CN113116987A - 一种用于治疗肿瘤的中药组合物及其制备方法 - Google Patents
一种用于治疗肿瘤的中药组合物及其制备方法 Download PDFInfo
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Abstract
本发明属于中药制剂技术领域,公开了一种用于治疗肿瘤的中药组合物及其制备方法。由选定重量份的蛇舌草、半枝莲、老鼠簕根、甘草、贝母、土必虫、黄芪、白术、天龙、地龙等多种药物配伍而成。所述中药组合物具有消炎解毒、软坚化结、活血止痛、健脾补血的功效,通过抑制肿瘤生长,缓解疼痛,并使肿瘤缩小直至消失,可以实现各种早、中、晚期的恶性肿瘤及良性肿瘤的治疗,且效果显著,达到提高肿瘤患者的生存质量具有良好的临床应用价值。本发明通过对药物原料进行大量筛选,从而确定了相互配伍的原料物质,各原料物质通过相互配伍,最大程度地发挥了各自的功效,从而形成了一种见效快、疗效好且价格实惠的用于治疗肿瘤的中药组合物。
Description
技术领域
本发明涉及中药制剂技术领域,具体涉及一种用于治疗肿瘤的中药组合物及其制备方法。
背景技术
肿瘤是机体在各种致癌因子长期协同作用下,某部易感细胞群逐渐发生的过度而异常的反应性增生,往往持续增长,且与整体不相协调。肿瘤细胞是由正常细胞获得了新的生物学遗传特性转变而来,伴有分化和调控的障碍。肿瘤细胞的生长发展与机体免疫防御功能有关。学界一般将肿瘤分为良性和恶性两大类。
肿瘤在本质上是基因病,各种环境的和遗传的致癌因素以协同或序贯的方式引起DNA损害,从而激活原癌基因和(或)灭活肿瘤抑制基因,加上凋亡调节基因和(或)DNA修复基因的改变,继而引起表达水平的异常,使靶细胞发生转化。被转化的细胞先多呈克隆性的增生,经过一个漫长的多阶段的演进过程,其中一个克隆相对无限制的扩增,通过附加突变,选择性地形成具有不同特点的亚克隆(异质化),从而获得浸润和转移的能力(恶性转化),形成恶性肿瘤。
良性肿瘤对机体的影响较小,主要表现为局部压迫和阻塞症状,其影响主要与发生部位和继发变化有关。若发生在重要器官也可产生严重后果,如消化道良性肿瘤可引起肠套叠、肠梗阻。颅内的良性肿瘤如脑膜瘤、星形细胞胶质瘤可压迫脑组织、阻塞脑室系统而引起颅内压升高和相应的神经症状。良性肿瘤的继发性改变,也可对机体造成不同程度的影响,如肠的腺癌性息肉、膀胱乳头状瘤等表面可发生溃疡而引起出血和感染。
恶性肿瘤由于分化不成熟、生长较快,浸润破坏器官的结构和功能,并可发生转移,因而对机体影响严重。恶性肿瘤除可引起与上述良性肿瘤相似的局部压迫和阻塞症状外,还可有发热、顽固性疼痛,晚期可出现严重消瘦、乏力、贫血和全身衰竭的状态。一些非内分泌腺肿瘤能产生和分泌激素或激素类物质,引起内分泌紊乱的临床症状,这种肿瘤称为异位内分泌性肿瘤,其所引起的临床症状称为异位内分泌综合征。此类肿瘤多为恶性肿瘤,以癌居多,如胃癌、肝癌、结肠癌,也可见于肉瘤如纤维肉瘤、平滑肌肉瘤等。此外APUD系统(弥散性神经内分泌系统)的肿瘤,也可产生生物胺或多肽激素,如类癌、嗜铬细胞瘤等。
在现代社会中,受到日益恶化的环境及日常压力的影响,恶性肿瘤已经逐渐发展为常见病及多发病,它和心血管病、脑血管病一起,构成了对人类生命健康形成极大威胁的“三大杀手”。在我国,每年约有200万人患癌症,其中死亡近100万,现患者保持在150万左右,全世界每年净增21.58%,据调查,某高校英年早逝的中年知识分子中,被癌症夺取生命的占38%,说明癌症不仅是我国人口的主要死亡原因之一,而且对青壮年、中年的危害很严重,而这一年龄层的人对社会的重要性不言而喻。目前,治疗肿瘤的方法很多,如手术切除、放射治疗、化学治疗、中医中药及免疫治疗、激光、冷冻等,疗效较为确切、适应面较广的为手术、放疗、化疗和中医中药治疗方法,由于其中的中医中药治疗方法在治疗癌症方面有奇效,本发明人十二岁开始学医,经过几十年的艰苦奋斗和钻研,为此提供一种在治疗肿瘤方面药效显著的中药组合物。
发明内容
针对现有技术中存在的上述缺陷,本发明所要解决的技术问题在于提供一种用于治疗肿瘤的中药组合物及其制备方法,该中药组合物用于治疗肿瘤,通过方药物组合,具有清热解毒,软坚化结,活血止痛,补血通络,消肿祛腹水,健脾补血气,通过抗肿瘤抑制肿瘤生长,缓解疼痛,使肿瘤缩小直至消失达到提高肿瘤患者生存质量,延长生命。
本发明所公开的用于治疗肿瘤的中药组合物,由以下多种配方的中药原料按照以下重量份数配制而成:
第一方药:
蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山枝子、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角龙、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草,重量份数均为150~250重量份;
第二方药:
桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草,重量份数均为150~250重量份;
第三方药:
天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子,重量份数均为50~150重量份;以及
老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白,重量份数均为150~250重量份;
第四方药:
蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫,重量份数均为50~150重量份;以及
红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草,重量份数均为150~250重量份;以及
黑豆、罂粟壳,重量份数均为250~350重量份;
第五方药:
黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草,重量份数均为150~250重量份;以及400~600重量份数的赤小豆。
第六方药:
人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草,重量份数均150~250重量份。
本发明另一方面还提供了制备本发明所述的中药组合物的方法,包括如下步骤:
(1)分别取相应重量份数的蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山枝子、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角龙、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草研磨成粉状并混合,对混合后的药物进行乙醇消毒,加水提取,提取液经浓缩获得浓缩液;
(2)分别取相应重量份数的桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草研磨成粉状并混合,对混合后的药物进行乙醇消毒,加水提取,提取液经浓缩获得浓缩液;
(3)分别取相应重量份数的天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子研磨成粉状并混合;以及将老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白研磨成粉状并最终混合,对混合后的药物进行乙醇消毒,加水提取,提取液经浓缩获得浓缩液;
(4)分别取相应重量份数的蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫研磨成粉状;以及
将红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草研磨成粉状混合;以及
将黑豆、罂粟壳研磨成粉状,进行最终混合,混合后的药物进行乙醇消毒,加水提取,提取液经浓缩获得浓缩液;
(5)分别取相应重量份数的黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草;以及赤小豆,分别研磨成粉状并混合,对混合后的药物进行乙醇消毒,加水提取,提取液经浓缩获得浓缩液;
(6)分别取相应重量份数的人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草研磨成粉状并混合,对混合后的药物进行乙醇消毒,加水提取,提取液经浓缩获得浓缩液;
(7)混匀上述六种浓缩液,再次进行浓缩。
本发明通过对药物原料进行大量筛选,从而确定了相互配伍的原料物质,各原料物质通过相互配伍,最大程度地发挥了各自的功效,从而形成了一种见效快、疗效好且价格实惠的用于治疗肿瘤的中药组合物。
本发明与现有的治疗肿瘤的中草药物相比,通过消炎杀菌、软坚散结、抗癌、活血止痛、消肿祛腹水、补血复正气六步完成,从而形成了一种见效快、疗效好且价格实惠的用于治疗肿瘤的中药组合物。
第一步:清热解毒消炎杀菌。充分发挥蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山枝子、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角龙、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草的功效,刺激体内外粒细胞增生,抑制其活力。
第二步:软坚散结,化痰止咳。充分发挥桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草的功效,散寒行气。
第三步:止痛抗癌。充分发挥天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子、老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白的功效,散瘀止血,消肿定痛;
