CN113101347A - Dendrobium chewing gum with effects of promoting fluid production and benefiting stomach and preparation method and application thereof - Google Patents
Dendrobium chewing gum with effects of promoting fluid production and benefiting stomach and preparation method and application thereof Download PDFInfo
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- CN113101347A CN113101347A CN202110473984.5A CN202110473984A CN113101347A CN 113101347 A CN113101347 A CN 113101347A CN 202110473984 A CN202110473984 A CN 202110473984A CN 113101347 A CN113101347 A CN 113101347A
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- dendrobium
- chewing gum
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- fresh
- body fluid
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
- A61K36/8984—Dendrobium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/068—Chewing gum characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/10—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biochemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Confectionery (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a dendrobium chewing gum with the effects of promoting the secretion of saliva or body fluid and benefiting stomach and a preparation method and application thereof, wherein the effective components are prepared from the following raw materials in parts by weight: 5-30 parts of fresh dendrobium, 1-20 parts of fresh reed rhizome, 1-5 parts of radix puerariae, 1-5 parts of Chinese yam, 1-5 parts of radix ophiopogonis and 1-5 parts of hawthorn. The preparation method of the dendrobium chewing gum comprises the following steps: cleaning fresh dendrobium strips and fresh reed rhizome to obtain juice; extracting other materials including radix Puerariae, rhizoma Dioscoreae, radix Ophiopogonis and fructus crataegi with water, concentrating, and making into fluid extract; heating and uniformly mixing the chewing gum ingredients, and cooling for later use; mixing the fresh herba Dendrobii juice, fresh rhizoma Phragmitis juice, fluid extract and chewing gum ingredients, extrusion molding, cutting, and making into herba Dendrobii chewing gum. The herba Dendrobii chewing gum has effects of promoting fluid production and benefiting stomach, and can be used for preparing food or medicine with effects of promoting fluid production and benefiting stomach.
Description
Technical Field
The invention relates to the technical field of dendrobium chewing gum, in particular to dendrobium chewing gum with effects of promoting fluid production and benefiting stomach and a preparation method and application thereof.
Background
The xerostomia is a symptom caused by lack of saliva in the oral cavity, is not rare clinically, and is dry in the oral cavity, foreign body sensation and burning sensation are felt by patients due to reduction of salivary secretion, so that when food, particularly dry food, is chewed, the food cannot be formed into a bolus to influence swallowing. The saliva secretion is less, the washing effect on teeth and oral mucosa is less, and the self-cleaning effect of the oral cavity is poor. Therefore, the caries rate of the xerostomia patient is higher. The taste sensation of most dry mouth patients is also affected, does not stimulate appetite effectively, and affects the function of the entire digestive system. According to traditional Chinese medicine, dry mouth is caused by liver-kidney yin deficiency and insufficient body fluid, or caused by excessive heat consuming body fluid and burning body fluid.
Chewing gum is a common food form, the gum base of the chewing gum is very viscous, and the chewing gum can clean food residues on the surfaces of teeth and has certain function of cleaning the oral cavity when being chewed. The chewing movement can also promote the blood circulation of the face and the exercise of muscles, and has the function of promoting the development of the tooth jaw face. When the chewing gum is chewed, the mechanical stimulation can also increase the secretion of saliva, and the chewing gum has certain benefits for patients with xerostomia, but can not treat the root cause, for example, traditional Chinese medicines for nourishing liver and kidney, nourishing yin and promoting the production of body fluid can be added to treat the root cause, and the effect of treating both principal and secondary aspect of disease can be achieved.
Dendrobe is a plant of the genus dendrobe of the family orchidaceae, the second largest genus of the family orchidaceae following the genus physalis. Dendrobe is a traditional rare traditional Chinese medicine in China, has the effects of tonifying stomach, promoting the production of body fluid, nourishing yin and clearing heat, and is recorded in medical classics in past generations. It is commonly indicated for heat disease with body fluid deficiency, dry mouth, polydipsia, stomach yin deficiency, poor appetite, retching, persistent asthenic fever after disease, hyperactivity of fire due to yin deficiency, bone steaming, fatigue heat, dim eyesight, flaccidity of tendons and bones.
