CN113015715A - 铁催化选择性由醛制备甲酯 - Google Patents
铁催化选择性由醛制备甲酯 Download PDFInfo
- Publication number
- CN113015715A CN113015715A CN201980074542.4A CN201980074542A CN113015715A CN 113015715 A CN113015715 A CN 113015715A CN 201980074542 A CN201980074542 A CN 201980074542A CN 113015715 A CN113015715 A CN 113015715A
- Authority
- CN
- China
- Prior art keywords
- catalyst
- aldehydes
- methyl
- methyl esters
- methanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 title claims abstract description 36
- 229910052742 iron Inorganic materials 0.000 title claims abstract description 18
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- 150000004702 methyl esters Chemical class 0.000 title abstract description 14
- 150000001299 aldehydes Chemical class 0.000 title description 12
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims abstract description 71
- 239000003054 catalyst Substances 0.000 claims abstract description 32
- 238000000034 method Methods 0.000 claims abstract description 12
- 150000001298 alcohols Chemical class 0.000 claims abstract description 7
- 125000001931 aliphatic group Chemical group 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 13
- 150000002148 esters Chemical class 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 125000002723 alicyclic group Chemical group 0.000 claims description 2
- 238000010438 heat treatment Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 claims 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 abstract description 16
- 230000015572 biosynthetic process Effects 0.000 abstract description 12
- 238000005859 coupling reaction Methods 0.000 abstract description 10
- 230000008878 coupling Effects 0.000 abstract description 8
- 238000010168 coupling process Methods 0.000 abstract description 8
- 150000003934 aromatic aldehydes Chemical class 0.000 abstract description 5
- YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 21
- KICUISADAVMYCJ-UHFFFAOYSA-N methyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OC KICUISADAVMYCJ-UHFFFAOYSA-N 0.000 description 10
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
- 239000004809 Teflon Substances 0.000 description 8
- 229920006362 Teflon® Polymers 0.000 description 8
- PYLMCYQHBRSDND-UHFFFAOYSA-N 2-ethyl-2-hexenal Chemical compound CCCC=C(CC)C=O PYLMCYQHBRSDND-UHFFFAOYSA-N 0.000 description 6
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 6
- 230000003197 catalytic effect Effects 0.000 description 5
- -1 ester compounds Chemical class 0.000 description 5
- 239000012299 nitrogen atmosphere Substances 0.000 description 5