第四步:止痛止血、杀菌、消臃肿、散瘀化结、除腐烂,排胧生肌、活血、凉血、补血、通络。充分发挥蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫、红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草、黑豆、罂粟壳等的功效,活血止痛,化解肿瘤。
第五步:进一步消肿祛腹水,排毒通便。充分发挥黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草以及赤小豆的功效。通过第五步的配方,肿瘤基本完全消除。
第六步:健脾胃、补气血、促消化、止呕吐、扶正气、还复源。充分发挥人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草的功效。恢复气血。
由此可见,本发明的用于治疗肿瘤的中药组合物与现有的同类产品相比,具有如下的优势。
1、方子大。君臣佐使各种药材通过消毒杀菌、消肿散结、软坚散结、补气养血、五脏同调,进行人体全面的修复。
2、药材好。近280味配方,中草药中有40%是名贵中草药,如血竭、党参、牡蛎、元参、贝母、黄芪等都是中草药中的精品。
3、工艺好。在制备工艺中,将具有清热消毒、软坚散结、止痛抗癌、活血除腐烂、消肿祛腹水、健脾补血气功能的中草药分别进行提取,更加充分地保证了各种中草药药效成分的发挥。
4、效果好。与现有的同类产品相比,患有肿瘤的患者服用本发明的中药组合物两个疗程,坚持用药12个月基本可根治,前五个月控制肿瘤不恶化,六至十个月消除癌瘤,十一至十二月为根治期,严重者,可继续服用至18个月可基本痊愈。
具体实施方式
下面通过实施例对本发明作进一步的详细说明,旨在用于说明本发明而非限定本发明。应当指出,对于本领域技术人员而言,在不脱离本发明原理的前提下,还可以对本发明进行若干改进和修饰,这些改进和修饰也同样落入本发明的保护范围之内。
实施例1、本发明内服液的制备
1、分别称取蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山栀子(山枝子)、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角笼(八角龙)、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草,各200g,混合均匀研磨,在一个疗程使用时每次称取50g,每日两次共100g;
2、分别称取桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草,各200g,混合均匀研磨,使用时每次选取30g,每日两次共60g。
3、分别称取天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子,各100g,混合均匀研磨;分别称取老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白,各200g;共研磨,在一个疗程使用选取30g,每日两次共60g。
4、分别称取蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫各100g,研磨成粉;分别称取红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草各200g;称取黑豆、罂粟壳各300g,研磨成粉;然后均匀混合为一起,在一个疗程中,每次选取30g,每日两次共60g。
5、分别称取黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草各200g,赤小豆500g,研磨成粉,在一个疗程中,每次选取30g,每日两次共60g,混合均匀。
6、分别称取人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草各200g,在一个疗程中,每次选取30g,每日两次共60g,混合均匀,。
7、将上述六种混合液一日量加起来总共400g,先加水浸泡十分钟,当药全部湿透后再用猛火煮滚,再换用效果煮12~18分钟,即获得所述内用口服液。对混匀后的药物还可以进行乙醇消毒,加水提取,加水量是药物重量的5倍,提取2小时,共提取2次。压液浓缩离心过滤洗脱减压收取浓缩液。之后,患者即可服用,每日两次。
实施例2、本发明内服液的制备
1、分别称取蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山栀子(山枝子)、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角笼(八角龙)、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草,各250g,混合均匀研磨,在一个疗程使用时每次称取60g,每日两次共120g;