Currently, there are some patents disclosing dendrobium chewing gum. The invention discloses a dendrobium chewing gum and a preparation method thereof, and discloses the dendrobium chewing gum and a preparation method thereof, wherein the dendrobium chewing gum comprises 10-50 parts by weight of dendrobium raw powder and/or dendrobium dry extract and 50-90 parts by weight of chewing gum ingredients, and the dendrobium chewing gum can enhance oral hygiene, eliminate oral odor, promote salivary gland secretion, moisten dry oral cavity, prevent bacteria and decayed teeth, and is particularly suitable for users with dysphagia.
The invention discloses a chewing gum containing dendrobium officinale and a preparation method thereof, which belong to the technical field of chewing gum preparation, and particularly relates to a chewing gum containing dendrobium officinale and a preparation method thereof, wherein the application number of the Chinese invention patent application is 201710283839.4 (the application publication number is CN 107223757A). The chewing gum comprises the following raw materials in parts by mass: 20-25 parts of colloid, 4-5 parts of softener, 8-9 parts of freshener, 20-30 parts of traditional Chinese medicine components for relieving sore throat and/or 20-30 parts of traditional Chinese medicine components for nourishing stomach and 20-30 parts of dendrobium officinale fiber; the stomach nourishing component contains oligosaccharide extract of Dendrobium officinale. The traditional Chinese medicine components for relieving sore throat and the traditional Chinese medicine components for nourishing the stomach prepared by the method can retain the drug effects of various important components to the maximum extent, so that the prepared chewing gum can really play the effects of relieving sore throat and/or invigorating the stomach.
The Chinese patent application with the application number of 201811578653.2 (the application publication number is CN 109566836A) discloses a natural plant health-care chewing gum, and discloses a natural plant health-care chewing gum which comprises a chewing gum chewing matrix and a conditioning agent; the chewing gum chewing matrix comprises herba Dendrobii, radix Puerariae, radix astragali, and fructus Rosae Laevigatae; the regulator comprises fructus crataegi, mume fructus, pericarpium Citri Tangerinae, flos Caryophylli, Glycyrrhrizae radix, herba Menthae, herba Eupatorii, rhizoma Polygonati Odorati, flos Puerariae Lobatae, radix Platycodi, cortex Cinnamomi, and folium Eriobotryae; decocting the regulator, adding taste regulator to obtain soaking solution, absorbing the soaking solution with chewing gum matrix, and drying to obtain chewing gum. The invention is easy to degrade, and has the health care functions of refreshing, restoring consciousness, promoting the production of body fluid to quench thirst, improving pharyngitis symptom, alleviating hangover, preventing three highs, nourishing stomach and the like. After careful reading, the "chewing gum" is known as a chewable tablet, not a chewing gum in modern food forms.
In conclusion, the prior art adopts the dry dendrobium, and has the functions of cleaning the oral cavity, clearing heat from throat, invigorating stomach, promoting salivary secretion and the like. However, the fresh dendrobium nobile has a stronger effect of promoting the secretion of body fluid than the dry dendrobium nobile, for example, the fresh dendrobium nobile is taken as a main raw material, a prescription with the effects of promoting the secretion of body fluid and benefiting the stomach is formed according to the theory of traditional Chinese medicine, the effective ingredients of the traditional Chinese medicine are effectively blended into the chewing gum formulation through the modern advanced process to prepare the dendrobium nobile chewing gum, the formulation not only has the effects of cleaning the oral cavity and the like of common chewing gum, but also has the effects of promoting the secretion of body fluid and benefiting the stomach.
Disclosure of Invention
The invention aims to provide dendrobium chewing gum with the effects of promoting the secretion of saliva or body fluid and benefiting stomach and a preparation method and application thereof.
