CN113018210A - Skin repair composition and preparation method and application thereof - Google Patents
Skin repair composition and preparation method and application thereof Download PDFInfo
- Publication number
- CN113018210A CN113018210A CN202110274810.6A CN202110274810A CN113018210A CN 113018210 A CN113018210 A CN 113018210A CN 202110274810 A CN202110274810 A CN 202110274810A CN 113018210 A CN113018210 A CN 113018210A
- Authority
- CN
- China
- Prior art keywords
- parts
- skin
- oligopeptide
- fibronectin
- panthenol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 76
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 230000008439 repair process Effects 0.000 title abstract description 47
- 229920001184 polypeptide Polymers 0.000 claims abstract description 32
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract description 32
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract description 32
- 102000016359 Fibronectins Human genes 0.000 claims abstract description 31
- 108010067306 Fibronectins Proteins 0.000 claims abstract description 31
- 239000002537 cosmetic Substances 0.000 claims abstract description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 66
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims description 30
- 150000001413 amino acids Chemical class 0.000 claims description 30
- 239000011703 D-panthenol Substances 0.000 claims description 28
- 235000004866 D-panthenol Nutrition 0.000 claims description 28
- 108010068370 Glutens Proteins 0.000 claims description 28
- 240000008042 Zea mays Species 0.000 claims description 28
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 28
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 28
- 235000005822 corn Nutrition 0.000 claims description 28
- 229960003949 dexpanthenol Drugs 0.000 claims description 28
- 235000021312 gluten Nutrition 0.000 claims description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 25
- 229920002385 Sodium hyaluronate Polymers 0.000 claims description 24
- 229940010747 sodium hyaluronate Drugs 0.000 claims description 24
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 24
- 239000008367 deionised water Substances 0.000 claims description 22
- 229910021641 deionized water Inorganic materials 0.000 claims description 22
- 239000000230 xanthan gum Substances 0.000 claims description 22
- 229920001285 xanthan gum Polymers 0.000 claims description 22
- 229940082509 xanthan gum Drugs 0.000 claims description 22
- 235000010493 xanthan gum Nutrition 0.000 claims description 22
- 241000196324 Embryophyta Species 0.000 claims description 21
- 230000003716 rejuvenation Effects 0.000 claims description 10
- 238000003756 stirring Methods 0.000 claims description 9
- 150000001720 carbohydrates Chemical class 0.000 claims description 8
- 230000001804 emulsifying effect Effects 0.000 claims description 7
- 229960005150 glycerol Drugs 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 4
- 230000001965 increasing effect Effects 0.000 claims description 4
- 229920002494 Zein Polymers 0.000 claims description 2
- 239000005019 zein Substances 0.000 claims description 2
- 229940093612 zein Drugs 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000003491 skin Anatomy 0.000 description 95
- 235000001014 amino acid Nutrition 0.000 description 25
- 210000002615 epidermis Anatomy 0.000 description 15
- 230000000052 comparative effect Effects 0.000 description 13
- 239000010410 layer Substances 0.000 description 10
- 210000002469 basement membrane Anatomy 0.000 description 9
- 210000004207 dermis Anatomy 0.000 description 9
- 239000000284 extract Substances 0.000 description 9
- 230000004888 barrier function Effects 0.000 description 8
- 230000006378 damage Effects 0.000 description 8
- 230000000694 effects Effects 0.000 description 8
- 102000015636 Oligopeptides Human genes 0.000 description 7
- 108010038807 Oligopeptides Proteins 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 230000002829 reductive effect Effects 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 5
- 210000000434 stratum corneum Anatomy 0.000 description 5
- 230000000813 microbial effect Effects 0.000 description 4
- 230000035755 proliferation Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- 241000186427 Cutibacterium acnes Species 0.000 description 3
- 206010043189 Telangiectasia Diseases 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 230000032683 aging Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000010261 cell growth Effects 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000003020 moisturizing effect Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 229940055019 propionibacterium acne Drugs 0.000 description 3
- 230000037307 sensitive skin Effects 0.000 description 3
- 230000008591 skin barrier function Effects 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 230000002195 synergetic effect Effects 0.000 description 3
- 208000009056 telangiectasis Diseases 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 208000012641 Pigmentation disease Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 230000001914 calming effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002708 enhancing effect Effects 0.000 description 2
- 210000001339 epidermal cell Anatomy 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 210000002510 keratinocyte Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 230000019612 pigmentation Effects 0.000 description 2
- 230000008929 regeneration Effects 0.000 description 2
- 238000011069 regeneration method Methods 0.000 description 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 1
- MXOAEAUPQDYUQM-QMMMGPOBSA-N (S)-chlorphenesin Chemical compound OC[C@H](O)COC1=CC=C(Cl)C=C1 MXOAEAUPQDYUQM-QMMMGPOBSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 240000004246 Agave americana Species 0.000 description 1
- 240000000572 Blumea balsamifera Species 0.000 description 1
