CN113069482B

CN113069482B - Honey wine fried codonopsis pilosula and preparation method thereof

Info

Publication number: CN113069482B
Application number: CN202110373470.2A
Authority: CN
Inventors: 姚方程; 张青; 崔家泉; 陈华师; 罗敏; 易斌; 韩雅慧; 陈西勇
Original assignee: Jianchangbang Pharmacy Co ltd
Current assignee: Jianchangbang Pharmacy Co ltd
Priority date: 2021-04-07
Filing date: 2021-04-07
Publication date: 2022-05-20
Anticipated expiration: 2041-04-07
Also published as: CN113069482A

Abstract

The invention discloses honey wine fried codonopsis pilosula and a preparation method thereof, relating to the technical field of traditional Chinese medicines and comprising the following steps: s1, washing and moistening raw medicinal materials of radix codonopsis, cutting into radix codonopsis segments, and airing; s2, mixing and dissolving the refined honey and the yellow wine into a honey wine solution; placing the radix Codonopsis section in a container, adding Mel wine solution, stirring, moistening until the medicinal liquid is completely removed; s3, putting the dried bran into a hot pot, continuously stir-frying with slow fire until the bran is hot, spraying the honey water solution while stir-frying to obtain honey bran, and spreading the honey bran around; s4, adding radix Codonopsis soaked in Mel wine, parching with slow fire and slow fire, and taking out when the medicinal materials turn golden yellow and stick to hands; and S5, removing bran and ash, and hermetically storing when the mixture is dry, crisp and non-sticky. The invention has the advantages of strengthening the middle-jiao and Qi, reducing the loss of effective components, improving the drug effect, and conforming the contents of impurities, water, total ash content, sulfur dioxide residual quantity and extract to the regulations in Chinese pharmacopoeia.

Description

Honey wine fried codonopsis pilosula and preparation method thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to honey wine fried codonopsis pilosula and a preparation method thereof.

Background

The codonopsis pilosula is prepared from dried roots of codonopsis pilosula, codonopsis pilosula with vegetarian flowers or codonopsis pilosula with Sichuan roots and the like which are plants in the family of Campanulaceae, is a commonly used qi-tonifying traditional Chinese medicine, has the effects of tonifying middle-jiao and qi, harmonizing stomach and nourishing blood and the like, has mild property and sweet taste, enters spleen and lung channels, is most suitable for qi deficiency patients with lassitude, hypodynamia, lassitude, short subjective breath and dyspnea with short breath on slight activity, and is also suitable for patients with qi deficiency of both qi and blood, pale complexion, dizziness, poor appetite, loose stool and easy cold due to the fact that the qi is also helpful for hematopoiesis.

Because most of the traditional Chinese medicines are crude drugs which are often accompanied by soil and other foreign matters, or have peculiar smell, or have toxicity, or are not easy to store due to moisture, and the like, the traditional Chinese medicines can achieve the purposes of purity, taste correction, toxicity reduction, dryness and no deterioration through certain processing treatment, so the traditional Chinese medicines can be used after being processed, which is a characteristic of traditional Chinese medicine and is also a great characteristic of traditional Chinese medicine. The processing of traditional Chinese medicine is a pharmaceutical technology adopted according to the traditional Chinese medicine theory, the requirements of treatment based on syndrome differentiation, the properties of the medicine and different requirements of preparation and preparation. The purpose of processing traditional Chinese medicines often comprises the following aspects: reduce or eliminate toxicity or side effects of the drug; altering or moderating the properties of the drug; enhancing the curative effect of the medicine; altering or enhancing the location and orientation of the drug's action; convenient preparation and preparation; is favorable for storage and preservation of drug effect.

The processing method of the codonopsis pilosula specified in the Chinese pharmacopoeia of the prior edition only makes simple text description and does not specify in detail, so that the processing method of the codonopsis pilosula is different, the processed products of the codonopsis pilosula can not fully exert the effect of preparing the codonopsis pilosula, and the appearance color and the character of the codonopsis pilosula are neglected. However, no relevant processing method is disclosed to solve the problem, and the processing technology of codonopsis pilosula is yet to be improved.

Disclosure of Invention

The invention aims to at least solve one of the technical problems in the prior art and provides honey-fried codonopsis pilosula and a preparation method thereof.

The technical solution of the invention is as follows:

a preparation method of honey wine fried radix codonopsis comprises the following steps:

s1, washing and moistening raw medicinal materials of radix codonopsis, cutting into radix codonopsis segments, and airing;

s2, mixing and dissolving the refined honey and the yellow wine into a honey wine solution; placing the radix Codonopsis section in a container, adding Mel wine solution, stirring, moistening until the medicinal liquid is completely removed;

s3, putting the dried clean bran coat or bran coat into a hot pot, continuously stir-frying with slow fire until the bran coat or bran coat is hot, then frying while spraying the honey water solution to obtain honey bran or honey bran, and spreading the honey bran or honey bran around;

s4, adding radix Codonopsis soaked in Mel wine, parching with slow fire and slow fire, and taking out when the medicinal materials turn golden yellow and stick to hands;

and S5, removing bran or bran and dust, and hermetically storing when the mixture is dry, crisp and non-sticky.

