CN209166973U - Liquid channel system and device for analyzing samples - Google Patents
Liquid channel system and device for analyzing samples Download PDFInfo
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- CN209166973U CN209166973U CN201821428857.3U CN201821428857U CN209166973U CN 209166973 U CN209166973 U CN 209166973U CN 201821428857 U CN201821428857 U CN 201821428857U CN 209166973 U CN209166973 U CN 209166973U
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Abstract
The utility model discloses a kind of liquid channel systems of evenly mixing device, the liquid channel system and device for analyzing samples of device for analyzing samples, which includes: specimen needle；Sheath liquid syringe is connect by pipeline with the specimen needle；Driving mechanism is connect with the sheath liquid syringe, for driving the syringe that the magnetic bead and/or sheath fluid to be mixed being accommodated in reaction cup is sucked into the specimen needle and being expelled to the reaction cup.By the above-mentioned means, the utility model can simplify the structure of evenly mixing device liquid channel system, is conducive to the miniaturization of related device and reduces cost.
Description
Technical field
The utility model relates to the field of medical instrument technology, liquid channel system, sample more particularly to a kind of evenly mixing device
The liquid channel system and device for analyzing samples of analytical equipment.
Background technique
As attention rate of the people to health improves year by year, put forward miniaturization and simple to what medical instrument used
The demand of change.And accurate testing result is obtained, uniformly mixed sample is obtained in medical instrument commonly using rabbling mechanism
This.
In the prior art, the mode that mechanical stirring or bubble mixing are generallyd use in the medical instruments such as device for analyzing samples obtains
The sample that must be uniformly mixed.And mechanical stirring needs to introduce the mechanical structures such as additional stirring rod, bubble blending process then needs
Normal pressure is generated in pipeline, not only structure is complicated and higher cost, is not able to satisfy user demand.
Present inventor has found the liquid channel system of existing evenly mixing device, especially in long-term R&D process
Structure is complicated for liquid channel system in immunoassay device, and higher cost, inconvenient to use.
Utility model content
The utility model is mainly solving the technical problems that provide a kind of liquid channel system of evenly mixing device, device for analyzing samples
Liquid channel system and device for analyzing samples, the structure of evenly mixing device liquid channel system can be simplified, be conducive to the small-sized of related device
Change and reduces cost.
In order to solve the above technical problems, the technical solution that the utility model uses is: providing a kind of evenly mixing device
Liquid channel system.
Wherein, the liquid channel system includes:
Specimen needle；
Sheath liquid syringe is connect by pipeline with the specimen needle；
Driving mechanism is connect with the sheath liquid syringe, for driving the sheath liquid syringe that will be accommodated in reaction cup
Magnetic bead and/or sheath fluid to be mixed be sucked into the specimen needle and be expelled to the reaction cup.
In order to solve the above technical problems, another technical solution that the utility model uses is: providing a kind of sample analysis
The liquid channel system of device.
Wherein, the liquid channel system includes:
The liquid channel system of evenly mixing device, the flow-through assay device being connected to the liquid channel system of the evenly mixing device and control system
System；
Wherein, the liquid channel system of the evenly mixing device includes: specimen needle；Sheath liquid syringe passes through pipeline and the sample
Needle connection；Driving mechanism, for driving the syringe to suck the magnetic bead to be mixed and/or sheath fluid that are accommodated in reaction cup
To the specimen needle and it is expelled to the reaction cup.
In order to solve the above technical problems, another technical solution that the utility model uses is: providing a kind of sample analysis
Device.
Wherein, the device for analyzing samples includes the liquid channel system and control circuit of any evenly mixing device.
The beneficial effects of the utility model are: being in contrast to the prior art, the utility model passes through will be to be mixed
Magnetic bead and/or sheath fluid alternately suck specimen needle and are discharged into reaction cup from the specimen needle, can by the magnetic bead to be mixed with
The sheath fluid is uniformly mixed.Compared with bubble mixes, do not need to be formed in sub- pipeline by the way of compressing mixing it is lasting just
Pressure, it is not only easy to operate, at low cost, be conducive to the simplification of the liquid channel system structure.
