CN112791167A - Preparation process of pain-relieving and stasis-removing hydrogel patch - Google Patents
Preparation process of pain-relieving and stasis-removing hydrogel patch Download PDFInfo
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- CN112791167A CN112791167A CN202110035212.3A CN202110035212A CN112791167A CN 112791167 A CN112791167 A CN 112791167A CN 202110035212 A CN202110035212 A CN 202110035212A CN 112791167 A CN112791167 A CN 112791167A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention discloses a preparation process of a pain-relieving and stasis-removing hydrogel patch, which comprises the following steps: firstly, uniformly mixing powdery medicinal material raw materials to obtain mixed powder; secondly, carrying out alcohol extraction treatment on the mixed powder extract to obtain a mixed extracting solution; thirdly, concentrating the mixed extracting solution to obtain a concentrated solution; step four, uniformly mixing the concentrated solution and the hydrogel to obtain mixed hydrogel; step five, uniformly coating the mixed hydrogel on a patch, pasting glassine paper on the mixed hydrogel, and cutting and slicing to obtain a finished product; in the first step, the powdery medicinal material comprises the following components in parts by weight: 95-105 parts of curcuma zedoary; 98-110 parts of turmeric; 95-105 parts of phellodendron amurense; 48-52 parts of frankincense; 45-55 parts of myrrh; 110 portions and 130 portions of angelica dahurica; 95-105 parts of garden balsam seed; 98-102 parts of semen momordicae; 95-105 parts of muskroot-like semiaquilegia root. The invention has the characteristics of improving the use comfort and improving the treatment effect.
Description
Technical Field
The invention relates to an analgesic stasis-removing plaster, in particular to a preparation process of an analgesic stasis-removing hydrogel plaster.
Background
When a human body is subjected to external violent impact, injury, swelling and pain of limbs can be caused. For traumatic swelling and pain, the treatment mode mainly comprises activating blood circulation, removing stasis, relieving swelling and pain. The medicine for treatment is mainly divided into oral medicine and external plaster. At present, the externally applied plaster is mainly a rubber type plaster, which has poor compatibility with skin, general air permeability, easy skin allergy and poor use comfort; moreover, the rubber-type plaster has a low drug loading (less than 2%), which results in an unsatisfactory treatment effect and a long treatment period. Therefore, the prior art has the problems of poor use comfort and poor treatment effect.
Disclosure of Invention
The invention aims to provide a preparation process of a pain-relieving and stasis-removing hydrogel patch. The invention has the characteristics of improving the use comfort and improving the treatment effect.
The technical scheme of the invention is as follows: a preparation process of a hydrogel patch for relieving pain and eliminating stagnation comprises the following steps:
firstly, uniformly mixing powdery medicinal material raw materials to obtain mixed powder;
secondly, carrying out alcohol extraction treatment on the mixed powder extract to obtain a mixed extracting solution;
thirdly, concentrating the mixed extracting solution to obtain a concentrated solution;
step four, uniformly mixing the concentrated solution and the hydrogel to obtain mixed hydrogel;
step five, uniformly coating the mixed hydrogel on a patch, pasting glassine paper on the mixed hydrogel, and cutting and slicing to obtain a finished product;
in the first step, the powdery medicinal material comprises the following components in parts by weight: 95-105 parts of curcuma zedoary; 98-110 parts of turmeric; 95-105 parts of phellodendron amurense; 48-52 parts of frankincense; 45-55 parts of myrrh; 110 portions and 130 portions of angelica dahurica; 95-105 parts of garden balsam seed; 98-102 parts of semen momordicae; 95-105 parts of muskroot-like semiaquilegia root.
In the preparation process of the hydrogel plaster for relieving pain and removing stasis, the powdery medicinal materials comprise the following components in parts by weight: zedoary, 100 parts; 100 parts of turmeric; 100 parts of phellodendron amurense; 50 parts of frankincense; 50 parts of myrrh; 120 parts of radix angelicae; garden balsam seed 100 parts; 100 parts of semen momordicae; 100 parts of muskroot-like semiaquilegia root.
In the preparation process of the hydrogel patch for relieving pain and removing stasis, the mesh number of the powdery medicinal material is less than 80 meshes.
In the preparation process of the hydrogel plaster for relieving pain and dissipating binds, the temperature of the concentration tank is 95 ℃ and the negative pressure is-0.06 Mpa during the concentration treatment in the step C.
In the preparation process of the hydrogel plaster for relieving pain and dissipating binds, the specific alcohol extraction process is as follows: uniformly mixing the wine vinegar solution and the mixed powder at the temperature of 30-33 ℃ to obtain a mixed solution, wherein the mixing ratio of the wine vinegar solution to the mixed powder is 2: 1; then, raising the temperature of the mixed solution to 40-42 ℃ at a linear temperature rise speed of 0.1 ℃/min, and preserving the temperature for 30 min; and finally, reducing the temperature of the mixed solution to 16-20 ℃ at a cooling speed of 2 ℃/min, and preserving the temperature for 10-15min to obtain a mixed extracting solution.