- 238000003756 stirring Methods 0.000 description 5
- URLKBWYHVLBVBO-UHFFFAOYSA-N Para-Xylene Chemical group CC1=CC=C(C)C=C1 URLKBWYHVLBVBO-UHFFFAOYSA-N 0.000 description 4
- 239000006227 byproduct Substances 0.000 description 4
- WOZVHXUHUFLZGK-UHFFFAOYSA-N dimethyl terephthalate Chemical compound COC(=O)C1=CC=C(C(=O)OC)C=C1 WOZVHXUHUFLZGK-UHFFFAOYSA-N 0.000 description 4
- 239000007788 liquid Substances 0.000 description 4
- QPJVMBTYPHYUOC-UHFFFAOYSA-N methyl benzoate Chemical compound COC(=O)C1=CC=CC=C1 QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 4
- PYLMCYQHBRSDND-VURMDHGXSA-N (Z)-2-ethyl-2-hexenal Chemical compound CCC\C=C(\CC)C=O PYLMCYQHBRSDND-VURMDHGXSA-N 0.000 description 3
- LGYNIFWIKSEESD-UHFFFAOYSA-N 2-ethylhexanal Chemical compound CCCCC(CC)C=O LGYNIFWIKSEESD-UHFFFAOYSA-N 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 238000006356 dehydrogenation reaction Methods 0.000 description 3
- 238000002290 gas chromatography-mass spectrometry Methods 0.000 description 3
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 3
- 230000009257 reactivity Effects 0.000 description 3
- 239000003039 volatile agent Substances 0.000 description 3
- SPEUIVXLLWOEMJ-UHFFFAOYSA-N 1,1-dimethoxyethane Chemical compound COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 2
- OUCGJMIVSYHBEC-UHFFFAOYSA-N 2-ethylhexyl 2-ethylhexanoate Chemical compound CCCCC(CC)COC(=O)C(CC)CCCC OUCGJMIVSYHBEC-UHFFFAOYSA-N 0.000 description 2
- 238000006555 catalytic reaction Methods 0.000 description 2
- AUHZEENZYGFFBQ-UHFFFAOYSA-N mesitylene Substances CC1=CC(C)=CC(C)=C1 AUHZEENZYGFFBQ-UHFFFAOYSA-N 0.000 description 2
- 125000001827 mesitylenyl group Chemical group [H]C1=C(C(*)=C(C([H])=C1C([H])([H])[H])C([H])([H])[H])C([H])([H])[H] 0.000 description 2
- 229940095102 methyl benzoate Drugs 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000000758 substrate Substances 0.000 description 2
- CABSVPYOYMDJNZ-UHFFFAOYSA-N C(CCCCCCCCCCC)[Fe] Chemical compound C(CCCCCCCCCCC)[Fe] CABSVPYOYMDJNZ-UHFFFAOYSA-N 0.000 description 1
- 229910021640 Iridium dichloride Inorganic materials 0.000 description 1
- 238000004639 Schlenk technique Methods 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- PLGPSDNOLCVGSS-UHFFFAOYSA-N Tetraphenylcyclopentadienone Chemical compound O=C1C(C=2C=CC=CC=2)=C(C=2C=CC=CC=2)C(C=2C=CC=CC=2)=C1C1=CC=CC=C1 PLGPSDNOLCVGSS-UHFFFAOYSA-N 0.000 description 1
- 239000003849 aromatic solvent Substances 0.000 description 1
- NQZFAUXPNWSLBI-UHFFFAOYSA-N carbon monoxide;ruthenium Chemical compound [Ru].[Ru].[Ru].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-].[O+]#[C-] NQZFAUXPNWSLBI-UHFFFAOYSA-N 0.000 description 1
