CN112839923A - 用于制备肼化合物的合成方法 - Google Patents

用于制备肼化合物的合成方法 Download PDF

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Publication number
CN112839923A
CN112839923A CN201980063929.XA CN201980063929A CN112839923A CN 112839923 A CN112839923 A CN 112839923A CN 201980063929 A CN201980063929 A CN 201980063929A CN 112839923 A CN112839923 A CN 112839923A
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CN
China
Prior art keywords
compound
nitrite
reaction mass
reaction
salt
Prior art date
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Pending
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CN201980063929.XA
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English (en)
Chinese (zh)
Inventor
李云中
姜晓斌
尼克·约翰内斯·朗德
卡门·鲁伊斯
杰罗姆·道弗涅
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Mereo Biopharma 1 Ltd
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Mereo Biopharma 1 Ltd
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Filing date
Publication date
Application filed by Mereo Biopharma 1 Ltd filed Critical Mereo Biopharma 1 Ltd
Publication of CN112839923A publication Critical patent/CN112839923A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C241/00—Preparation of compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C241/02—Preparation of hydrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C07C243/10—Hydrazines
    • C07C243/22—Hydrazines having nitrogen atoms of hydrazine groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201980063929.XA 2018-09-26 2019-09-26 用于制备肼化合物的合成方法 Pending CN112839923A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1815696.8A GB201815696D0 (en) 2018-09-26 2018-09-26 Synthetic method
GB1815696.8 2018-09-26
PCT/GB2019/052719 WO2020065324A1 (en) 2018-09-26 2019-09-26 Synthetic method for the preparation of an hydrazine compound

Publications (1)

Publication Number Publication Date
CN112839923A true CN112839923A (zh) 2021-05-25

Family

ID=64024292

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980063929.XA Pending CN112839923A (zh) 2018-09-26 2019-09-26 用于制备肼化合物的合成方法

Country Status (12)

Country Link
US (1) US20210340108A1 (enExample)
EP (1) EP3856711B1 (enExample)
JP (1) JP2022502415A (enExample)
KR (1) KR20210065111A (enExample)
CN (1) CN112839923A (enExample)
AU (1) AU2019349863A1 (enExample)
CA (1) CA3112998A1 (enExample)
DK (1) DK3856711T3 (enExample)
ES (1) ES2933568T3 (enExample)
GB (1) GB201815696D0 (enExample)
IL (1) IL281637A (enExample)
WO (1) WO2020065324A1 (enExample)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723483A (en) * 1995-04-11 1998-03-03 Sanofi Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them
US20050256113A1 (en) * 2004-05-12 2005-11-17 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
CN1832928A (zh) * 2003-06-26 2006-09-13 诺瓦提斯公司 以5元杂环为基础的p38激酶抑制剂
CN102964270A (zh) * 2012-11-21 2013-03-13 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法
WO2018059533A1 (zh) * 2016-09-29 2018-04-05 南京明德新药研发股份有限公司 p38αMAPK激酶抑制剂及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1326029C (zh) * 2003-07-10 2007-07-11 富士施乐株式会社 印刷装置、印刷指示装置、印刷处理系统及印刷处理方法
US20100292290A1 (en) * 2007-08-02 2010-11-18 Vinayak Gore Novel process to prepare almotriptan
CN101910139B (zh) * 2008-01-10 2012-09-26 北兴化学工业株式会社 苯基三唑啉酮类的制造方法
JP5602387B2 (ja) * 2008-05-02 2014-10-08 キヤノン株式会社 インクジェット用インク、インクジェット記録方法、インクカートリッジ、記録ユニット、及びインクジェット記録装置
JP2016204436A (ja) * 2015-04-17 2016-12-08 日本化薬株式会社 水溶性アゾ化合物又はその塩、インク組成物及び着色体

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723483A (en) * 1995-04-11 1998-03-03 Sanofi Substituted 1-phenyl-3-pyrazolecarboxamides active on neurotensin receptors, their preparation and pharmaceutical compositions containing them
CN1184469A (zh) * 1995-04-11 1998-06-10 萨诺费公司 对神经紧张素受体有活性的1－苯基－3－吡唑甲酰胺类化合物
CN1832928A (zh) * 2003-06-26 2006-09-13 诺瓦提斯公司 以5元杂环为基础的p38激酶抑制剂
US20050256113A1 (en) * 2004-05-12 2005-11-17 Boehringer Ingelheim Pharmaceuticals, Inc. Anti-cytokine heterocyclic compounds
CN102964270A (zh) * 2012-11-21 2013-03-13 合肥星宇化学有限责任公司 一种亚硫酸钠还原重氮盐合成肼的方法
WO2018059533A1 (zh) * 2016-09-29 2018-04-05 南京明德新药研发股份有限公司 p38αMAPK激酶抑制剂及其制备方法和应用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
敬玲玲 等: "４-肼基苯甲酸的合成", 《化学世界》 *

Also Published As

Publication number Publication date
GB201815696D0 (en) 2018-11-07
EP3856711A1 (en) 2021-08-04
IL281637A (en) 2021-05-31
DK3856711T3 (da) 2022-12-12
ES2933568T3 (es) 2023-02-10
JP2022502415A (ja) 2022-01-11
KR20210065111A (ko) 2021-06-03
CA3112998A1 (en) 2020-04-02
EP3856711B1 (en) 2022-11-16
WO2020065324A1 (en) 2020-04-02
US20210340108A1 (en) 2021-11-04
AU2019349863A1 (en) 2021-04-15

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Application publication date: 20210525