- 235000007866 Chamaemelum nobile Nutrition 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 102000001187 Collagen Type III Human genes 0.000 description 1
- 108010069502 Collagen Type III Proteins 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 244000042664 Matricaria chamomilla Species 0.000 description 1
- 235000007232 Matricaria chamomilla Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 240000001659 Oldenlandia diffusa Species 0.000 description 1
- IOUVKUPGCMBWBT-DARKYYSBSA-N Phloridzin Natural products O[C@H]1[C@@H](O)[C@H](O)[C@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-DARKYYSBSA-N 0.000 description 1
- 240000001341 Reynoutria japonica Species 0.000 description 1
- 235000018167 Reynoutria japonica Nutrition 0.000 description 1
- 244000178231 Rosmarinus officinalis Species 0.000 description 1
- 240000004534 Scutellaria baicalensis Species 0.000 description 1
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 1
- 206010040799 Skin atrophy Diseases 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 206010040880 Skin irritation Diseases 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 229940069521 aloe extract Drugs 0.000 description 1
- 230000003796 beauty Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000005282 brightening Methods 0.000 description 1
- 229960001631 carbomer Drugs 0.000 description 1
- 229940059958 centella asiatica extract Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229960003993 chlorphenesin Drugs 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000006003 cornification Effects 0.000 description 1
- 239000006071 cream Substances 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000001784 detoxification Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000001947 glycyrrhiza glabra rhizome/root Substances 0.000 description 1
- 230000012010 growth Effects 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 235000020721 horse chestnut extract Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 150000002559 kavalactones Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- IOUVKUPGCMBWBT-UHFFFAOYSA-N phloridzosid Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-UHFFFAOYSA-N 0.000 description 1
- IOUVKUPGCMBWBT-QNDFHXLGSA-N phlorizin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=CC(O)=C1C(=O)CCC1=CC=C(O)C=C1 IOUVKUPGCMBWBT-QNDFHXLGSA-N 0.000 description 1
- 235000019139 phlorizin Nutrition 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000011241 protective layer Substances 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007665 sagging Methods 0.000 description 1
- 230000036573 scar formation Effects 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- 230000037380 skin damage Effects 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 230000037394 skin elasticity Effects 0.000 description 1
- 230000036556 skin irritation Effects 0.000 description 1
- 231100000475 skin irritation Toxicity 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- -1 tea leaf extract Substances 0.000 description 1
- 229940092665 tea leaf extract Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 229960004418 trolamine Drugs 0.000 description 1
- 230000037303 wrinkles Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention relates to the technical field of cosmetics, and particularly relates to a skin repair composition, a preparation method and an application thereof, wherein the skin repair composition comprises the following components: PLANT 21N, AERN EX-PHAVA, transdermal polypeptide, fibronectin and oligopeptide-1.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a skin repair composition and a preparation method and application thereof.
Background
The integrity of the skin is the ultimate goal sought for restorative cosmetics. However, most of the existing repair cosmetics only act on the epidermis layer of the skin to promote the proliferation of epidermal cells, so as to repair the epidermis layer of the skin and achieve the integrity of the barrier of the epidermis. The integrity of the skin is not limited to the epidermis which is a physiological barrier, but also comprises the restoration of a microbial layer which is a biochemical barrier, a basement membrane which supports a skin structure, a dermis layer and other physiological structures, so that the skin exists in an integral form.
The microbial layer of the skin is the habitat on which microbial flora live, about one billion bacteria per square centimeter are flatly co-located in the epidermis of the skin, and a microecological 'protective shield' is formed. The skin micro-ecology is a unity composed of skin microorganisms, host skin and the environment. They are restricted and coordinated with each other, keep dynamic balance, and are the first biological barrier of skin, and the balance is broken in any ring to cause micro-ecological imbalance. For example, when the skin environment is abnormal or is stimulated by external factors, some bacteria usually colonized on the skin can cause diseases. For example, Propionibacterium acnes is a resident microorganism of the skin, but excessive secretion of facial oil due to excessive human stress causes massive proliferation of Propionibacterium acnes, resulting in the formation of acne and tissue destruction. Excessive proliferation of propionibacterium acnes can also lead to an imbalance in the microecology of the whole skin, which can also lead to damage to this biochemical barrier at the outermost skin, leading to deterioration of the physical barrier of the skin, invasion of harmful substances and thus to a more profound destruction of the skin. Thus, when considering repairing the integrity of the skin, not only the structure of the skin, i.e. the repair of the physiological structure of the skin, but also the repair of the microbial layer, i.e. the repair of the biochemical structure of the skin, must be considered.
