CN113069375A - Hair growth liquid containing high-content adenosine and derivatives thereof, and preparation method and application thereof - Google Patents
Hair growth liquid containing high-content adenosine and derivatives thereof, and preparation method and application thereof Download PDFInfo
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- CN113069375A CN113069375A CN202110421871.0A CN202110421871A CN113069375A CN 113069375 A CN113069375 A CN 113069375A CN 202110421871 A CN202110421871 A CN 202110421871A CN 113069375 A CN113069375 A CN 113069375A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention discloses a hair growth lotion containing high-content adenosine and derivatives thereof, a preparation method and application thereof, wherein the hair growth lotion comprises the following components: adenosine and derivatives thereof, polyhydroxy compounds and derivatives thereof, solvent, cacumen biotae, eclipta, ginseng, radix rehmanniae, glossy privet fruit, fleece-flower root, Chinese angelica, salvia miltiorrhiza, peach kernel, safflower, ligusticum wallichii, mulberry and antibacterial agent; the preparation method comprises the following steps: (1) pulverizing folium Platycladi, Ecliptae herba, Ginseng radix, radix rehmanniae, fructus Ligustri Lucidi, Polygoni Multiflori radix, radix Angelicae sinensis, Saviae Miltiorrhizae radix, semen Persicae, Carthami flos, rhizoma Ligustici Chuanxiong, and Mori fructus, heating and stirring with solvent to obtain A; (2) adding purified water into the A, heating, filtering, adding an antibacterial agent, and stirring to obtain a mixture B for later use; (3) adding adenosine and derivatives thereof into an aqueous solution of polyhydroxy compound derivatives, heating, stirring until the adenosine and the derivatives are dissolved, cooling to room temperature, adding an antibacterial agent, and stirring to obtain a mixture C; (4) adding the mixture B into the mixture C and stirring to obtain a finished product. The product of the invention has good hair growth effect.
Description
Technical Field
The invention relates to the technical field of cosmetics, in particular to a hair growth lotion containing high-content adenosine and derivatives thereof, and a preparation method and application thereof.
Background
With the increase of the living pressure of people in modern society and the influence of various adverse environmental factors, a large number of people can seriously lose hair or even baldness, and endless embarrassment, trouble and even pain are brought to the life of people.
At present, a great amount of popular minoxidil, prostaglandins, finasteride and other hair loss prevention and hair growth products are sold in the international market, particularly in the European and American markets, but minoxidil has dependence and can cause increase of body hair, and the minoxidil is always listed as a prohibited use range of cosmetics in China; prostaglandins are effective in a short period of time, but break and fall off after 3 to 5 months, and are also in a forbidden range in the Chinese market; finasteride can effectively improve alopecia in a short period of time, but has more obvious side effects, such as erectile dysfunction, sexual dysfunction, male breast enlargement and the like, and is forbidden to be used in China; at present, in domestic market, a plurality of hair loss prevention and hair growth products with the concept of traditional Chinese medicine are developed, and have great market demands, but the whole effect of the hair loss prevention and hair growth products is not satisfactory.
In addition, it has been reported that adenosine is used for skin care and hair growth, and a part of foreign brands use low-content adenosine to be added into skin care products to improve the effect of the skin care products; when the adenosine is singly used for growing the hair, the effect is not ideal when the adenosine is singly used, and particularly, the hair growing effect is not generated when the mass content of the adenosine is lower than 2 percent through trial. The skin care product is added with adenosine, because of the characteristic of adenosine insoluble cold water, the content of adenosine added in the skin care product is basically only below 1%, and at present, no report is given to the skin care product which contains adenosine and derivatives thereof and has the effect of promoting hair growth when the content of adenosine is lower than 2%. The preparation of high-content adenosine and derivative solution with the content of more than 2 percent is always a blank point in the industry, and related application and introduction are not provided in the industry. Although adenosine and its derivatives are well soluble in dilute alkaline or acid solutions, they are not suitable for use in the cosmetics industry because the PH of such alkaline or acid solutions is below 4.5 or above 8.5.
Disclosure of Invention
Aiming at the defects of the prior art, the invention solves the technical problem of how to use the high content of more than 2 percent of adenosine and derivatives thereof in an anti-alopecia product to improve the hair growth effect.