In an embodiment of the present invention, the step S1 further includes: adding the aired radix codonopsitis sections into plant extract with the mass of 2-4 times, cooking for 30-100 min at 50-70 ℃, and drying the radix codonopsitis sections by using microwaves with the frequency of 400-600 MHz until the water content of the medicinal materials is 10-20% and taking out; the plant extracting solution comprises the following raw materials in parts by mass: 5-10 parts of Chinese yam, 2-6 parts of salvia miltiorrhiza, 1-5 parts of ailanthus bark, 2-6 parts of poria cocos, 1-5 parts of bighead atractylodes rhizome, 4-10 parts of radix ophiopogonis and 4-8 parts of schisandra chinensis.

In an embodiment of the present invention, the method for preparing the plant extract includes: adding Chinese yam, salvia miltiorrhiza, ailanthus bark, poria cocos, bighead atractylodes rhizome, radix ophiopogonis and schisandra chinensis into water with the mass being 3-5 times of that of the Chinese yam, heating for 20-40 min at 40-60 ℃, then carrying out ultrasonic treatment for 20-40 min with the power of 1500-2000 w, and filtering to obtain an extracting solution.

In an embodiment of the invention, in the step S2, the temperature of the yellow wine is 30 to 50 ℃.

In an embodiment of the invention, in the step S2, the mass ratio of the refined honey to the yellow wine is 4-6: 1, preferably 4.5-5.5: 1, and more preferably 5: 1.

In an embodiment of the present invention, the step S2 specifically includes: putting the codonopsis pilosula section into a container, pouring the honey wine solution, stirring uniformly, covering the codonopsis pilosula section with a breathable cloth, moistening for 4-12 hours, preferably 6-8 hours, and turning over the codonopsis pilosula section in the moistening process to ensure that the codonopsis pilosula section is fully contacted with the honey wine solution until the medicine is thoroughly soaked.

In an embodiment of the present invention, in step S2, the addition amount of the honey wine solution is 14 to 34% by mass of the codonopsis pilosula section, preferably 20 to 28%, and more preferably 24%.

In an embodiment of the present invention, in step S3, the amount of the clean bran or wheat bran added is 40 to 60% of the mass of the codonopsis pilosula section, preferably 45 to 55%, and more preferably 50%; the addition amount of the honey water solution is 5-7% of the mass of the codonopsis pilosula section, preferably 5.5-6.5%, and more preferably 6%;

in an embodiment of the invention, in the step S3, the mass ratio of the refined honey to the water in the honey water solution is 4 to 6:1, preferably 4.5 to 5.5:1, and more preferably 5: 1.

In an embodiment of the present invention, in step S3, the stir-frying is continuously carried out to 60 to 80 ℃ with a fire of 80 to 100 ℃, and then the stir-frying is carried out while the honey solution is poured.

In an embodiment of the present invention, in step S4, the stir-frying is continuously performed for 0.5 to 2 hours with a fire of 80 to 100 ℃, and then for 0.5 to 2 hours with a fire of 60 to 80 ℃.

In an embodiment of the invention, in the step S5, the stir-fried codonopsis pilosula section of the honey wine is spread and cooled to 20-30 ℃ and is stored in a sealed manner until the codonopsis pilosula section is dry, crisp and non-sticky.

A honey wine fried radix Codonopsis is prepared by the above preparation method.

The honey wine prepared by the invention has the advantages of long-section radix codonopsitis, brown yellow inside and outside, luster, slight stickiness in case of wind, and sweet and fragrant taste.

The invention has at least one of the following beneficial effects:

the Chinese yam, the salvia miltiorrhiza, the toona sinensis root bark, the poria cocos, the bighead atractylodes rhizome, the radix ophiopogonis and the schisandra chinensis are subjected to low-temperature cooking and ultrasonic treatment, so that the medicinal materials are heated firstly, and then under the mechanical and cavitation action of ultrasonic waves, the leaching of effective components in the medicinal materials is facilitated, and the effective components in the medicinal materials are not damaged, so that a plant extracting solution is obtained; firstly, the codonopsis pilosula is treated by using plant extracting solution, and simultaneously, the codonopsis pilosula is subjected to low-temperature cooking and microwave treatment, so that the conversion and leaching of active ingredients in the codonopsis pilosula are facilitated under the action of plant enzymes in the plant extracting solution, the content of the active ingredients in the codonopsis pilosula is further facilitated to be improved, and the damage effect on the active ingredients in the achyranthes bidentata can be reduced by adopting the microwave treatment; meanwhile, the codonopsis pilosula, the Chinese yam, the salvia miltiorrhiza, the toona sinensis root bark, the poria cocos, the bighead atractylodes rhizome, the radix ophiopogonis and the schisandra chinensis in the plant extracting solution are combined, so that the effects of strengthening the middle-jiao and replenishing qi, strengthening the spleen and nourishing the stomach, nourishing yin and clearing heat, tonifying the kidney and nourishing the heart of the codonopsis pilosula are enhanced, the medicine property of the codonopsis pilosula is mild, and the side effect on a human body is reduced; then soaking the raw medicinal materials of the codonopsis pilosula by using a honey wine solution, so that the honey wine permeates the raw medicinal materials of the codonopsis pilosula, and the effects of tonifying middle-jiao and Qi can be enhanced; then, the clean bran or wheat bran is fried and heated, and the honey water solution is added to form honey bran or honey bran; finally, stir-frying the codonopsis pilosula section moistened by the honey wine and the honey bran to form honey wine fried codonopsis pilosula; the radix codonopsitis and honey bran or honey bran are stir-fried together, so that the nutrient substances in the radix codonopsitis are kept, the loss of the active ingredients of the radix codonopsitis is reduced, the drug effect is improved, and the prepared honey wine stir-fried radix codonopsitis not only has good color, flavor and taste, uniform and clean honey absorption, no sticky paste or double skin and good appearance and shape, but also has the determination that the impurities, water, total ash content, sulfur dioxide residual quantity and extract content in the radix codonopsitis accord with the regulations in Chinese pharmacopoeia.

Detailed Description

The present invention will be described in further detail with reference to the following examples, but the present invention is not limited to the following examples.

Example 1

s1, taking 1kg of radix codonopsis raw medicinal materials, cleaning with cold water, draining off residual water, cutting into radix codonopsis segments, and airing;

s2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 30 ℃, and the mass ratio of the refined honey to the yellow wine is 4: 1; placing the radix Codonopsis section in a container, adding 0.34kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 4 hr, frequently turning over the radix Codonopsis section during moistening process to make the radix Codonopsis section contact with Mel wine solution completely;

s3, putting 0.4kg of dry bran into a hot pot, continuously stir-frying to 60 ℃ with fire at 80 ℃, and spraying 0.05kg of honey water solution while stir-frying, wherein the mass ratio of honey to water in the honey water solution is 4:1, so as to obtain honey bran, and spreading the honey bran around;

s4, adding radix Codonopsis soaked with Mel wine into a hot pan, parching with 80 deg.C fire for 2 hr, parching with 60 deg.C fire for 2 hr, parching for 4 hr, and taking out when the medicinal materials turn golden yellow and slightly stick to hands;

s5, removing bran and ash, spreading to cool to 20 ℃, and hermetically storing when the dried, crisp and non-sticky food is dry.

Example 2

s2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 35 ℃, and the mass ratio of the refined honey to the yellow wine is 4.5: 1; placing the radix Codonopsis section in a container, adding 0.3kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 6 hr, frequently turning over the radix Codonopsis section during moistening process to make the radix Codonopsis section contact with Mel wine solution completely until the medicine is thoroughly soaked;

s3, putting 0.45kg of dried wheat bran into a hot pot, continuously stir-frying to 65 ℃ with a fire at 85 ℃, and spraying 0.055kg of honey water solution while stir-frying, wherein the mass ratio of honey to water in the honey water solution is 4.5:1, so as to obtain honey bran, and spreading the honey bran around;

s4, adding radix Codonopsis soaked with Mel wine into a hot pan, parching with 85 deg.C fire for 1.6 hr, parching with 65 deg.C fire for 1.6 hr, parching for 3.2 hr, and taking out when the medicinal materials turn golden yellow inside and outside and slightly stick to hands;

s5, removing bran and ash, spreading to 22 deg.C, drying, and storing in a sealed condition when it is crisp and not sticky.

Example 3

s2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 40 ℃, and the mass ratio of the refined honey to the yellow wine is 5: 1; placing the radix Codonopsis section in a container, adding 0.24kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 8 hr, frequently turning over the radix Codonopsis section during moistening process, and making the radix Codonopsis section contact with Mel wine solution thoroughly until the medicinal liquid is completely extracted;

s3, putting 0.5kg of dry bran into a hot pot, continuously stir-frying to 70 ℃ with fire at 90 ℃, and spraying 0.06kg of honey water solution while stir-frying, wherein the mass ratio of honey to water in the honey water solution is 5:1, so as to obtain honey bran, and spreading the honey bran around;

s4, adding radix Codonopsis soaked with Mel wine into a hot pan, parching with 90 deg.C fire for 1.2 hr, parching with 70 deg.C fire for 1.2 hr, parching for 2.4 hr, and taking out when the medicinal materials turn into golden yellow inside and outside and slightly stick to hands;

s5, removing bran and ash, spreading to 25 deg.C, drying, and storing in a sealed condition when it is crisp and not sticky.