- 230000006315 carbonylation Effects 0.000 description 1
- 238000005810 carbonylation reaction Methods 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 238000007036 catalytic synthesis reaction Methods 0.000 description 1
- 210000000080 chela (arthropods) Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000006880 cross-coupling reaction Methods 0.000 description 1
- UHOVQNZJYSORNB-MICDWDOJSA-N deuteriobenzene Chemical compound [2H]C1=CC=CC=C1 UHOVQNZJYSORNB-MICDWDOJSA-N 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 125000000524 functional group Chemical group 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000004636 glovebox technique Methods 0.000 description 1
- 239000002638 heterogeneous catalyst Substances 0.000 description 1
- 238000009815 homocoupling reaction Methods 0.000 description 1
- 239000002815 homogeneous catalyst Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- CJTCBBYSPFAVFL-UHFFFAOYSA-N iridium ruthenium Chemical compound [Ru].[Ir] CJTCBBYSPFAVFL-UHFFFAOYSA-N 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 239000002808 molecular sieve Substances 0.000 description 1
- COCAUCFPFHUGAA-MGNBDDOMSA-N n-[3-[(1s,7s)-5-amino-4-thia-6-azabicyclo[5.1.0]oct-5-en-7-yl]-4-fluorophenyl]-5-chloropyridine-2-carboxamide Chemical compound C=1C=C(F)C([C@@]23N=C(SCC[C@@H]2C3)N)=CC=1NC(=O)C1=CC=C(Cl)C=N1 COCAUCFPFHUGAA-MGNBDDOMSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 150000002902 organometallic compounds Chemical class 0.000 description 1
- 239000007800 oxidant agent Substances 0.000 description 1
- WQIQNKQYEUMPBM-UHFFFAOYSA-N pentamethylcyclopentadiene Chemical compound CC1C(C)=C(C)C(C)=C1C WQIQNKQYEUMPBM-UHFFFAOYSA-N 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000013557 residual solvent Substances 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 239000011997 shvo catalyst Substances 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- KUCOHFSKRZZVRO-UHFFFAOYSA-N terephthalaldehyde Chemical compound O=CC1=CC=C(C=O)C=C1 KUCOHFSKRZZVRO-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/22—Organic complexes
- B01J31/2282—Unsaturated compounds used as ligands
- B01J31/2295—Cyclic compounds, e.g. cyclopentadienyls
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/44—Preparation of carboxylic acid esters by oxidation-reduction of aldehydes, e.g. Tishchenko reaction
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/02—Iron compounds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
- B01J2231/70—Oxidation reactions, e.g. epoxidation, (di)hydroxylation, dehydrogenation and analogues