The physiological structure of the skin, including the epidermis, basement membrane and dermis, is accompanied by aging and external irritation of the human body, and the aging phenomenon of the skin is manifested by wrinkles, sagging, loss of elasticity, roughness, pigmentation, skin atrophy and telangiectasia. These skin aging phenomena can be attributed to damage of the epidermis, basement membrane and dermis. Damage to the epidermis and dermis layers is manifested by the death and withering of keratinocytes and fibroblasts, which is also a major cosmetic concern at present, while damage to the basement membrane is not a great concern at present. The change of the basement membrane can have a profound effect on the dermis and the epidermis, and after the continuity of the basement membrane is damaged, epidermal cells lose the connection with the basement membrane and are directly connected with the naked dermis, so that the structural support of the epidermis and the dermis and the transportation of nutrient substances and water are influenced. The epidermis is not normally supplied with nutrients and water, and cornification itself is affected, which eventually results in a loss of barrier function of the stratum corneum, the outermost protective layer of the skin. Furthermore, damage to the basement membrane will also lead to conduction of several growth factors in the dermis and epidermis, and these conduction barriers will further lead to structural damage of the skin. Care should be taken to repair the basement membrane while repairing the stratum corneum and dermis layers to promote keratinocyte and fibroblast proliferation so that the structure of the skin remains intact.
Chinese patent application CN105708724A discloses a cosmetic composition for repairing skin, which is prepared from the following raw materials by weight percent: 14-18% of water, 11-15% of glycerol, 14-18% of propylene glycol, 14-18% of collagen cross-linked body, 11-15% of oligopeptide-1, 11-15% of oligopeptide-2 and 11-15% of oligopeptide-5. The invention can promote the rapid repair of skin damage parts, regulate fibroblast disorder, effectively inhibit scar formation, promote the skin to restore and smooth, rebuild skin barrier, and has the functions of repairing epidermis, increasing blood circulation of skin capillary vessels and lightening pigmentation. However, the cosmetic composition of the present invention acts mainly on the epidermis layer, and has a limited skin-repairing effect.
Chinese patent application CN108078881A discloses a skin repair liquid, which comprises the following components: propylene glycol, butylene glycol, carbomer, triethanolamine, sodium hyaluronate, horse chestnut extract, agave stem extract, centella asiatica extract, polygonum cuspidatum root extract, scutellaria baicalensis root extract, tea leaf extract, glycyrrhiza glabra root extract, chamomile flower extract, rosemary flower extract, chlorphenesin, blumea balsamifera oil, oldenlandia diffusa extract, aloe extract, phloridzin and deionized water. The skin repair liquid provided by the technical scheme of the invention has good repairing and relieving effects on the sunburned damaged erythema, has a good moisturizing effect, can improve the blood circulation of the skin, renews the regeneration of skin cells, and is smooth, tender, white and bright after being used. However, the repairing liquid contains a plurality of extracts, the action mechanism is unclear, the action effect is uncontrollable, and side effects are easy to generate.
Therefore, it is necessary to develop a skin repair composition, a method for preparing the same, and applications thereof, which can solve the above technical problems.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provide a skin repair composition which has good skin repair effect, skin soothing, no side effect and moisturizing effect, and a preparation method and application thereof.
The invention is realized by the following technical scheme:
a skin rejuvenation composition comprising the following components: PLANT 21N, AERN EX-PHAVA, transdermal polypeptide, fibronectin, and oligopeptide-1.
Preferably, the skin repair composition comprises the following components in parts by weight: 2-8 parts of PLANT 21N, 2-8 parts of AERN EX-PHAVA, 1-6 parts of transdermal polypeptide, 1-6 parts of fibronectin and 11-6 parts of oligopeptide-11.
Preferably, the mass ratio of the transdermal polypeptide, fibronectin and oligopeptide-1 is 1:1.25-2.25: 1-2.
More preferably, the mass ratio of the transdermal polypeptide, fibronectin and oligopeptide-1 is 1:1.5-2: 1.2-1.8.
Preferably, the skin repair composition further comprises the following components: d-panthenol, sodium hyaluronate, biogel-1, corn gluten amino acids, glycerol, xanthan gum and deionized water.