The dendrobium chewing gum with the effects of promoting the secretion of saliva or body fluid and benefiting stomach is prepared from the following raw materials in parts by weight:
preferably, the dendrobium chewing gum is prepared from the following raw materials in parts by weight:
preferably, in the dendrobium chewing gum, the mass ratio of the fresh dendrobium to the fresh reed rhizome to the kudzu vine root to the Chinese yam to the dwarf lilyturf tuber to the hawthorn is 30: 10: 3: 3: 2: 2. the above effective components have stronger synergistic effect in the mass ratio. The dendrobium chewing gum is characterized in that the effective components of the dendrobium chewing gum are prepared from the following raw materials in parts by weight:
the weight of the pachyrhizua angulatus, the yam, the ophiopogon root and the hawthorn refers to the mass of the pachyrhizua angulatus decoction pieces, the yam decoction pieces, the ophiopogon root decoction pieces and the hawthorn decoction pieces which correspond to each other.
A preparation method of dendrobium chewing gum with effects of promoting fluid production and benefiting stomach comprises the following steps:
(1) cleaning fresh dendrobium strips, airing, cutting into sections, smashing in a stone mortar or a ceramic container or a special crusher until the dendrobium strips are thin, and taking fresh juice after smashing;
(2) cleaning fresh rhizoma Phragmitis, air drying, cutting into segments, mashing in stone mortar or ceramic container or special pulverizer, and collecting fresh juice;
(3) extracting radix Puerariae, rhizoma Dioscoreae, radix Ophiopogonis and fructus crataegi with 10 times of water for 2 hr, filtering, extracting the residue with the same water for 2 hr, filtering, mixing filtrates, and concentrating under reduced pressure to obtain fluid extract;
(4) heating the chewing gum ingredients to 90-100 ℃, uniformly mixing, and cooling for later use;
(5) and (3) uniformly mixing the fresh dendrobe juice in the step (1), the fresh reed rhizome juice in the step (2), the fluid extract in the step (3) and the chewing gum ingredients in the step (4), carrying out extrusion forming, and cutting to obtain the dendrobe chewing gum.
In the step (1), the fresh dendrobium stem strips are fresh stems of dendrobium officinale, dendrobium devonianum, dendrobium huoshanense, dendrobium moniliforme, dendrobium nobile, drumstick, dendrobium fimbriatum and the like, the fresh dendrobium nobile are put into a stone mortar or a ceramic container and smashed to be thin, juice is squeezed out by gauze after the smashing, the fresh dendrobium juice is brewed by adopting an ancient method, or the fresh dendrobium nobile is smashed by a special crusher, and the fresh juice is obtained.
In the step (3), the extraction temperature is 90-100 ℃, the concentration temperature of the filtrate (namely, the reduced pressure concentration) is 65-75 ℃, and the temperature is controlled well, so that the preservation of effective substances is facilitated.
More preferably, the extract is extracted with 8 to 12 times of water for 1 to 3 hours and then filtered, the dregs of a decoction are extracted with the same water for 1 to 3 hours, most preferably, the extract is extracted with 10 times of water for 2 hours and then filtered, and the dregs of a decoction are extracted with the same water for 2 hours.
In the step (4), the chewing gum ingredients are prepared from the following materials in percentage by weight:
other food additives can be added according to the requirement to prepare various required tastes.
