CN112858661B - Sample detection system and sample analyzer - Google Patents
Sample detection system and sample analyzer Download PDFInfo
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- CN112858661B CN112858661B CN201911193465.2A CN201911193465A CN112858661B CN 112858661 B CN112858661 B CN 112858661B CN 201911193465 A CN201911193465 A CN 201911193465A CN 112858661 B CN112858661 B CN 112858661B
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/533—Production of labelled immunochemicals with fluorescent label
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
- G01N2021/0106—General arrangement of respective parts
- G01N2021/0112—Apparatus in one mechanical, optical or electronic block
Abstract
The application discloses sample detecting system and sample analysis appearance, this sample detecting system includes: the sheath liquid interface is used for connecting a sheath liquid container to provide sheath liquid; detection mechanism is used for detecting the sample that awaits measuring, includes: a sheath fluid inlet connected to the sheath fluid port for receiving sheath fluid from the sheath fluid container through the sheath fluid port; a sample inlet for receiving a sample to be tested; the detection area is used for receiving sheath liquid entering from the sheath liquid inlet and a sample to be detected entering from the sample inlet so as to detect the sample to be detected; the first filter, set up in sheath liquid interface and between the sheath liquid entry, be used for after the process sheath liquid interface and get into before the sheath liquid entry is right the sheath liquid filters. By means of the method, the sensitivity and the accuracy of the sample detection result can be improved.
Description
Technical Field
The present application relates to the field of medical device technology, and in particular, to a sample testing system and a sample analyzer.
Background
The fluorescence immunoassay technology is a rapid detection technology commonly used in biomedical inspection, and has the main advantages of strong specificity, high sensitivity, high speed and the like.
However, in actual detection, bubbles, impurities and the like are often carried in the sheath fluid used for detection due to some reasons, so that more background signals appear during detection, and the sensitivity and accuracy of a sample detection result are affected.
Disclosure of Invention
The technical problem that this application mainly solved provides a sample detecting system and sample analysis appearance, sensitivity, the accuracy that can sample testing result.
In order to solve the technical problem, the application adopts a technical scheme that: providing a sheath fluid interface, a detection mechanism and a first filter, wherein the sheath fluid interface is used for connecting a sheath fluid container to provide sheath fluid; detection mechanism is used for detecting the sample that awaits measuring, includes: a sheath fluid inlet connected to the sheath fluid port for receiving sheath fluid from the sheath fluid container through the sheath fluid port; a sample inlet for receiving a sample to be tested; the detection area is used for receiving sheath liquid entering from the sheath liquid inlet and a sample to be detected entering from the sample inlet so as to detect the sample to be detected; the first filter, set up in sheath liquid interface and between the sheath liquid entry, be used for after the process sheath liquid interface and get into before the sheath liquid entry is right the sheath liquid filters.
In order to solve the above technical problem, another technical solution adopted by the present application is: there is provided a sample analyser comprising a sample detection system as described above.
The beneficial effect of this application is: be different from prior art's condition, this application sample detecting system sets up first filter at sheath liquid interface, filters the sheath liquid that gets into by the sheath liquid interface to detach bubble, the foreign particle that at least part was carried by sheath liquid itself, thereby reduce the influence to the testing result of bubble, foreign particle etc. that sheath liquid itself carried, with sensitivity, the accuracy that improves sample testing result.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the description below are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings without creative efforts. Wherein:
FIG. 1 is a schematic diagram of an embodiment of a sample detection system according to the present application;
FIG. 2 is a schematic diagram of the structure of an embodiment of the sample analyzer of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1, fig. 1 is a schematic structural diagram of an embodiment of a sample detection system according to the present application.
In this embodiment, the sample detection system includes a detection mechanism for detecting a sample to be detected, specifically, the detection mechanism may be a fluorescence detection mechanism 11, and in some application scenarios, the detection mechanism may be a flow-type fluorescence detection mechanism.
The fluorescence detection mechanism 11 may include a sheath fluid inlet 111, a sample inlet 112, a detection zone 113, a flow chamber 114 in communication with the sheath fluid inlet 111, a sample buffer zone 115 in communication with the sample inlet 112 and disposed between the sample inlet 112 and the detection zone 113, and a waste fluid outlet 116 in communication with the detection zone 113.
Specifically, the sheath fluid inlet 111 is configured to receive a sheath fluid, the sample inlet 112 is configured to receive a sample to be detected, and the detection region 113 is configured to receive the sample to be detected entering from the sample inlet 112 and the sheath fluid entering from the sheath fluid inlet 111, so as to detect the sample to be detected under the sheath fluid flow. Specifically, a laser is disposed on one side of the sheath fluid flow, and the particles and the like in the sheath fluid flow are excited by the laser signal and then scatter to generate a fluorescence signal, and the fluorescence signal is further processed by collection, analysis and the like, so as to obtain a detection result.