More preferably, the skin repair composition further comprises the following components in parts by weight: 0.5-2 parts of D-panthenol, 0.1-1 part of sodium hyaluronate, 12-8 parts of biogum carbohydrate gum, 3-10 parts of corn gluten amino acids, 2-10 parts of glycerol, 0.1-1 part of xanthan gum and 100 parts of deionized water.
More preferably, the mass ratio of the D-panthenol to the bioglycan-1 to the corn gluten amino acids is 1:4-8: 10-15.
The invention also relates to a preparation process of the skin repair composition, which comprises the following steps:
(1) adding deionized water, glycerol, sodium hyaluronate and xanthan gum into an emulsifying pot, and stirring until the materials are completely dissolved to obtain a mixture 1;
(2) adding PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol into mixture 1.
Preferably, in the step (1), deionized water, glycerol, sodium hyaluronate and xanthan gum are added into an emulsifying pot, the temperature is increased to 80-90 ℃, the mixture is stirred until the mixture is completely dissolved, and the temperature is kept for 25-35min to obtain a mixture 1.
Preferably, after the mixture 1 is cooled to 45-55 ℃ in the step (2), PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol are added and stirred uniformly to obtain the composition.
The invention also relates to the application of the skin repairing composition or the composition prepared by the preparation process in preparing cosmetics.
The invention has the beneficial effects that:
the skin repair composition provided by the invention has a calming and soothing effect, and the AERN EX-PHAVA is rich in kavalactones, and has the effects of immediately calming, relieving sensitivity and relieving skin irritation.
The skin repair composition contains various extracts, and has a synergistic effect, so that the inflammation can be inhibited, the skin can be relieved, histamine can be reduced, allergy and itching can be resisted, free radicals can be eliminated, skin injury can be reduced, cell detoxification can be reduced, irritation can be reduced, the skin can be activated, and the skin barrier can be protected.
The invention uses the synergistic effect of transdermal polypeptide, fibronectin and oligopeptide-1, the transdermal polypeptide directly promotes the cell growth, and the fibronectin improves the growth environment of the cell by supplying nutrition to the cell, thereby promoting the cell growth. Oligopeptide-1 is a small molecular polypeptide widely existing in human and animal bodies, can promote epidermal regeneration, stimulate the generation of extracellular matrix (ECM) and type I type III collagen, and can be used for repairing skin barrier, improving red blood, resisting aging, caring skin, and brightening skin. The three functions in one: promoting cell growth, repairing damaged skin surface, enhancing skin resistance, and improving skin quality, thereby relieving skin sensitivity, irritation, redness, and pruritus, promoting metabolism of superficial mottle, improving skin color, and making skin bright and lustrous.
The skin moisturizing cream disclosed by the invention can be used for repairing the skin, enhancing the skin water-locking capacity, improving the skin water-deficiency condition and restoring the water-moistening and tenderness through the actions of D-panthenol, sodium hyaluronate, biological carbohydrate gum-1 and corn gluten amino acids. Particularly, the synergistic effect of the D-panthenol, the bioglycan-1 and the corn gluten amino acids is better by optimizing the proportion of the D-panthenol, the bioglycan-1 and the corn gluten amino acids.
Drawings
FIG. 1 is a graph showing the healing effect of a scalded patient using the skin healing composition of example 3 of the present invention.
FIG. 2 is a graph showing the healing effect of a patient with sensitive skin using the skin-healing composition of example 3 of the present invention.
Detailed Description
The invention will be further described with reference to specific embodiments, and the advantages and features of the invention will become apparent as the description proceeds. These examples are illustrative only and do not limit the scope of the present invention in any way. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention, and that such changes and modifications may be made without departing from the spirit and scope of the invention.
In the examples and comparative examples of the present application, the producer of PLANT 21N was the Spanish NCKemic Biotechnology S.L laboratory and the supplier was Guangzhou city district trade, Inc.; AERN EX-PHAVA was obtained from Guangzhou Korea Lird History technology, transdermal polypeptide was obtained from Fujia Longsheng Biotech, fibronectin was obtained from Guangzhou Liumai Biotech, oligopeptide-1 was obtained from Shenzhen Viqi Biotech, D-panthenol was obtained from Imperial group of the Netherlands, sodium hyaluronate was obtained from Guangzhou Mega Probiotics, bioglycan-1 was obtained from Guangzhou Mega Cheng Chemicals, zein aminoacids were obtained from Guangzhou Baistet Biotech, and xanthan gum was obtained from Guangzhou Wanlu Chemicals.