Example 4

s2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 45 ℃, and the mass ratio of the refined honey to the yellow wine is 5.5: 1; placing the radix Codonopsis section in a container, adding 0.2kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 10 hr, frequently turning over the radix Codonopsis section during moistening process, and making the radix Codonopsis section contact with Mel wine solution thoroughly until the medicinal liquid is completely extracted;

s3, putting 0.55kg of dried wheat bran into a hot pot, continuously stir-frying to 75 ℃ with fire at 95 ℃, simultaneously frying and spraying 0.065kg of honey water solution, wherein the mass ratio of honey to water in the honey water solution is 5.5:1, so as to obtain honey bran, and spreading the honey bran around;

s4, adding radix Codonopsis soaked with Mel wine into a hot pan, parching with 95 deg.C fire for 0.8 hr, parching with 75 deg.C fire for 0.8 hr, parching for 1.6 hr, and taking out when the medicinal materials turn into golden yellow inside and outside and slightly stick to hands;

s5, removing bran and ash, spreading to cool to 28 ℃, and hermetically storing when the dried, crisp and non-sticky food is dry.

Example 5

s2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 50 ℃, and the mass ratio of the refined honey to the yellow wine is 6: 1; putting the radix Codonopsis section in a container, adding 0.14kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 12 hr, frequently turning over the radix Codonopsis section during moistening process to make the radix Codonopsis section contact with Mel wine solution thoroughly;

s3, putting 0.6kg of dry bran into a hot pot, continuously stir-frying to 80 ℃ with fire at 100 ℃, and spraying 0.07kg of honey water solution while stir-frying, wherein the mass ratio of honey to water in the honey water solution is 6:1, so as to obtain honey bran, and spreading the honey bran around;

s4, adding radix Codonopsis soaked with Mel wine into a hot pan, parching with 100 deg.C fire for 0.5 hr, parching with 80 deg.C fire for 0.5 hr, parching for 1 hr, and taking out when the medicinal materials turn golden yellow and slightly stick to hands;

s5, removing bran and ash, spreading to cool to 30 ℃, and hermetically storing when the mixture is dry, crisp and not sticky.

Example 6

s1, taking 1kg of radix codonopsis raw medicinal materials, cleaning with cold water, draining off residual water, cutting into radix codonopsis segments, and airing; adding the air-dried radix Codonopsis segments into 2 times of the plant extractive solution, decocting at 50 deg.C for 30min, and drying with 400MHz microwave until the water content of the medicinal material is 20%; the plant extracting solution comprises the following raw materials in parts by mass: 5 parts of Chinese yam, 2 parts of salvia miltiorrhiza, 1 part of ailanthus bark, 2 parts of tuckahoe, 1 part of atractylodes macrocephala, 4 parts of ophiopogon root and 4 parts of schisandra chinensis. The preparation method of the plant extract comprises the following steps: adding rhizoma Dioscoreae, Saviae Miltiorrhizae radix, cortex Ailanthi, Poria, Atractylodis rhizoma, radix Ophiopogonis and fructus Schisandrae into 3 times of water, heating at 40 deg.C for 40min, performing ultrasonic treatment at power of 2000w for 20min, and filtering to obtain extractive solution.

S2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 30 ℃, and the mass ratio of the refined honey to the yellow wine is 4: 1; placing the radix Codonopsis section in a container, adding 0.34kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 4 hr, frequently turning over the radix Codonopsis section during moistening process to make the radix Codonopsis section contact with Mel wine solution thoroughly;

s4, adding radix Codonopsis wetted with Mel into a hot pan, parching with 80 deg.C fire for 2 hr, parching with 60 deg.C fire for 2 hr, parching for 4 hr, and taking out when the medicinal materials turn golden yellow inside and outside and stick to hands slightly;

s5, removing bran and ash, spreading to 20 deg.C, drying, and storing in a sealed condition when it is crisp and not sticky.

Example 7

s1, taking 1kg of radix codonopsis raw medicinal materials, cleaning with cold water, draining off residual water, cutting into radix codonopsis segments, and airing; adding the air-dried radix Codonopsis segments into 2.5 times of the plant extractive solution, steaming at 55 deg.C for 50min, and drying with 450MHz microwave until the water content is 18%; the plant extracting solution comprises the following raw materials in parts by mass: 6 parts of Chinese yam, 3 parts of salvia miltiorrhiza, 2 parts of toona sinensis root bark, 3 parts of poria cocos, 2 parts of bighead atractylodes rhizome, 5 parts of radix ophiopogonis and 5 parts of schisandra chinensis. The preparation method of the plant extract comprises the following steps: adding rhizoma Dioscoreae, Saviae Miltiorrhizae radix, cortex Ailanthi, Poria, Atractylodis rhizoma, radix Ophiopogonis and fructus Schisandrae into 3.5 times of water, heating at 45 deg.C for 25min, performing ultrasonic treatment at 1900w for 25min, and filtering to obtain extractive solution.

s5, removing bran and ash, spreading to cool to 22 ℃, and hermetically storing when the dried, crisp and non-sticky food is dry.

