CN113082177A

CN113082177A - Capsule for treating chronic bronchitis and preparation method thereof

Info

Publication number: CN113082177A
Application number: CN202110309473.XA
Authority: CN
Inventors: 王志敏; 连莎莎; 武燕
Original assignee: Shanxi Huayuan Medicine Biotechnology Co ltd
Current assignee: Shanxi Huayuan Medicine Biotechnology Co ltd
Priority date: 2021-03-23
Filing date: 2021-03-23
Publication date: 2021-07-09

Abstract

The invention relates to a capsule for treating chronic bronchitis and a preparation method thereof, belongs to the technical field of medicines, and aims to solve the technical problem of providing a capsule for treating chronic bronchitis and a preparation method thereof, wherein the technical scheme is as follows: the feed comprises the following raw materials in parts by weight: 45-60 parts of mulberry bark, 30-45 parts of loquat leaf, 55-70 parts of lophatherum gracile, 15-28 parts of abalone shell, 8-22 parts of radix ophiopogonis, 25-40 parts of arisaema tuber, 26-40 parts of radix stemonae, 30-45 parts of herba hyperici japonici, 45-65 parts of radix peucedani, 15-30 parts of blackberrylily rhizome, 8-20 parts of ginkgo leaf, 40-60 parts of common coltsfoot flower, 15-30 parts of dried orange peel and 15-30 parts of Chinese yam, and a preparation method of the capsule; the traditional Chinese medicine composition has the effects of freeing lung, relieving exterior syndrome, relieving cough, reducing sputum and relieving asthma, and has quick response and obvious effect on the treatment of chronic bronchitis.

Description

Capsule for treating chronic bronchitis and preparation method thereof

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to a capsule for treating chronic bronchitis and a preparation method thereof.

Background

Chronic bronchitis is a chronic nonspecific inflammation of trachea, bronchial mucosa and surrounding tissues, is a common disease and a frequently encountered disease of a respiratory system, and is clinically characterized by cough, expectoration or asthma, and with the development of the disease, complications such as emphysema, pulmonary hypertension, pulmonary heart disease and the like occur, and even the life is endangered. Although a lot of existing cough and asthma relieving medicines are available, western medicines generally use antibiotic medicines, but the long-term use of antibiotics can generate serious drug resistance, finally, the medicines of a lot of antibiotics fail, and inflammatory diseases are more and more difficult to cure; the existing Chinese patent medicine has mild potency and unsatisfactory curative effect on chronic bronchitis.

Disclosure of Invention

The invention overcomes the defects of the prior art, provides the capsule for treating chronic bronchitis and the preparation method thereof, has the effects of freeing lung and relieving exterior syndrome, relieving cough and reducing sputum and relieving asthma, and has quick response and obvious effect on treating the chronic bronchitis.

In order to solve the technical problems, the invention adopts the technical scheme that: a capsule for treating chronic bronchitis comprises the following raw materials in parts by weight:

45-60 parts of mulberry bark, 30-45 parts of loquat leaves, 55-70 parts of lophatherum gracile, 15-28 parts of abalone shell, 8-22 parts of radix ophiopogonis, 25-40 parts of arisaema consanguineum, 26-40 parts of radix stemonae, 30-45 parts of herba hyperici japonici, 45-65 parts of radix peucedani, 15-30 parts of blackberrylily rhizome, 8-20 parts of ginkgo leaves, 40-60 parts of common coltsfoot flower, 15-30 parts of dried orange peel and 15-30 parts of Chinese yam.

Preferably, the capsule for treating chronic bronchitis comprises the following raw materials in parts by weight:

48-52 parts of mulberry bark, 35-42 parts of loquat leaf, 60-65 parts of lophatherum gracile, 18-22 parts of abalone shell, 9-16 parts of radix ophiopogonis, 28-32 parts of arisaema tuber, 30-35 parts of radix stemonae, 37-43 parts of herba hyperici japonici, 50-55 parts of radix peucedani, 18-22 parts of blackberry lily, 10-16 parts of ginkgo leaf, 45-52 parts of coltsfoot flower, 20-25 parts of dried orange peel and 18-23 parts of Chinese yam.