In order to solve the technical problems, the invention adopts the technical scheme that the hair growth lotion containing high-content adenosine and derivatives thereof comprises the following components in percentage by mass:
2 to 10 percent of adenosine and derivatives thereof,
10 to 55 percent of polyhydroxy compound and derivatives,
10 to 30 percent of solvent,
0.01 to 3 percent of lateral burl leaves,
0.01 to 3 percent of yerbadetajo herb,
0.01 to 2 percent of ginseng,
0.01 to 2 percent of radix rehmanniae recen,
0.01 to 3 percent of glossy privet fruit,
0.01 to 3 percent of fleece-flower root,
0.01 to 2 percent of angelica,
0.01 to 2 percent of salvia miltiorrhiza,
0.01 to 3 percent of peach kernel,
0.01 to 2 percent of safflower,
0.01 to 2 percent of Szechuan lovage rhizome,
0.01 to 2 percent of mulberry,
0.001-2% of antibacterial agent,
the balance being purified water.
The polyhydroxy compound and the derivative at least contain a five-membered heterocyclic molecular structure or a six-membered heterocyclic molecular structure. Further, the polyhydroxy compound and the derivative are polyalcohol derivatives or monosaccharide and derivatives thereof.
The solvent is at least one of ethanol, propylene glycol and butanediol.
The antibacterial agent comprises at least one of phenoxyethanol, ethylhexyl glycerol, methylisothiazolinone, pentanediol, hexanediol, octanediol, chlorphenesin, imidazolidinyl urea and iodopropynyl butylcarbamate.
The invention provides another technical scheme that the preparation method of the hair tonic containing high-content adenosine and derivatives thereof comprises the following steps:
(1) pulverizing folium Potentillae chinensis, Ecliptae herba, Ginseng radix, radix rehmanniae, fructus Ligustri Lucidi, Polygoni Multiflori radix, radix Angelicae sinensis, Saviae Miltiorrhizae radix, semen Persicae, Carthami flos, rhizoma Ligustici Chuanxiong, and Mori fructus, heating and stirring with solvent at 30-50rpm, heating to 80-85 deg.C, maintaining for 20-30min, cooling to 50-60 deg.C, and stirring for 2-3 hr to obtain A;
(2) adding purified water into A, heating to 80-85 deg.C, stirring for 20-30min, cooling to 50-60 deg.C, stirring for 3-5 hr, stirring at 30-50rpm, cooling to 35-45 deg.C, filtering, adding antibacterial agent, and stirring to obtain mixture B;
(3) adding adenosine and derivatives thereof into an aqueous solution of polyhydroxy compound derivatives, heating to 70-90 ℃, continuously stirring until the adenosine and the derivatives are completely dissolved, cooling to room temperature, adding an antibacterial agent, and uniformly stirring to obtain a mixture C;
(4) and adding the mixture B into the mixture C, and stirring and uniformly mixing to obtain a finished product.
The other technical scheme provided by the invention is that the hair growth liquid containing high-content adenosine and derivatives thereof can be used for preparing other hair care products to achieve the aim of preventing hair loss and growing hair.
Compared with the prior art, the invention adopts the polyhydroxy compound and the derivatives as the auxiliary agent to effectively dissolve the high-content adenosine and the derivatives thereof, so that the product containing the high-content adenosine and the derivatives thereof has better hair growth effect.
Detailed Description
The following examples are given to further illustrate the embodiments of the present invention, but are not intended to limit the invention.
Example 1:
a hair growth promoting liquid containing high-content adenosine and derivatives thereof comprises the following components in percentage by mass:
adenosine and derivatives thereof 2%,
55 percent of polyhydroxy compound and derivatives thereof,
10 percent of ethanol,
3 percent of lateral primary leaves,
0.01 percent of yerbadetajo herb,
2 percent of ginseng,
0.01 percent of radix rehmanniae recen,
3 percent of glossy privet fruit,
0.01 percent of fleece-flower root,
2 percent of angelica sinensis,
0.01 percent of salvia miltiorrhiza bunge,
3 percent of peach kernel,
0.01 percent of safflower,
2 percent of Szechuan lovage rhizome,
0.01 percent of mulberry fruit,
2 percent of phenoxyethanol,
the balance being purified water.
