CN113068825A - A nutritional product for adjuvant treatment of cancer after radiotherapy and chemotherapy, and its preparation method - Google Patents
A nutritional product for adjuvant treatment of cancer after radiotherapy and chemotherapy, and its preparation method Download PDFInfo
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- CN113068825A CN113068825A CN202110484919.2A CN202110484919A CN113068825A CN 113068825 A CN113068825 A CN 113068825A CN 202110484919 A CN202110484919 A CN 202110484919A CN 113068825 A CN113068825 A CN 113068825A
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- superoxide dismutase
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- adjuvant therapy
- roxburgh rose
- chemotherapy
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
- A23L2/382—Other non-alcoholic beverages fermented
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/185—Vegetable proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
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- A23V2400/113—Acidophilus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
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- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention relates to a nutriment for adjuvant therapy after radiotherapy and chemotherapy of cancer, the raw materials of the nutriment for adjuvant therapy after radiotherapy and chemotherapy of cancer adopt fructus Rosae Normalis as main raw materials, enrich multiple nutrient components through extraction technique and nano wall-breaking technique, then mix with mogroside, etc., ferment, make nutriment for adjuvant therapy, does not use any chemical additive, is purely natural beverage, and nutritious; through detection, the nutrition product for adjuvant therapy contains various nutritional components, including superoxide dismutase (SOD), polysaccharide, various vitamins, trace elements, triterpenes, various amino acids and the like, and can enhance the immunity of the organism, resist atherosclerosis, detoxify and protect the kidney, resist tumors, invigorate the stomach, prevent and treat diabetes, delay aging and the like; especially has better auxiliary treatment effect on patients after cancer radiotherapy and chemotherapy.
Description
Technical Field
The invention belongs to the technical field of food processing, and particularly relates to a nutriment for preventing cancer or adjuvant therapy after radiotherapy and chemotherapy and a preparation method thereof.
Background
Cancer, also known as malignant tumor, is a very harmful and largely invisible early stage of the color change, and is often found in a late stage, which results in a very high mortality rate.
Although each type of cancer is unique, it has its own genetic changes and growth characteristics. However, with the development of medical technology, there is an ideal treatment for cancer, and the common methods are surgery, radiotherapy and chemotherapy.
The tumor patients are easy to have symptoms of nausea, vomit, hypodynamia, oral ulcer and the like during radiotherapy and chemotherapy, so that the problems of nutrient deficiency, nutrient difficult absorption, leucocyte reduction and the like caused by chewing, swallowing and poor digestion and absorption are caused. Therefore, tumor patients need to be supplemented with various nutrients during radiotherapy and chemotherapy.
The roxburgh rose is an ancient wild fruit with homology of medicine and food, has various medicinal values, has high content of vitamin P and vitamin C, SOD which are all higher than the content of various fruits and vegetables, is called 'the fruit of the three kings', and also contains vitamin B1, vitamin B2, vitamin A, vitamin E, vitamin K, flavonoid, linolenic acid, calcium, phosphorus, iron, selenium, zinc, protein, beta-sitosterol, roxburgh rose polysaccharide, polyphenol, folic acid, dietary fiber, glycoside, tannic acid, protocatechuic acid, tannin, roxburgh rose triterpene, carbohydrate, linolenic acid, 15 amino acids: phenylalanine, arginine, threonine, lysine, leucine, isoleucine, aspartic acid, serine, glutamic acid, glycine, alanine, tyrosine, methionine, histidine, valine, a large amount of higher fatty acids and polybasic acids, particularly unsaturated fatty acids with high content, such as linoleic acid, linolenic acid, oleic acid, palmitic acid, stearic acid, citric acid, malic acid and other various nutrient substances. A plurality of research results show that the roxburgh rose can eliminate free radicals, resist oxidation, prevent and treat cancers, enhance immunity, reduce high blood pressure, high blood sugar, high blood fat and high blood sugar, prevent and assist in treating diabetes, resist radiation, discharge heavy metals and relieve fatigue.
In view of this, this patent is filed.
Disclosure of Invention
In order to solve the problems in the prior art, the invention provides a nutriment for adjuvant therapy and a preparation method thereof, and the nutriment for adjuvant therapy is mainly used for adjuvant therapy after radiotherapy and chemotherapy of cancer.
The invention aims to provide a nutrient for adjuvant therapy.
Still another object of the present invention is to provide a method for preparing the above-mentioned nutrition product for adjuvant therapy.