Example 8

s1, taking 1kg of radix codonopsis raw medicinal materials, cleaning with cold water, draining residual water, cutting into radix codonopsis sections, and airing; adding the aired radix Codonopsis segments into 3 times of the plant extract, steaming at 60 deg.C for 60min, and drying with 500MHz microwave until the water content is 15%; the plant extracting solution comprises the following raw materials in parts by mass: 7 parts of Chinese yam, 4 parts of salvia miltiorrhiza, 3 parts of ailanthus bark, 4 parts of poria cocos, 3 parts of bighead atractylodes rhizome, 7 parts of radix ophiopogonis and 6 parts of schisandra chinensis. The preparation method of the plant extracting solution comprises the following steps: adding rhizoma Dioscoreae, Saviae Miltiorrhizae radix, cortex Ailanthi, Poria, Atractylodis rhizoma, radix Ophiopogonis and fructus Schisandrae into 4 times of water, heating at 50 deg.C for 30min, performing ultrasonic treatment at 1700w for 30min, and filtering to obtain extractive solution.

S2, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 40 ℃, and the mass ratio of the refined honey to the yellow wine is 5: 1; placing the radix Codonopsis section in a container, adding 0.24kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 8 hr, frequently turning over the radix Codonopsis section during moistening process, and making the radix Codonopsis section contact with Mel wine solution thoroughly until the medicinal liquid is completely extracted;

Example 9

s1, taking 1kg of radix codonopsis raw medicinal materials, cleaning with cold water, draining off residual water, cutting into radix codonopsis segments, and airing; adding the aired radix Codonopsis segments into 3.5 times of the plant extract, steaming at 65 deg.C for 80min, and drying with 550MHz microwave until the water content of the medicinal material is 12%; the plant extracting solution comprises the following raw materials in parts by mass: 9 parts of Chinese yam, 6 parts of salvia miltiorrhiza, 4 parts of toona sinensis root bark, 5 parts of poria cocos, 4 parts of bighead atractylodes rhizome, 9 parts of radix ophiopogonis and 7 parts of schisandra chinensis. The preparation method of the plant extract comprises the following steps: adding rhizoma Dioscoreae, Saviae Miltiorrhizae radix, cortex Ailanthi, Poria, Atractylodis rhizoma, radix Ophiopogonis and fructus Schisandrae into 4.5 times of water, heating at 55 deg.C for 35min, performing ultrasonic treatment at power of 1600w for 25min, and filtering to obtain extractive solution.

Example 10

s1, taking 1kg of radix codonopsis raw medicinal materials, cleaning with cold water, draining off residual water, cutting into radix codonopsis segments, and airing; adding the aired radix Codonopsis segments into 4 times of the plant extract, steaming at 70 deg.C for 30min, and drying with 600MHz microwave until the water content is 10%; the plant extracting solution comprises the following raw materials in parts by mass: 10 parts of Chinese yam, 6 parts of salvia miltiorrhiza, 5 parts of toona sinensis root bark, 6 parts of poria cocos, 5 parts of bighead atractylodes rhizome, 10 parts of radix ophiopogonis and 8 parts of schisandra chinensis. The preparation method of the plant extract comprises the following steps: adding rhizoma Dioscoreae, Saviae Miltiorrhizae radix, cortex Ailanthi, Poria, Atractylodis rhizoma, radix Ophiopogonis and fructus Schisandrae into 5 times of water, heating at 60 deg.C for 20min, performing ultrasonic treatment at power of 1500w for 40min, and filtering to obtain extractive solution.

S2, taking the refined honey and the warm yellow wine, mixing and dissolving the refined honey and the warm yellow wine into a honey wine solution, wherein the temperature of the warm yellow wine is 50 ℃, and the mass ratio of the refined honey to the yellow wine is 6: 1; placing the radix Codonopsis section in a container, adding 0.14kg Mel wine solution, stirring, covering the radix Codonopsis section with flax, moistening for 12 hr, frequently turning over the radix Codonopsis section during moistening process to make the radix Codonopsis section contact with Mel wine solution completely until the medicine is thoroughly soaked;

s4, adding radix Codonopsis wetted with Mel into a hot pan, parching with 100 deg.C fire for 0.5 hr, parching with 80 deg.C fire for 0.5 hr, parching for 1 hr, and taking out when the medicinal materials turn golden yellow inside and outside and slightly stick to hands;

s5, removing bran and ash, spreading to 30 deg.C, drying, and storing in a sealed condition when it is crisp and not sticky.

Comparative example 1

The difference from example 1 is that: removing step S3, namely adding no bran syrup, and adding the radix Codonopsis soaked with Mel wine in step S2 into pan for parching.

The other steps are the same as in example 1.

Comparative example 2

The difference from example 1 is that: removing step S2, i.e. not adding Mel solution, moistening, directly adding dried radix Codonopsis original medicinal material of step S1 into the hot pan of step S4, and parching with Mel bran.

The other steps are the same as in example 1.

Comparative example 3

The difference from example 6 is that: the plant extract is not added with raw materials of yam, atractylodes, ophiopogon root and schisandra;

the other steps are the same as in example 6.

Comparative example 4

The difference from example 6 is that: the plant extract is not added with raw materials of salvia miltiorrhiza, toona sinensis root bark and poria cocos;

the other steps were the same as in example 6.