In the dendrobium chewing gum raw material, the fresh stem of dendrobium of the dendrobium family orchidaceae includes dendrobium varieties such as dendrobium officinale, dendrobium devonianum, dendrobium moniliforme, dendrobium huoshanense, dendrobium nobile, dendrobium chrysotoxum, dendrobium fimbriatum and the like. The dendrobium is a traditional and rare traditional Chinese medicine in China, has the effects of tonifying stomach, promoting the secretion of saliva or body fluid, nourishing yin and clearing heat, has long-term application of a fresh product, and is recorded in Shen nong Ben Cao Jing, which is recorded in the following points: "sweet and mild". This is mainly due to injury, and can remove arthralgia. Descending qi, tonifying the five internal organs, asthenia, emaciation and yin-strengthening. It can be taken for a long time to nourish intestines and stomach. The statement of the book Ben Cao Bei Yao (herbal treatise): the fresh dendrobium stomach-nourishing holy medicine has cooler nature, moistens dryness and generates body fluid. "Ben Cao Chong Li" cloud: chuan Shi Hu, shao xuan Xian Shi Hu, is cold in nature and especially decreases deficiency heat. The dry syndrome is indicated for deficiency syndrome, and the fresh one is indicated for excess syndrome. The famous prescriptions such as the formula of Qu Xiang Yan Tang from Yi Xue Chun Yi (medical science and medical science of medical sciences), the formula of Ye Shi Yan Wei Tang from Lin Zheng guide, and the formula of san Xian Tang (fresh dendrobe, fresh rehmannia root, fresh adenophora stricta) are emphasized. Modern Chinese medicine also has the theory of 'non-fresh dendrobium is not used', and the fresh dendrobium is considered to have better effects of clearing heat and promoting fluid production than dry products, and is good at treating fever impairment of fluid, dry tongue and thirst. It is also reported that dry dendrobium stem is mainly used for clearing deficiency heat, but fresh dendrobium stem is used for clearing excess heat by doctors and can clear lung and stomach excess heat. Radix Puerariae is dried root of Pueraria thomsonii of Leguminosae, and has effects of relieving muscles and fever, promoting fluid production to quench thirst, promoting eruption, invigorating yang and relieving diarrhea, dredging meridian passage, and relieving alcoholism, and is superior to radix Puerariae in promoting fluid production.
The prescription of the invention is based on the traditional Chinese medicine theory, the fresh dendrobium is used in the prescription for nourishing yin and promoting the production of body fluid, especially for nourishing stomach yin, which is suitable for the symptoms of yin impairment due to heat disease, insufficient body fluid, dry mouth and lips, dry teeth, vexation, thirst and the like, and the dendrobium is used as a monarch drug in the prescription; the fresh reed rhizome is matched with the ministerial drugs of heat clearing, fire purging, body fluid production promoting and thirst quenching, the pachyrhizus angulatus body fluid production promoting and thirst quenching, the meridian passage dredging and activating, the Chinese yam has the effects of tonifying spleen and stomach, body fluid production promoting and lung benefiting, and the dwarf lilyturf tuber has the effects of nourishing yin and body fluid, moistening lung and clearing away; hawthorn fruit, fructus crataegi, as an adjuvant drug, has the effects of promoting blood circulation, promoting the circulation of qi, removing blood stasis, and guiding the drugs into the blood. The whole formula is viewed, and the specimens are both solid. The medicines are used together to play the role of promoting the production of body fluid and benefiting the stomach, and are mainly used for treating fever body fluid impairment, dry mouth, polydipsia and stomach yin deficiency. The dendrobium chewing gum can be used for preparing food or medicines with the effects of promoting the secretion of saliva or body fluid and benefiting stomach.
According to the invention, the fresh dendrobium is combined with the fresh reed rhizome, the pachyrhizua angulatus, the Chinese yam, the radix ophiopogonis and the hawthorn to prepare the dendrobium chewing gum, and all components can generate synergistic effects and are mutually enhanced to form a new whole with more remarkable effect. According to the experimental result, the dendrobium chewing gum has the effect of promoting saliva secretion of rats with xerostomia induced by atropine, and the dendrobium chewing gum has the effects of promoting the production of body fluid and benefiting the stomach. Therefore, according to the invention, the dendrobium has the effects of tonifying stomach and promoting fluid production, the fresh reed rhizome is used for clearing heat and purging fire, the radix puerariae powder is used for promoting fluid production and quenching thirst, the Chinese yam is used for tonifying spleen and nourishing stomach, the radix ophiopogonis is used for nourishing yin and promoting fluid production, the hawthorn is used for activating blood and promoting blood circulation, and the medicines are introduced into the blood, so that the six components are combined to generate a synergistic effect, the specimen and the body can be cured, the dendrobium has good effects of promoting fluid production and tonifying stomach, and can be used for.