Detailed description of the invention
It, below will be to required in embodiment description in order to illustrate more clearly of the technical scheme in the embodiment of the utility model
Attached drawing to be used is briefly described, it should be apparent that, the accompanying drawings in the following description is only some realities of the utility model
Example is applied, it for those of ordinary skill in the art, without creative efforts, can also be according to these attached drawings
Obtain other attached drawings.Wherein:
Fig. 1 is a kind of structural schematic diagram of one embodiment of liquid channel system of evenly mixing device of the utility model；
Fig. 2 is a kind of structural schematic diagram of another embodiment of the liquid channel system of evenly mixing device of the utility model；
Fig. 3 is a kind of structural schematic diagram of one embodiment of liquid channel system of device for analyzing samples；
Fig. 4 is a kind of flow diagram of one embodiment of mixing method of the utility model；
Fig. 5 is a kind of structural schematic diagram of one embodiment of device for analyzing samples of the utility model.
Specific embodiment
The following will be combined with the drawings in the embodiments of the present invention, carries out the technical scheme in the embodiment of the utility model
It clearly and completely describes, it is clear that the described embodiments are only a part of the embodiments of the utility model, rather than all real
Apply example.Based on the embodiments of the present invention, those of ordinary skill in the art are not under the premise of making creative labor
Every other embodiment obtained, fall within the protection scope of the utility model.
Refering to fig. 1, Fig. 1 is a kind of structural schematic diagram of one embodiment of liquid channel system of evenly mixing device of the utility model,
The liquid channel system includes:
Specimen needle Z5；Sheath liquid syringe ZS0 is connect by pipeline with the specimen needle Z5；Driving mechanism QD10, and it is described
The ZS0 connection of sheath liquid syringe, the magnetic bead to be mixed for driving the sheath liquid syringe ZS0 that will be accommodated in reaction cup FB1
And/or sheath fluid is sucked into the specimen needle Z5 and is expelled to the reaction cup FB1.
In the present embodiment, by the way that magnetic bead and/or sheath fluid to be mixed alternately are sucked specimen needle Z5 and from described
Specimen needle Z5 is discharged into reaction cup FB1, can be uniformly mixed the magnetic bead to be mixed with the sheath fluid.Compared with bubble mixes,
It does not need to form lasting normal pressure in sub- pipeline by the way of compressing mixing, it is not only easy to operate, at low cost, be conducive to institute
State the simplification of liquid channel system structure.
In the present embodiment, the driving mechanism QD10 includes linear motor, and the magnetic bead to be mixed has magnetic bead-
Ag-Ab-bioluminescence element interlayer structure.Further, the side wall of the specimen needle Z5 is open at least provided with one, with
So that the sheath fluid washed away, mixed to magnetic bead to be mixed described in being located on the reaction cup FB1 inner wall, help to obtain more
Good mixed effect.
It in one embodiment, is a kind of fluid path of evenly mixing device of the utility model please also refer to Fig. 1 and Fig. 2, Fig. 2
The structural schematic diagram of another embodiment of system, the sheath liquid syringe include the first syringe ZS1, the second syringe ZS2, and
The liquid channel system further includes the first valve LV01, the second valve LV02 and third valve LV03,
The first valve LV01 is connected to the specimen needle Z5, the second valve LV02 respectively with first valve
LV01 is connected to the injection port S11 of first syringe, and the side wall of the third valve LV03 and first syringe are opened
Mouth S12 is connected to the second syringe ZS2；Wherein, the injection port S11 of first syringe is and first syringe
The opening that the piston of ZS1 is oppositely arranged.