Comparative example 5

The difference from example 6 is that: in step S1, no microwave processing is performed;

the other steps are the same as in example 6.

Comparative example 6

The difference from example 6 is that: in the step S1, ultrasonic treatment is not carried out in the preparation method of the plant extract;

the other steps are the same as in example 6.

Measurement of

The content of the achyranthes finished products prepared in the examples 1 to 10 and the comparative examples 1 to 6 and the content of the extract, lobetyolin, crude polysaccharide of codonopsis pilosula and total flavone in raw codonopsis pilosula are determined, and the determination method comprises the following steps:

the method for measuring the extract content comprises the following steps:

the measurement was carried out by the hot dipping method under the section of alcohol-soluble extract measurement method (general rule 2201) using 45% ethanol as a solvent.

Taking about 3g of a sample, precisely weighing, placing in a 250ml conical flask, precisely adding 100ml of 45% ethanol, sealing, weighing, standing for 1 hour, connecting with a reflux condenser tube, heating to boil, and keeping slightly boiling for 1 hour. After cooling, the erlenmeyer flask is taken down, the stopple is sealed, the mass is weighed again, the loss mass is complemented by 45 percent ethanol, the erlenmeyer flask is shaken up, the erlenmeyer flask is filtered by a drying filter, 25ml of filtrate is precisely measured, the filtrate is placed in an evaporating dish which is dried to constant weight, the erlenmeyer flask is dried on a water bath, dried for 3 hours at 105 ℃, placed in a drier for cooling for 30 minutes, and the erlenmeyer flask is quickly and precisely weighed. The content (%) of the water-soluble extract in the test sample was calculated on a dry basis, unless otherwise specified.

The method for measuring the content of lobetyolin comprises the following steps:

1. chromatographic conditions

A chromatographic column: thermo Hypersil Gold-C18 (150X 4.6mm, 5 μm); acetonitrile-water (20: 80) is used as a mobile phase, the detection wavelength is 268nm, and the number of theoretical plates is calculated according to the lobetyolin peak and is not less than 8500.

2. Preparation of control solutions

Accurately weighing dried radix Codonopsis alkyne glycoside reference substance, adding methanol to dissolve, and making into reference substance solution of 50 μ g per 1ml radix Codonopsis alkyne glycoside reference substance.

3. Preparation of test solution

Taking 1.0g of red codonopsis pilosula sample powder, precisely weighing, placing in a 100ml round bottom flask, precisely adding 50ml of methanol, heating and refluxing for 60min, filtering, taking 25ml of subsequent filtrate, evaporating in a water bath, and adding methanol to be dissolved in a 10ml volumetric flask.

4. Determination of lobetyolin content in sample

Taking 15 radix Codonopsis samples respectively, preparing test solution according to the above 3 determined test preparation methods, measuring according to 4.1.1 chromatographic conditions, injecting 10.0 μ l sample, recording peak area, and calculating radix Codonopsis alkynoside content in the test sample.

(III) the method for measuring the content of the crude polysaccharide of the codonopsis pilosula comprises the following steps:

1. preparation of control solutions

Taking a proper amount of anhydrous glucose reference substance which is dried to constant weight, precisely weighing, and adding water to prepare a solution containing about 600ug of anhydrous glucose per 1mL, thus obtaining a reference substance stock solution.

2. Preparation of test solution

Taking 1g of radix codonopsitis powder, precisely weighing, placing in a round bottom flask, adding 100mL of water, heating and refluxing in a water bath kettle for 1 hour, filtering, repeatedly extracting for 1 time, combining and concentrating the two filtrates, transferring to a 100mL measuring flask, adding water to a scale, shaking uniformly, precisely measuring 2mL into a scale centrifuge tube, adding 10mL of ethanol, stirring, centrifuging for 5min at 3000r/min, discarding the supernatant, washing the precipitate with ethanol (10 mL each time), centrifuging, discarding the supernatant, and repeatedly operating for 3 times. Dissolving the precipitate in water, placing in a 50mL measuring flask, diluting with water to scale, and shaking to obtain the sample solution.

3. Methodology survey

(1) Investigation of linear relationship

Accurately weighing 15.25mg of anhydrous glucose dried to constant weight, placing the anhydrous glucose in a 25mL measuring flask, adding water to dissolve the anhydrous glucose and dilute the anhydrous glucose to a scale, shaking up, accurately measuring 0, 1.0, 1.5, 2.0, 2.5 and 3.0mL of the solution, respectively placing the solution in a 50mL measuring flask, adding water to the scale, and shaking up. The linear regression equation is operated according to the linear relation investigation method under the quality standard term, wherein y is 0.012x +0.0191, and r is 0.9993(n is 6). The results show that the anhydrous glucose concentration is in the range of 12.2-42.7ug/mL and has good linear relation with the absorbance.