2、分别称取桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草,各250g,混合均匀研磨,使用时每次选取40g,每日两次共80g。
3、分别称取天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子,各150g,混合均匀研磨;分别称取老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白,各250g;共研磨,在一个疗程使用选取40g,每日两次共80g。
4、分别称取蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫各150g,研磨成粉;分别称取红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草各250g;称取黑豆、罂粟壳各350g,研磨成粉;然后均匀混合为一起,在一个疗程中,每次选取45g,每日两次共90g。
5、分别称取黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草各250g,赤小豆550g,研磨成粉,在一个疗程中,每次选取40g,每日两次共80g,混合均匀。
6、分别称取人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草各250g,在一个疗程中,每次选取40g,每日两次共80g,混合均匀,。
7、将上述六种混合液一日量加起来总共530g,先加水浸泡十五分钟,当药全部湿透后再用猛火煮滚,再换用效果煮15~20分钟,即获得所述内用口服液。对混匀后的药物还可以进行乙醇消毒,加水提取,加水量是药物重量的6倍,提取2小时,共提取2次。压液浓缩离心过滤洗脱减压收取浓缩液。
实施例3、本发明口服液的制备
1、分别称取蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山栀子(山枝子)、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角笼(亦可称八角龙)、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草,各150g,混合均匀研磨,在一个疗程使用时每次称取30g,每日三次共90g;
2、分别称取桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草,各150g,混合均匀研磨,使用时每次选取20g,每日三次共60g。
3、分别称取天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子,各60g,混合均匀研磨;分别称取老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白,各150g;共研磨,在一个疗程使用选取20g,每日三次共60g。
4、分别称取蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫各60g,研磨成粉;分别称取红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草各150g;称取黑豆、罂粟壳各250g,研磨成粉;然后均匀混合为一起,在一个疗程中,每次选取20g,每日三次共60g。
5、分别称取黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草各150g,赤小豆450g,研磨成粉,在一个疗程中,每次选取20g,每日三次共60g,混合均匀。
6、分别称取人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草各150g,在一个疗程中,每次选取20g,每日三次共60g,混合均匀,。
7、将上述六种混合液一日量加起来总共390g,先加水浸泡十二分钟,当药全部湿透后再用猛火煮滚,再换用效果煮15~20分钟,即获得所述内用口服液。对混匀后的药物还可以进行乙醇消毒,加水提取,加水量是药物重量的4倍,提取2小时,共提取2次。压液浓缩离心过滤洗脱减压收取浓缩液。
此外,在加热混合药物当中,在制作成口服液之外,还可以制作成片剂或者胶囊形式,故在浓缩制作过程中还可以增加赋形剂,赋形剂包括粘合剂、填充剂、稀释剂、压片剂、崩解剂、润滑剂和湿润剂,必要时还可以进行包衣,其中,增加的填充剂包括蜂蜜、淀粉、糖粉、糊精、可压性淀粉、淀粉浆、微晶纤维素、滑石粉和微粉蛙胶,如此可制成可售卖的片剂或者胶囊。
本发明的中药组合物,在服用时,通常为一年时间为一个疗程,在一个疗程内,基本能够痊愈,正常生活。
实验例本发明中药组合物治疗肿瘤的临床观察
1、资料与方法
临床资料:本发明对1046例患有肿瘤的患者进行临床观察,上述患者的病情包括恶性肿瘤和良性肿瘤患者,其肿瘤类型如下列表。