A preparation method of a capsule for treating chronic bronchitis specifically comprises the following steps:

1) extraction process

Putting the weighed mulberry bark, loquat leaf and lophatherum gracile into a hot reflux extraction tank, extracting for the first time, adding 95% ethanol which is 5 times of the medicinal materials, soaking for 1 hour, performing reflux extraction for 1.5 hours, timing from boiling, filtering the extracting solution, and injecting the filtrate into an extracting solution storage tank; performing second extraction, namely adding 50% ethanol in an amount which is 5 times that of the medicinal materials into the first decoction dregs, performing reflux extraction for 1 hour, filtering an extracting solution, injecting the extracting solution into an extracting solution storage tank, performing third extraction, adding water in an amount which is 5 times that of the second decoction dregs, decocting for 1 hour, filtering, and injecting into an extracting solution storage tank;

2) recovery of ethanol

Firstly, decompressing and recovering ethanol from the filtrate obtained in the first extraction to obtain a clear paste with the density of 1.07-1.10, measuring the concentration at 60-70 ℃, injecting the clear paste into a concentrated solution storage tank, recovering ethanol from the filtrate obtained in the second extraction, and transferring the ethanol recovered in the two times into a diluted alcohol storage tank;

3) concentrating

Mixing the second filtrate and the third filtrate, concentrating to obtain fluid extract with relative density of 1.18-1.22, measuring the concentration at 60-70 deg.C, and mixing the fluid extracts obtained by two times of concentration in a concentrated solution storage tank; transferring the combined fluid extract into a spherical vacuum concentrator for concentration, and concentrating the liquid medicine to obtain an extract with a relative density of 1.23-1.26, wherein the concentration is measured at 60-70 ℃;

4) recovery cream

Opening vacuum, sucking the concentrated extract into a vacuum material receiving tank, putting into a clean extract barrel, weighing, and sealing;

5) mixing and drying

Putting the fine powder of the abalone shell, the dwarf lilyturf tuber, the arisaema tuber, the sessile stemona root, the buddha, the whiteflower hogfennel root, the blackberry lily, the ginkgo leaf, the common coltsfoot flower, the tangerine peel and the Chinese yam and the extract into a groove-shaped mixing machine, wet mixing for 3 minutes, putting the materials into a tray of a low-temperature vacuum drying oven after mixing is finished, wherein the thickness of the materials is about 1.5 cm;

drying the materials in a drying room according to the standard operation and maintenance regulations of the low-temperature vacuum drying box;

the technological parameters are as follows: the drying temperature is 65 +/-5 ℃, the drying time is 10-12 h, the steam pressure is 0.2 +/-0.05 MPa, and the vacuum degree is-0.07 +/-0.01 MPa;

6) pulverizing

Crushing the dried dry paste into 100-mesh fine powder in a crushing and sieving room according to the requirements of standard operation and maintenance regulations of a 40B-X efficient crusher, and packaging the fine powder in a double-layer polyethylene bag;

7) filling in

The average grain weight is weighed by an AR1530/CP213 electronic balance by adopting an NJP-3200/3200C type capsule filling machine and a YJP-III/JMJ-1 polishing machine;

the specific filling process is as follows:

a. during production, the average grain weight is measured every 15 minutes and is faithfully recorded;

b. timely feeding, and keeping the hopper at 1/3-2/3 of volume;

c. the filled capsules are put in a clean stainless steel barrel for standby;

8) capsule polishing

The filled capsules are poured into a polishing machine for polishing after unqualified capsules such as bad heads, empty shells, powder leakage and the like are removed. The polished capsule is put into a clean stainless steel barrel with a polyethylene bag inside and is bound with a cover;

9) aluminum-plastic composite

The production is carried out in an aluminum-plastic packaging room of a clean area by adopting a full-automatic high-speed aluminum-plastic blister packaging machine or a flat-plate aluminum-plastic blister packaging machine, and an aluminum-plastic post operator sets the temperatures of an upper heating plate and a lower heating plate of the aluminum-plastic packaging machine at 120 +/-10 ℃ and the heat sealing temperature at 220 +/-10 ℃ or depends on the quality of medicinal PVC. Adjusting the machine, checking the specification, batch number and validity period to be correct, and formally producing after clear writing. The aluminum-plastic plate with good aluminum is sent into the outer package room through the wire connecting device.

The application method and the dosage are as follows: the patient takes the medicine with warm water after meals 2 granules each time, 3 times a day.