- B01J2231/76—Dehydrogenation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2531/00—Additional information regarding catalytic systems classified in B01J31/00
- B01J2531/80—Complexes comprising metals of Group VIII as the central metal
- B01J2531/84—Metals of the iron group
- B01J2531/842—Iron
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2540/00—Compositional aspects of coordination complexes or ligands in catalyst systems
- B01J2540/10—Non-coordinating groups comprising only oxygen beside carbon or hydrogen
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
- B01J31/16—Catalysts comprising hydrides, coordination complexes or organic compounds containing coordination complexes
- B01J31/20—Carbonyls
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/003—Esters of saturated alcohols having the esterified hydroxy group bound to an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/013—Esters of alcohols having the esterified hydroxy group bound to a carbon atom of a ring other than a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
提供了一种以高产率制备甲酯的方法。该方法包括使脂族或芳族醛和甲醇与铁催化剂接触,以催化脂族或芳族醛和甲醇之间的脱氢偶联。该反应对甲酯的形成相对于单酯和醇具有高度选择性(<99.9%),并且在低于100℃的温度下操作2至8小时。
Description
技术领域
本发明总体上涉及有机化学领域。本发明特别涉及使用新型铁基催化剂由醛制备甲酯。
背景技术
酯是化学中最重要和丰富的官能团之一,并且它们广泛地应用于食品、药物、香料以及精细和散装化学工业中。存在一些经典的方法,例如与羧酸衍生物的反应、羰基化和Tischenko反应,它们可用于制备酯化合物。在外部氧化剂存在下醛与醇的偶联和两种醇的偶联也可形成酯。另一种方法是两种醇或醛与醇的脱氢偶联,释放H2。
已经报道了醇的无受体脱氢自偶联(acceptorless dehydrogenative homo-coupling),然而仍然需要允许醛与甲醇的化学选择性脱氢交叉偶联以高产率(yield)和适度选择性得到相应甲酯的催化方法。
本发明解决这种需要以及其它需要,这将从下面的描述和所附权利要求中变得显而易见。
发明内容
本发明在所附权利要求中阐述。
在一个实施例中,本发明是一种用于制备酯的方法,包括:
a)将具有式R1CO的醛与具有式R2OH的醇混合以形成第一混合物;
b)在铁催化剂存在下加热第一混合物,以形成具有式R1COR2O的酯和H2;
其中R1为C4至C8脂族、脂环族或芳族基团,并且其中R2为C1至C4基团。
在另一个实施例中,催化剂具有结构(1):
已经令人惊奇地发现,铁催化剂在温和条件(<100℃)下通过2-乙基己烯醛(2-EHenal)和MeOH之间的反应来介导2-乙基己酸甲酯的选择性形成。我们还证明当使用2-HEH作为原料时,产生等摩尔的2-EHMe和2-EH醇的混合物。
具体实施方式
如本文所用,以下术语具有如下所述的含义:
术语“M2EH”是指2-乙基己酸甲酯(methyl-2-ethylhexanoate)。
术语“TEG”是指三甘醇(triethylene glycol)。
术语“TEG-2EH”是指三甘醇2-乙基己酸酯(triethylene glycol2-ethylhexanoate)。
术语“2-HEH”是指2-乙基己醛(2-ethylhexaldehyde)。
术语“MeOH”是指甲醇。
术语“2-EHMe”是指2-乙基己酸甲酯(methyl 2-ethylhexanoate)。
术语“2EH”是指2-乙基己醇(2-ethylhexyl alcohol)。
术语“2EH2EH”是指(2-乙基己基)2-乙基己酸酯((2-ethylhexyl)2-ethylhexanoate)。
如本文所用,不定冠词“一”和“一个”是指一个或多个,除非上下文另外明确地暗示。类似地,名词的单数形式包括其复数形式,反之亦然,除非上下文清楚地另外暗示。
尽管已经做出了精确的尝试,但是本文所述的数值和范围应当被认为是近似值(即使当不被术语“约”限定时)。这些值和范围可以根据本发明寻求获得的所需性能以及由测量技术中发现的标准偏差产生的变化而不同于它们的规定数值。此外,本文所述的范围旨在并且具体地预期包括所述范围内的所有子范围和值。例如,0至100的范围旨在描述和包括该范围内的所有值,包括子范围,例如0.1-99.9、60至90和70至80。