(2) Determination of crude polysaccharide content in sample

Taking 15 samples respectively, preparing test solution according to the method, measuring absorbance after color development, and calculating the content of crude polysaccharide (calculated by anhydrous glucose) in the samples according to a standard curve.

(IV) the content determination method of the total flavone comprises the following steps:

1. preparation of control solutions

Precisely weighing rutin standard substance dried at 105 deg.C to constant weight of about 10mg, placing in 50ml volumetric flask, adding appropriate amount of methanol to dissolve, metering to scale with methanol, and shaking to obtain rutin standard substance solution with concentration of 0.199mg/ml for use.

2. Preparation of test solution

Precisely weighing 1g of sample powder, placing the sample powder in a 150ml round-bottom flask, heating and refluxing for 2 times and 30min each time by taking a proper amount of methanol as a solvent, filtering the filtrate to a 100ml volumetric flask, metering the volume to a scale by using methanol, shaking up, and filtering by using a microporous membrane to obtain a subsequent filtrate, namely the test solution.

3. Methodology investigation

(1) Investigation of Linear relationships

Precisely measuring 0.0 ml, 1.0 ml, 2.0 ml, 3.0ml, 4.0 ml, 5.0 ml and 6.0ml of the rutin standard solution, placing the solution in a 25ml volumetric flask, adding water to 6.0ml, adding 1ml of 5% sodium nitrite solution, shaking uniformly, placing the solution for 6min, adding 1ml of 10% aluminum nitrate solution, shaking uniformly, placing the solution for 6min, adding 10ml of 4% sodium hydroxide solution, adding water to the scale, shaking uniformly, placing the solution for 15min, taking a negative reagent of the rutin-free standard solution as a blank, measuring the absorbance at the wavelength of 510nm, drawing a calibration curve by taking the absorbance value (Y) as a vertical coordinate and the concentration (X) as a horizontal coordinate, and obtaining a regression equation of Y ═ 0.0186X +0.0129 and r ═ 0.9988, wherein the regression equation shows that the sample concentration has a good relationship in the range of 6.96-41.76 mug/ml.

(2) Determination of total flavonoids in samples 15 samples prepared above are respectively taken, a test solution is prepared according to the method, the absorbance is determined after color development, and the total flavonoids content (in terms of rutin) in each sample is calculated according to a standard curve.

The measurement results are shown in table 1:

TABLE 1

Group of	Extract content (%)	Codonopsis pilosula alkyne glycoside (mg/g)	Polysaccharide (%)	Total Flavonoids (%)
					Example 1	79.1	1.35	33.4	1.07
Example 2	78.8	1.37	34.1	1.09
					Example 3	80.4	1.41	34.2	1.12
Example 4	80.6	1.38	34.6	1.10
					Example 5	80.1	1.36	33.7	1.08
Example 6	83.5	1.50	36.2	1.20
					Example 7	83.4	1.55	36.4	1.21
Example 8	83.7	1.57	37.7	1.25
					Example 9	84.4	1.51	36.9	1.24
Example 10	83.6	1.53	36.6	1.19
					Comparative example 1	66.3	1.15	23.4	0.84
Comparative example 2	65.9	1.10	15.8	0.75
					Comparative example 3	81.2	1.39	34.9	1.12
Comparative example 4	80.3	1.37	34.4	1.11
					Comparative example 5	81.5	1.41	35.1	1.15
Comparative example 6	81.3	1.42	35.3	1.14
					Radix Codonopsis	38.6	0.57	10.6	0.43

As can be seen from Table 1, the content of the extract, lobetyolin, polysaccharide and total flavone in the codonopsis pilosula finished product obtained in examples 1 to 10 is significantly higher than that of raw codonopsis pilosula, and comparing examples 6 to 10 with examples 1 to 5, it can be seen that the content of the extract, lobetyolin, polysaccharide and total flavone in codonopsis pilosula can be increased by placing codonopsis pilosula in a plant extract for cooking and microwave treatment in examples 6 to 10. Comparing examples 1-5 with comparative examples 1-2, it can be seen that the content of extract, lobetyolin, polysaccharide and total flavone in the codonopsis pilosula finished product obtained in examples 1-5 is higher than that in comparative example 1 (honey bran is not added) and that in comparative example 2 (honey wine is not added), thus indicating that whether honey wine is adopted for moistening codonopsis pilosula, whether honey bran is added for stir-frying and stir-frying temperature influence the content of extract, lobetyolin, polysaccharide and total flavone in the obtained codonopsis pilosula finished product; therefore, compared with the prior art, the invention firstly soaks the raw medicinal materials of the codonopsis pilosula by using the honey wine solution, so that honey permeates the raw medicinal materials of the codonopsis pilosula, and the effects of tonifying middle-jiao and Qi can be enhanced; then, frying the clean bran to be hot, and adding a honey water solution to form honey bran; finally, stir-frying the codonopsis pilosula section moistened by the honey wine and the honey bran to form honey wine fried codonopsis pilosula; by stir-frying the codonopsis pilosula and the honey bran, the nutrient substances in the codonopsis pilosula are reserved, the loss of active ingredients of the codonopsis pilosula is reduced, and the drug effect is improved, so that the prepared honey wine fried codonopsis pilosula is good in color, flavor and taste, uniform and clean in honey absorption, free of paste or double skin and good in appearance and shape. Comparing examples 6-10 with comparative examples 3-6, it can be seen that the content of codonopsis pilosula extracts, lobetyolin, polysaccharides and total flavonoids obtained in examples 6-10 are significantly greater than those in comparative example 3 (the extract is not added with raw materials of Chinese yam, bighead atractylodes rhizome, dwarf lilyturf tuber and Chinese magnoliavine fruit), comparative example 4 (the extract is not added with raw materials of red sage root, ailanthus root bark and poria cocos), comparative example 5 (no microwave treatment) and comparative example 6 (no ultrasonic treatment), which shows that the composition and preparation method of raw materials in plant extract and whether microwave treatment is carried out can affect the content of codonopsis pilosula extracts, lobetyolin, polysaccharides and total flavonoids to a certain extent.