The nutrition product for adjuvant therapy according to the embodiment of the invention is prepared from main materials and ingredients, wherein the main materials comprise:
rosa roxburghii, superoxide dismutase and mogroside.
Furthermore, the nutrition product for adjuvant therapy is prepared from main materials and auxiliary materials, wherein the main materials comprise the following components in parts by weight:
70-90 parts of rosa roxburghii tratt, 9-15 parts of superoxide dismutase and 2-5 parts of mogroside.
Further, the main material also comprises a fermentation microbial inoculum, and the fermentation microbial inoculum comprises bifidobacterium lactis and lactobacillus acidophilus.
Further, the total amount of viable bacteria of Lactobacillus acidophilus added to 100g of the adjuvant therapy nutritional product is 1.0-5.0 × 108cfu/g, wherein the total amount of viable bacteria of Bifidobacterium lactis is 1.0-5.0 × 10 per 100g of adjuvant nutritional product8cfu/g; the ingredients are chicory, xylitol and/or fructo-oligosaccharide.
Specifically, the preparation method of the superoxide dismutase comprises the following steps:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach water content of 10-20%;
II: crushing wild roxburgh rose fruits by using a crusher, and sieving the wild roxburgh rose fruits and impurities by using a sieve with 10-20 meshes to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 3.8-5.2; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
A method of preparing said adjunctive therapeutic nutritional product, comprising the steps of:
(1) pulverizing fructus Rosae Normalis by nanometer wall-breaking technology, and filtering to obtain fructus Rosae Normalis wall-broken slurry;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken pulp obtained in the step (1), and uniformly mixing to form mixed pulp, thus obtaining the nutrition for adjuvant therapy.
Further, in the step (1), the roxburgh rose comprises a kernel of the roxburgh rose and pulp of the roxburgh rose, and the particle size of the roxburgh rose wall-breaking pulp is 800-1000 nm.
Further, in the step (2), the mixed slurry is subjected to centrifugal spray drying, and the nutrition for adjuvant therapy is obtained.
Further, in the step (2), a zymophyte agent is added into the mixed slurry, and the mixture is uniformly mixed and fermented for 1 to 2 days, so that the nutrition for the adjuvant therapy is obtained. The mixed slurry is fermented by the zymophyte agent, so that the protein in the mixed slurry is decomposed into micromolecular peptide and amino acid, and the micromolecular peptide and amino acid are easier to absorb by human bodies.
The roxburgh rose contains various components for preventing and resisting cancers: each cancer patient can take 10g or more vitamin C every day to play a role in treating cancer, S0D is an internationally recognized anti-aging and anti-cancer active substance, can improve the activity of SOD in human bodies, reduce Lipid Peroxide (LPO), and can inhibit carcinogens in cells, has the functions of resisting virus and radiation, and forms two major barriers of cancer prevention and cancer resistance with vitamin C.
The superoxide dismutase as the raw material is extracted from the roxburgh rose and then added into the pulp obtained after the wall of the roxburgh rose is broken, so that the content of the superoxide dismutase in the finished product is increased. The raw materials of the invention are simple and easy to obtain, the processing method is unique, and the obtained product can have better cancer prevention and anticancer effects and can better resist the side effects after chemotherapy.
Effect of superoxide dismutase (SOD):
oxidation resistance-medical reports indicate that the decline period of the oxidation resistance is advanced to about 35 years old, and the oxidation pressure formed inside and outside a human body by light on vegetables and fruits is not enough to be eliminated.
Secondly, the prevention of chronic diseases and complications thereof, namely free radicals, is a culprit that scientists find various chronic diseases and aging recently, is a big enemy of human health, the damage of the free radicals to the body is accumulated day by day, especially the diabetes and cardiovascular diseases, and the SOD has better free radical resistance and can prevent the chronic diseases and the complications thereof.
③ anti-aging, which is the aging of people, the aging signs are observed one by one, such as pigmentation and physical strength decline, because of the oxidation in vivo, and the SOD is used as an antioxidant, which is helpful for reducing the oxidation speed and slowing the aging footsteps.
Anti-fatigue, excessive free radicals remain in the body, so that people are easy to fatigue, tired, not concentrated in attention, often faint and heavy, and the SOD has obvious effect on the aspect of vibration improvement; and can effectively relieve asthenia, fatigue, etc. after chemotherapy.
