CN112823039A - 用于治疗和预防皮肤衰老和光老化的肽 - Google Patents

用于治疗和预防皮肤衰老和光老化的肽 Download PDF

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Publication number
CN112823039A
CN112823039A CN201980066612.1A CN201980066612A CN112823039A CN 112823039 A CN112823039 A CN 112823039A CN 201980066612 A CN201980066612 A CN 201980066612A CN 112823039 A CN112823039 A CN 112823039A
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CN
China
Prior art keywords
peptide
use according
seq
skin
cosmetic composition
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201980066612.1A
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English (en)
Chinese (zh)
Inventor
P·佩莱格里尼
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rome United Chemical Center Co Ltd Abbreviated C4t Co ltd AS
Original Assignee
Rome United Chemical Center Co Ltd Abbreviated C4t Co ltd AS
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Application filed by Rome United Chemical Center Co Ltd Abbreviated C4t Co ltd AS filed Critical Rome United Chemical Center Co Ltd Abbreviated C4t Co ltd AS
Publication of CN112823039A publication Critical patent/CN112823039A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A61K8/042—Gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Psychology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Cosmetics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN201980066612.1A 2018-10-11 2019-10-10 用于治疗和预防皮肤衰老和光老化的肽 Pending CN112823039A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT102018000009384A IT201800009384A1 (it) 2018-10-11 2018-10-11 Peptide for cosmetic application
IT102018000009384 2018-10-11
PCT/IB2019/058641 WO2020075108A1 (en) 2018-10-11 2019-10-10 Peptides for use in treating and preventing skin aging and photo-aging

Publications (1)

Publication Number Publication Date
CN112823039A true CN112823039A (zh) 2021-05-18

Family

ID=65010824

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201980066612.1A Pending CN112823039A (zh) 2018-10-11 2019-10-10 用于治疗和预防皮肤衰老和光老化的肽

Country Status (13)

Country Link
US (1) US20210395305A1 (enExample)
EP (1) EP3863728A1 (enExample)
JP (1) JP2022508676A (enExample)
KR (1) KR20210075098A (enExample)
CN (1) CN112823039A (enExample)
AU (1) AU2019357261A1 (enExample)
BR (1) BR112021006742A2 (enExample)
CA (1) CA3115025A1 (enExample)
EA (1) EA202190888A1 (enExample)
IL (1) IL282064B (enExample)
IT (1) IT201800009384A1 (enExample)
SG (1) SG11202103026YA (enExample)
WO (1) WO2020075108A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000020287A1 (it) * 2020-08-20 2022-02-20 Colosseum Combinatorial Chemistry Centre For Tech Societa A Responsabilita Limitata In Forma Abbrevi Peptide per applicazioni terapeutiche in campo dermatologico
KR102774179B1 (ko) * 2021-09-29 2025-03-04 (주)케어젠 항노화 활성을 갖는 펩타이드 및 이의 용도
KR102726837B1 (ko) * 2021-09-29 2024-11-07 (주)케어젠 항노화 활성을 갖는 펩타이드 및 이의 용도
KR102736940B1 (ko) * 2021-09-30 2024-12-03 (주)케어젠 항노화 활성을 갖는 펩타이드 및 이의 용도
KR102877905B1 (ko) * 2021-09-30 2025-10-30 (주)케어젠 항노화 활성을 갖는 펩타이드 및 이의 용도

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998049308A1 (en) * 1997-04-25 1998-11-05 Genentech, Inc. Ngf variants
WO1999039728A2 (en) * 1998-02-04 1999-08-12 Trustees Of Boston University Methods of inducing hair growth and coloration
US6029114A (en) * 1996-07-31 2000-02-22 Queen's University At Kingston Molecular modelling of neurotrophin-receptor binding
US20140242007A1 (en) * 2011-11-02 2014-08-28 Biomed Venture S.R.L. Societa Unipersonale Topical preparation containing ngf for inducing skin pigmentation and for the treatment of cutaneous dyschromias and vitiligo
CN107286233A (zh) * 2016-04-13 2017-10-24 舒泰神（北京）生物制药股份有限公司 低痛神经生长因子突变体
CN107973848A (zh) * 2017-12-28 2018-05-01 未名生物医药有限公司 一种从混合物中分离天然序列神经生长因子的方法

Family Cites Families (13)