Compared with the prior art, the method has the following advantages:
according to the invention, the product for promoting the secretion of saliva or body fluid and benefiting the stomach is creatively prepared by taking the fresh dendrobium as a main raw material, and meanwhile, according to the formula of the theory of traditional Chinese medicine, the fresh dendrobium and other traditional Chinese medicines form a new whole to play a more prominent role in promoting the secretion of saliva or body fluid and benefiting the stomach. The dendrobium in the formula has the effects of tonifying stomach and promoting fluid production, the fresh reed rhizome has the effects of clearing heat and purging fire, the radix puerariae powder has the effects of promoting fluid production to quench thirst, the Chinese yam has the effects of tonifying spleen and nourishing stomach, the radix ophiopogonis has the effects of nourishing yin and promoting fluid production, the hawthorn has the effects of activating blood and promoting blood circulation and guiding medicine into blood, and the six components are combined to generate a synergistic effect, so that the dendrobium can play a role in tonifying the body and the stomach, and is particularly suitable for symptoms such as yin-deficiency and fluid-.
In the invention, the traditional Chinese medicine prescription which takes the fresh dendrobium as the main drug and has the effects of promoting the production of body fluid and benefiting the stomach is effectively combined with the food form of the chewing gum, and besides the mentioned advantages, the chewing gum has two creative remarkable progresses: firstly, when the chewing gum preparation is continuously chewed in the oral cavity, the chewing gum preparation directly acts on a target organ, and can more directly and effectively promote salivation; secondly, the chewing gum preparation is continuously chewed in the oral cavity, so that the medicine stays in the oral cavity for a longer time, and the active ingredients can be absorbed from the oral cavity.
The dendrobium, the reed rhizome, the radix puerariae, the Chinese yam, the radix ophiopogonis and the hawthorn in the dendrobium chewing gum raw materials are both medicinal and edible traditional Chinese medicines or are recorded in a health food list, can be used for preparing common food or health food, are suitable for people's requirements on oral cavity cleaning, body fluid production and stomach benefiting, and are particularly suitable for people with dry mouth and polydipsia.
The preparation method of the dendrobium chewing gum is simple and easy to implement, is suitable for industrial production, and has wide application prospect.
Detailed Description
The present invention is further illustrated by the following examples, which should not be construed as limiting the scope of the invention.
Example 1
The dendrobium chewing gum comprises the following raw material medicines in proportion:
raw materials: 30g of dendrobium officinale fresh strips, 10g of fresh reed rhizome, 3g of radix puerariae, 3g of Chinese yam, 2g of radix ophiopogonis and 2g of hawthorn.
The preparation is carried out according to the following specific mode:
(1) cleaning fresh dendrobium strips, airing, cutting into sections, placing the sections into a stone mortar or a ceramic container, smashing until the sections are thin, and squeezing juice out by using gauze after smashing for later use;
(2) cleaning fresh rhizoma Phragmitis, air drying, cutting into segments, mashing in stone mortar or ceramic container, and squeezing with gauze to obtain juice;
(3) mixing radix puerariae decoction pieces, Chinese yam decoction pieces, radix ophiopogonis decoction pieces and hawthorn decoction pieces, adding 10 times of water, extracting for 2 hours at 90-100 ℃, filtering, adding the same water into decoction dregs, extracting for 2 hours at 90-100 ℃, filtering, combining filtrates, and concentrating the filtrate under reduced pressure at 65-75 ℃ to obtain a fluid extract for later use;
(4) heating chewing gum ingredients (edible gum base 30%, xylitol 40%, sorbitol 29.5%, and citric acid 0.5%) to 90-100 ℃, mixing uniformly, and cooling for later use;
(5) and (3) uniformly mixing the fresh dendrobe juice in the step (1), the fresh reed rhizome juice in the step (2), the fluid extract in the step (3) and the chewing gum ingredients in the step (4), carrying out extrusion forming, and cutting to obtain the dendrobe chewing gum.