The polyhydroxy compound and the derivative at least contain a five-membered heterocyclic molecular structure or a six-membered heterocyclic molecular structure, and further are polyalcohol derivatives or monosaccharides and derivatives thereof.
Example 2:
a hair growth promoting liquid containing high-content adenosine and derivatives thereof comprises the following components in percentage by mass:
adenosine and derivatives thereof 5 percent,
40 percent of polyhydroxy compound and derivatives,
12 percent of propylene glycol,
1 percent of lateral bur leaves,
1 percent of the yerbadetajo herb,
1 percent of ginseng,
1 percent of radix rehmanniae recen,
1 percent of glossy privet fruit,
1 percent of fleece-flower root,
1 percent of angelica sinensis,
1 percent of salvia miltiorrhiza bunge,
1 percent of peach kernel,
1 percent of safflower is added into the mixture,
1 percent of Szechuan lovage rhizome,
1 percent of mulberry fruit,
1 percent of ethyl hexyl glycerol,
the balance being purified water.
The polyhydroxy compound and the derivative at least contain a five-membered heterocyclic molecular structure or a six-membered heterocyclic molecular structure, and further are polyalcohol derivatives or monosaccharides and derivatives thereof.
Example 3:
a hair growth promoting liquid containing high-content adenosine and derivatives thereof comprises the following components in percentage by mass:
10 percent of adenosine and derivatives thereof,
10% of polyhydroxy compound and derivative,
30 percent of butanediol,
0.01 percent of lateral bur leaves,
3 percent of the yerbadetajo herb,
0.01 percent of ginseng,
2 percent of radix rehmanniae recen,
0.01 percent of glossy privet fruit,
3 percent of fleece-flower root,
0.01 percent of angelica,
2 percent of salvia miltiorrhiza bunge,
0.01 percent of peach kernel,
2 percent of safflower is added into the mixture,
0.01 percent of Szechuan lovage rhizome,
2 percent of mulberry fruit,
0.001 percent of methyl isothiazolinone,
the balance being purified water.
The polyhydroxy compound and the derivative at least contain a five-membered heterocyclic molecular structure or a six-membered heterocyclic molecular structure, and further are polyalcohol derivatives or monosaccharides and derivatives thereof.
The method for preparing the hair tonic containing high content of adenosine and its derivatives of the above examples 1 to 3, comprising the steps of:
(1) pulverizing folium Potentillae chinensis, Ecliptae herba, Ginseng radix, radix rehmanniae, fructus Ligustri Lucidi, Polygoni Multiflori radix, radix Angelicae sinensis, Saviae Miltiorrhizae radix, semen Persicae, Carthami flos, rhizoma Ligustici Chuanxiong, and Mori fructus, heating and stirring with solvent at 30-50rpm, heating to 80-85 deg.C, maintaining for 20-30min, cooling to 50-60 deg.C, and stirring for 2-3 hr to obtain A;
(2) adding purified water into A, heating to 80-85 deg.C, stirring for 20-30min, cooling to 50-60 deg.C, stirring for 3-5 hr, stirring at 30-50rpm, cooling to 35-45 deg.C, filtering, adding antibacterial agent, and stirring to obtain mixture B;
(3) adding adenosine and derivatives thereof into an aqueous solution of polyhydroxy compound derivatives, heating to 70-90 ℃, continuously stirring until the adenosine and the derivatives are completely dissolved, cooling to room temperature, adding an antibacterial agent, and uniformly stirring to obtain a mixture C;
(4) and adding the mixture B into the mixture C, and stirring and uniformly mixing to obtain a finished product.
The hair growth promoting liquid containing high content of adenosine and its derivatives can be used for preparing other skin care products to achieve the purpose of hair growth promotion.
The key point of the technical scheme is to solve the problem of dissolving high-content adenosine and derivatives thereof, and the polyhydroxy compound and the derivatives (at least containing a five-membered heterocyclic molecular structure or a six-membered heterocyclic molecular structure) are utilized to help the adenosine and the derivatives thereof to dissolve, the good dissolving aiding performance of the polyhydroxy compound and the derivatives to the adenosine and the derivatives thereof has a direct relation with the five-membered heterocyclic molecular structure or the six-membered heterocyclic molecular structure, the corresponding adenosine structure also has a five-membered heterocyclic molecular structure or a six-membered heterocyclic molecular structure, namely the two components have partial structures which are highly similar.