Example 1
The skin repair composition comprises the following components in parts by weight: 2 parts of PLANT 21N, 2 parts of AERN EX-PHAVA, 1 part of transdermal polypeptide, 1 part of fibronectin, 11 parts of oligopeptide, 0.5 part of D-panthenol, 0.1 part of sodium hyaluronate, 12 parts of biogum, 3 parts of corn gluten amino acids, 2 parts of glycerol, 0.1 part of xanthan gum and 100 parts of deionized water.
The preparation process of the skin repair composition comprises the following steps:
(1) adding deionized water, glycerol, sodium hyaluronate and xanthan gum into an emulsifying pot, heating to 80 ℃, stirring until the materials are completely dissolved, and keeping the temperature for 25min to obtain a mixture 1;
(2) cooling the mixture 1 to 45 deg.C, adding PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol, and stirring.
Example 2
The skin repair composition comprises the following components in parts by weight: the skin care composition comprises, by weight, 8 parts of PLAANT 21N, 8 parts of AERN EX-PHAVA, 6 parts of transdermal polypeptide, 6 parts of fibronectin, 16 parts of oligopeptide, 2 parts of D-panthenol, 1 part of sodium hyaluronate, 18 parts of bioglycan-18, 10 parts of corn gluten amino acids, 10 parts of glycerol, 1 part of xanthan gum and 100 parts of deionized water.
The preparation process of the skin repair composition comprises the following steps:
(1) adding deionized water, glycerol, sodium hyaluronate and xanthan gum into an emulsifying pot, heating to 90 ℃, stirring until the materials are completely dissolved, and preserving heat for 35min to obtain a mixture 1;
(2) cooling the mixture 1 to 55 deg.C, adding PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol, and stirring.
Example 3
The skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 4 parts of transdermal polypeptide, 3 parts of fibronectin, 14 parts of oligopeptide, 1 part of D-panthenol, 0.5 part of sodium hyaluronate, 15 parts of bioglycan, 6 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
The preparation process of the skin repair composition comprises the following steps:
(1) adding deionized water, glycerol, sodium hyaluronate and xanthan gum into an emulsifying pot, heating to 85 ℃, stirring until the materials are completely dissolved, and preserving heat for 30min to obtain a mixture 1;
(2) cooling the mixture 1 to 50 deg.C, adding PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol, and stirring.
Example 4
The difference from example 3 is only the mass ratio of transdermal polypeptide, fibronectin and oligopeptide-1, and the rest conditions are the same, as follows:
the skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 3.3 parts of transdermal polypeptide, 4.2 parts of fibronectin, 13.5 parts of oligopeptide-13, 1 part of D-panthenol, 0.5 part of sodium hyaluronate, 15 parts of biogum carbohydrate, 6 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Example 5
The difference from example 3 is only the mass ratio of transdermal polypeptide, fibronectin and oligopeptide-1, and the rest conditions are the same, as follows:
the skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 2.1 parts of transdermal polypeptide, 4.7 parts of fibronectin, 14.2 parts of oligopeptide-14, 1 part of D-panthenol, 0.5 part of sodium hyaluronate, 15 parts of biogum carbohydrate, 6 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Example 6
The difference from the example 3 is only that the mass ratio of the D-panthenol, the bioglycan-1 and the corn gluten amino acids is different, and the rest conditions are the same, and are as follows:
the skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 4 parts of transdermal polypeptide, 3 parts of fibronectin, 14 parts of oligopeptide, 0.8 part of D-panthenol, 0.5 part of sodium hyaluronate, 13.2 parts of biogum carbohydrate, 8 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Example 7
The difference from the example 3 is only that the mass ratio of the D-panthenol, the bioglycan-1 and the corn gluten amino acids is different, and the rest conditions are the same, and are as follows:
the skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 4 parts of transdermal polypeptide, 3 parts of fibronectin, 14 parts of oligopeptide, 0.5 part of D-panthenol, 0.5 part of sodium hyaluronate, 14 parts of biogum, 7.5 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Comparative example 1
The difference from the example 3 is only that the dosage and the proportion of each component in the skin repair composition are different, and the rest conditions are the same, and the specific conditions are as follows:
the skin repair composition comprises the following components in parts by weight: 1 part of PLANT 21N, 7 parts of AERN EX-PHAVA, 8 parts of transdermal polypeptide, 0.5 part of fibronectin, 16.5 parts of oligopeptide-16, 3 parts of D-panthenol, 0.5 part of sodium hyaluronate, 11 parts of biogum carbohydrate, 6 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Comparative example 2
The difference from the example 3 is only that the D-panthenol and the bioglycan-1 are not added, the using amount of the corn gluten amino acids is replaced by 12 parts, and the rest conditions are the same, and the specific conditions are as follows:
the skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 4 parts of transdermal polypeptide, 3 parts of fibronectin, 14 parts of oligopeptide, 0.5 part of sodium hyaluronate, 12 parts of corn gluten amino acids, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Comparative example 3
The difference from the example 3 is only that corn gluten amino acids are not added, 1 part of D-panthenol and 15 parts of biological carbohydrate gum are replaced, and the rest conditions are the same, and the specific conditions are as follows:
the skin repair composition comprises the following components in parts by weight: 5 parts of PLANT 21N, 5 parts of AERN EX-PHAVA, 4 parts of transdermal polypeptide, 3 parts of fibronectin, 14 parts of oligopeptide, 2 parts of D-panthenol, 0.5 part of sodium hyaluronate, 110 parts of bioglycan, 6 parts of glycerol, 0.5 part of xanthan gum and 100 parts of deionized water.
