CN112805036A - 通过施用抗体-药物缀合物对转移性脑肿瘤的治疗 - Google Patents

通过施用抗体-药物缀合物对转移性脑肿瘤的治疗 Download PDF

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CN112805036A
CN112805036A CN201980064765.2A CN201980064765A CN112805036A CN 112805036 A CN112805036 A CN 112805036A CN 201980064765 A CN201980064765 A CN 201980064765A CN 112805036 A CN112805036 A CN 112805036A
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antibody
amino acid
therapeutic agent
cancer
agent according
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CN201980064765.2A
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杉原洁
石井千晶
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Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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CN201980064765.2A 2018-07-31 2019-07-30 通过施用抗体-药物缀合物对转移性脑肿瘤的治疗 Pending CN112805036A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2018-143372 2018-07-31
JP2018143372 2018-07-31
PCT/JP2019/029765 WO2020027100A1 (ja) 2018-07-31 2019-07-30 抗体－薬物コンジュゲート投与による転移性脳腫瘍の治療

Publications (1)

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CN112805036A true CN112805036A (zh) 2021-05-14

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CN201980064765.2A Pending CN112805036A (zh) 2018-07-31 2019-07-30 通过施用抗体-药物缀合物对转移性脑肿瘤的治疗

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Country Link
US (1) US12220604B2 (https=)
EP (1) EP3831412A4 (https=)
JP (4) JP7473474B2 (https=)
KR (2) KR102894505B1 (https=)
CN (1) CN112805036A (https=)
AU (1) AU2026202582A1 (https=)
BR (1) BR112021001509A2 (https=)
CA (1) CA3108044A1 (https=)
EA (1) EA202190403A1 (https=)
IL (2) IL325918A (https=)
SG (1) SG11202100947SA (https=)
TW (3) TW202537643A (https=)
WO (1) WO2020027100A1 (https=)

Cited By (2)

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TWI862982B (zh) * 2021-09-15 2024-11-21 日商第一三共股份有限公司 抗體–藥物結合物之用途
WO2025002310A1 (zh) * 2023-06-29 2025-01-02 石药集团巨石生物制药有限公司 抗体-药物偶联物及其用途

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AU2018320470B2 (en) * 2017-08-23 2025-04-24 Daiichi Sankyo Company, Limited Antibody-drug conjugate preparation and lyophilization for same
IL288485B2 (en) * 2019-05-29 2026-04-01 Daiichi Sankyo Co Ltd Anti-TROP2 antibody conjugates - a drug for use in cancer treatment
CN115348971A (zh) * 2020-03-30 2022-11-15 国立研究开发法人国立癌症研究中心 抗体-药物缀合物
US20250388669A1 (en) * 2022-01-21 2025-12-25 Jieyi Wang Multi-specific antibodies in uses thereof in avidity receptor crosslinking and immune modulation
CN119255825A (zh) * 2022-05-24 2025-01-03 第一三共株式会社 抗-cdh6抗体-药物缀合物的剂量方案
EP4451526A1 (de) * 2023-04-18 2024-10-23 HSP Hochspannungsgeräte GmbH Verfahren zum fügen von elektroblechlamellen sowie vorrichtung zur durchführung eines solchen verfahrens

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CN104755494A (zh) * 2012-10-11 2015-07-01 第一三共株式会社 抗体-药物偶联物
CN105829346A (zh) * 2014-01-31 2016-08-03 第三共株式会社 抗her2抗体－药物偶联物
CN105849126A (zh) * 2013-12-25 2016-08-10 第三共株式会社 抗trop2抗体－药物偶联物
CN106163559A (zh) * 2014-04-10 2016-11-23 第三共株式会社 抗her3抗体‑药物偶联物
WO2018135501A1 (ja) * 2017-01-17 2018-07-26 第一三共株式会社 抗ｇｐｒ２０抗体及び抗ｇｐｒ２０抗体－薬物コンジュゲート
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