In the present embodiment, the second syringe ZS2 and the first syringe ZS1 can be used to accommodate the sheath
Liquid, and the volume of the two is different, e.g., volume of the volume less than the second syringe ZS2 of the first syringe ZS5, correspondingly,
The second syringe ZS2 and the first syringe ZS1 keeps the amplitude of pressure change in pipeline different, second syringe
ZS2 carries out the coarse adjustment of the order of magnitude to the pressure in pipeline, and the first syringe ZS1 specifically counts the pressure in pipeline
The thin tuning of value, can be fast and accurately in pipeline in such a way that big volume syringe and small volume syringe combine
The volume of the sheath fluid conveyed in the size and pipeline of pressure is controlled, and preferable compressing mixed effect is obtained.Further
, the driving mechanism QD10 includes the first driving mechanism QD11 and the second driving mechanism QD12, is injected respectively with described first
Device ZS1 and the second syringe ZS2 are driven, and can be carried out to the size of each self drive by the way of being operated alone
It accurately controls, is also convenient for the maintenance of different driving mechanism and different syringes.
Further, with continued reference to FIG. 2, the liquid channel system further includes the 4th valve LV04 and sheath fluid storage tank 500,
The first interface 041 of 4th valve is connected to the second syringe ZS2, the second interface 042 of the 4th valve with
The sheath fluid storage tank 500 is connected to；Wherein, connection the 4th valve of 041 selectivity of first interface of the 4th valve
Second interface 042 and the 4th valve third interface 043.
During use, the third interface 043 of the first interface 041 of the 4th valve and the 4th valve connects
Logical, the first valve LV01, the second valve LV02 and the third valve LV03 are in the open state, second note
The piston of the piston of emitter ZS2 and the first syringe ZS1 are infused sheath fluid by the specimen needle Z5 under the action of thrust
Enter into the reaction cup FB1 for being equipped with the sample to be tested, and by the sheath fluid in the reaction cup FB1 described in
First syringe ZS1 and/or the second syringe ZS2 sucks sample to be tested acquisition needle Z5 repeatedly, and from described to be measured
It spues to the reaction cup FB1 in sample collection needle Z5 the sample to be tested to be uniformly mixed.By the way of compressing mixing
The sample to be tested is uniformly mixed and does not also need to generate the normal pressure in bubble blending process, knot without stirring for structures such as bars
Structure is simple, is conducive to improve detection efficiency.
In addition, the first interface 041 when the 4th valve is connected to and described with the second interface 042 of the 4th valve
When the piston under tension effect of the second syringe ZS2, the sheath fluid in the sheath fluid storage tank 500 enters second note
In emitter ZS2.
Further, the liquid channel system further includes buffer unit 510, and the buffer unit 510 is arranged in the sheath
On pipeline between liquid storage tank ontology 520 and the 4th valve LV04.The buffer unit is arranged can be to described
In order to solve the above technical problems, another technical solution that the utility model uses is: providing a kind of sample analysis
The liquid channel system of device.
It is a kind of one reality of liquid channel system of device for analyzing samples of the utility model please also refer to Fig. 1, Fig. 2 and Fig. 3, Fig. 3
Apply the structural schematic diagram of mode, wherein the liquid channel system includes: the liquid channel system 01 and the evenly mixing device of evenly mixing device
Liquid channel system 01 be connected to flow-through assay device 02 and control system (not shown)；
Wherein, the liquid channel system 01 of the evenly mixing device includes: specimen needle Z5；Sheath liquid syringe ZS00, by pipeline with
The specimen needle Z5 connection；Driving mechanism QD10, for driving the sheath liquid syringe ZS00 that will be accommodated in reaction cup FB1
Magnetic bead and/or sheath fluid to be mixed is sucked into the specimen needle Z5 and is expelled to the reaction cup FB1.
