CN113150109A - 密封蛋白-6特异性免疫受体和t细胞表位 - Google Patents
密封蛋白-6特异性免疫受体和t细胞表位 Download PDFInfo
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- CN113150109A CN113150109A CN202110278993.9A CN202110278993A CN113150109A CN 113150109 A CN113150109 A CN 113150109A CN 202110278993 A CN202110278993 A CN 202110278993A CN 113150109 A CN113150109 A CN 113150109A
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- C07—ORGANIC CHEMISTRY
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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- A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
- A61K40/31—Chimeric antigen receptors [CAR]
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- A61K40/42—Cancer antigens
- A61K40/428—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
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- A61P37/02—Immunomodulators
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- G01N33/56972—White blood cells
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Tropical Medicine & Parasitology (AREA)
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- Pharmacology & Pharmacy (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EPPCT/EP2014/000868 | 2014-04-01 | ||
| EP2014000868 | 2014-04-01 | ||
| EP2014072864 | 2014-10-24 | ||
| EPPCT/EP2014/072864 | 2014-10-24 | ||
| CN201580017607.3A CN106459165B (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201580017607.3A Division CN106459165B (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN113150109A true CN113150109A (zh) | 2021-07-23 |
Family
ID=52745896
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110279207.7A Pending CN113150110A (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
| CN201580017607.3A Active CN106459165B (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
| CN202110278993.9A Pending CN113150109A (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110279207.7A Pending CN113150110A (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
| CN201580017607.3A Active CN106459165B (zh) | 2014-04-01 | 2015-03-30 | 密封蛋白-6特异性免疫受体和t细胞表位 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US10370423B2 (enExample) |
| EP (3) | EP3126381B2 (enExample) |
| JP (3) | JP6726656B2 (enExample) |
| CN (3) | CN113150110A (enExample) |
| AU (3) | AU2015239683B2 (enExample) |
| CA (1) | CA2942459C (enExample) |
| CY (1) | CY1121539T1 (enExample) |
| DK (3) | DK3126381T4 (enExample) |
| ES (3) | ES2717530T5 (enExample) |
| FI (1) | FI3708579T3 (enExample) |
| HR (2) | HRP20240926T1 (enExample) |
| HU (3) | HUE044515T2 (enExample) |
| LT (2) | LT3126381T (enExample) |
| ME (1) | ME03407B (enExample) |
| MX (1) | MX376026B (enExample) |
| PL (3) | PL3708579T3 (enExample) |
| PT (3) | PT3708579T (enExample) |
| RS (2) | RS58627B2 (enExample) |
| SI (3) | SI3708579T1 (enExample) |
| SM (1) | SMT201900262T1 (enExample) |
| WO (1) | WO2015150327A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024165057A1 (en) * | 2023-02-07 | 2024-08-15 | LaNova Medicines Limited | Antibodies and antibody-drug conjugates targeting claudin 6 |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ716587A (en) * | 2009-11-11 | 2017-10-27 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (cldn6) |
