CN112912493A - 用于治疗癌症的嵌合抗原受体t细胞(car-t) - Google Patents

用于治疗癌症的嵌合抗原受体t细胞(car-t) Download PDF

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CN112912493A
CN112912493A CN201980050879.1A CN201980050879A CN112912493A CN 112912493 A CN112912493 A CN 112912493A CN 201980050879 A CN201980050879 A CN 201980050879A CN 112912493 A CN112912493 A CN 112912493A
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cell
car
tcar
cells
seq
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J·F·迪珀西奥
M·库珀
J·奥尼尔
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University of Washington
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University of Washington
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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CN201980050879.1A 2018-05-31 2019-05-31 用于治疗癌症的嵌合抗原受体t细胞(car-t) Pending CN112912493A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862678878P 2018-05-31 2018-05-31
US62/678878 2018-05-31
US201962799513P 2019-01-31 2019-01-31
US62/799513 2019-01-31
PCT/US2019/035010 WO2019232444A1 (en) 2018-05-31 2019-05-31 Chimeric antigen receptor t cells (car-t) for the treatment of cancer

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CN112912493A true CN112912493A (zh) 2021-06-04

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US (2) US20200071397A1 (https=)
EP (1) EP3802798A4 (https=)
JP (2) JP7542854B2 (https=)
KR (1) KR102921474B1 (https=)
CN (1) CN112912493A (https=)
AU (2) AU2019279021A1 (https=)
CA (1) CA3101505A1 (https=)
IL (1) IL279063B1 (https=)
SG (1) SG11202011383VA (https=)
WO (1) WO2019232444A1 (https=)

Cited By (8)

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CN114317607A (zh) * 2021-12-31 2022-04-12 西安桑尼赛尔生物医药有限公司 融合一代靶向cd7 car和二代靶向bcma的双靶点通用car-t细胞及制备方法
CN114369622A (zh) * 2021-12-31 2022-04-19 西安桑尼赛尔生物医药有限公司 同时靶向cd7和cd19的双特异通用型car-t细胞及其制备方法
CN116284435A (zh) * 2022-09-19 2023-06-23 卡瑞济(北京)生命科技有限公司 EGFRvIII嵌合抗原受体及其用途
CN117866110A (zh) * 2023-12-27 2024-04-12 广东唯泰生物科技有限公司 一种靶向flt-3的第四代嵌合抗原受体及其应用
WO2025002315A1 (zh) * 2023-06-29 2025-01-02 上海细胞治疗集团股份有限公司 一种评估car产生细胞免疫应答的方法
WO2025030965A1 (en) * 2023-08-10 2025-02-13 Gracell Biotechnologies (Shanghai) Co., Ltd. Use of dual-target car-t cells in treating b-cell autoimmune diseases
CN119685260A (zh) * 2024-12-17 2025-03-25 上海交通大学医学院附属瑞金医院 一种具有新型穿膜区的嵌合抗原受体t细胞及其应用
WO2025237403A1 (zh) * 2024-05-16 2025-11-20 浙江大学 靶向整合素αVβ6的CAR-免疫细胞在预防和/或治疗纤维化疾病中的应用

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EP4400516A1 (en) 2014-12-15 2024-07-17 The Regents of the University of California Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20
EP3234120B1 (en) 2014-12-15 2025-09-03 The Regents of the University of California Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing
DK3368571T5 (da) 2015-10-30 2024-09-30 Univ California Transformerende, vækstfaktor-beta-responsive polypeptider og fremgangsmåder til anvendelse deraf
NZ750256A (en) 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
CN108395482B (zh) 2017-02-08 2021-02-05 西比曼生物科技（香港）有限公司 一种靶向cd20抗原嵌合抗原受体的构建及其工程化t细胞的活性鉴定
CA3287539A1 (en) 2017-06-21 2026-03-02 Icell Gene Therapeutics Llc CHIMERIC ANTIGEN RECEPTORS (CARs), COMPOSITIONS AND METHODS THEREOF
CN110616188B (zh) * 2018-06-20 2023-05-09 上海隆耀生物科技有限公司 一种通用型car-t细胞及其制备方法和应用
US12359169B2 (en) 2018-06-20 2025-07-15 Shanghai Longyao Biotechnology Inc., Ltd. Universal CAR-T cell and preparation method and use thereof
SG11202104524YA (en) 2018-11-01 2021-05-28 Gracell Biotechnologies Shanghai Co Ltd Compositions and methods for t cell engineering
CA3139346A1 (en) 2019-05-07 2020-11-12 Gracell Biotechnologies (Shanghai) Co., Ltd. Engineered immune cell targeting bcma and use thereof
IL322315A (en) 2019-05-14 2025-09-01 Provention Bio Inc Methods and preparations for preventing type 1 diabetes
CA3154389A1 (en) * 2019-09-13 2021-03-18 Memorial Sloan-Kettering Cancer Center Antigen recognizing receptors targeting cd371 and uses thereof
CN113402612A (zh) 2020-03-17 2021-09-17 西比曼生物科技（香港）有限公司 靶向cd19和cd20的联合嵌合抗原受体及其应用
CN115443140A (zh) * 2020-04-02 2022-12-06 苏州恒康生命科学有限公司 人ror-1抗体和抗ror-1-car-t细胞
AU2021287998B2 (en) 2020-06-11 2026-03-12 Benaroya Research Institute At Virginia Mason Methods and compositions for preventing type 1 diabetes
CN113214396B (zh) * 2020-07-31 2022-04-19 北京市神经外科研究所 抗tim3的单链抗体及其在制备治疗肿瘤的药物中的用途
WO2022056459A1 (en) * 2020-09-14 2022-03-17 Vor Biopharma, Inc. Compositions and methods for cd5 modification
EP4232465A4 (en) * 2020-10-26 2024-10-23 Memorial Sloan Kettering Cancer Center Cells with cd70 knockout and uses for immunotherapy
WO2022098756A1 (en) * 2020-11-03 2022-05-12 WUGEN, Inc. Chimeric antigen receptor cell therapy
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KR102824136B1 (ko) * 2021-04-05 2025-06-25 주식회사 셀렌진 Pdcd-1 유전자에 상보적인 가이드 rna 및 이의 용도
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