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US6664230B1 (en) * 2000-08-24 2003-12-16 The Regents Of The University Of California Orally administered peptides to ameliorate atherosclerosis
US6919426B2 (en) 2002-09-19 2005-07-19 Amgen Inc. Peptides and related molecules that modulate nerve growth factor activity
MEP31508A (hr) 2003-07-15 2010-10-10 Amgen Inc Humana anti-ngf neutrališuća antitijela kao selektivni ihibitori ngf signalne kaskade
ME00226B (me) 2004-07-15 2011-02-10 Medarex Llc Humana anti-ngf neutrališuća antitijela kao selektivni inhibitori ngf signalne kaskade
EP2144615A4 (en) * 2007-04-06 2011-02-16 Kai Pharmaceuticals Inc METHOD OF USE OF GAMMA INHIBITOR COMPOUNDS FOR PAIN LIFTING
IT1394690B1 (it) * 2008-10-23 2012-07-13 Carli De Metodo di trattamento dermocosmetico della cute mediante applicazione di composizioni contenenti ngf.
KR101520333B1 (ko) * 2008-11-25 2015-05-14 (주)아모레퍼시픽 글루타밀아미도에틸 인돌을 함유하는 항노화용 화장료 조성물
EP2547365A1 (en) 2010-03-17 2013-01-23 Abbott Research B.V. Anti-nerve growth factor (ngf) antibody compositions
IE20100174A1 (en) * 2010-03-25 2012-02-29 Trinity College Dublin Transdermal administration of peptides
FR2961814B1 (fr) * 2010-06-29 2014-09-26 Isp Investments Inc Nouveaux peptides activateurs de la sirtuine 6 et composition cosmetique ou pharmaceutiques les comprenant.
JP6042343B2 (ja) * 2010-11-18 2016-12-14 スティーヴン ヨーリン 毛髪成長のための組成物及び方法
EP3352853B1 (en) * 2015-09-22 2022-09-21 Johnson & Johnson Consumer Inc. Methods for enhancing topical application of a benefit agent
KR20170049299A (ko) * 2015-10-28 2017-05-10 경상대학교산학협력단 성장인자와 사이토카인을 포함하는 조성물

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6029114A (en) * 1996-07-31 2000-02-22 Queen's University At Kingston Molecular modelling of neurotrophin-receptor binding
WO1998049308A1 (en) * 1997-04-25 1998-11-05 Genentech, Inc. Ngf variants
WO1999039728A2 (en) * 1998-02-04 1999-08-12 Trustees Of Boston University Methods of inducing hair growth and coloration
US20140242007A1 (en) * 2011-11-02 2014-08-28 Biomed Venture S.R.L. Societa Unipersonale Topical preparation containing ngf for inducing skin pigmentation and for the treatment of cutaneous dyschromias and vitiligo
CN107286233A (zh) * 2016-04-13 2017-10-24 舒泰神（北京）生物制药股份有限公司 低痛神经生长因子突变体
CN107973848A (zh) * 2017-12-28 2018-05-01 未名生物医药有限公司 一种从混合物中分离天然序列神经生长因子的方法

Non-Patent Citations (2)

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Title
ALESSIO TRAVAGLIA ET AL.: "A Small Linear Peptide Encompassing the NGF N-Terminus Partly Mimics the Biological Activities of the Entire Neurotrophin in PC12 Cells", 《ACS CHEMICAL NEUROSCIENCE》, vol. 6, pages 1379 - 1392 *
FRANCESCA STANZIONE ET AL.: "Role of the Conformational Versatility of the Neurotrophin N-Terminal Regions in Their Recognition by Trk Receptors", 《BIOPHYSICAL JOURNAL》, vol. 99, pages 2273 - 2278, XP055281247, DOI: 10.1016/j.bpj.2010.07.054 *

Also Published As

Publication number Publication date
JP2022508676A (ja) 2022-01-19
EA202190888A1 (ru) 2021-07-07
KR20210075098A (ko) 2021-06-22
EP3863728A1 (en) 2021-08-18
AU2019357261A1 (en) 2021-05-13
BR112021006742A2 (pt) 2021-09-21
IL282064A (en) 2021-05-31
SG11202103026YA (en) 2021-04-29
WO2020075108A1 (en) 2020-04-16
US20210395305A1 (en) 2021-12-23
IL282064B (en) 2022-09-01
IT201800009384A1 (it) 2020-04-11
CA3115025A1 (en) 2020-04-16

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Application publication date: 20210518