The anti-oxidation ability of cancer patient will be reduced greatly, the free radical will damage cell, mucous membrane, internal organs, brain, central nerve, etc. the anti-oxidation agent should be supplemented to maintain good physical strength. The japan ministry of pachysand and the american cancer center (NCI) also recommend the use of antioxidants to prevent cancer or treat diseases caused by oxygen radical damage to cells. Reduce the side effects of anticancer drugs, such as vomiting, inappetence, hair loss, etc. SOD has good free radical resisting ability, and can effectively reduce side effects of chemotherapy.
Sixthly, avoiding secondary injury of operation, which causes a large amount of free radicals, so that the oral administration of the antioxidant before and after the operation is recommended to quickly recover the physical strength and accelerate wound recovery.
The strong oxidation resistance to women can relieve the following symptoms: A. the skin has spot wrinkles, because oxygen free radicals are not effectively removed, collagen and elastin are destroyed, the functions of skin moisturizing and elasticity maintaining are lost, wrinkles grow transversely, and the precipitation of melanin is accelerated. B. Poor blood circulation, irregular menstrual period, dark eye circles, dull and lusterless skin color. C. Climacteric disorder: because of the lack of oestrogen and the reduced antioxidant capacity in the body, the following symptoms often occur: paroxysmal fever, insomnia, night sweating, headache, emotional instability and restlessness.
The nutrition product for auxiliary treatment of the invention is detected by a Meniere test in 2019, 9-10 months, and the result shows that the nutrition product contains more vitamin C, superoxide dismutase, various amino acids and the like, and the specific formula is shown in the following table 1:
table 1 test results for adjunctive therapeutic nutrients
Compared with the prior art, the invention has the following beneficial effects:
(1) the raw materials of the nutrition product for the adjuvant therapy adopt the roxburgh rose as the main raw material, various nutrient components are enriched by the SOD extraction technology and the nano wall breaking technology, and then the nutrition product is mixed with the mogroside and the like and fermented to prepare the nutrition product for the adjuvant therapy. The molecular weight of the broken wall is extremely low, which is beneficial to the absorption of human body;
(2) the invention adopts the roxburgh rose as the raw material and adopts a full physical method to extract the SOD, the process is simple, the condition is mild, and neither environmental pollution nor endogenous chemical pollution is caused; the extraction cost is reduced, and the method can be used for large-scale production;
(3) through detection, the nutrition product for adjuvant therapy contains various nutritional components, including superoxide dismutase (SOD), polysaccharide, various vitamins, trace elements, triterpenes, various amino acids and the like, and can enhance the immunity of the organism, resist atherosclerosis, detoxify and protect the kidney, resist tumors, invigorate the stomach, prevent and treat diabetes, delay aging and the like; especially has better auxiliary treatment effect on patients after radiotherapy and chemotherapy of cancer, not only can supplement more nutrition and improve the immunity of the organisms, but also better prevent the reoccurrence of the cancer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be described in detail below. It is to be understood that the described embodiments are merely exemplary of the invention, and not restrictive of the full scope of the invention. All other embodiments, which can be derived by a person skilled in the art from the examples given herein without any inventive step, are within the scope of the present invention.
In some more specific embodiments, the nutrition product for adjuvant therapy is prepared from main materials and ingredients, wherein the main materials comprise, by weight:
70-90 parts of rosa roxburghii tratt, 9-15 parts of superoxide dismutase and 2-5 parts of mogroside.
Further, the main material also comprises a fermentation microbial inoculum, and the fermentation microbial inoculum comprises bifidobacterium lactis and lactobacillus acidophilus.
Further, the total amount of viable bacteria of Lactobacillus acidophilus added to 100g of the adjuvant therapy nutritional product is 1.0-5.0 × 108cfu/g, wherein the total amount of viable bacteria of Bifidobacterium lactis is 1.0-5.0 × 10 per 100g of adjuvant nutritional product8cfu/g; the ingredients are chicory, xylitol and/or fructo-oligosaccharide.
Furthermore, the addition amount of the ingredients is 3-5 parts by weight.
Specifically, the preparation method of the superoxide dismutase comprises the following steps:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach water content of 10-20%;
II: crushing wild roxburgh rose fruits by using a crusher, and sieving the wild roxburgh rose fruits and impurities by using a sieve with 10-20 meshes to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 3.8-5.2; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
A method of preparing said adjunctive therapeutic nutritional product, comprising the steps of:
(1) pulverizing fructus Rosae Normalis by nanometer wall-breaking technology, and filtering to obtain fructus Rosae Normalis wall-broken slurry;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken pulp obtained in the step (1), and uniformly mixing to form mixed pulp, thus obtaining the nutrition for adjuvant therapy.
