KR20220130761A - 호흡기 세포융합 바이러스 억제제의 합성 및 사용 - Google Patents
호흡기 세포융합 바이러스 억제제의 합성 및 사용 Download PDFInfo
- Publication number
- KR20220130761A KR20220130761A KR1020227028783A KR20227028783A KR20220130761A KR 20220130761 A KR20220130761 A KR 20220130761A KR 1020227028783 A KR1020227028783 A KR 1020227028783A KR 20227028783 A KR20227028783 A KR 20227028783A KR 20220130761 A KR20220130761 A KR 20220130761A
- Authority
- KR
- South Korea
- Prior art keywords
- group
- amino
- substituted
- halogen
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010075139.8 | 2020-01-22 | ||
| CN202010075139.8A CN113149977A (zh) | 2020-01-22 | 2020-01-22 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
| PCT/CN2021/073042 WO2021147947A1 (zh) | 2020-01-22 | 2021-01-21 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20220130761A true KR20220130761A (ko) | 2022-09-27 |
Family
ID=76881779
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020227028783A Withdrawn KR20220130761A (ko) | 2020-01-22 | 2021-01-21 | 호흡기 세포융합 바이러스 억제제의 합성 및 사용 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12582661B2 (https=) |
| EP (1) | EP4095136A4 (https=) |
| JP (1) | JP7726487B2 (https=) |
| KR (1) | KR20220130761A (https=) |
| CN (2) | CN113149977A (https=) |
| WO (1) | WO2021147947A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113149977A (zh) * | 2020-01-22 | 2021-07-23 | 苏州爱科百发生物医药技术有限公司 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
| CN116425754A (zh) * | 2021-12-30 | 2023-07-14 | 苏州爱科百发生物医药技术有限公司 | 芳杂双环化合物及其抗病毒用途 |
| CN120794971A (zh) * | 2024-04-10 | 2025-10-17 | 广州医科大学 | 二氨基嘧啶化合物及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5760230A (en) * | 1996-10-11 | 1998-06-02 | Bayer Aktiengesellschaft | 4, 4'-bridged bis-2, 4-diaminoquinazolines |
| US8871756B2 (en) | 2011-08-11 | 2014-10-28 | Hoffmann-La Roche Inc. | Compounds for the treatment and prophylaxis of Respiratory Syncytial Virus disease |
| NO3004079T3 (https=) | 2013-06-04 | 2018-06-16 | ||
| AR099134A1 (es) * | 2014-01-24 | 2016-06-29 | Hoffmann La Roche | Procedimiento para la preparación de n-[(3-aminooxetán-3-il)metil]-2-(1,1-dioxo-3,5-dihidro-1,4-benzotiazepín-4-il)-6-metil-quinazolín-4-amina |
| EP3322704B1 (en) * | 2015-07-16 | 2019-11-27 | H. Hoffnabb-La Roche Ag | Crystalline form of n-[(3-amino-3-oxetanyl)methyl]-2-(2,3-dihydro-1,1-dioxido-1,4-benzothiazepin-4(5h)-yl)-6-methyl-4-quinazolinamine for the treatment of respiratory syncytial virus (rsv) infections |
| DK3324977T3 (da) | 2015-07-22 | 2022-10-17 | Enanta Pharm Inc | Benzodiazepinderivater som rsv-inhibitorer |
| CN113149977A (zh) | 2020-01-22 | 2021-07-23 | 苏州爱科百发生物医药技术有限公司 | 一类呼吸道合胞病毒抑制剂的合成与用途 |
-
2020
- 2020-01-22 CN CN202010075139.8A patent/CN113149977A/zh not_active Withdrawn
-
2021
- 2021-01-21 KR KR1020227028783A patent/KR20220130761A/ko not_active Withdrawn
- 2021-01-21 EP EP21744323.3A patent/EP4095136A4/en active Pending
- 2021-01-21 CN CN202180010637.7A patent/CN115023423B/zh active Active
- 2021-01-21 US US17/790,987 patent/US12582661B2/en active Active
- 2021-01-21 WO PCT/CN2021/073042 patent/WO2021147947A1/zh not_active Ceased
- 2021-01-21 JP JP2022544247A patent/JP7726487B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021147947A1 (zh) | 2021-07-29 |
| EP4095136A4 (en) | 2023-07-05 |
| EP4095136A1 (en) | 2022-11-30 |
| CN115023423B (zh) | 2025-07-25 |
| CN115023423A (zh) | 2022-09-06 |
| JP2023511152A (ja) | 2023-03-16 |
| JP7726487B2 (ja) | 2025-08-20 |
| US20230090060A1 (en) | 2023-03-23 |
| US12582661B2 (en) | 2026-03-24 |
| CN113149977A (zh) | 2021-07-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| PC1203 | Withdrawal of no request for examination |
St.27 status event code: N-1-6-B10-B12-nap-PC1203 |