Test example 1
70 healthy female volunteers of 25-50 years old without skin diseases are selected and randomly divided into 10 groups of 7 persons, the skin repair composition of the invention of the examples 1-7 and the comparative examples 1-3 is used on the face with the trial area of 200 cm and 250cm2After 30min, an intelligent skin detector, model MLB-D0028, was used to test the skin moisture and elasticity before and after using the composition of the present invention, and the skin moisture increase rate and elasticity increase rate were calculated and averaged, the results are shown in Table 1, using a manufacturer, California Millibao beauty treatment facility, Inc.
TABLE 1
| Skin moisture increment (%) | Skin elasticity increasing rate (%) | |
| Example 1 | 42.8 | 22.9 |
| Example 2 | 44.5 | 22.6 |
| Example 3 | 45.6 | 23.8 |
| Example 4 | 50.1 | 26.3 |
| Example 5 | 51.4 | 28.1 |
| Example 6 | 54.2 | 27.4 |
| Example 7 | 54.7 | 28.5 |
| Comparative example 1 | 38.3 | 17.7 |
| Comparative example 2 | 32.5 | 11.5 |
| Comparative example 3 | 34.7 | 13.1 |
Test example 2
When a patient cooks, hands of the patient are scalded by pot steam until the epidermis layer is ulcerated, the skin repair composition of the invention in the embodiment 3 is applied for 2 times a day, 1mL of the composition is applied every time, the injured skin is obviously repaired after one week, the injured skin is basically healed after two weeks, the product is stopped, and the injured part of the hands is recovered as before after one month. The whole process does not use any other products or medicines. As shown in particular in figure 1.
The remaining steam-scalded patients (similar to the case of scalding) were tested using the compositions of examples 4-7 and comparative examples 1-3, respectively, at the same amount per unit area as the patient of fig. 1, which was about 0.05mL/cm2The results are as follows: patients using the skin repair compositions of examples 4-7 recovered as early as three weeks later. The patient using the skin repair composition of comparative example 1 received significant repair after two weeks and substantially healed after four weeks. Patients using the skin repair compositions of comparative examples 2-3 had significant repair after three weeks and had substantial recovery after six weeks.
Test example 3
For a sensitive skin patient, the stratum corneum is thinner and there are more subcutaneous red blood streaks. After 3 months, the skin repair composition of example 3 of the present invention was applied 2 times a day, 0.3-0.5mL each time, and the subcutaneous telangiectasia was significantly alleviated, the stratum corneum was thickened, and the skin sensitivity was reduced. As shown in particular in fig. 2.
The remaining sensitive skin patients were tested using the compositions of examples 4-7 and comparative examples 1-3, respectively, and the trial area was 200-250cm2The trial amount is 0.3-0.5mL, and the results are as follows: after two and a half months, the subcutaneous telangiectasia was significantly relieved, the stratum corneum was thickened, and the skin sensitivity was reduced in the patients using the skin repair compositions of examples 4-7. The skin sensitivity of the patients using the skin repair compositions of comparative examples 1 to 3 was not significantly improved after 4 months.
The above detailed description is specific to one possible embodiment of the present invention, and the embodiment is not intended to limit the scope of the present invention, and all equivalent implementations or modifications without departing from the scope of the present invention should be included in the technical scope of the present invention.
Claims (10)
1. A skin rejuvenation composition comprising the following components: PLANT 21N, AERN EX-PHAVA, transdermal polypeptide, fibronectin, and oligopeptide-1.