Example 1
The embodiment provides a nutrition product for adjuvant therapy, which is prepared from main materials and auxiliary materials, wherein the main materials comprise:
70g of rosa roxburghii tratt, 15g of superoxide dismutase and 2g of mogroside; the ingredient is 1g of fructo-oligosaccharide;
specifically, the preparation method of the superoxide dismutase comprises the following steps:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach the water content of 10%;
II: crushing the wild roxburgh rose fruits by using a crusher, and screening the wild roxburgh rose fruits and impurities by using a 20-mesh sieve to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 3.8; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
A method of preparing said adjunctive therapeutic nutritional product, comprising the steps of:
(1) crushing the roxburgh rose through a nano wall-breaking technology, wherein the roxburgh rose comprises a kernel of the roxburgh rose and pulp of the roxburgh rose, the particle size of the roxburgh rose wall-breaking pulp is 800-1000 nm, and filtering to form roxburgh rose wall-breaking pulp for later use;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken pulp obtained in the step (1), and uniformly mixing to form mixed pulp, thus obtaining the nutrition for adjuvant therapy.
Example 2
The embodiment provides a nutrition product for adjuvant therapy, which is prepared from main materials and auxiliary materials, wherein the main materials comprise:
80g of roxburgh rose, 10g of superoxide dismutase and 3g of mogroside; bifidobacterium lactis and Lactobacillus acidophilus, wherein the total amount of viable bacteria of Lactobacillus acidophilus is 3.0 × 10 per 100g of the adjuvant-treated nutritional product8cfu/g, wherein the total amount of viable bacteria of the Bifidobacterium lactis added in each 100g of the adjuvant therapy nutriment is 3.4 × 108cfu/g; the ingredient is chicory;
the preparation method of the superoxide dismutase comprises the following steps:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach the water content of 20%;
II: crushing the wild roxburgh rose fruits by using a crusher, and screening the wild roxburgh rose fruits and impurities by using a 10-mesh sieve to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 4.3; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
A method of preparing said adjunctive therapeutic nutritional product, comprising the steps of:
(1) crushing the roxburgh rose through a nano wall-breaking technology, wherein the roxburgh rose comprises a kernel of the roxburgh rose and pulp of the roxburgh rose, the particle size of the roxburgh rose wall-breaking pulp is 800-1000 nm, and filtering to form roxburgh rose wall-breaking pulp for later use;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken slurry obtained in the step (1), uniformly mixing to form mixed slurry, adding a zymophyte agent into the mixed slurry, uniformly mixing, and fermenting for 2 days to obtain the nutrition for adjuvant therapy.
Example 3
The embodiment provides a nutrition product for adjuvant therapy, which is prepared from main materials and auxiliary materials, wherein the main materials comprise:
90g of roxburgh rose, 9g of superoxide dismutase and 5g of mogroside; bifidobacterium lactis and Lactobacillus acidophilus, wherein the total amount of viable bacteria of Lactobacillus acidophilus is 1.0 × 108cfu/g, wherein the total amount of viable bacteria of the Bifidobacterium lactis added in each 100g of the adjuvant therapy nutriment is 5.0 × 108cfu/g; the ingredient is xylitol;
the preparation method of the superoxide dismutase comprises the following steps:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach a water content of 15%;
II: crushing the wild roxburgh rose fruits by using a crusher, and screening the wild roxburgh rose fruits and impurities by using a 10-mesh sieve to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 5.2; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
A method of preparing said adjunctive therapeutic nutritional product, comprising the steps of:
(1) crushing the roxburgh rose through a nano wall-breaking technology, wherein the roxburgh rose comprises a kernel of the roxburgh rose and pulp of the roxburgh rose, the particle size of the roxburgh rose wall-breaking pulp is 800-1000 nm, and filtering to form roxburgh rose wall-breaking pulp for later use;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken slurry obtained in the step (1), uniformly mixing to form mixed slurry, adding a zymophyte agent into the mixed slurry, uniformly mixing, fermenting for 1 day, and filling the fermented slurry to obtain the auxiliary treatment nutrient.