In the actual detection process, the sheath liquid carries bubbles, impurity particles and the like, so that when the sheath liquid passes through the detection area 113, a background signal is generated, and the background signal affects the sensitivity and accuracy of the detection result, so that the bubbles, the impurity particles and the like in the sheath liquid need to be removed.
Accordingly, in this embodiment, the sample detection system further includes: a sheath fluid interface 12, a sample sucking needle 13, a first filter 14a, a second filter 14b, a first injector 15a, a second injector 15b, a first valve 16a, a second valve 16b, a third valve 16c, a fourth valve 16d, a three-way joint 17, a waste liquid treatment mechanism 18, and the like, as well as pipelines for connecting the components. The first valve 16a may be a three-way valve, and the second valve 16b, the third valve 16c, and the fourth valve 16d may be two-way valves.
The sheath liquid interface 12 is used to connect the sheath liquid container 20, so as to provide sheath liquid for the detection of the sample to be detected. The first filter 14a is connected to the sheath fluid port 12 to perform a preliminary filtration of the sheath fluid entering the sample detection system through the sheath fluid port 12.
Further, the first syringe 15a is connected to the common end of the first valve 16a, the first switching end of the first valve 16a is connected to the first filter 14a, the second switching end is connected to the first end of the three-way joint 17, the first end of the second valve 16b is connected to the second end of the three-way joint 17, and the second filter 14b is connected between the sheath fluid inlet 111 of the fluorescence detection mechanism 11 and the second end of the second valve 16 b.
A first end of the third valve 16c is connected to the third end of the tee 17 and a second end of the third valve 16c is connected to the second injector 15b, such that a connection is established between the first injector 15a and the second injector 15b through the first valve 16a, the tee 17 and the third valve 16 c.
Further, the second syringe 15b is further connected to the sample inlet 112 of the fluorescence detection mechanism 11, a first end of the fourth valve 16d is connected to the sample suction needle 13, and a second end of the fourth valve 16d is connected to the sample inlet 112, so that a connection is established between the sample suction needle 13 and the sample inlet 112.
In the actual operation process, the sheath fluid and the sample to be detected can be respectively extracted by the first syringe 15a and the second syringe 15b, and further pushed to the detection area 113 to perform fluorescence detection on the sample to be detected.
Specifically, when the sheath liquid is sucked, the common end of the first valve 16a is communicated with the first switching end, and under the suction action of the first syringe 15a, the sheath liquid in the sheath liquid container 20 is sucked into the pipeline of the sample detection system through the sheath liquid interface 12, filtered by the first filter 14a, and then further enters the first syringe 15a through the first valve 16 a.
In this embodiment, the first filter 14a is used to perform a preliminary filtering on the sheath fluid entering the sample detection system from the sheath fluid interface 12 to filter out at least a portion of bubbles and foreign particles carried by the sheath fluid itself. In one application scenario, the first filter 14a may be used to filter bubbles and contaminant particles carried in the sheath fluid that are larger than 20 μm in size.
When the sample to be detected is sucked, the first end of the fourth valve 16d is communicated with the second end, the one end of the third valve 16c is disconnected from the second end, and the sample to be detected is sucked to the sample inlet 112 of the fluorescence detection mechanism 11 through the sample suction needle 13 under the suction action of the second syringe 15 b.
It should be noted that, in the present embodiment, the order of the step of sucking the sample to be measured by the first syringe 15a and the step of sucking the sheath fluid by the second syringe 15b is not limited.
It should be further noted that, before performing fluorescence detection, the sample to be detected at the sample inlet 112 needs to be pushed to the sample buffer 115, and when performing detection, the sample to be detected is pushed out from the sample buffer 115 to enter the sheath fluid flow, and enters the detection area 113 under the wrapping of the sheath fluid flow to perform fluorescence detection.
Specifically, both ends of the second valve 16b and the fourth valve 16d are disconnected, both ends of the third valve 16c are connected, the common end of the first valve 16a is connected with the second switching end, and under the pushing action of the first syringe 15a, at least a part of the sheath fluid in the first syringe 15a is pushed out, and the sample to be measured at the sample inlet 112 is pushed into the sample buffer 115 by the second syringe 15 b; then disconnecting both ends of the third valve 16c, connecting both ends of the second valve 16b, and then simultaneously pushing the first syringe 15a and the second syringe 15b, at this time, under the pushing action of the first syringe 15a, the sheath fluid enters the flow chamber 114 from the sheath fluid inlet 111 after being filtered by the second filter 14b, forming a stable sheath fluid flow; the sample to be detected forms a stable sample flow under the pushing action of the second syringe 15b, and enters the sheath fluid flow from the sample buffer area 115, and further passes through the detection area 113 under the wrapping of the sheath fluid flow for fluorescence detection.