| KR101935088B1 (ko) | 2012-08-24 | 2019-01-04 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | Ror1 암을 치료하고 전이를 저해하는데 이용을 위한 항체와 백신 |
| US10053511B2 (en) | 2013-11-06 | 2018-08-21 | Abbvie Stemcentrx Llc | Anti-claudin antibodies and methods of use |
| MA40921A (fr) * | 2014-11-05 | 2017-09-12 | Abbvie Stemcentrx Llc | Récepteurs antigéniques chimériques anti-cldn et procédés d'utilisation |
| EP3808770B1 (en) * | 2014-11-14 | 2025-10-29 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Anti-thyroglobulin t cell receptors |
| CN106146666B (zh) * | 2015-03-26 | 2019-09-06 | 科济生物医药(上海)有限公司 | 靶向cldn6的免疫效应细胞及其制备方法和应用 |
| WO2016180468A1 (en) | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Claudin-18.2-specific immunoreceptors and t cell epitopes |
| WO2016180467A1 (en) | 2015-05-11 | 2016-11-17 | Biontech Cell & Gene Therapies Gmbh | Enhancing the effect of car-engineered t cells by means of nucleic acid vaccination |
| DK3298033T4 (da) | 2015-05-18 | 2023-10-02 | Tcr2 Therapeutics Inc | Sammensætninger og medicinske anvendelser til tcr-reprogrammering under anvendelse af fusionsproteiner |
| EP3932428A1 (en) | 2015-05-21 | 2022-01-05 | Harpoon Therapeutics, Inc. | Trispecific binding proteins and methods of use |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201607534D0 (en) | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201602918D0 (en) * | 2016-02-19 | 2016-04-06 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against NHL and other cancers |
| MA55153A (fr) | 2016-02-19 | 2021-09-29 | Immatics Biotechnologies Gmbh | Nouveaux peptides et combinaison de peptides pour une utilisation dans l'immunothérapie contre le lymphome non hodgkinien et d'autres cancers |
| AU2017276706B2 (en) * | 2016-06-07 | 2024-08-15 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Chimeric antigen receptor and CAR-T cells that bind BCMA |
| IL299099B2 (en) | 2016-06-27 | 2025-07-01 | Univ California | Cancer treatment combinations |
| WO2018011421A1 (en) | 2016-07-14 | 2018-01-18 | Genmab A/S | Multispecific antibodies against cd40 and cd137 |
| CA3036745A1 (en) * | 2016-10-07 | 2018-04-12 | TCR2 Therapeutics Inc. | Compositions and methods for t-cell receptors reprogramming using fusion proteins |
| BR112019011277A2 (pt) | 2016-12-02 | 2019-10-22 | University Of Southern California | polinucleotídeo, sistema de expressão recombinante, vetor, polipeptídeo, célula recombinante, polipeptídeo de receptor imune sintético isolado ou heterodímero de polipeptídeo, célula efetora imune ou célula-tronco, população de células imunes ou efetoras, métodos de fabricação de uma célula efetora imune que expressa sir, de geração de uma população de células modificadas por rna, de fornecimento de imunidade antidoença e de tratamento ou prevenção de uma doença, composição, uso ou método, kit, e, sequência de aminoácidos. |
| SG11201908527SA (en) * | 2017-03-15 | 2019-10-30 | Hutchinson Fred Cancer Res | High affinity mage-a1-specific tcrs and uses thereof |
| US20210122831A1 (en) * | 2017-03-27 | 2021-04-29 | Noile-Immune Biotech, Inc. | Chimeric antigen receptor |
| CN111406067B (zh) | 2017-08-04 | 2022-11-08 | 健玛保 | 与pd-l1和cd137结合的结合剂及其用途 |
| NO20210351A1 (en) * | 2017-09-18 | 2021-03-18 | Univ California | Claudin6 antibodies and methods of treating cancer |