Example 4
The embodiment provides a nutrition product for adjuvant therapy, which is prepared from main materials and auxiliary materials, wherein the main materials comprise:
80g of roxburgh rose, 10g of superoxide dismutase and 3g of mogroside; bifidobacterium lactis and Lactobacillus acidophilus, wherein the total amount of viable bacteria of Lactobacillus acidophilus is 3.0 × 10 per 100g of the adjuvant-treated nutritional product8cfu/g, wherein the total amount of viable bacteria of the Bifidobacterium lactis added in each 100g of the adjuvant therapy nutriment is 3.4 × 108cfu/g; the ingredient is chicory;
the preparation method of the superoxide dismutase comprises the following steps:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach the water content of 20%;
II: crushing the wild roxburgh rose fruits by using a crusher, and screening the wild roxburgh rose fruits and impurities by using a 10-mesh sieve to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 4.3; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
A method of preparing said adjunctive therapeutic nutritional product, comprising the steps of:
(1) crushing the roxburgh rose through a nano wall-breaking technology, wherein the roxburgh rose comprises a kernel of the roxburgh rose and pulp of the roxburgh rose, the particle size of the roxburgh rose wall-breaking pulp is 800-1000 nm, and filtering to form roxburgh rose wall-breaking pulp for later use;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken slurry obtained in the step (1), uniformly mixing to form mixed slurry, adding a zymophyte agent into the mixed slurry, uniformly mixing, fermenting for 2 days, and performing spray drying on the fermented slurry at 48 ℃ to obtain the auxiliary treatment nutrient.
The nutrition for adjuvant therapy of the invention is pure natural concentrated extraction without any essence and preservative, thus being applicable to any healthy, sub-healthy and sick people and being taken by children and the old. Is particularly suitable for the following people to take:
1. people with low immunity (children, physically weak people, hepatitis B people, etc.)
2. Cancer patients
3. Diabetic patients
4. Patients with liver diseases
5. People with hypertension, hyperglycemia and hyperlipidemia and cardiovascular and cerebrovascular diseases
6. Sub-health population
7. Elderly population
8. Beauty-loving people
9. People who are drunk, smokes and drinks tea
10. Crowd with heavy metal exceeding standard
11. And others: oral ulcer, insomnia, constipation, dyspepsia
Typical cases
1. Zhangyi, female, age 46, refractory canker sore due to chemotherapy; 1 bag of the adjuvant therapy nutrient of the embodiment 3 of the invention is started every day after breakfast, lunch and dinner, each bag is 30ml, and the canker sore is healed after 3 days without relapse within half a year.
2. Wangzhi, female, age 58, morning diarrhea all year round; the treatment-assisting nutrition product of the embodiment 3 of the invention is 1 bag after breakfast, lunch and dinner every day, 30ml of the nutrition product is put in each bag, the improvement is achieved after 2 days, 4 days later, the delay is basically more than 6 am, and the stool is formed.
3. Plum, woman, age 36, has severe halitosis due to chemotherapy and chronic inflammation of throat; 1 bag of the adjuvant therapy nutrition product of the embodiment 2 of the invention is started every day after breakfast, lunch and dinner, each bag is 30ml, and the symptoms disappear according to the self-description of the patients after half a month.
4. For example, men, age 41, often feel tired and weak due to chemotherapy, have poor sleep and high blood sugar, and often have long blisters on the soles of the feet; 1 bag of the adjuvant therapy nutriment of the embodiment 4 of the invention is started after breakfast, lunch and supper every day, 30ml of the nutriment is used for each bag, the body feels strong after 5 days, the sleep is better after about 10 days, the foot bottom is not soaked for more than 20 days, the rotten place is healed, and the blood sugar is reduced.
5. Wu-Dynasty, female age 57, age after chemotherapy, the leucocytes are always maintained at about 3000, and are often cold and powerless, 1 bag of the adjuvant therapy nutriment of the embodiment 3 of the invention starts to be respectively used after breakfast, lunch and supper every day, 30ml of each bag has better body feeling after three weeks, and compared with the prior art, the symptom of leucocyte low is normal, and the number of leucocytes is increased by 5000; the cold symptom can be better if the patient drinks the medicine for two days in increased dose (two bags are taken each time).
6. The subsidiary treatment nutrition of the embodiment 3 of the invention is 30ml per bag, 1 bag of the subsidiary treatment nutrition after breakfast, lunch and dinner in 2019, the white bubbles in the mouth become small after 2 days, the oral ulcer heals gradually in 3 days, the pain is relieved, the immunity is improved, the sleep is improved, and the sleep can go to rest quietly.
7. For any woman, the woman is 46 years old, suffers from thymic squamous carcinoma in 2012, cannot be operated, has low immunity, has long tumors, and has 1 bag of the adjuvant therapy nutriment of the embodiment 3 of the invention after breakfast, lunch and dinner every day, wherein each bag contains 30ml, and after one month, the woman has good sleep, does not feel pain, has improved immunity and has good spirit; many oral ulcers were also good after chemotherapy.