我们检测了用2-乙基己醛(2-HEH)和甲醇(MeOH)的反应(表1)。在没有催化剂的情况下,使2-乙基己醛与过量MeOH(5当量)反应,在90℃下在MeOH中将醛转化成二甲基缩醛。在无催化剂条件下,没有观察到酯形成。接着,筛选几种均相催化剂以促进形成相应的甲酯(2-乙基己酸甲酯)。这些结果总结于表1中。在这些反应中,简单的金属前体络合物,例如[Cp*RhCl2]2、[Cp*IrCl2]2、Ru3(CO)12(Cp*=1,2,3,4,5-五甲基环戊二烯),不能产生2-乙基己酸甲酯(条目1至3),仅生成微量的2-乙基己醇。由钳型配体负载的钌基和铱基均相脱氢催化剂也显示出对形成2-EHMe可忽略的反应性和选择性。例如,Milstein的(PNN)Ru(H)(CO)Cl催化剂在KOH存在下以1:1.2的相对比例提供2-EHMe和2-乙基己醇(2-EH),并且在90℃下6小时后2-HEH的总转化率达到22%(条目4)。在该反应期间,还形成相当大量的(11%)2-HEH醛、(2-乙基己基)2-乙基己酸酯(2EH2EH)的单酯(homoester)。除了Milstein催化剂之外,Takasago的Ru-MACHO催化剂提供了2-EH和2EH2EH作为主要产物,并且仅产生了少量2-EHMe(条目5)。
表1:2EH-MeOH偶联反应的催化剂筛选研究
本发明可以通过其优选实施例的以下实施例进一步举例说明,但是应当理解,除非另外具体指出,这些实施例仅仅是为了举例说明的目的而包括的,并且不旨在限制本发明的范围。
示例
通用实验资料
除非另有说明,所有有机金属化合物都在氮气氛下使用标准Schlenk和手套箱技术处理。无水甲醇(99.7%等级)、甲苯、对二甲苯、Aromatic 200和均三甲苯(98%)购自商业来源,并与分子筛一起储存。所有醛均购自商业来源并在使用前新鲜地真空蒸馏。其他可商购的催化剂购自各自的商业来源,并在使用时没有进一步提纯。1H NMR光谱在Bruker Avance-500 MHz光谱仪上记录。1H NMR光谱中的化学位移值内部参考残余溶剂共振(residual solvent resonance)(苯-d6为δ7.16)。铁催化剂使用文献程序(方案1)制备。
合成铁催化剂(1),方案3。
在氮气氛下,在装有冷凝器和搅拌棒的500mL施兰克瓶(Schlenk flask)中加入十二羰基铁、四苯基环戊二烯酮和200mL无水甲苯。将所得混合物加热至80℃ 20小时,冷却至室温,使混合物通过硅胶柱,以洗脱所需催化剂,为橙黄色液体。蒸发溶剂得到产物,分离产率为86%。
由2-乙基己醛合成2-乙基己酸甲酯。
在氮气氛下,向装有磁力搅拌棒和特氟龙塞(Teflon plug)的烘箱干燥的25mL施兰克管中加入铁催化剂(1mol%)、2-乙基己醛(2-HEH)(1.6mL,10mmol)和无水甲醇(2mL)。使用油浴在90℃加热所得混合物3小时。然后使容器逐渐达到室温,并通过打开在罩子内的特氟龙塞小心除去挥发物(H2,MeOH蒸气)。通过GC和GC-MS分析液体样品以测定2-乙基己酸甲酯的产率并鉴定副产物。
由2-EHenal合成2-乙基己酸甲酯。
在氮气氛下,向装有磁力搅拌棒和特氟龙塞的烘箱干燥的100mL施兰克管中加入铁催化剂(1mol%)、2-乙基-2-己烯醛(2EHenal)(1.57mL,10mmol)和无水甲醇(2mL)。使用油浴在90℃加热所得混合物3小时。然后使容器逐渐达到室温,并通过打开在罩子内的特氟龙塞小心除去挥发物(H2,MeOH蒸气)。通过GC和GC-MS分析液体样品以测定2-乙基己酸甲酯的产率(97.8重量%)并鉴定其它副产物。
由苯甲醛合成苯甲酸甲酯。
在氮气氛下,向装有磁力搅拌棒和特氟龙塞(Teflon plug)的烘箱干燥的100mL施兰克管中加入铁催化剂(1.0mol%)、苯甲醛(1.35g,10mmol,99%纯度)和无水甲醇(2mL)。使用油浴在90℃加热所得混合物3小时。然后使容器逐渐达到室温,并通过打开在罩子内的特氟龙塞小心除去挥发物(H2,MeOH蒸气)。通过GC和GC-MS分析液体样品以测定苯甲酸甲酯的产率并鉴定洽谈副产物。
总之,我们已经证明Shvo催化剂催化脂族或芳族醛与MeOH之间的脱氢偶联,以高产率得到相应的甲酯。该反应对甲酯的形成具有高度选择性(高达<99.9%),并且在温和条件(<100℃,2-8小时)下操作。在几次催化运行后,催化剂的催化活性和结构保持不变。下面所示的铁催化剂(1)对由相应的醛经由与MeOH偶联形成甲酯表现出优异的反应性和选择性。当在90℃下,在1mol%的(μ4-CpMe4)Fe(CO)3催化剂(1)存在下用五当量MeOH处理一当量2-EH时,3小时后形成含有比率为50:45的2-EHMe和2-EH的混合物(表2,条目1)。反应后没有残留起始醛,表明100%的醛转化率。在该反应中还产生了作为副产物的痕量2EH2EH和不饱和2-EH甲酯。催化反应也可以在非极性芳族溶剂如甲苯、对二甲苯、均三甲苯和Aromatic200中进行,而不影响反应性和选择性。
表2:由醛铁催化合成甲酯。a
a催化条件:[催化剂]=0.025(M),[醛]=2.5(M),MeOH=25mmol,1mL,纯净条件,搅拌速度=350rpm,90℃(油浴温度)。
我们已经证明,铁催化剂(1)催化脂族或芳族醛与MeOH的脱氢偶联,以中到高的产率得到相应的甲酯。当使用含有内部C=C键的底物并且反应在温和条件(<100℃,2-8小时)下操作时,反应对于甲酯的形成是化学选择性的。实验表明,催化剂(1)的催化活性和结构在两次催化运行后保持不变。
值得注意的是,2-EHenal和MeOH之间的偶联反应以89.2%的产率产生饱和的2-乙基己酸甲酯(表2,条目2)。剩余的材料是未反应的2EHenal、2EH2EH、不饱和酯和2-EH。该结果表明在铁催化剂存在下,在第一个2EHenal-甲醇偶联步骤中产生的H2气体用于氢化C=C双键。2-EHenal与甲醇的直接偶联是重要的发现,因为它消除了通过用多相催化剂氢化由2-EHenal制备2-HEH的反应步骤(方案1)。除了脂肪族底物之外,芳香醛如苯甲醛也以约56%的产率获得相应的甲酯。该反应可用于使用对苯二甲醛作为试剂的对苯二甲酸二甲酯(DMT)合成。