The above are merely characteristic embodiments of the present invention, and do not limit the scope of the present invention in any way. All technical solutions formed by equivalent exchanges or equivalent substitutions fall within the protection scope of the present invention.

Claims

1. A preparation method of honey wine fried codonopsis pilosula is characterized by comprising the following steps:

s1, washing and moistening raw medicinal materials of radix codonopsis, cutting into radix codonopsis segments, and airing; adding the aired radix codonopsitis sections into 2-4 times of the weight of the plant extract, cooking for 30-100 min at 50-70 ℃, and drying the radix codonopsitis sections by using microwaves with the frequency of 400-600 MHz until the water content of the medicinal materials is 10-20% and taking out; the plant extracting solution comprises the following raw materials in parts by mass: 5-10 parts of Chinese yam, 2-6 parts of salvia miltiorrhiza, 1-5 parts of ailanthus bark, 2-6 parts of poria cocos, 1-5 parts of bighead atractylodes rhizome, 4-10 parts of radix ophiopogonis and 4-8 parts of schisandra chinensis;

s3, putting the dried and cleaned bran into a hot pan, continuously stir-frying with slow fire until the bran is hot, then frying while pouring the honey water solution to obtain honey bran or honey bran, and spreading the honey bran or honey bran around;

and S5, removing bran or wheat bran and ash, and hermetically storing when the mixture is dry, crisp and non-sticky.

2. The method for preparing codonopsis pilosula fried with honey wine according to claim 1, wherein the method for preparing the plant extract comprises the following steps: adding Chinese yam, salvia miltiorrhiza, ailanthus bark, poria cocos, bighead atractylodes rhizome, radix ophiopogonis and schisandra chinensis into water with the mass being 3-5 times of that of the Chinese yam, heating for 20-40 min at 40-60 ℃, then carrying out ultrasonic treatment for 20-40 min with the power of 1500-2000 w, and filtering to obtain an extracting solution.

3. The preparation method of honey-fried codonopsis pilosula as claimed in claim 1, wherein in the step S2, the temperature of yellow wine is 30-50 ℃, and the mass ratio of refined honey to yellow wine is 4-6: 1.

4. The method for preparing honey-fried codonopsis pilosula according to claim 1, wherein the step S2 specifically comprises: putting the codonopsis pilosula section into a container, pouring the honey wine solution, stirring uniformly, covering the codonopsis pilosula section with breathable cloth, moistening the codonopsis pilosula section for 4-12 hours, turning over the codonopsis pilosula section in the moistening process to enable the codonopsis pilosula section to be fully contacted with the honey wine solution until the medicine is thoroughly soaked, wherein the adding amount of the honey wine solution is 14-34% of the mass of the codonopsis pilosula section.

5. The method for preparing codonopsis pilosula roasted with honey wine according to claim 1, wherein in the step S3, the addition amount of the clean bran coat or the clean bran coat is 40-60% of the mass of the codonopsis pilosula section, and the addition amount of the honey water solution is 5-7% of the mass of the codonopsis pilosula section.

6. The method for preparing codonopsis pilosula fried with honey wine according to claim 1, wherein in step S3, continuously stir-frying to 60-80 ℃ with fire of 80-100 ℃, and then frying while pouring honey water solution; the mass ratio of the refined honey to the water in the honey water solution is 4-6: 1.

7. The method for preparing honey-fried codonopsis pilosula according to claim 1, wherein in step S4, the stir-frying is continuously carried out for 0.5-2 h with fire at 80-100 ℃, and then the stir-frying is carried out for 0.5-2 h with fire at 60-80 ℃.

8. The preparation method of honey-fried codonopsis pilosula according to claim 1, wherein in the step S5, the fried honey-fried codonopsis pilosula is spread and cooled to 20-30 ℃ and is stored in a sealed manner until the fried honey-fried codonopsis pilosula is dry, crisp and non-sticky.

9. A honey-processed codonopsis pilosula, which is characterized by being obtained by the preparation method of any one of claims 1 to 8.