8. Yan A certain woman is 69 years old and 2011 suffers from breast cancer, and the symptoms of 40 times of chemotherapy, nausea, vomiting and multiple oral ulcers after chemotherapy, and various discomfort; 1 bag of the adjuvant therapy nutrient of the embodiment 3 of the invention is taken by a patient every morning, noon and evening meal in 2015, each bag is 30ml, the symptoms of nausea and vomiting are gradually reduced, the pain of the patient is relieved, the spirit is improved, and the oral ulcer is improved.
The above description is only for the specific embodiments of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art can easily conceive of the changes or substitutions within the technical scope of the present invention, and all the changes or substitutions should be covered within the scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the appended claims.
Claims (9)
1. The nutriment for the adjuvant therapy after radiotherapy and chemotherapy of cancer is characterized by being prepared from main materials and auxiliary materials, wherein the main materials comprise:
rosa roxburghii, superoxide dismutase and mogroside.
2. The nutrition product of claim 1, wherein the nutrition product of adjuvant therapy is prepared from main materials and ingredients, and the main materials comprise, by weight:
70-90 parts of rosa roxburghii tratt, 9-15 parts of superoxide dismutase and 2-5 parts of mogroside.
3. The therapeutic-aiding nutraceutical of claim 1, wherein the main material further comprises a zymogen agent, and the zymogen agent comprises bifidobacterium lactis and lactobacillus acidophilus.
4. The nutrition product of claim 3, wherein the total viable count of Lactobacillus acidophilus added to each 100g of the nutrition product is 1.0-5.0 x 108cfu/g, wherein the total amount of viable bacteria of Bifidobacterium lactis is 1.0-5.0 × 10 per 100g of adjuvant nutritional product8cfu/g; the ingredients are chicory, xylitol and/or fructo-oligosaccharide.
5. The therapeutic supplement of claim 1, wherein the superoxide dismutase is produced by a method comprising the steps of:
i: washing wild fructus Rosae Normalis with water; naturally drying to reach water content of 10-20%;
II: crushing wild roxburgh rose fruits by using a crusher, and sieving the wild roxburgh rose fruits and impurities by using a sieve with 10-20 meshes to obtain wild roxburgh rose fruit blocks;
III: dividing the wild roxburgh rose fruit blocks obtained in the step (II) into a plurality of parts, loosely wrapping the parts by using gauze, putting the parts into purified water with the weight of 20 times of the parts, heating the parts to 55 ℃, preserving the heat and leaching the parts for 24 hours, and stirring the parts once every 2 hours to obtain leaching liquor;
IV: centrifuging and separating the leaching solution obtained in the step (III), standing for 2 hours, and taking supernatant to obtain crude superoxide dismutase solution;
v: carrying out ultrafiltration on the crude superoxide dismutase solution obtained in the step (IV), wherein the small molecular substance with the molecular weight cutoff of 20000-;
VI: adjusting the pH of the superoxide dismutase solution obtained in the step (V) to 3.8-5.2; vacuum concentrating at 80 deg.C under reduced pressure to obtain superoxide dismutase concentrated solution; and then centrifuging, spraying and drying the superoxide dismutase concentrated solution to obtain the superoxide dismutase.
6. A method of preparing a therapeutic-aiding nutritional product according to any one of claims 1 to 5, wherein the method comprises the steps of:
(1) pulverizing fructus Rosae Normalis by nanometer wall-breaking technology, and filtering to obtain fructus Rosae Normalis wall-broken slurry;
(2) adding mogroside, superoxide dismutase and other ingredients into the roxburgh rose wall-broken pulp obtained in the step (1), and uniformly mixing to form mixed pulp, thus obtaining the nutrition for adjuvant therapy.
7. The preparation method of the nutrition product for adjuvant therapy according to claim 6, wherein in the step (1), the Rosa roxburghii comprises the kernel and pulp of Rosa roxburghii, and the particle size of the wall-broken pulp of Rosa roxburghii is 800-1000 nm.
8. The method for preparing a nutritional product for adjuvant therapy according to claim 6, wherein in the step (2), the mixed slurry is subjected to centrifugal spray drying to obtain the nutritional product for adjuvant therapy.
9. The method for preparing a nutrition product for adjuvant therapy according to claim 6, wherein in the step (2), a zymophyte agent is added into the mixed slurry, and the mixture is uniformly mixed and fermented for 1 to 2 days to obtain the nutrition product for adjuvant therapy.
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