在说明书中,已经公开了本发明的某些实施例,并且尽管采用了特定术语,但是它们仅以一般性和描述性意义使用,而不是为了限制的目的,本发明的范围在所附权利要求中阐述。
Claims (8)
1.一种制备酯的方法,包括:
a)将具有式R1CO的醛与具有式R2OH的醇混合以形成第一混合物;
b)在铁催化剂存在下加热所述第一混合物,以形成具有式R1COR2O的酯和H2;
其中R1为C4至C8脂族、脂环族或芳族基团,并且其中R2为C1至C4基团。
2.根据权利要求1所述的方法,其中,R2选自甲醇、乙醇、丙醇、异丙醇、丁醇、异丁醇和乙二醇。
3.根据权利要求1所述的方法,其中,R2是甲醇。
4.根据权利要求1所述的方法,其中,步骤b在低于100℃的温度下进行约2小时至约8小时。
5.根据权利要求1所述的方法,其中,在所述第一混合物中R1CO与R2OH的摩尔比为1:1至1:5。
6.根据权利要求1所述的方法,其中,所述第一混合物中催化剂的摩尔量为约0.25摩尔%至约1摩尔%。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US16/188,976 | 2018-11-13 | ||
US16/188,976 US10590062B1 (en) | 2018-11-13 | 2018-11-13 | Iron-catalyzed selective production of methyl esters from aldehydes |
PCT/US2019/060818 WO2020102126A1 (en) | 2018-11-13 | 2019-11-12 | Iron-catalyzed selective production of methyl esters from aldehydes |
Publications (1)
Publication Number | Publication Date |
---|---|
CN113015715A true CN113015715A (zh) | 2021-06-22 |
Family
ID=68848373
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201980074542.4A Pending CN113015715A (zh) | 2018-11-13 | 2019-11-12 | 铁催化选择性由醛制备甲酯 |
Country Status (4)
Country | Link |
---|---|
US (1) | US10590062B1 (zh) |
EP (1) | EP3880647A1 (zh) |
CN (1) | CN113015715A (zh) |
WO (1) | WO2020102126A1 (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3880645A1 (en) | 2018-11-13 | 2021-09-22 | Eastman Chemical Company | Ester synthesis using heterogeneous au/tio2catalyst |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5750942A (en) * | 1980-09-12 | 1982-03-25 | Japan Synthetic Rubber Co Ltd | Preparation of carboxylic ester |
JPS5750941A (en) * | 1980-09-12 | 1982-03-25 | Japan Synthetic Rubber Co Ltd | Preparation of carboxylic ester |
CN106163662A (zh) * | 2014-03-31 | 2016-11-23 | 宝洁公司 | 酯采用铁络合物作为催化剂的均相氢化 |
CN107531611A (zh) * | 2015-04-07 | 2018-01-02 | 伊士曼化工公司 | 使用均相催化剂来生产两种酯 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB885514A (en) * | 1957-01-18 | 1961-12-28 | Union Carbide Corp | Acetylene transition metal carbonyl derivatives |
JPH0899933A (ja) | 1994-09-29 | 1996-04-16 | Mitsubishi Chem Corp | メタクリル酸エステルの製造法 |
JPH09216850A (ja) * | 1996-02-09 | 1997-08-19 | Mitsubishi Rayon Co Ltd | カルボン酸エステルの製造方法 |
JPH1143463A (ja) * | 1997-07-30 | 1999-02-16 | Mitsubishi Rayon Co Ltd | カルボン酸エステルの製造方法 |
US6278006B1 (en) | 1999-01-19 | 2001-08-21 | Cargill, Incorporated | Transesterified oils |
JP2001220367A (ja) | 2000-02-09 | 2001-08-14 | Asahi Kasei Corp | カルボン酸エステルの製造方法および製造用触媒 |
US20100317824A1 (en) | 2009-06-15 | 2010-12-16 | Dow Global Technologies Inc. | Polyether derivatives of secondary hydroxy fatty acids and derivatives thereof |