| CN117003875A (zh) | 2017-09-29 | 2023-11-07 | 第一三共株式会社 | 抗体或其功能性片段、多核苷酸、表达载体、宿主细胞、糖链重构抗体、药物组合物、应用 |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| KR20210124959A (ko) | 2018-11-06 | 2021-10-15 | 젠맵 에이/에스 | 항체 제제 |
| CA3119188A1 (en) * | 2018-11-09 | 2020-05-14 | Fred Hutchinson Cancer Research Center | T cell receptors specific for mesothelin and their use in immunotherapy |
| AU2019394940A1 (en) * | 2018-12-05 | 2021-06-24 | Genentech, Inc. | Diagnostic methods and compositions for cancer immunotherapy |
| RS66364B1 (sr) * | 2019-02-08 | 2025-01-31 | Biontech Cell & Gene Therapies Gmbh | Ćelije modifikovane himerinim antigenskim receptorima za lečenje kancera koji eksprimiraju cldn6 |
| CN114174829A (zh) * | 2019-03-01 | 2022-03-11 | 磨石生物公司 | T细胞受体的选择 |
| SI3941946T1 (sl) | 2019-03-20 | 2025-09-30 | The Regents Of The University Of California | Protitelesa proti klavdinu-6 in konjugati zdravil |
| WO2021129927A1 (en) * | 2019-12-23 | 2021-07-01 | Biontech Cell & Gene Therapies Gmbh | Treatment with immune effector cells engineered to express an antigen receptor |
| US20230087164A1 (en) | 2020-02-04 | 2023-03-23 | Genmab A/S | Antibodies for use in therapy |
| MX2023005386A (es) | 2020-11-11 | 2023-05-23 | BioNTech SE | Anticuerpos monoclonales dirigidos contra la proteina de muerte programada-1 y su uso en medicina. |
| US20240216427A1 (en) * | 2020-12-30 | 2024-07-04 | St. Jude Children's Research Hospital, Inc. | Chimeric antigen receptors targeting splice variants of the extracellular matrix proteins tenascin c (tnc) and procollagen 11a1 (col11a1) |
| IL309319A (en) | 2021-06-21 | 2024-02-01 | Genmab As | Combined dosage regimen CD137 and PD-L1 binding agents |
| CA3225254A1 (en) | 2021-07-13 | 2023-01-19 | BioNTech SE | Multispecific binding agents against cd40 and cd137 in combination therapy for cancer |
| AU2022337286A1 (en) * | 2021-09-03 | 2024-02-29 | Novarock Biotherapeutics, Ltd. | Bispecific binding proteins that bind cd137 and a tumor associated antigen |
| US20250002600A1 (en) | 2021-10-06 | 2025-01-02 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination therapy |
| EP4412714A1 (en) | 2021-10-06 | 2024-08-14 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 in combination with anti pd-1 antibodies for treating cancers |
| CA3234897A1 (en) * | 2021-10-14 | 2023-04-20 | Kunle Odunsi | Compositions and methods for use of recombinant t cell receptors against claudin 6 |
| CA3252821A1 (en) | 2022-05-12 | 2023-11-16 | BioNTech SE | LIAISON AGENTS CAPABLE OF BINDING TO CD27 IN POLYTHERAPY |
| US11932693B2 (en) | 2022-05-12 | 2024-03-19 | BioNTech SE | Monoclonal antibodies directed against programmed death-1 protein and their use in medicine |
| JP2025516631A (ja) | 2022-05-12 | 2025-05-30 | ジェンマブ エー/エス | 併用療法においてcd27に結合する能力を有する結合剤 |
| CN115232207B (zh) * | 2022-05-19 | 2023-06-13 | 河南大学 | 抗体-溶菌素(SM-ScFv-Fc-Ly)在治疗变形链球菌感染中的应用 |
| WO2024209072A1 (en) | 2023-04-06 | 2024-10-10 | Genmab A/S | Multispecific binding agents against pd-l1 and cd137 for treating cancer |
| US12403202B2 (en) | 2023-05-25 | 2025-09-02 | The Regents Of The University Of California | Dosage of claudin-6 conjugates for cancer treatment |
| WO2025114541A1 (en) | 2023-11-30 | 2025-06-05 | Genmab A/S | Antibodies capable of binding to ox40 in combination therapy |