In one embodiment, the sheath liquid syringe ZS0 includes the first syringe ZS1, the second syringe ZS2, institute
Stating flow-through assay device 02 includes flow chamber 40, and the liquid channel system further includes the first valve LV01, the 5th valve LV05, second
Valve LV02, third valve LV03 and the 4th valve LV04, the sample to be tested flow duct 410 of the flow chamber 40 and described first
Valve LV01 and the second valve LV02 are respectively communicated with, and are set in the sheath fluid circulation of 410 periphery of sample to be tested flow duct
The sidewall opening 421 of pipe 420 is connected to the 5th valve LV05；The first valve LV01 also connects with the specimen needle Z5
It is logical；The 5th valve LV05 is also connected to the third interface 043 of the 4th valve；The second valve LV02 also with it is described
The injection port Z11 of first syringe is connected to；The third valve LV03 respectively with the sidewall opening Z51 of first syringe and
The third interface 043 of 4th valve is connected to；The first interface 041 and the second syringe ZS2 of 4th valve connect
Logical, the second interface 042 of the 4th valve is connected to the sheath fluid storage tank 500；Wherein, the injection of first syringe
Mouth Z11 is the opening being oppositely arranged with the piston of the first syringe ZS1, and the first interface 041 of the 4th valve selects
Property is connected to the third interface 043 of the second interface 042 of the 4th valve, the 4th valve.Further, the liquid
Road system further includes waste liquid storage tank 700, and the waste liquid storage tank 700 is connected to the top opening 422 of the sheath fluid flow duct.
In use, the piston of the first syringe of Xiang Suoshu ZS1 applies pulling force, and the sample to be tested after mixing is sucked
On pipeline between the one valve LV01 and the second valve LV02 and adjust the first valve LV01 and described second
Valve LV02 to off state so that the sample to be tested be enclosed in the first valve LV01 and the second valve LV02 it
Between pipeline on.Apply thrust to the piston of the first syringe ZS1, and opening the second valve LV02 will be described to be checked
Test sample sheet enters the sample to be tested flow duct 410 under the sweeping along of the sheath fluid；Meanwhile the first interface of the 4th valve
041 is connected to the third interface 043 of the 4th valve, and the piston of the second syringe ZS2 is under the action of thrust by institute
Sheath fluid is stated to inject by the sidewall opening 421 of the sheath fluid runner pipe and full of the sheath fluid runner pipe 420.And described to be measured
410 exit of sample flow duct, the sheath fluid full of the sheath fluid runner pipe 420 wrap up the sample to be tested, and in the sheath fluid
At the top opening 422 of flow duct, the magnetic bead of the sample to be tested of sheath fluid parcel form one is forced to pass through under the effect of the pressure
Detection zone.Further, the detection zone is equipped with optical detection apparatus.In the present embodiment, the sample to be tested
The detection process for mixing operation and the sample to be tested is completed by same mechanism, is conducive to the structure and the raising that simplify described device
Detection efficiency.And sample to be tested described in laser excitation is used then to be without the use of reaction solution, testing process can be simplified, reduced simultaneously
Cost.
Further, the liquid channel system further includes negative pressure generating device VAC, the negative pressure generating device VAC setting
On pipeline between the flow chamber 40 and the waste liquid storage tank 700.Specifically, the top opening of the sheath fluid flow duct
422 are connected to the waste liquid storage tank 700, for so that the liquid that the top opening 422 of the sheath fluid flow duct is discharged passes through
6th valve LV06, the negative pressure generating device VAC, the 7th valve LV07 and diaphragm pump P1 are discharged into the waste liquid storage tank 700.
The negative pressure device VAC, which is arranged, to provide power to pipeline, improve the transmission efficiency of liquid in pipeline.
In order to solve the above technical problems, the technical solution that the utility model uses is: providing a kind of mixing method.
It is a kind of flow diagram of one embodiment of mixing method of the utility model please also refer to Fig. 3 and Fig. 4, Fig. 4,
The method includes the steps:
S100, the liquid channel system of evenly mixing device is provided, the liquid channel system includes: specimen needle；Sheath liquid syringe, passes through pipe
Road is connect with the specimen needle；Driving mechanism is connect with the sheath liquid syringe.