Example 2
The dendrobium chewing gum comprises the following raw material medicines in proportion:
raw materials: 30g of dendrobium officinale fresh strips, 5g of fresh reed rhizome, 1g of radix puerariae, 1g of Chinese yam, 1g of radix ophiopogonis and 1g of hawthorn.
The preparation method is the same as example 1.
Example 3
The dendrobium chewing gum comprises the following raw material medicines in proportion:
raw materials: 30g of purple peel dendrobium fresh strips, 10g of fresh reed rhizome, 3g of radix puerariae, 3g of Chinese yam, 2g of radix ophiopogonis and 2g of hawthorn.
The preparation method is the same as example 1.
Comparative example 1
The dendrobium chewing gum comprises the following raw material medicines in proportion:
raw materials: 6g of dendrobium officinale dry strips (equivalent to about 30g of fresh strips), 10g of fresh reed rhizome, 3g of radix puerariae, 3g of Chinese yam, 2g of radix ophiopogonis and 2g of hawthorn.
The preparation is carried out according to the following specific mode:
(1) cutting the dried dendrobium into segments, adding 30 times of water, extracting for 3 hours at 90-100 ℃, filtering, adding 30 times of water into filter residues, extracting for 3 hours at 90-100 ℃, filtering, combining the two filtrates, and concentrating under reduced pressure at 65-75 ℃ for later use;
the following preparation process was the same as in example 1.
Test of drug efficacy
Animal experiments prove that the invention has the function of promoting salivary secretion.
1 materials and methods
1.1 materials
Sample preparation: the test group was a mixed sample prepared according to the formulation steps (1) to (3) of example 1; the comparative example group is a mixed sample prepared according to comparative example 1 formulation steps (1) to (3).
Experimental animals: SD rats, male, body weight 170-200 g. Provided by the experimental animal center in Zhejiang province, animal qualification number: SCXK (Zhe) 2016-.
The main reagents are as follows: uratan, 0.9% sodium chloride injection, pilocarpine eye drops, and atropine sulfate injection.
The main apparatus is as follows: analytical balance, syringe.
1.2 methods
Healthy SD rats were taken 70, females, and randomly divided into 7 groups by body weight: normal control group (normal saline), model control group (normal saline), positive control group (pilocarpine), low, medium and high sample test group, and comparative control group, the administration dosage is shown in table 1. Rat intraperitoneal injection of urethane (1.3g kg)-1) For anesthesia, the M receptor blocker atropine (1 mg. kg) was administered into the tail vein according to the literature method-1) A rat model of xerostomia was prepared. After the molding is successfully carried out for 20min, the medicines are respectively administrated by intragastric administration. After all animals were administered, 30mg dry cotton balls were placed under the tongue, the salivary secretion of rats was measured, each cotton ball was replaced every 30min for 1 time, the measurement was continued for 150min, the salivary secretion was calculated by weighing the difference in weight between the dry cotton balls before and after the measurement, and the results were statistically analyzed.
2 results
As shown in Table 1, the saliva secretion amount of the rats in the model group of xerostomia modeled by atropine was significantly reduced (P <0.05) compared with that in the normal control group, and the modeling was successful. Compared with the model control group, each dosage group of the sample can effectively promote the secretion of saliva of the xerostomia rat modeled by atropine (P < 0.001). Compared with the comparative example group, the saliva secretion amount of each dose group of the sample test group is also significantly different, and the difference is statistically significant (P < 0.05).