2. The skin rejuvenation composition as claimed in claim 1 which comprises, in parts by weight: 2-8 parts of PLANT 21N, 2-8 parts of AERN EX-PHAVA, 1-6 parts of transdermal polypeptide, 1-6 parts of fibronectin and 11-6 parts of oligopeptide-11.
3. The skin rejuvenation composition as claimed in claim 1 wherein the mass ratio of transdermal polypeptide, fibronectin and oligopeptide-1 is from 1:1.25 to 2.25:1 to 2.
4. The skin rejuvenation composition as claimed in claim 3 wherein the mass ratio of transdermal polypeptide, fibronectin and oligopeptide-1 is from 1:1.5 to 2:1.2 to 1.8.
5. The skin rejuvenation composition as claimed in claim 1 further including the following components: d-panthenol, sodium hyaluronate, biogel-1, corn gluten amino acids, glycerol, xanthan gum and deionized water.
6. The skin rejuvenation composition as defined in claim 5 further including the following components in parts by weight: 0.5-2 parts of D-panthenol, 0.1-1 part of sodium hyaluronate, 12-8 parts of biogum carbohydrate gum, 3-10 parts of corn gluten amino acids, 2-10 parts of glycerol, 0.1-1 part of xanthan gum and 100 parts of deionized water.
7. The skin rejuvenation composition as claimed in claim 6 wherein the mass ratio of D-panthenol, bioglycan-1 and zein amino acids is from 1:4 to 8:10 to 15.
8. A process for preparing a skin rejuvenating composition as claimed in any one of claims 5 to 7 which comprises the steps of:
(1) adding deionized water, glycerol, sodium hyaluronate and xanthan gum into an emulsifying pot, and stirring until the materials are completely dissolved to obtain a mixture 1;
(2) adding PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol into mixture 1.
9. The preparation process of claim 8, wherein the deionized water, glycerol, sodium hyaluronate and xanthan gum are added into an emulsifying pot in the step (1), the temperature is increased to 80-90 ℃, the mixture is stirred until the mixture is completely dissolved, and the temperature is kept for 25-35min to obtain a mixture 1; cooling the mixture 1 to 45-55 ℃, adding PLANT 21N, AERN EX-PHAVA, fibronectin, transdermal polypeptide, oligopeptide-1, bioglycan-1, corn gluten amino acids and D-panthenol, and uniformly stirring to obtain the composition.
10. Use of a skin rejuvenating composition according to any one of claims 1 to 7 or prepared according to the preparation process according to any one of claims 8 to 9 for the preparation of a cosmetic product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110274810.6A CN113018210B (en) | 2021-03-15 | 2021-03-15 | Skin repair composition and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110274810.6A CN113018210B (en) | 2021-03-15 | 2021-03-15 | Skin repair composition and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN113018210A true CN113018210A (en) | 2021-06-25 |
| CN113018210B CN113018210B (en) | 2021-12-28 |
Family
ID=76469161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202110274810.6A Active CN113018210B (en) | 2021-03-15 | 2021-03-15 | Skin repair composition and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN113018210B (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999025369A1 (en) * | 1997-11-17 | 1999-05-27 | Sederma S.A. | Compositions for cosmetic and dermopharmaceutical use containing a plant extract obtained from kava piper methysticum roots |
| CN104666179A (en) * | 2015-02-06 | 2015-06-03 | 广州九美仟惠生物科技有限公司 | Facial mask capable of relieving and repairing weak skin and enhancing skin activity and preparation method of facial mask |
| CN105853301A (en) * | 2016-05-26 | 2016-08-17 | 彭之玉 | Biological polypeptide repairing essence |
| CN109453062A (en) * | 2018-12-07 | 2019-03-12 | 广州天玺生物科技有限公司 | A kind of preparation method of polypeptide anti-wrinkle maintenance essence |
| CN109875910A (en) * | 2019-04-19 | 2019-06-14 | 武汉百思凯瑞生物科技有限公司 | A kind of complex polypeptide nano vesicle and its preparation method and application with skin repair function |
| CN111346033A (en) * | 2020-05-12 | 2020-06-30 | 广州怡嘉生物科技有限公司 | Fibronectin repair water |
| CN111588650A (en) * | 2020-05-26 | 2020-08-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN112402347A (en) * | 2020-12-18 | 2021-02-26 | 东莞市羽馨化妆品有限公司 | Acne-removing repair composition containing fibronectin and preparation method thereof |
-
2021