Mulberry bark: cold in nature, sweet in flavor, entering lung meridian. Has effects in purging lung, relieving asthma, and eliminating edema, and can be used for treating cough and asthma due to lung heat, edema of face, dysuresia, hypertension, and diabetes. In addition, sang Bai Pi has some sedative effect.

Loquat leaf: bitter and cool, entering lung and stomach meridians. Clear lung heat and stop cough, check adverse rise of qi and arrest vomiting. Can be used for treating cough due to lung heat, asthma, vomiting due to stomach heat, dysphoria with smothery sensation, and thirst.

Herba lophatheri: sweet, bland and cold in nature, entering heart, stomach and small intestine meridians. Clearing heat, relieving restlessness and promoting urination, and can be used for treating fever, polydipsia, dark urine, stranguria, aphtha of the mouth and tongue.

Abalone shell: salty in property, even enters liver and kidney meridians. Pacify liver and subdue yang, clear heat, tomorrow. It is indicated for wind-yang disturbance, headache, vertigo, convulsion, bone-steaming, fever, and cataract due to cyanosis.

Radix ophiopogonis: sweet, slightly bitter and cold, entering heart, lung and stomach meridians. Nourishing yin, promoting fluid production, moistening lung, and clearing heart fire, and can be used for treating lung dryness, dry cough, consumptive disease, cough, body fluid injury, thirst, vexation, insomnia, internal heat, diabetes, and constipation due to intestinal dryness; pharyngeal diphtheria; palpitation due to heart yin deficiency and fluid impairment due to heat in the late stage of fever.

Rhizoma arisaematis: bitter and pungent in flavor, warm in nature, entering lung, liver and spleen meridians. Resolve stagnation and relieve swelling, it is indicated for abscess and swelling, snake and insect bite. Rhizoma arisaematis preparata has effects in eliminating dampness and phlegm, dispelling pathogenic wind, relieving spasm, resolving hard mass, and relieving swelling, and can also be used for treating intractable phlegm cough, wind phlegm giddiness, apoplexy phlegm stagnation, wry eye and mouth, hemiplegia, epilepsy, infantile convulsion, and tetanus; it is used externally to treat carbuncle, swelling, snake and insect bite.

Stemona root: sweet, bitter and slightly cold in flavor, entering lung meridian. Moistening lung, descending qi to arrest cough, and killing parasite; can be used for treating chronic cough, pulmonary tuberculosis cough, and pertussis; it is used for treating head louse, body louse, enterobiasis, and pudendal pruritus; honey radix Stemonae has effects of moistening lung and relieving cough; can be used for treating cough due to yin deficiency.

Herba pteridis: sweet and neutral, relieving cough and asthma, lowering blood pressure, dispelling wind-damp. Can be used for treating common cold with cough, bronchitis, asthma, hypertension, fava bean disease, rheumatism, lumbago, and skelalgia; it is used externally to treat traumatic injury and venomous snake bite.

Radix peucedani: bitter and pungent with slight cold entering lung meridian. Dispel wind and clear heat, direct qi downward and resolve phlegm, and can be used for treating wind-heat cough with excessive phlegm, phlegm-heat dyspnea with fullness, yellow and thick sputum.

Shooting: bitter and cold in property entering lung meridian. Clearing away heat and toxic materials, eliminating phlegm and saliva, and relieving sore throat;

folium Ginkgo, a dry leaf of Ginkgo plant, is sweet and neutral in nature, bitter and astringent in taste, and has effects of promoting blood circulation, removing blood stasis, dredging collaterals, relieving pain, astringing lung, relieving asthma, eliminating turbid pathogen, and reducing blood lipid, and can be used for treating blood stasis, obstruction of collaterals, thoracic obstruction, cardialgia, apoplexy, hemiplegia, cough with asthma due to lung deficiency, and hyperlipidemia.

And (3) common coltsfoot flower: pungent, slightly bitter and warm, entering lung meridian. Moisten lung and descend qi, relieve cough and resolve phlegm, and can be used for treating chronic cough, cough with dyspnea and profuse sputum, and cough with blood.

Dried orange peel: bitter and pungent in flavor, warm in nature, entering lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. It is mainly indicated for abdominal distention, poor appetite, vomiting and diarrhea, cough and profuse sputum.