Compared with the prior art, the hydrogel is effectively combined with the medicine with the functions of relieving pain and removing blood stasis, so that the medicine-loading rate can be greatly improved to 15-65%, and meanwhile, the hydrogel has good moisture retention property, can quickly hydrate skin keratinocytes, and is beneficial to transdermal absorption of the medicine (has the advantage of quick response); the present invention strictly limits the components and the proportion of the pain-relieving medicine to ensure that the medicine can be fully matched with the hydrogel, thereby greatly improving the treatment effect and shortening the treatment period. Meanwhile, hydrogel is used as a drug-carrying matrix, so that the hydrogel has excellent biocompatibility, affinity, air permeability and sweat resistance with skin, is not easy to cause allergy and is comfortable to use; no residue is left after use, and the clothes are not polluted; has no irritation and sensitization to skin, and can be repeatedly removed and attached without affecting curative effect. In conclusion, the invention has the characteristics of improving the use comfort and improving the treatment effect.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention.
Example 1. A preparation process of a hydrogel patch for relieving pain and eliminating stagnation comprises the following steps:
firstly, uniformly mixing powdery medicinal material raw materials to obtain mixed powder;
secondly, carrying out alcohol extraction treatment on the mixed powder extract to obtain a mixed extracting solution;
thirdly, concentrating the mixed extracting solution to obtain a concentrated solution;
step four, uniformly mixing the concentrated solution and the hydrogel to obtain mixed hydrogel;
step five, uniformly coating the mixed hydrogel on a patch, pasting glassine paper on the mixed hydrogel, and cutting and slicing to obtain a finished product;
in the first step, the powdery medicinal material comprises the following components in parts by weight: 95-105 parts of curcuma zedoary; 98-110 parts of turmeric; 95-105 parts of phellodendron amurense; 48-52 parts of frankincense; 45-55 parts of myrrh; 110 portions and 130 portions of angelica dahurica; 95-105 parts of garden balsam seed; 98-102 parts of semen momordicae; 95-105 parts of muskroot-like semiaquilegia root.
The mesh number of the powdery medicinal material is less than 80 meshes.
And C, during the concentration treatment in the step C, the temperature of the concentration tank is 95 ℃, and the negative pressure is-0.06 MPa.
The specific process of alcohol extraction is as follows: uniformly mixing the wine vinegar solution and the mixed powder at the temperature of 30-33 ℃ to obtain a mixed solution, wherein the mixing ratio of the wine vinegar solution to the mixed powder is 2: 1; then, raising the temperature of the mixed solution to 40-42 ℃ at a linear temperature rise speed of 0.1 ℃/min, and preserving the temperature for 30 min; and finally, reducing the temperature of the mixed solution to 16-20 ℃ at a cooling speed of 2 ℃/min, and preserving the temperature for 10-15min to obtain a mixed extracting solution.
The hydrogel adopts a water-soluble macromolecular gel matrix.
Example 2. A preparation process of the pain-relieving and stasis-removing hydrogel patch comprises the following steps:
firstly, uniformly mixing powdery medicinal material raw materials to obtain mixed powder;
secondly, carrying out alcohol extraction treatment on the mixed powder extract to obtain a mixed extracting solution;
thirdly, concentrating the mixed extracting solution to obtain a concentrated solution;
step four, uniformly mixing the concentrated solution and the hydrogel to obtain mixed hydrogel;
step five, uniformly coating the mixed hydrogel on a patch, pasting glassine paper on the mixed hydrogel, and cutting and slicing to obtain a finished product;
in the first step, the powdery medicinal material comprises the following components in parts by weight: zedoary, 100 parts; 100 parts of turmeric; 100 parts of phellodendron amurense; 50 parts of frankincense; 50 parts of myrrh; 120 parts of radix angelicae; garden balsam seed 100 parts; 100 parts of semen momordicae; 100 parts of muskroot-like semiaquilegia root.
The mesh number of the powdery medicinal material is 60 meshes.
And C, during the concentration treatment in the step C, the temperature of the concentration tank is 95 ℃, and the negative pressure is-0.06 MPa.
The specific process of alcohol extraction is as follows: uniformly mixing the wine vinegar solution and the mixed powder at the temperature of 32 ℃ to obtain a mixed solution, wherein the mixing ratio of the wine vinegar solution to the mixed powder is 2: 1; then, raising the temperature of the mixed solution to 41 ℃ at a linear temperature rise speed of 0.1 ℃/min, and preserving the temperature for 30 min; and finally, reducing the temperature of the mixed solution to 18 ℃ at a cooling speed of 2 ℃/min, and preserving the temperature for 13min to obtain a mixed extracting solution.