In the step S100, the driving mechanism QD10 includes linear motor, and the magnetic bead to be mixed has magnetic
Pearl-Ag-Ab-bioluminescence element interlayer structure.Further, the side wall of the specimen needle Z5 is opened at least provided with one
Mouthful, so that the sheath fluid washes away magnetic bead to be mixed described in being located on the reaction cup FB1 inner wall, mixes, be conducive to
Obtain better mixed effect.
S200, pulling force and thrust are alternately applied to the sheath liquid syringe by the driving mechanism, by reaction cup to
The magnetic bead and/or sheath fluid of mixing are sucked into after the specimen needle is discharged into the reaction cup again.
In the step S200, the first interface 041 of the 4th valve and the third interface 043 of the 4th valve
Connection, the first valve LV13, the second valve LV02 and the third valve LV03 are in the open state, and described second
Sheath fluid is passed through the specimen needle Z5 under the action of thrust by the piston of the piston of syringe ZS2 and the first syringe ZS1
It is injected into the reaction cup FB1 for being equipped with the sample to be tested, and the sheath fluid in the reaction cup FB1 is passed through into institute
State the first syringe ZS1 and/or the second syringe ZS2 and suck sample to be tested acquisition needle Z5 repeatedly, and from it is described to
It surveys in sample collection needle Z5 and spues to the reaction cup FB1 so that the sample to be tested to be uniformly mixed.Wherein, it sucks and is discharged
Number can be determined according to the quantity of magnetic bead to be mixed in the reaction cup and the volume of the sheath fluid, not limited herein
System.
Further, before the step S200 further include: Xiang Suoshu sheath liquid syringe applies thrust, makes to be accommodated in institute
It states the sheath fluid in sheath liquid syringe and is injected by pipeline and the specimen needle and is equipped with described in the magnetic bead to be mixed
In reaction cup.In the present embodiment, using the second interface of the first interface 041 of the 4th valve and the 4th valve
042 is connected to and applies to the piston of the second syringe ZS2 the mode of pulling force, the sheath in the sheath fluid storage tank 500
Liquid enters in the second syringe ZS2.
In order to solve the above technical problems, another technical solution that the utility model uses is: providing a kind of sample analysis
Device.
It is a kind of structural schematic diagram of one embodiment of device for analyzing samples of the utility model with reference to Fig. 5, Fig. 5, wherein institute
State the liquid channel system 10 and control circuit 20 that device for analyzing samples 1 includes any evenly mixing device.In the present embodiment, institute
Control circuit is stated to be connected to the liquid channel system 10.The device for analyzing samples, which can be to be immunized, answers analytical equipment, especially changes
Learn fluoroimmunoassay device.
In conclusion the utility model discloses a kind of liquid channel system of evenly mixing device, sample analysis liquid channel system and
Mixing method, the liquid channel system include: specimen needle；Sheath liquid syringe is connect by pipeline with the specimen needle；Driving mechanism,
It is connect with the sheath liquid syringe, the magnetic bead and/or sheath to be mixed for driving the syringe that will be accommodated in reaction cup
Liquid is sucked into the specimen needle and is expelled to the reaction cup.By the above-mentioned means, the utility model can simplify evenly mixing device
The structure of liquid channel system is conducive to the miniaturization of related device and reduces cost.
The foregoing is merely the embodiments of the present invention, and therefore it does not limit the scope of the patent of the utility model, all
It is equivalent structure or equivalent flow shift made based on the specification and figures of the utility model, directly or indirectly uses
In other related technical areas, it is also included in the patent protection scope of the utility model.
Claims (10)
1. a kind of liquid channel system of evenly mixing device, which is characterized in that the liquid channel system includes:
Specimen needle；
Sheath liquid syringe is connect by pipeline with the specimen needle；
Driving mechanism is connect with the sheath liquid syringe, for drive the sheath liquid syringe by be accommodated in reaction cup to
The magnetic bead and/or sheath fluid of mixing are sucked into the specimen needle and are expelled to the reaction cup.