Chinese yam: sweet in taste and neutral in nature, enters spleen, lung and kidney channels, has the effects of tonifying qi and yin, tonifying spleen, lung and kidney, strengthening channels and arresting leucorrhea, can tonify spleen qi, tonify spleen yin, relieve constipation, promote the production of body fluid to quench thirst, invigorate spleen and arrest diarrhea.

Compared with the prior art, the invention has the following beneficial effects.

The invention selects the medicinal components under the guidance of the traditional Chinese medicine theory and clinical experience, the medicinal components are compatible according to syndrome differentiation, are mutually assisted in action, have synergistic effect, play the efficacies of freeing lung and relieving exterior syndrome, relieving cough and reducing sputum and relieving asthma, and can directly reach the focus and remove the disease root when the chronic bronchitis is treated in a targeted manner. Cortex mori, folium eriobotryae and lophatherum gracile are monarch drugs and play a leading role in the capsule, and can purge lung and relieve asthma, clear lung and relieve cough, and check adverse rise of qi and relieve vomiting; abalone shell, dwarf lilyturf tuber, arisaema tuber, sessile stemona root, buddleia and whiteflower hogfennel root are used as ministerial drugs, can enhance the drug effect of monarch drugs, can calm the liver and suppress yang, relieve cough and reduce swelling, and can lower qi and reduce phlegm; the blackberry lily, the ginkgo leaf, the coltsfoot flower, the dried orange peel and the Chinese yam have a coordination effect on active ingredients of monarch drugs and ministerial drugs, the blackberry lily, the ginkgo leaf and the coltsfoot flower have the effects of astringing lung and relieving asthma and dissolving phlegm and saliva, the dried orange peel and the Chinese yam can regulate qi and invigorate spleen, supplement qi and nourish yin, and the drugs are synergistic, so that the cough and phlegm can be quickly relieved, the inflammation can be eliminated, the chronic bronchitis can be effectively treated, and the traditional Chinese medicine.

The invention adopts natural medicines, and has simple preparation, wide medicine source and low cost. The invention follows the prescription principle of traditional Chinese medicine, and clinical application verifies that the curative effect is obvious and reliable, and the efficacy is mild.

Detailed Description

The present invention is further illustrated by the following specific examples.

Example 1

A capsule for treating chronic bronchitis comprises the following raw materials in parts by weight:

45 parts of mulberry bark, 30 parts of loquat leaf, 55 parts of lophatherum gracile, 15 parts of abalone shell, 18 parts of dwarf lilyturf tuber, 35 parts of arisaema consanguineum, 28 parts of radix stemonae, 40 parts of herba hyperici japonici, 60 parts of radix peucedani, 28 parts of blackberry lily, 12 parts of ginkgo leaf, 55 parts of common coltsfoot flower, 15 parts of dried orange peel and 28 parts of Chinese yam.

Example 2

55 parts of mulberry bark, 38 parts of loquat leaf, 68 parts of lophatherum gracile, 18 parts of abalone shell, 12 parts of dwarf lilyturf tuber, 25 parts of arisaema consanguineum, 26 parts of radix stemonae, 30 parts of herba hyperici japonici, 48 parts of radix peucedani, 15 parts of blackberry lily, 8 parts of ginkgo leaf, 40 parts of common coltsfoot flower, 18 parts of dried orange peel and 15 parts of Chinese yam.

Example 3

52 parts of mulberry bark, 33 parts of loquat leaf, 63 parts of lophatherum gracile, 24 parts of abalone shell, 20 parts of dwarf lilyturf tuber, 30 parts of arisaema consanguineum, 30 parts of radix stemonae, 37 parts of herba hyperici japonici, 45 parts of radix peucedani, 18 parts of blackberry lily, 10 parts of ginkgo leaf, 45 parts of common coltsfoot flower, 20 parts of dried orange peel and 20 parts of Chinese yam.

Example 4

58 parts of mulberry bark, 35 parts of loquat leaf, 58 parts of lophatherum gracile, 22 parts of abalone shell, 8 parts of dwarf lilyturf tuber, 28 parts of arisaema consanguineum, 35 parts of radix stemonae, 33 parts of herba hyperici japonici, 50 parts of radix peucedani, 22 parts of blackberrykiky rhizome, 13 parts of ginkgo leaf, 52 parts of common coltsfoot flower, 23 parts of dried orange peel and 18 parts of Chinese yam.