In the present embodiment, the second filter 14b is provided at the sheath fluid inlet 111, and filters the sheath fluid pushed into the sheath fluid inlet 111 by the first syringe 15a.
It should be noted that after the sheath fluid enters the sample detection system, bubbles still occur after passing through the reducing pipeline and the valves, and if the bubbles are not filtered, the bubbles still enter the detection area 113 of the fluorescence detection mechanism 11 along with the sheath fluid, thereby affecting the detection result. In this embodiment, the second filter 14b is arranged to filter the sheath liquid again before the sheath liquid enters the fluorescence detection device, so as to filter out bubbles generated when the sheath liquid passes through the reducing pipeline and the valve, thereby further reducing the interference of the background signal.
Specifically, the second filter 14b may be used to filter bubbles and particles having a size greater than 5 μm in the sheath fluid, so as to filter not only newly generated bubbles after the sheath fluid passes through the reducing pipe and the valve, but also further filter bubbles, foreign particles, and the like carried by the sheath fluid itself.
Further, the waste liquid treatment mechanism 18 includes a waste liquid buffer tank 181, a liquid pump 182, and a waste liquid interface 183. Wherein, one end of the waste liquid buffer tank 181 is connected to the waste liquid outlet 116 of the fluorescence detection mechanism 11, the other end is connected to the liquid pump 182, one end of the waste liquid interface 183 is connected to the liquid pump 182, and the other end is used for connecting to the waste liquid container 30.
In the process of sample detection, the generated waste liquid enters the waste liquid buffer tank 181 through the waste liquid outlet 116 and is temporarily stored in the waste liquid buffer tank 181; after the end of the sample test, the liquid suction pump 182 is turned on to suck the waste liquid in the waste liquid buffer tank 181, so that the waste liquid in the waste liquid buffer tank 181 is sucked into the waste liquid container 30 through the waste liquid port 183.
In the above-described aspect, on one hand, the first filter 14a is provided at the sheath fluid port 12, and the sheath fluid entering from the sheath fluid port 12 is filtered to remove at least part of bubbles and foreign particles carried by the sheath fluid itself, thereby reducing the influence of the bubbles, foreign particles, and the like carried by the sheath fluid itself on the detection result; on the other hand, a second filter 14b is further disposed at the sheath fluid inlet 111 of the fluorescence detection mechanism 11 to re-filter the sheath fluid that is about to enter the fluorescence detection mechanism 11, so as to remove at least part of bubbles and impurity particles carried by the sheath fluid itself, and bubbles generated after passing through the reducing pipeline, the valve, and the like, thereby further reducing the influence of the bubbles and impurity particles carried by the sheath fluid on the detection result, and improving the sensitivity and accuracy of the detection result.
Referring to fig. 2, fig. 2 is a schematic structural diagram of an embodiment of the sample analyzer 100 of the present application, which includes a sample detection system 10.
It should be noted that the structure and function of the sample testing system 10 are the same as those of the above-mentioned sample testing system embodiments of the present application, and detailed description thereof is omitted here for brevity.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (7)
1. A sample detection system, comprising:
a sheath fluid port for connecting a sheath fluid container to provide a sheath fluid;
detection mechanism for detect the sample that awaits measuring, detection mechanism is fluorescence detection mechanism, includes:
a sheath fluid inlet connected to the sheath fluid port to receive sheath fluid from the sheath fluid reservoir through the sheath fluid port;
a sample inlet for receiving a sample to be tested;
the detection area is used for receiving the sheath liquid entering from the sheath liquid inlet and a sample to be detected entering from the sample inlet so as to detect the sample to be detected;
a first filter disposed between the sheath fluid port and the sheath fluid inlet for filtering the sheath fluid after passing through the sheath fluid port and before entering the sheath fluid inlet; the first filter is used for filtering bubbles and impurity particles with the size larger than 20 mu m in the sheath fluid;
a first syringe;
a common end of the first valve is connected with the first injector, a first switching end of the first valve is connected with the first filter, and a second switching end of the first valve is connected with the sheath fluid inlet;
a second filter disposed between the second switching end of the first valve and the sheath fluid inlet, for filtering the sheath fluid pushed into the sheath fluid inlet by the first injector; the second filter is used for filtering bubbles and impurity particles with the size larger than 5 mu m in the sheath fluid.