To better illustrate the dissolution effect of the polyhydroxy compounds and derivatives used in the present invention on adenosine and derivatives thereof, the following dissolution comparative evaluation experiments were conducted, the results of which are shown in table 1 below:
from the above table, the dissolving method in the technical scheme of the invention can effectively dissolve adenosine and derivatives thereof with the high content of more than 2%, the pH value is between 5.5 and 8.5, the cosmetic is more suitable for use, no precipitation exists at the temperature of-5 ℃, and the using condition is achieved.
To better illustrate the beneficial effects of the present invention, the following efficacy evaluation experiments were performed:
inviting 30 alopecia patients with age of 30-60 years, wherein 13 female patients with severe alopecia comprise 6 female patients with severe alopecia and patients with scalp observation at interval of 5 m, the hair is sparse, the scalp is white and obvious, and 7 female patients with general alopecia have uniform but sparse and non-dense hair growth; 17 men, 7 of them had severe hair loss in the mediterranean region, 8 had severe hair loss, two meters of patients with outward appearance had thin hair and obvious white scalp, and 2 had complete baldness for more than 2 years.
The finished product spray is provided for each patient, the spray is required to be sprayed once in the morning and at night, and is properly massaged and absorbed after being sprayed, and the shampoo prepared by the finished product is provided for 13 women, wherein the content of the finished product is 15 percent, and the shampoo is required to be washed once in 2-3 days.
The trial returns 29 persons with the trial time of 60-90 days, wherein 13 women and 16 men are accompanied by 20 persons with the before-after-trial comparison photos.
Female:
of 6 patients with severe alopecia: 2 people are very satisfied, the hair loss is fed back and improved after about 30 days of trial, the growth of villi is fed back after 50 days, the hair becomes coarse and black in the subsequent use, and the hair quantity is obviously increased after about 70 days of use; 3 people are satisfied, the alopecia is improved by feedback in 40 days, the hair is increased by feedback in 60 days, and the hair quantity is increased by comparison in about 80 days, and the hair is increased obviously; 1 felt unobvious.
Of 7 patients with general alopecia: 5 people feel satisfied, and the alopecia is improved by feedback when the hair conditioner is used for about 25 days, and the hair loss is reduced every day; 2 people feel effective, and the feedback alopecia has no serious trend and is willing to be continuously used.
Male:
of 7 patients with severe thalassemia alopecia: 2 patients are satisfied, the number of the 2 patients using the Mediterranean central hair is about 5-20 hairs with more than 3CM, the hair growth is fed back when the 2 patients are used for 50 days, and the hair growth is found to be more than 60 hairs with more than 3CM and the hair is increased when the 2 patients are used for 90 days; 4, people feel effective, the mediterranean sea is fed back without expansion, the villi on the edge are obviously increased, the villi develop towards the middle, and when the Chinese medicinal tea is used for 90 days, the early stage villi are found to be black and coarse; 1 felt unnoticeable but wanted to continue using.
Of 8 male patients with severe alopecia: 1 person is very satisfied with feedback after using for 70 days, has villus to grow, use the contrast to find that the hair volume obviously increases 90 days, observe outside 2 meters, the white scalp obviously reduces, the black covers and increases; after the hair loss-preventing and hair-restoring agent is used for 4 people for 60 days, the feedback is satisfied, the hair loss is not increased continuously, but the original hair is thickened, and the hair is increased; 3 people feel common, the alopecia is not aggravated, the original hair is thickened, the scalp is white and is reduced, and the hair is not obviously increased.
One person of 1 bald patient feels effective after 70 days of use, and villi grow on both sides. And is willing to continue to be used.
The results of the evaluation experiments are shown in table 2 below:
evaluation experiment result analysis:
in the experiment, the female effective rate is 92.31 percent, the male effective rate is 75 percent, the female effective rate is higher than that of the male, the frequency and the dosage of the product are related, 13 women use the spray of the invention and simultaneously use the shampoo of the invention for 2-3 days, and the other 13 female sprays are used for more than 3 times every day and have a massage step. The male in the experiment only provides the spray, and a part of the male sprays 3 times or more per day, sometimes, the spray is forgotten at intervals.
The experiment shows that the product of the invention can produce obvious visible effect in 50-60 days, and is superior to the similar products in the current market.