Example 5

48 parts of mulberry bark, 42 parts of loquat leaf, 70 parts of lophatherum gracile, 28 parts of abalone shell, 9 parts of dwarf lilyturf tuber, 32 parts of arisaema consanguineum schott, 40 parts of radix stemonae, 35 parts of herba hyperici japonici, 53 parts of radix peucedani, 30 parts of blackberry lily, 16 parts of ginkgo leaf, 60 parts of common coltsfoot flower, 25 parts of dried orange peel and 23 parts of Chinese yam.

Example 6

51 parts of mulberry bark, 32 parts of loquat leaf, 65 parts of lophatherum gracile, 25 parts of abalone shell, 16 parts of dwarf lilyturf tuber, 37 parts of arisaema consanguineum schott, 37 parts of radix stemonae, 43 parts of herba hyperici japonici, 55 parts of radix peucedani, 25 parts of blackberry lily, 20 parts of ginkgo leaf, 47 parts of common coltsfoot flower, 30 parts of dried orange peel and 26 parts of Chinese yam.

Example 7

60 parts of mulberry bark, 45 parts of loquat leaf, 60 parts of lophatherum gracile, 16 parts of abalone shell, 22 parts of dwarf lilyturf tuber, 40 parts of arisaema consanguineum, 33 parts of radix stemonae, 45 parts of herba hyperici japonici, 65 parts of radix peucedani, 27 parts of blackberry lily, 18 parts of ginkgo leaf, 57 parts of common coltsfoot flower, 28 parts of dried orange peel and 30 parts of Chinese yam.

Example 8

1000 capsules for treating chronic bronchitis are produced, and comprise the following raw materials in parts by weight:

47.5g of mulberry bark, 38.1g of loquat leaf, 57g of lophatherum gracile, 19g of abalone shell, 9.6g of dwarf lilyturf tuber, 28.5g of arisaema tuber, 28.5g of sessile stemona root, 38.1g of buddleia, 47.5g of whiteflower hogfennel root, 19g of blackberry lily, 9.6g of ginkgo leaf, 47.5g of common coltsfoot flower, 19.6g of tangerine peel and 19g of Chinese yam.

Example 9

50.3g of mulberry bark, 33.6g of loquat leaf, 60.2g of lophatherum gracile, 18.2g of abalone shell, 13.2g of dwarf lilyturf tuber, 25.8g of arisaema tuber, 26.6g of stemona root, 39.4g of buddleia, 45.8g of peucedanum root, 15.8g of blackberry lily, 13.3g of ginkgo leaf, 44.3g of common coltsfoot flower, 25.1g of tangerine peel and 17.9g of yam.

Examples 1 to 9 methods for preparing capsules for treating chronic bronchitis, each specifically comprising the steps of:

1) extraction process

2) recovery of ethanol

3) concentrating

4) recovery cream

5) mixing and drying

6) pulverizing

7) filling in

the specific filling process is as follows:

b. timely feeding, and keeping the hopper at 1/3-2/3 of volume;

c. the filled capsules are put in a clean stainless steel barrel for standby;

8) capsule polishing

9) aluminum-plastic composite

Clinical trials were conducted using the products prepared in examples 8 and 9 above:

symptoms of the test subjects: the patient has cough, asthma and phlegm as main symptoms.

The test subjects: 70 people, and is administered for 1 month.

The using method comprises the following steps: the patient takes the medicine with warm water after meals 2 granules each time, 3 times a day.

The administration effect is shown in the following table:

	number of people	Show effect	Improvement of life	Mean time to improvement
					Example 8	38 persons	33 persons (87%)	5 persons (13%)	20 days
Example 9	32 persons	25 persons (78%)	7 persons (22%)	22 days

The effect is shown: clinical symptoms disappear or are relieved from serious symptoms to mild symptoms after treatment;

improvement: the frequency, degree and duration of the attack are obviously reduced.

Clinical observation shows that: the medicament of the invention has quick response to the treatment of chronic bronchitis. No adverse reactions were seen in all patients. The medicine for treating chronic bronchitis has the advantages of good treatment effect, quick response and no obvious toxic or side effect, and fully embodies the curative effect advantage of compatibility of traditional Chinese medicines.