TABLE 1 Effect on salivary secretion in rats
| Group of | dose/mL. only-1 | Saliva secretion/mg |
| Normal group | - | 66.6±12.4 |
| Model control group | - | 17.6±6.9# |
| Positive control group | - | 43.0±12.8* |
| Low dose test group | 5 | 53.0±11.5*△ |
| Middle dose test group | 15 | 67.3±19.6*△ |
| High dose test group | 45 | 53.8±13.1*△ |
| Comparative example group | 15 | 39.3±9.4* |
Note: in comparison with the normal group,#p is less than 0.05; in comparison with the set of models,*p is less than 0.001; in comparison with the comparative example group,△P＜0.05。
3 conclusion
The research shows that the sample and the comparative example group have the function of promoting saliva secretion of the rats with xerostomia modeled by atropine, wherein the salivation function of the sample is more obvious, and the effect of the sample is obviously better than that of the comparative example group. The dendrobium chewing gum has obvious effects of promoting the secretion of saliva or body fluid and benefiting stomach.
Claims (9)
1. The dendrobium chewing gum with the effects of promoting production of body fluid and benefiting stomach is characterized in that the effective components of the dendrobium chewing gum are prepared from the following raw materials in parts by weight:
2. the dendrobium chewing gum with effects of promoting production of body fluid and benefiting stomach according to claim 1, wherein the effective ingredients are prepared from the following raw materials in parts by weight:
3. the dendrobium chewing gum with effects of promoting production of body fluid and benefiting stomach according to claim 1, wherein the effective ingredients are prepared from the following raw materials in parts by weight:
4. the preparation method of dendrobium nobile chewing gum with effects of promoting production of body fluid and benefiting stomach according to any one of claims 1-3, which is characterized by comprising the following steps:
(1) cleaning fresh dendrobium strips, airing, cutting into sections, smashing in a stone mortar or a ceramic container or a special crusher until the dendrobium strips are thin, and taking fresh juice after smashing;
(2) cleaning fresh rhizoma Phragmitis, air drying, cutting into segments, mashing in stone mortar or ceramic container or special pulverizer, and collecting fresh juice;
(3) extracting radix puerariae, Chinese yam, radix ophiopogonis and hawthorn decoction pieces together with water for 1-5 hours, filtering, extracting the decoction dregs with water for 1-5 hours, filtering, combining the filtrates, and concentrating under reduced pressure to obtain a fluid extract;
(4) heating the chewing gum ingredients to 90-100 ℃, uniformly mixing, and cooling for later use;
(5) and (3) uniformly mixing the fresh dendrobe juice in the step (1), the fresh reed rhizome juice in the step (2), the fluid extract in the step (3) and the chewing gum ingredients in the step (4), carrying out extrusion forming, and cutting to obtain the dendrobe chewing gum.
5. The preparation method of dendrobium chewing gum with effects of promoting production of body fluid and benefiting stomach according to claim 4, wherein in step (1), the fresh dendrobium stem is fresh stem of dendrobium officinale, dendrobium devonianum, dendrobium huoshanense, dendrobium stem, dendrobium nobile, dendrobium chrysotoxum, dendrobium fimbriatum and the like.
6. The preparation method of dendrobium nobile chewing gum with effects of promoting production of body fluid and benefiting stomach according to claim 4, wherein in the step (3), the extraction temperature is 90-100 ℃, and the reduced pressure concentration temperature is 65-75 ℃.
7. The preparation method of dendrobium chewing gum with effects of promoting fluid production and benefiting stomach as claimed in claim 4, wherein in step (3), 8-12 times of water is added for 1-3 hours, the mixture is filtered, and the medicine residue is extracted with the same water for 1-3 hours.
8. The preparation method of dendrobe chewing gum with effects of promoting production of body fluid and benefiting stomach according to claim 4, wherein in the step (3), the chewing gum ingredients are prepared from the following materials in percentage by weight:
9. use of the dendrobium nobile chewing gum with effects of promoting production of body fluid and benefiting stomach according to any one of claims 1-3 in preparation of food or medicine with effects of promoting production of body fluid and benefiting stomach.
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