| WO2025184170A1 (en) | 2024-02-27 | 2025-09-04 | Overt Bio, Inc. | Methods and compositions for improving t cell function in an immunosuppressive environment |
| CN118812714B (zh) * | 2024-08-21 | 2025-05-27 | 广州百吉生物制药有限公司 | 一种紧密连接蛋白抗体b3及其应用 |
| CN119320451B (zh) * | 2024-08-21 | 2025-05-16 | 百吉生物医药(广州)股份有限公司 | 一种紧密连接蛋白抗体d03及其应用 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008114733A1 (ja) * | 2007-03-16 | 2008-09-25 | Kyowa Hakko Kirin Co., Ltd. | 抗Claudin-4抗体 |
| CN101316610A (zh) * | 2005-09-22 | 2008-12-03 | 艾润·R·科恩 | T细胞受体恒定区的免疫原性片段及其衍生的肽 |
| WO2011130346A1 (en) * | 2010-04-13 | 2011-10-20 | Sigma-Aldrich Co. | Methods for generating endogenously tagged protein |
| CN102325885A (zh) * | 2009-02-20 | 2012-01-18 | 加尼梅德药物公司 | 用于癌症诊断和治疗的方法和组合物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| WO1997024447A1 (en) | 1996-01-02 | 1997-07-10 | Chiron Corporation | Immunostimulation mediated by gene-modified dendritic cells |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| US7435596B2 (en) * | 2004-11-04 | 2008-10-14 | St. Jude Children's Research Hospital, Inc. | Modified cell line and method for expansion of NK cell |
| EP2103628A4 (en) * | 2006-12-14 | 2012-02-22 | Forerunner Pharma Res Co Ltd | MONOCLONAL ANTIBODY ANTI-CLAUDIN 3, AND TREATMENT AND DIAGNOSIS OF CANCER USING SUCH ANTIBODY |
| SG187457A1 (en) * | 2008-01-11 | 2013-02-28 | Univ Tokyo | Anti-cldn6 antibody |
| EP2322555A1 (en) * | 2009-11-11 | 2011-05-18 | Ganymed Pharmaceuticals AG | Antibodies specific for claudin 6 (CLDN6) |
| NZ716587A (en) * | 2009-11-11 | 2017-10-27 | Ganymed Pharmaceuticals Ag | Antibodies specific for claudin 6 (cldn6) |
| EP2547695B1 (en) * | 2010-03-16 | 2018-05-09 | Biontech Protein Therapeutics GmbH | Tumor vaccination involving a humoral immune response against self-protein cldn18.2 |
| EP2404936A1 (en) * | 2010-07-06 | 2012-01-11 | Ganymed Pharmaceuticals AG | Cancer therapy using CLDN6 target-directed antibodies in vivo |
| ES2754394T3 (es) * | 2010-09-08 | 2020-04-17 | Chemotherapeutisches Forschungsinstitut Georg Speyer Haus | Receptores de antígenos quiméricos con una región bisagra optimizada |
| NZ724296A (en) * | 2011-05-13 | 2020-05-29 | Ganymed Pharmaceuticals Ag | Antibodies for treatment of cancer expressing claudin 6 |
| CN104159909A (zh) | 2012-02-22 | 2014-11-19 | 宾夕法尼亚大学董事会 | 产生用于癌症治疗的t细胞持续性群体的组合物和方法 |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101316610A (zh) * | 2005-09-22 | 2008-12-03 | 艾润·R·科恩 | T细胞受体恒定区的免疫原性片段及其衍生的肽 |
| WO2008114733A1 (ja) * | 2007-03-16 | 2008-09-25 | Kyowa Hakko Kirin Co., Ltd. | 抗Claudin-4抗体 |
| EP2138576A1 (en) * | 2007-03-16 | 2009-12-30 | Kyowa Hakko Kirin Co., Ltd. | Anti-claudin-4 antibody |
| CN102325885A (zh) * | 2009-02-20 | 2012-01-18 | 加尼梅德药物公司 | 用于癌症诊断和治疗的方法和组合物 |
| WO2011130346A1 (en) * | 2010-04-13 | 2011-10-20 | Sigma-Aldrich Co. | Methods for generating endogenously tagged protein |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2024165057A1 (en) * | 2023-02-07 | 2024-08-15 | LaNova Medicines Limited | Antibodies and antibody-drug conjugates targeting claudin 6 |
| US12180276B2 (en) | 2023-02-07 | 2024-12-31 | LaNova Medicines Limited | Antibodies and antibody-drug conjugates targeting claudin 6 |
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