The above embodiments are merely illustrative of the principles of the present invention and its effects, and do not limit the present invention. It will be apparent to those skilled in the art that modifications and improvements can be made to the above-described embodiments without departing from the spirit and scope of the invention. Accordingly, it is intended that all equivalent modifications or changes be made by those skilled in the art without departing from the spirit and technical spirit of the present invention, and be covered by the claims of the present invention.

Claims

1. A capsule for treating chronic bronchitis is characterized by comprising the following raw materials in parts by weight:

2. The capsule for treating chronic bronchitis according to claim 1, comprising the following raw materials in parts by weight:

3. A method for preparing a capsule for the treatment of chronic bronchitis according to claim 1 or 2, characterized in that it comprises the following steps:

1) extraction process

Putting the weighed mulberry bark, loquat leaf and lophatherum gracile into a hot reflux extraction tank, extracting for the first time, adding 95% ethanol which is 5 times of the medicinal materials, soaking for 1 hour, extracting for 1.5 hours in a reflux manner, filtering the extracting solution, and injecting the filtrate into an extracting solution storage tank; performing second extraction, namely adding 50% ethanol which is 5 times of the medicinal materials into the first decoction dregs, performing reflux extraction for 1 hour, filtering the extracting solution, and injecting the filtering solution into an extracting solution storage tank; the third extraction, adding 5 times of water into the second decoction dregs, decocting for 1 hour, filtering, and injecting into an extracting solution storage tank;

2) recovery of ethanol

Firstly, decompressing and recovering ethanol from the filtrate obtained in the first extraction to obtain clear paste with the density of 1.07-1.10, injecting the clear paste into a concentrated solution storage tank, recovering ethanol from the filtrate obtained in the second extraction, and transferring the ethanol recovered in the two times into a diluted alcohol storage tank;

3) concentrating

Mixing the second filtrate and the third filtrate, concentrating to obtain fluid extract with the relative density of 1.18-1.22, mixing the fluid extracts obtained by two times of concentration in a concentrated solution storage tank, transferring the mixed fluid extract into a spherical vacuum concentrator for concentration, and concentrating the liquid medicine to obtain fluid extract with the relative density of 1.23-1.26;

4) recovery cream

5) mixing and drying

Putting the fine powder of the abalone shell, the dwarf lilyturf tuber, the arisaema tuber, the sessile stemona root, the buddha, the whiteflower hogfennel root, the blackberry lily, the ginkgo leaf, the common coltsfoot flower, the dried orange peel and the Chinese yam into a groove-shaped mixing machine, putting the materials into a tray of a low-temperature vacuum drying oven after mixing, and drying the materials;

6) pulverizing

Pulverizing dried dry extract into 100 mesh fine powder, and packaging with double-layer polyethylene bag;

7) filling in

Producing by adopting a capsule filling machine and a polishing machine, and weighing the average grain weight by an electronic balance;

8) capsule polishing

Removing the unqualified capsules with bad heads, empty shells and leaked powder from the filled capsules, and pouring the unqualified capsules into a polishing machine for polishing;

9) aluminum-plastic composite

The capsule for treating chronic bronchitis is produced by adopting a full-automatic high-speed aluminum-plastic blister packaging machine or a flat plate type aluminum-plastic blister packaging machine, wherein the temperature of an upper heating plate and a lower heating plate of the aluminum-plastic packaging machine is set at 120 +/-10 ℃, the temperature of a heat sealing plate is set at 220 +/-10 ℃, and after the specification, the batch number and the validity period are checked to be correct and clear, the capsule is formally produced after the handwriting is clear.

4. The method for preparing a capsule for treating chronic bronchitis according to claim 3, wherein the drying in step 5) has the following process parameters: the drying temperature is 65 +/-5 ℃, the drying time is 10-12 h, the steam pressure is 0.2 +/-0.05 MPa, and the vacuum degree is-0.07 +/-0.01 MPa.

5. The method for preparing a capsule for treating chronic bronchitis according to claim 3 or 4, wherein the specific filling process in step 7) is as follows:

a) during production, the average grain weight is measured every 15 minutes and is faithfully recorded;

b) timely feeding, and keeping the hopper at 1/3-2/3 of volume;

c) the filled capsules are placed in a clean stainless steel barrel for later use.

6. The method for preparing a capsule for treating chronic bronchitis according to claim 5, wherein the wet mixing time in step 5) is 3 minutes.