- 2021-03-15 CN CN202110274810.6A patent/CN113018210B/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999025369A1 (en) * | 1997-11-17 | 1999-05-27 | Sederma S.A. | Compositions for cosmetic and dermopharmaceutical use containing a plant extract obtained from kava piper methysticum roots |
| CN104666179A (en) * | 2015-02-06 | 2015-06-03 | 广州九美仟惠生物科技有限公司 | Facial mask capable of relieving and repairing weak skin and enhancing skin activity and preparation method of facial mask |
| CN105853301A (en) * | 2016-05-26 | 2016-08-17 | 彭之玉 | Biological polypeptide repairing essence |
| CN109453062A (en) * | 2018-12-07 | 2019-03-12 | 广州天玺生物科技有限公司 | A kind of preparation method of polypeptide anti-wrinkle maintenance essence |
| CN109875910A (en) * | 2019-04-19 | 2019-06-14 | 武汉百思凯瑞生物科技有限公司 | A kind of complex polypeptide nano vesicle and its preparation method and application with skin repair function |
| CN111346033A (en) * | 2020-05-12 | 2020-06-30 | 广州怡嘉生物科技有限公司 | Fibronectin repair water |
| CN111588650A (en) * | 2020-05-26 | 2020-08-28 | 合肥卡迪尔生物科技有限公司 | Repairing composition, repairing mask liquid and repairing mask |
| CN112402347A (en) * | 2020-12-18 | 2021-02-26 | 东莞市羽馨化妆品有限公司 | Acne-removing repair composition containing fibronectin and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN113018210B (en) | 2021-12-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105125476B (en) | A kind of anti-wrinkle essence and preparation method thereof | |
| CN104173251B (en) | A kind of bone glue of yak former peptide cleawhite pack and preparation method thereof | |
| CN110882207B (en) | Preparation process and method of essence for skin repair | |
| CN111388346A (en) | Freeze-dried powder live mask with vegetable protein and polypeptide formula and preparation method thereof | |
| CN109953926B (en) | Skin care product with five-vitamin anti-wrinkle and anti-aging effects and preparation method thereof | |
| CN111228130B (en) | Composition with skin cell energy stimulating and skin barrier repairing effects and preparation method and application thereof | |
| CN113368018A (en) | Anti-inflammatory acne-removing composition and preparation method thereof | |
| CN108042436B (en) | Anti-aging and moisturizing blue copper peptide essence cream | |
| CN114712275A (en) | Anti-wrinkle repair composition and preparation method thereof, and cosmetic and preparation method thereof | |
| CN111067852A (en) | Essence containing polypeptide and preparation method thereof | |
| CN107753357A (en) | Toning lotion containing stem cell secretion factors | |
| CN114288221A (en) | A method for preparing essence containing polypeptide and plant extractive solution with hair growth promoting effect and its application | |
| CN109528592A (en) | Facial mask and preparation method thereof is repaired in a kind of moisturizing whitening | |
| CN113018210B (en) | Skin repair composition and preparation method and application thereof | |
| CN107648585A (en) | A kind of anti-ageing anti-wrinkle Essence containing white fungus, aurantiamarin and soluble protein | |
| CN112370411A (en) | Whitening and repairing essence and preparation method thereof | |
| CN112773761A (en) | Cosmetic composition, essence and preparation method thereof | |
| CN108210442A (en) | Skin care compositions of mild high nutrition and its preparation method and application | |
| CN116035982A (en) | Marine biological activity repair cream | |
| CN115006295B (en) | Anti-aging composition, preparation method and application thereof in preparation of anti-aging cosmetics | |
| CN110882177A (en) | Skin repair oligopeptide composition and preparation method thereof | |
| CN109662926A (en) | A kind of polywater moisturizing essence dew and preparation method thereof | |
| CN113797153A (en) | Composition for effectively relieving skin allergy red blood streak and preparation method and application thereof | |
| CN113662876A (en) | Polypeptide beautifying essence and preparation method thereof | |
| CN111053721B (en) | Silky glowing eye cream and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20231121 Address after: 510000, 3rd and 4th floors, Building A, No. 5 Longxing East Road, Taihe Town, Baiyun District, Guangzhou City, Guangdong Province Patentee after: Guangzhou yanzhibao Cosmetics Co.,Ltd. Address before: 510163 2nd floor, No.41, Yingbin Road, Shangyu village, Luopu street, Panyu District, Guangzhou City, Guangdong Province (Location: Shop 213) Patentee before: Jiyuan spoon (Guangdong) skin Management Technology Co.,Ltd. |