The hydrogel adopts a water-soluble macromolecular gel matrix.
Claims (5)
1. A preparation process of the pain-relieving and stasis-removing hydrogel patch is characterized by comprising the following steps:
firstly, uniformly mixing powdery medicinal material raw materials to obtain mixed powder;
secondly, carrying out alcohol extraction treatment on the mixed powder extract to obtain a mixed extracting solution;
thirdly, concentrating the mixed extracting solution to obtain a concentrated solution;
step four, uniformly mixing the concentrated solution and the hydrogel to obtain mixed hydrogel;
step five, uniformly coating the mixed hydrogel on a patch, pasting glassine paper on the mixed hydrogel, and cutting and slicing to obtain a finished product;
in the first step, the powdery medicinal material comprises the following components in parts by weight: 95-105 parts of curcuma zedoary; 98-110 parts of turmeric; 95-105 parts of phellodendron amurense; 48-52 parts of frankincense; 45-55 parts of myrrh; 110 portions and 130 portions of angelica dahurica; 95-105 parts of garden balsam seed; 98-102 parts of semen momordicae; 95-105 parts of muskroot-like semiaquilegia root.
2. The preparation process of the hydrogel plaster for relieving pain and dissipating binds as claimed in claim 1, wherein the powdered medicinal materials comprise the following components in parts by weight: zedoary, 100 parts; 100 parts of turmeric; 100 parts of phellodendron amurense; 50 parts of frankincense; 50 parts of myrrh; 120 parts of radix angelicae; garden balsam seed 100 parts; 100 parts of semen momordicae; 100 parts of muskroot-like semiaquilegia root.
3. The preparation process of the hydrogel patch for relieving pain and dissipating binds as claimed in claim 1 or 2, wherein: the mesh number of the powdery medicinal material is less than 80 meshes.
4. The preparation process of the hydrogel plaster for relieving pain and dissipating binds as claimed in claim 1, wherein: and C, during the concentration treatment in the step C, the temperature of the concentration tank is 95 ℃, and the negative pressure is-0.06 MPa.
5. The preparation process of the hydrogel plaster for relieving pain and dissipating binds according to claim 1, which is characterized in that the alcohol extraction process comprises the following steps: uniformly mixing the wine vinegar solution and the mixed powder at the temperature of 30-33 ℃ to obtain a mixed solution, wherein the mixing ratio of the wine vinegar solution to the mixed powder is 2: 1; then, raising the temperature of the mixed solution to 40-42 ℃ at a linear temperature rise speed of 0.1 ℃/min, and preserving the temperature for 30 min; and finally, reducing the temperature of the mixed solution to 16-20 ℃ at a cooling speed of 2 ℃/min, and preserving the temperature for 10-15min to obtain a mixed extracting solution.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110035212.3A CN112791167A (en) | 2021-01-12 | 2021-01-12 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110035212.3A CN112791167A (en) | 2021-01-12 | 2021-01-12 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
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| CN112791167A true CN112791167A (en) | 2021-05-14 |
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| CN202110035212.3A Pending CN112791167A (en) | 2021-01-12 | 2021-01-12 | Preparation process of pain-relieving and stasis-removing hydrogel patch |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593599A (en) * | 2004-06-23 | 2005-03-16 | 齐齐哈尔鹤翔制药有限责任公司 | Ointment for dispersing breast nodules and preparation method thereof |
| CN101147798A (en) * | 2007-08-28 | 2008-03-26 | 武修春 | Galactophore paste and its preparing process |
| CN109260426A (en) * | 2018-12-11 | 2019-01-25 | 周金 | A kind of disease eliminating powder junction pain-stopping external use Chinese medicine and its preparation method and application |
-
2021
- 2021-01-12 CN CN202110035212.3A patent/CN112791167A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1593599A (en) * | 2004-06-23 | 2005-03-16 | 齐齐哈尔鹤翔制药有限责任公司 | Ointment for dispersing breast nodules and preparation method thereof |
| CN101147798A (en) * | 2007-08-28 | 2008-03-26 | 武修春 | Galactophore paste and its preparing process |
| CN109260426A (en) * | 2018-12-11 | 2019-01-25 | 周金 | A kind of disease eliminating powder junction pain-stopping external use Chinese medicine and its preparation method and application |
Non-Patent Citations (3)
| Title |
|---|
| 徐建光等: "高效液相色谱法测定散结乳癖贴膏中姜黄素的含量 ", 《齐齐哈尔医学院学报》 * |
| 杨小红等: "消结膏外敷治疗肝郁痰凝型乳腺增生病疗效观察", 《山西中医》 * |
| 裴晓华等: "中药敷贴治疗乳腺增生病的临床研究", 《北京中医药大学学报(中医临床版)》 * |
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Application publication date: 20210514 |