Compared with the prior art, the invention adopts the polyhydroxy compound derivative as the auxiliary agent to effectively dissolve the high-content adenosine and the derivative thereof, so that the product containing the high-content adenosine and the derivative thereof has better alopecia prevention effect.
The embodiments of the present invention have been described in detail with reference to the examples, but the present invention is not limited to the described embodiments. It will be apparent to those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention.
Claims (9)
1. A hair restorer containing high-content adenosine and derivatives thereof is characterized by comprising the following components in percentage by mass:
2 to 10 percent of adenosine and derivatives thereof,
10 to 55 percent of polyhydroxy compound and derivatives,
10 to 30 percent of solvent,
0.01 to 3 percent of lateral burl leaves,
0.01 to 3 percent of yerbadetajo herb,
0.01 to 2 percent of ginseng,
0.01 to 2 percent of radix rehmanniae recen,
0.01 to 3 percent of glossy privet fruit,
0.01 to 3 percent of fleece-flower root,
0.01 to 2 percent of angelica,
0.01 to 2 percent of salvia miltiorrhiza,
0.01 to 3 percent of peach kernel,
0.01 to 2 percent of safflower,
0.01 to 2 percent of Szechuan lovage rhizome,
0.01 to 2 percent of mulberry,
0.001-2% of antibacterial agent,
the balance being purified water.
2. The hair restorer according to claim 1, wherein the polyol and derivatives have at least one five-membered heterocyclic molecular structure.
3. The hair restorer according to claim 1, which contains high levels of adenosine and derivatives thereof, wherein the polyhydroxy compounds and derivatives contain at least one six membered heterocyclic molecular structure.
4. The hair restorer according to claim 2, which contains high content of adenosine and its derivatives, wherein the polyhydroxy compound and its derivatives are polyol derivatives or monosaccharides and their derivatives.
5. The hair restorer according to claim 3, which contains high content of adenosine and its derivatives, wherein the polyhydroxy compound and its derivatives are polyol derivatives or monosaccharides and their derivatives.
6. The hair restorer according to claim 1, wherein the solvent is at least one of ethanol, propylene glycol and butylene glycol.
7. The hair restorer according to claim 1, which contains adenosine and its derivatives in high content, wherein the antibacterial agent comprises at least one of phenoxyethanol, ethylhexylglycerol, pentanediol, hexanediol, octanediol, chlorphenesin, imidazolidinylurea, iodopropynyl butylcarbamate, methylisothiazolinone.
8. A method for preparing the hair tonic containing high content of adenosine and its derivatives according to claim 1, comprising the steps of:
(1) pulverizing folium Potentillae chinensis, Ecliptae herba, Ginseng radix, radix rehmanniae, fructus Ligustri Lucidi, Polygoni Multiflori radix, radix Angelicae sinensis, Saviae Miltiorrhizae radix, semen Persicae, Carthami flos, rhizoma Ligustici Chuanxiong, and Mori fructus, heating and stirring with solvent at 30-50rpm, heating to 80-85 deg.C, maintaining for 20-30min, cooling to 50-60 deg.C, and stirring for 2-3 hr to obtain A;
(2) adding purified water into A, heating to 80-85 deg.C, stirring for 20-30min, cooling to 50-60 deg.C, stirring for 3-5 hr, stirring at 30-50rpm, cooling to 35-45 deg.C, filtering, adding antibacterial agent, and stirring to obtain mixture B;
(3) adding adenosine and derivatives thereof into aqueous solution of polyhydroxy compounds and derivatives, heating to 70-90 ℃, continuously stirring until the adenosine and the derivatives are completely dissolved, cooling to room temperature, adding an antibacterial agent, and uniformly stirring to obtain a mixture C;
(4) and adding the mixture B into the mixture C, and stirring and uniformly mixing to obtain a finished product.
9. A hair tonic containing high content of adenosine and its derivatives as claimed in any one of claims 1 to 7 for use in the preparation of other hair care products.
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| CN116920068A (en) * | 2022-03-31 | 2023-10-24 | 深圳市华元生物技术股份有限公司 | Medicine formula for preventing hair loss and growing hair, microneedle patch and preparation method thereof |
| CN117137835A (en) * | 2023-04-25 | 2023-12-01 | 广州君奕科技有限公司 | Alopecia preventing composition, daily chemical product and application |
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