CN113149977A - 一类呼吸道合胞病毒抑制剂的合成与用途 - Google Patents

一类呼吸道合胞病毒抑制剂的合成与用途 Download PDF

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Publication number
CN113149977A
CN113149977A CN202010075139.8A CN202010075139A CN113149977A CN 113149977 A CN113149977 A CN 113149977A CN 202010075139 A CN202010075139 A CN 202010075139A CN 113149977 A CN113149977 A CN 113149977A
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CN
China
Prior art keywords
amino
substituted
methyl
hydroxy
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN202010075139.8A
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English (en)
Chinese (zh)
Inventor
彭程
吕遐师
钱梦飞
尹伟
龚超骏
韩健
沈微
李丹彬
邹罡
袁海卿
邬征
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Suzhou Ark Biopharmaceutical Co Ltd
Original Assignee
Suzhou Ark Biopharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Suzhou Ark Biopharmaceutical Co Ltd filed Critical Suzhou Ark Biopharmaceutical Co Ltd
Priority to CN202010075139.8A priority Critical patent/CN113149977A/zh
Priority to CN202180010637.7A priority patent/CN115023423B/zh
Priority to PCT/CN2021/073042 priority patent/WO2021147947A1/zh
Priority to US17/790,987 priority patent/US12582661B2/en
Priority to JP2022544247A priority patent/JP7726487B2/ja
Priority to EP21744323.3A priority patent/EP4095136A4/en
Priority to KR1020227028783A priority patent/KR20220130761A/ko
Publication of CN113149977A publication Critical patent/CN113149977A/zh
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN202010075139.8A 2020-01-22 2020-01-22 一类呼吸道合胞病毒抑制剂的合成与用途 Withdrawn CN113149977A (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CN202010075139.8A CN113149977A (zh) 2020-01-22 2020-01-22 一类呼吸道合胞病毒抑制剂的合成与用途
CN202180010637.7A CN115023423B (zh) 2020-01-22 2021-01-21 一类呼吸道合胞病毒抑制剂的合成与用途
PCT/CN2021/073042 WO2021147947A1 (zh) 2020-01-22 2021-01-21 一类呼吸道合胞病毒抑制剂的合成与用途
US17/790,987 US12582661B2 (en) 2020-01-22 2021-01-21 Synthesis and application of class of respiratory syncytial virus inhibitors
JP2022544247A JP7726487B2 (ja) 2020-01-22 2021-01-21 呼吸器合胞体ウイルス阻害剤の合成及び使用
EP21744323.3A EP4095136A4 (en) 2020-01-22 2021-01-21 Synthesis and use of class of respiratory syncytial virus inhibitors
KR1020227028783A KR20220130761A (ko) 2020-01-22 2021-01-21 호흡기 세포융합 바이러스 억제제의 합성 및 사용

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202010075139.8A CN113149977A (zh) 2020-01-22 2020-01-22 一类呼吸道合胞病毒抑制剂的合成与用途

Publications (1)

Publication Number Publication Date
CN113149977A true CN113149977A (zh) 2021-07-23

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CN202010075139.8A Withdrawn CN113149977A (zh) 2020-01-22 2020-01-22 一类呼吸道合胞病毒抑制剂的合成与用途
CN202180010637.7A Active CN115023423B (zh) 2020-01-22 2021-01-21 一类呼吸道合胞病毒抑制剂的合成与用途

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Country Status (6)

Country Link
US (1) US12582661B2 (https=)
EP (1) EP4095136A4 (https=)
JP (1) JP7726487B2 (https=)
KR (1) KR20220130761A (https=)
CN (2) CN113149977A (https=)
WO (1) WO2021147947A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115023423A (zh) * 2020-01-22 2022-09-06 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
WO2025214429A1 (zh) * 2024-04-10 2025-10-16 广州医科大学 二氨基嘧啶化合物及其用途

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116425754A (zh) * 2021-12-30 2023-07-14 苏州爱科百发生物医药技术有限公司 芳杂双环化合物及其抗病毒用途

Citations (3)

* Cited by examiner, † Cited by third party
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CN103717589A (zh) * 2011-08-11 2014-04-09 弗·哈夫曼-拉罗切有限公司 用于治疗或预防呼吸道合胞病毒疾病的化合物
CN106414436A (zh) * 2014-01-24 2017-02-15 豪夫迈·罗氏有限公司 制备n-[(3-氨基氧杂环丁烷-3-基)甲基]-2-(1, 1-二氧代-3, 5-二氢-1, 4-苯并硫杂氮杂环庚三烯-4-基)-6-甲基-喹唑啉-4-胺的方法
CN108290882A (zh) * 2015-07-16 2018-07-17 豪夫迈·罗氏有限公司 用于治疗呼吸道合胞病毒(rsv)感染的n-[(3-氨基-3-氧杂环丁基)甲基]-2-(2,3-二氢-1,1-二氧代-1,4-苯并噻氮*-4(5h)-基)-6-甲基-4-喹唑啉胺的晶形

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US5760230A (en) * 1996-10-11 1998-06-02 Bayer Aktiengesellschaft 4, 4'-bridged bis-2, 4-diaminoquinazolines
NO3004079T3 (https=) 2013-06-04 2018-06-16
DK3324977T3 (da) 2015-07-22 2022-10-17 Enanta Pharm Inc Benzodiazepinderivater som rsv-inhibitorer
CN113149977A (zh) 2020-01-22 2021-07-23 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103717589A (zh) * 2011-08-11 2014-04-09 弗·哈夫曼-拉罗切有限公司 用于治疗或预防呼吸道合胞病毒疾病的化合物
CN106414436A (zh) * 2014-01-24 2017-02-15 豪夫迈·罗氏有限公司 制备n-[(3-氨基氧杂环丁烷-3-基)甲基]-2-(1, 1-二氧代-3, 5-二氢-1, 4-苯并硫杂氮杂环庚三烯-4-基)-6-甲基-喹唑啉-4-胺的方法
CN108290882A (zh) * 2015-07-16 2018-07-17 豪夫迈·罗氏有限公司 用于治疗呼吸道合胞病毒(rsv)感染的n-[(3-氨基-3-氧杂环丁基)甲基]-2-(2,3-二氢-1,1-二氧代-1,4-苯并噻氮*-4(5h)-基)-6-甲基-4-喹唑啉胺的晶形

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
XIUFANG ZHENG，等: "Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor", 《JOURNAL OF MEDICINAL CHEMISTRY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115023423A (zh) * 2020-01-22 2022-09-06 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
CN115023423B (zh) * 2020-01-22 2025-07-25 苏州爱科百发生物医药技术有限公司 一类呼吸道合胞病毒抑制剂的合成与用途
US12582661B2 (en) 2020-01-22 2026-03-24 Shanghai Ark Biopharmaceutical Co., Ltd. Synthesis and application of class of respiratory syncytial virus inhibitors
WO2025214429A1 (zh) * 2024-04-10 2025-10-16 广州医科大学 二氨基嘧啶化合物及其用途

Also Published As

Publication number Publication date
WO2021147947A1 (zh) 2021-07-29
EP4095136A4 (en) 2023-07-05
EP4095136A1 (en) 2022-11-30
CN115023423B (zh) 2025-07-25
CN115023423A (zh) 2022-09-06
JP2023511152A (ja) 2023-03-16
JP7726487B2 (ja) 2025-08-20
KR20220130761A (ko) 2022-09-27
US20230090060A1 (en) 2023-03-23
US12582661B2 (en) 2026-03-24

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Application publication date: 20210723