DE102012018207A1 (de) | 2012-09-14 | 2014-03-20 | Oxea Gmbh | Verfahren zur Herstelluna von Polyolestern |
-
2018
- 2018-11-13 US US16/188,976 patent/US10590062B1/en active Active
-
2019
- 2019-11-12 WO PCT/US2019/060818 patent/WO2020102126A1/en unknown
- 2019-11-12 CN CN201980074542.4A patent/CN113015715A/zh active Pending
- 2019-11-12 EP EP19818316.2A patent/EP3880647A1/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5750942A (en) * | 1980-09-12 | 1982-03-25 | Japan Synthetic Rubber Co Ltd | Preparation of carboxylic ester |
JPS5750941A (en) * | 1980-09-12 | 1982-03-25 | Japan Synthetic Rubber Co Ltd | Preparation of carboxylic ester |
CN106163662A (zh) * | 2014-03-31 | 2016-11-23 | 宝洁公司 | 酯采用铁络合物作为催化剂的均相氢化 |
CN107531611A (zh) * | 2015-04-07 | 2018-01-02 | 伊士曼化工公司 | 使用均相催化剂来生产两种酯 |
Non-Patent Citations (1)
Title |
---|
TARN C. JOHNSON ET AL.: ""(Cyclopentadienone)iron Shvo Complexes: Synthesis and Applications to Hydrogen Transfer Reactions"", 《ORGANOMETALLICS》, vol. 30, no. 9, pages 1859 - 1868, XP002671677, DOI: 10.1021/om101101r * |
Also Published As
Publication number | Publication date |
---|---|
WO2020102126A1 (en) | 2020-05-22 |
US10590062B1 (en) | 2020-03-17 |
EP3880647A1 (en) | 2021-09-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FR2490216A1 (fr) | Procede de preparation d'ethers glycoliques | |
JP6101636B2 (ja) | バナジウム錯体を用いたファルネサールの製造方法 | |
CN110835343A (zh) | 一种含p、n多孔有机笼配体及其制备和应用 | |
JP3556686B2 (ja) | ヒドロホルミル化法およびそのためのバイメタル触媒 | |
JP2015523979A (ja) | アルデヒドを調製するための触媒及び方法 | |
CN113015715A (zh) | 铁催化选择性由醛制备甲酯 | |
JPH11100339A (ja) | トリシクロデカンジメタノールの製造法 | |
CN110605145B (zh) | 一种氢甲酯化反应催化剂及制备异壬酸的方法 | |
CN112996767A (zh) | 生产酯的方法 | |
JPH1180068A (ja) | トリシクロデカンジアルデヒドの製造方法 | |
JP3482371B2 (ja) | エポキシド誘導体のカルボニル化方法 | |
KR20010112941A (ko) | 푸마르산에스테르류의 제조방법 | |
US20140371493A1 (en) | Methods of converting polyols | |
Estorach et al. | Hydroesterification of 1-alkenes in Supercritical Carbon dioxide | |
EP2994450B1 (en) | Process of production of dehydrolinalyl acetate (ii) | |
JP7343501B2 (ja) | 有機化合物における、または、それに関連する改善 | |
CN110156837B (zh) | 用于烷氧羰基化的丙基桥联的二膦配体 | |
JP4290229B2 (ja) | 2−ヒドロキシ−4−メチルテトラヒドロフランの製造方法 | |
CN111484388B (zh) | 一种1,5-二烯衍生物的合成方法 | |
JPH046692B2 (zh) | ||
RU2313527C1 (ru) | Способ получения 1,7,8,9-тетраалкил-4-окса-10-магнезатрицикло[5.2.1.02,6]дец-8-ен-3,5-дионов | |
RU2313529C1 (ru) | Способ получения 1,7,8,9-тетраалкил-4-метил-4-аза-10-магнезатрицикло[5.2.1.02,6]дец-8-ен-3,5-дионов | |
CN112996766A (zh) | 三甘醇双(2-乙基己酸酯)的合成 | |
WO2023210296A1 (ja) | アルコールの製造方法 | |
KR20220037341A (ko) | 알데히드의 제조방법 및 알데히드의 제조장치 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination |