4272525A (en) * 1978-10-23 1981-06-09 Schering Corporation Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them
CA2394833A1 (en) * 2000-01-14 2001-07-19 Binh T. Dang Derivatives of polyene macrolides and preparation and use thereof
CN104520309A (zh) * 2012-06-15 2015-04-15 布里特股份公司 抗真菌抗生素两性霉素b的n-取代第二代衍生物及其制备方法和应用
US20170043029A1 (en) * 2015-08-13 2017-02-16 Ramot At Tel-Aviv University Ltd. Amphotericin b derivatives
CN107375939A (zh) * 2017-07-19 2017-11-24 中国药科大学 用于治疗真菌感染的两性霉素b多肽类水凝胶载药体系

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114133428A (zh) * 2021-12-09 2022-03-04 华东理工大学 两性霉素b亲水性多肽衍生物及其应用
CN114133428B (zh) * 2021-12-09 2023-10-27 华东理工大学 两性霉素b亲水性多肽衍生物及其应用

Also Published As

Publication number Publication date
CN113166188B (zh) 2023-06-20
WO2020119773A1 (zh) 2020-06-18

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