临床治疗效果的评价标准为:
(1)临床治愈:原有症状消失;
(2)显效:原有症状部分消失;
(3)有效:原有病情有所减轻;
(4)无效:症状体征无变化。
给药方法:取实施例1制备的中药组合物内服12个月,每天两次。
2、治疗结果
使用本发明实施例1制备的中药组合物治疗1个疗程后,观察1046例患者的肿瘤的治疗结果,见下表,临床有效率高达97.41%。
名称 | 临床治愈 | 显效 | 有效 | 无效 |
胃肿瘤 | 62 | 50 | 30 | 4 |
肠肿瘤 | 78 | 46 | 38 | 5 |
肝肿瘤 | 35 | 21 | 10 | 2 |
子宫肿瘤 | 50 | 20 | 36 | 3 |
肺肿瘤 | 58 | 44 | 28 | 5 |
肝硬化 | 101 | 88 | 50 | 6 |
乳腺肿瘤 | 26 | 22 | 9 | 1 |
鼻咽肿瘤 | 19 | 12 | 6 | 1 |
合计 | 429 | 383 | 207 | 27 |
毒副作用:在治疗结束后,复查血尿常规、大便、心、肝和肾功能未发现异常改变。
上述实验例中的典型病例患者的治疗情况如下:
(1)吴某某,男,53岁,肝肿癌,服用本发明实施例一的中药组合物,每日两次,熬制温水送服,用药一年两个月,肿瘤缩小至1.8cm,体重恢复,精神状态极好。
(2)李某某,男,61岁,肠癌,几无进食,疼痛难忍,服用本发明的实施例二的中药组合物,每日两次,熬制温水送服,用药一年,肠胃恢复。
(3)肖某某,65岁,患肝硬化,全身发黄,四肢无力,服用本发明实施例二的中药组合物,每日两次,熬制温水送服,用药10个月,身黄消退,肝部软化,可正常起居生活。
(4)吴某某,女,59岁,子宫癌,服用本发明实施例一的中药组合物,每日两次,熬制温水送服,用药12个月,基本康复。
(5)刘某某,女,52岁,乳腺癌,两乳各有4.2×3.8cm和4.8×4cm,服用本发明实施例二的中药组合物,每日两次,熬制温水送服,用药18个月,基本康复,肿瘤缩小,能正常起居并进行活动。
(6)陈某某,男,55岁,甲状腺癌瘤,疼痛难忍,吃饭少,睡眠差,服用本发明实施例三的中药组合物,每日三次,熬制温水送服,用药12个月,基本康复,肿瘤也消失了,随访身体健康。
(7)胡某某,男,67岁,直肠恶性肿瘤,在肿瘤医院进行切除手术,术后6个月复发,后服用本发明实施例三中的中药组合物,每日三次,用药一年,随访身体现恢复的比较健康。
(8)陈某某,男,51岁,患肺癌及肠胃溃疡,糜烂十余年,在医院多次就诊,不见根治,后服用本发明实施例三中的中药组合物,每日三次,用药一年零四个月,随访身体现恢复的比较健康。
本发明的中药组合物通过抑制肿瘤生长,缓解疼痛,并使肿瘤缩小直至消失,可以实现各种早、中、晚期的恶性肿瘤及良性肿瘤的治疗,且效果显著,达到提高肿瘤患者的生存质量具有良好的临床应用价值。
Claims (10)
1.一种用于治疗肿瘤的中药组合物,其特征在于,其由以下多种配方的中药原料按照以下重量份数配制而成:
第一方药:
蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山枝子、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角龙、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草,重量份数均为150~250重量份;
第二方药:
桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草,重量份数均为150~250重量份;
第三方药:
天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子,重量份数均为50~150重量份;以及
老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白,重量份数均为150~250重量份;
第四方药:
蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫,重量份数均为50~150重量份;以及
红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草,重量份数均为150~250重量份;以及
黑豆、罂粟壳,重量份数均为250~350重量份;
第五方药:
黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草,重量份数均为150~250重量份;以及400~600重量份数的赤小豆。
2.根据权利要求1所述的中药组合物,其特征在于,还包括如下第六方药:
人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草,重量份数均150~250重量份。
3.根据权利要求2所述的中药组合物,其特征在于,前五方药的重量份数分别为:
第一方药:
蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山枝子、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角龙、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草,均为200重量份;
第二方药:
桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草,均为200重量份;
第三方药:
天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子,重量份数均为100重量份;以及
老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白,均为200重量份;
第四方药:
蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫,均为100重量份;以及
红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草,均为200重量份;以及
黑豆、罂粟壳,均为300重量份;
第五方药:
黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草,均为200重量份;以及500重量份数的赤小豆。
4.根据权利要求3所述的中药组合物,其特征在于,第六方药的重量份数分别为:
人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草,均为200重量份。
5.根据权利要求1-4中任一项所述的中药组合物,其特征在于,所述中药组合物为内用口服制剂。
6.制备权利要求2-5中任一项所述的中药组合物的方法,包括如下步骤:
(1)分别将蛇舌草、半枝莲、地胆草、蒲公英、旱莲草、马齿苋、簕苋菜、山枝子、牛大力、绞股蓝、板蓝根、救必应、苏木、败酱草、八角龙、水杨梅、龙葵、白英、老鼠簕根、石见穿、白术、茯苓、大王、甘草研磨成粉状并混合;
(2)分别将桔核、海藻、海带、昆布、川楝子、桃仁、厚朴、木通、枳实、元胡、木香、枝子、水杨梅、白英、老鼠簕根、石见穿、夏枯草、半夏、薤白、仙茅、绞股蓝、百合、白芍、冬花、紫菀、马兜铃、白术、天冬、麦冬、防党、五味子、黄芪、当归、贝母、薏仁、续断、生地、炙草研磨成粉状并混合;
(3)将天龙、地龙、穿山甲、必甲、全虫、蜈蚣、茨菇、土必虫、生半夏、黄药子研磨成粉状并混合;以及
将老鼠簕根、狗奶字根、铁包金、水杨梅、皂刺、皂角、煅礞石、木必子、莱菔子、牡蛎、海浮石、山芝麻、哈壳、元参、重楼、贝母、桃仁、红花、山豆根、蟾蜍、夏菇草、蛇舌草、牛角尖、三七、人中白研磨成粉状并最终混合;
(4)将蜂房、姜蚕、虫退、田七、马钱子、天仙子、天南星、甘草、全虫、蜈蚣、地龙、山甲、必甲、土必虫研磨成粉状;以及
将红参、五灵脂、仓术、乳香、没药、威灵仙、五味子、灵芝、首乌、元胡、山豆根、黄芩、黄柏、丹参、毛冬青、旱莲草、蒲公英、草果、桔梗、泽兰、半枝莲、山楂、连招、救必应、鸡内金、千斤拔、黑老虎、土牛七、鸡血藤、宽根藤、牛大力、穿破石、两面针、枝子根、通脉草、杉木寄生、天龙、地龙、赤芍、桂枝、桑枝、白芍、炙芪、车前草、白术、川断、白芍、骨碎补、茯苓、当归、川穹、白芷、熟地、血竭、姜活、独活、沉香、花粉、木瓜、肉桂、生地、大王、代赭石、花蕊石、沙参、麦冬、藕节、鸡内金、木香、乌药、檀香、薤白、荔枝核、川楝子、甘草研磨成粉状混合;以及
将黑豆、罂粟壳研磨成粉状,进行最终混合;
(5)将黄芪、大子参、山药、白术、鸡内金、乌药、香附、白茅根、茯苓、半边莲、地胆草、木香、陈皮、柴胡、党参、桂枝、扁豆、大枣、干姜、肉桂、大麦芽、莱菔子、砂仁、了哥王、半枝莲、陈葫芦、蛇舌草、大王、山萸肉、泽兰、丹参、牛七、川穹、防杞、黄芩、甘草;以及赤小豆,分别研磨成粉状并混合;
(6)将人参、白术、茯苓、山萸肉、鸡内金、香附、当归、川穹、熟地、白药、黄芪、党参、枳实、半夏、竹茹、山楂、麦芽、神曲、淫羊藿、仙茅、炙草研磨成粉状并混合;
(7)加水为药量的3~6倍,加热浓缩。
7.根据权利要求6所述的方法,其中加水提取是按照药物重量的5倍加水,提取2-4小时,共提取2次。
8.根据权利要求6或7所述的方法,其中步骤(6)再次浓缩的标准为每千克原药浓缩成一千克浓缩液。
9.根据权利要求6-8中任一项所述的方法,其中,在加热混合药物当中,还增加有赋形剂,所述赋形剂包括粘合剂、填充剂、稀释剂、压片剂、崩解剂、润滑剂和湿润剂,必要时还可以进行包衣,制成片剂或胶囊。
10.根据权利要求9所述的方法,其中所述的填充剂包括蜂蜜、淀粉、糖粉、糊精、可压性淀粉、淀粉浆、微晶纤维素、滑石粉和微粉蛙胶。
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