2. liquid channel system according to claim 1, which is characterized in that the sheath liquid syringe includes the first syringe, the
Two syringes, and the liquid channel system further includes the first valve, the second valve and third valve,
First valve is connected to the specimen needle respectively, second valve respectively with first valve and described first
The injection port of syringe is connected to, and the sidewall opening and second syringe of the third valve and first syringe connect
It is logical；
Wherein, the injection port of first syringe is the opening being oppositely arranged with the piston of first syringe.
3. liquid channel system according to claim 2, which is characterized in that the liquid channel system further includes the 4th valve and sheath fluid
Storage tank,
The first interface of 4th valve is connected to second syringe, the second interface of the 4th valve and the sheath
The connection of liquid storage tank；
Wherein, the second interface of connection the 4th valve of the first interface selectivity of the 4th valve and the 4th valve
Third interface.
4. liquid channel system according to claim 3, which is characterized in that the liquid channel system further includes buffer unit, described
Buffer unit is arranged on the pipeline between the sheath fluid storage tank and the 4th valve.
5. liquid channel system according to claim 3, which is characterized in that the side wall of the specimen needle is opened at least provided with one
Mouthful.
6. a kind of liquid channel system of device for analyzing samples, which is characterized in that the liquid channel system includes: the fluid path system of evenly mixing device
System, the flow-through assay device being connected to the liquid channel system of the evenly mixing device and control system；
Wherein, the liquid channel system of the evenly mixing device includes: specimen needle；Sheath liquid syringe is connected by pipeline and the specimen needle
It connects；Driving mechanism, for driving the sheath liquid syringe to suck the magnetic bead to be mixed and/or sheath fluid that are accommodated in reaction cup
To the specimen needle and it is expelled to the reaction cup.
7. liquid channel system according to claim 6, which is characterized in that the sheath liquid syringe includes the first syringe, the
Two syringes, the flow-through assay device include flow chamber, and the liquid channel system further includes the first valve, the 5th valve, second
Valve, third valve and the 4th valve,
The sample to be tested flow duct of the flow chamber is respectively communicated with first valve and second valve, is set in described
The sidewall opening of the sheath fluid runner pipe of sample to be tested flow duct periphery is connected to the 5th valve；
First valve is also connected to sample to be tested acquisition needle；
Third orifice of 5th valve also with the 4th valve；
Second valve is also connected to the injection port of first syringe；
The third valve third orifice with the sidewall opening of first syringe and the 4th valve respectively；
The first interface of 4th valve is connected to second syringe, the second interface of the 4th valve and the sheath
The connection of liquid storage tank；
Wherein, the injection port of first syringe is the opening being oppositely arranged with the piston of first syringe, described the
The selective third orifice with the 4th valve second interface, the 4th valve of the first interface of four valves.
8. liquid channel system according to claim 7, which is characterized in that the liquid channel system further includes waste liquid storage tank, institute
Waste liquid storage tank is stated to be connected to the flow-through assay device.
9. liquid channel system according to claim 8, which is characterized in that the liquid channel system further includes negative pressure generating device,
The negative pressure generating device is arranged on the pipeline between the flow chamber and the waste liquid storage tank.
10. a kind of device for analyzing samples, which is characterized in that the device for analyzing samples includes described in claim any one of 1-4
The liquid channel system and control circuit of evenly mixing device.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821428857.3U CN209166973U (en) | 2018-08-31 | 2018-08-31 | Liquid channel system and device for analyzing samples |
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| Application Number | Priority Date | Filing Date | Title |
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| CN201821428857.3U CN209166973U (en) | 2018-08-31 | 2018-08-31 | Liquid channel system and device for analyzing samples |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112858661A (en) * | 2019-11-28 | 2021-05-28 | 深圳市帝迈生物技术有限公司 | Sample detection system and sample analyzer |
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2018
- 2018-08-31 CN CN201821428857.3U patent/CN209166973U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112858661A (en) * | 2019-11-28 | 2021-05-28 | 深圳市帝迈生物技术有限公司 | Sample detection system and sample analyzer |
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