CN113164626A - 嵌合受体多肽及其用途 - Google Patents

嵌合受体多肽及其用途 Download PDF

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Publication number
CN113164626A
CN113164626A CN202080006993.7A CN202080006993A CN113164626A CN 113164626 A CN113164626 A CN 113164626A CN 202080006993 A CN202080006993 A CN 202080006993A CN 113164626 A CN113164626 A CN 113164626A
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tcr
domain
chimeric receptor
extracellular
binding domain
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曾明
张辉辉
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Nanjing Legend Biotechnology Co Ltd
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Nanjing Legend Biotechnology Co Ltd
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CN202080006993.7A 2019-01-14 2020-01-14 嵌合受体多肽及其用途 Pending CN113164626A (zh)

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CN2019071609 2019-01-14
CNPCT/CN2019/071609 2019-01-14
PCT/CN2020/071947 WO2020147708A1 (en) 2019-01-14 2020-01-14 Chimeric receptor polypeptides and uses thereof

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EP (1) EP3911370A4 (https=)
JP (1) JP2022516496A (https=)
KR (1) KR20210116478A (https=)
CN (1) CN113164626A (https=)
AU (1) AU2020208110A1 (https=)
CA (1) CA3126422A1 (https=)
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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114560948A (zh) * 2022-03-07 2022-05-31 中国人民解放军空军军医大学 一种嵌合抗原受体、car-t细胞及其应用
CN114560949A (zh) * 2022-03-07 2022-05-31 中国人民解放军空军军医大学 一种具有增强car-t细胞抗肿瘤能力的嵌合抗原受体、d-car-t细胞及其应用
CN114573712A (zh) * 2022-03-07 2022-06-03 中国人民解放军空军军医大学 一种嵌合抗原受体、car-t细胞及其应用
WO2023193800A1 (zh) * 2022-04-07 2023-10-12 恺兴生命科技(上海)有限公司 嵌合多肽及其应用
CN117074674A (zh) * 2023-03-23 2023-11-17 武汉勖瑞生物科技有限责任公司 检测N-乙酰-β-D氨基葡萄糖苷酶的胶体金试纸及其制备方法
WO2024140981A1 (zh) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 细胞原位分泌抗体及其用途

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210104772A (ko) 2018-12-14 2021-08-25 블루버드 바이오, 인코포레이티드. 이량체화제로 조절된 면역수용체 복합체
WO2022228579A1 (en) * 2021-04-30 2022-11-03 Nanjing Legend Biotech Co., Ltd. Chimeric antigen receptors targeting gpc3 and methods of use thereof
CN117897411A (zh) * 2021-06-30 2024-04-16 华夏英泰（北京）生物技术有限公司 一种多靶点合成t细胞受体抗原/抗体受体及其应用
JP2024525727A (ja) * 2021-07-14 2024-07-12 ２セブンティ バイオ インコーポレイテッド 抗体由来の結合ドメインに融合した操作されたｔ細胞受容体
WO2023164698A2 (en) * 2022-02-27 2023-08-31 Health Research, Inc. FOLATE RECEPTOR ALPHA -TARGETING BI-SPECIFIC T CELL ENGAGERS (BiTEs) AND USES THEREOF
AR130387A1 (es) * 2022-09-08 2024-12-04 Hoffmann La Roche Receptores de linfocitos t recombinantes
WO2024100136A1 (en) * 2022-11-08 2024-05-16 Gadeta B.V. Novel method for obtaining gamma t-cell (or delta t-cell) receptor chains (or gamma delta t-cell receptors) or fragments thereof that mediate an anti-tumour or an anti-infective response
WO2024206992A2 (en) * 2023-03-30 2024-10-03 Yale University Universal antibody receptors, guar-t cells and therapeutic use thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016094304A2 (en) * 2014-12-12 2016-06-16 Bluebird Bio, Inc. Bcma chimeric antigen receptors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0908613D0 (en) * 2009-05-20 2009-06-24 Immunocore Ltd T Cell Reseptors
LT3030581T (lt) * 2013-08-07 2021-05-25 Affimed Gmbh Antikūno surišimo vietos specifiškos egfrviii
US9212225B1 (en) * 2014-07-01 2015-12-15 Amphivena Therapeutics, Inc. Bispecific CD33 and CD3 binding proteins
CA2970924A1 (en) * 2014-10-31 2016-05-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Tetravalent tlr9 bispecific antibody
PL3298033T5 (pl) * 2015-05-18 2023-10-30 TCR2 Therapeutics Inc. Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
GB201522592D0 (en) * 2015-12-22 2016-02-03 Immunocore Ltd T cell receptors
GB201604953D0 (en) * 2016-03-23 2016-05-04 Immunocore Ltd T cell receptors
CN105777911B (zh) * 2016-04-12 2019-07-02 上海优卡迪生物医药科技有限公司 抗bcma嵌合抗原受体、编码基因、重组表达载体及其构建方法和应用
CN110582509A (zh) * 2017-01-31 2019-12-17 诺华股份有限公司 使用具有多特异性的嵌合t细胞受体蛋白治疗癌症
JP7538601B2 (ja) * 2017-04-26 2024-08-22 ユーリカ セラピューティックス， インコーポレイテッド キメラ活性化受容体及びキメラ刺激受容体を発現する細胞並びにその使用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016094304A2 (en) * 2014-12-12 2016-06-16 Bluebird Bio, Inc. Bcma chimeric antigen receptors

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DINA SCHNEIDER等: "A Tandem CD19/CD20 CAR Lentiviral Vector Drives On-Target and Off-Target Antigen Modulation in Leukemia Cell Lines" *
KEVIN M. FRIEDMAN等: "Effective Targeting of Multiple B-Cell Maturation Antigen–Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells" *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114560948A (zh) * 2022-03-07 2022-05-31 中国人民解放军空军军医大学 一种嵌合抗原受体、car-t细胞及其应用
CN114560949A (zh) * 2022-03-07 2022-05-31 中国人民解放军空军军医大学 一种具有增强car-t细胞抗肿瘤能力的嵌合抗原受体、d-car-t细胞及其应用
CN114573712A (zh) * 2022-03-07 2022-06-03 中国人民解放军空军军医大学 一种嵌合抗原受体、car-t细胞及其应用
CN114560949B (zh) * 2022-03-07 2023-09-26 中国人民解放军空军军医大学 一种具有增强car-t细胞抗肿瘤能力的嵌合抗原受体、d-car-t细胞及其应用
WO2023193800A1 (zh) * 2022-04-07 2023-10-12 恺兴生命科技(上海)有限公司 嵌合多肽及其应用
WO2024140981A1 (zh) * 2022-12-30 2024-07-04 上药生物治疗（香港）有限公司 细胞原位分泌抗体及其用途
CN117074674A (zh) * 2023-03-23 2023-11-17 武汉勖瑞生物科技有限责任公司 检测N-乙酰-β-D氨基葡萄糖苷酶的胶体金试纸及其制备方法
CN117074674B (zh) * 2023-03-23 2024-01-23 武汉勖瑞生物科技有限责任公司 检测N-乙酰-β-D氨基葡萄糖苷酶的胶体金试纸及其制备方法

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CA3126422A1 (en) 2020-07-23
AU2020208110A1 (en) 2021-07-15
KR20210116478A (ko) 2021-09-27
SG11202106257WA (en) 2021-07-29
EP3911370A1 (en) 2021-11-24
WO2020147708A1 (en) 2020-07-23
JP2022516496A (ja) 2022-02-28
US20230192805A1 (en) 2023-06-22
EP3911370A4 (en) 2022-10-26

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