2. The sample testing system according to claim 1, wherein when the sheath fluid is drawn, the common end of the first valve is connected to the first switching end of the first valve, and under the pumping action of the first syringe, the sheath fluid in the sheath fluid container enters from the sheath fluid interface, and enters the first syringe after being filtered by the first filter; when sheath liquid is provided for the sheath liquid inlet, the common end of the first valve is communicated with the second switching end of the first valve, and the sheath liquid in the first injector enters the sheath liquid inlet under the pushing action of the first injector.
3. The sample testing system of claim 1, further comprising:
the sample sucking needle is connected with the sample inlet and is used for sucking a sample to be detected;
and the second injector is connected with the sample inlet and is communicated with the sample sucking needle at the sample inlet, wherein the sample to be detected is sucked into the sample inlet by the sample sucking needle under the suction action of the second injector.
4. The sample detection system of claim 3, further comprising:
the first end of the three-way joint is connected with the second switching end of the first valve;
one end of the second valve is connected with the second end of the three-way joint, and the other end of the second valve is connected with the second filter;
one end of the third valve is connected with the third end of the three-way joint, and the other end of the third valve is connected with the second injector;
one end of the fourth valve is connected with the sample sucking needle, and the other end of the fourth valve is connected with the sample inlet;
after the second syringe sucks the sample to be detected to the sample inlet, the common end of the first valve is communicated with the second switching end, the second valve and the fourth valve are disconnected, the third valve is communicated, and the sample to be detected positioned at the sample inlet is pushed to a sample buffer area between the sample inlet and the detection area under the pushing action of the first syringe; and then disconnecting the third valve, opening the second valve, and simultaneously pushing the first injector and the second injector to respectively push the sample to be detected in the sample buffer area into the detection area, and push sheath liquid in the first injector into the detection area from the sheath liquid inlet after being filtered by the second filter, so as to detect the sample to be detected.
5. The sample detection system of claim 1, wherein the detection mechanism further comprises a waste outlet in communication with the detection zone;
the sample detection system further comprises a waste liquid buffer pool communicated with the waste liquid outlet, and waste liquid generated in the sample detection process enters the waste liquid buffer pool through the waste liquid outlet.
6. The sample detection system of claim 5, further comprising:
the liquid pumping pump is connected with the waste liquid buffer pool and is used for pumping the waste liquid in the waste liquid buffer pool after detection is finished;
and one end of the waste liquid interface is connected with the liquid pump, and the other end of the waste liquid interface is used for being connected with a waste liquid container so as to discharge the waste liquid in the waste liquid buffer pool into the waste liquid container through the liquid pump.
7. A sample analyzer, characterized in that it comprises a sample detection system according to any one of claims 1-6.
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| CN201911193465.2A CN112858661B (en) | 2019-11-28 | 2019-11-28 | Sample detection system and sample analyzer |
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| CN201911193465.2A CN112858661B (en) | 2019-11-28 | 2019-11-28 | Sample detection system and sample analyzer |
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| CN112858661B true CN112858661B (en) | 2022-10-28 |
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| CN113628213B (en) * | 2021-10-12 | 2022-02-18 | 深圳市帝迈生物技术有限公司 | Sample analyzer, method for detecting liquid path thereof, and computer-readable storage medium |
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| CN107167416A (en) * | 2017-05-15 | 2017-09-15 | 中国科学院微生物研究所 | A kind of sorting type flow cytometer |
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| JP2763468B2 (en) * | 1992-12-25 | 1998-06-11 | 株式会社日立製作所 | Classification device for particles in liquids using light scattering |
| CN104458544B (en) * | 2014-12-29 | 2017-04-05 | 中国科学院长春光学精密机械与物理研究所 | A kind of liquid fluid system of flow cytometer |
| CN205209962U (en) * | 2015-12-26 | 2016-05-04 | 嘉兴凯实生物科技有限公司 | STREAMING fluorescence detector's liquid way system |
| CN205826387U (en) * | 2016-06-24 | 2016-12-21 | 上海市农业科学院 | A kind of pretreating device |
| CN106053321A (en) * | 2016-08-10 | 2016-10-26 | 成都索尔恩科技有限公司 | Liquid flow system used for flow cytometry |
| CN209166973U (en) * | 2018-08-31 | 2019-07-26 | 深圳市帝迈生物技术有限公司 | Liquid channel system and device for analyzing samples |
| CN109444028A (en) * | 2018-12-26 | 2019-03-08 | 常州必达科生物科技有限公司 | A kind of particle analyzer and its liquid channel system, discharging of waste liquid method |
| CN110118717A (en) * | 2019-05-28 | 2019-08-13 | 北京唯公医疗技术有限公司 | The liquid channel system and its application method and flow cytometer of flow cytometer |
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| CN107167416A (en) * | 2017-05-15 | 2017-09-15 | 中国科学院微生物研究所 | A kind of sorting type flow cytometer |
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